{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:20:49Z","timestamp":1782969649312,"version":"3.54.5"},"reference-count":23,"publisher":"Royal Society of Chemistry (RSC)","issue":"42","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"am","delay-in-days":479,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32172899"],"award-info":[{"award-number":["32172899"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MH108"],"award-info":[{"award-number":["ZR2021MH108"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Commun."],"abstract":"<jats:p>In this study, we propose a novel therapy system composed of UiO-66 nanoparticles, which contain quercetin combined with chloroquine (UQCNP), to achieve dual autophagy-ubiquitination blockade.<\/jats:p>","DOI":"10.1039\/d4cc00122b","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T04:40:38Z","timestamp":1713933638000},"page":"5514-5517","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quercetin@UiO-66 NPs and chloroquine in combined tumor therapy by dual autophagy-ubiquitination system blockade"],"prefix":"10.1039","volume":"60","author":[{"given":"Yinzhu","family":"Chen","sequence":"first","affiliation":[{"name":"China Agriculture University, College of Veterinary Medicine, Yuanmingyuan West Road No. 2, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7229-252X","authenticated-orcid":false,"given":"Feiyi","family":"Yan","sequence":"additional","affiliation":[{"name":"China Agriculture University, College of Veterinary Medicine, Yuanmingyuan West Road No. 2, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Yang","sequence":"additional","affiliation":[{"name":"China Agriculture University, College of Veterinary Medicine, Yuanmingyuan West Road No. 2, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lipeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong Chemical Design Institute, No. 80 Lishan Road, Lixia District, Jinan City, Shandong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuepeng","family":"Teng","sequence":"additional","affiliation":[{"name":"Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaiyu","family":"Wang","sequence":"additional","affiliation":[{"name":"China Agriculture University, College of Veterinary Medicine, Yuanmingyuan West Road No. 2, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7333-9353","authenticated-orcid":false,"given":"Tianlong","family":"Liu","sequence":"additional","affiliation":[{"name":"China Agriculture University, College of Veterinary Medicine, Yuanmingyuan West Road No. 2, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D4CC00122B\/cit1\/1","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1517\/14728222.2013.815728","volume":"17","author":"Shen","year":"2013","journal-title":"Expert Opin. Ther. Targets"},{"key":"D4CC00122B\/cit2\/1","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1007\/s12272-020-01281-8","volume":"43","author":"Park","year":"2020","journal-title":"Arch. Pharmacal Res."},{"key":"D4CC00122B\/cit3\/1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/onc.2009.343","volume":"29","author":"Zhu","year":"2010","journal-title":"Oncogene"},{"key":"D4CC00122B\/cit4\/1","doi-asserted-by":"crossref","first-page":"892450","DOI":"10.3389\/fcell.2022.892450","author":"Noh","year":"2022","journal-title":"Front. Cell. Dev. Biol."},{"key":"D4CC00122B\/cit5\/1","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1007\/s12272-020-01281-8","volume":"43","author":"Park","year":"2020","journal-title":"Arch. Pharmacal Res."},{"key":"D4CC00122B\/cit6\/1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00280-014-2451-7","volume":"74","author":"Min","year":"2014","journal-title":"Cancer Chemother. Pharmacol."},{"key":"D4CC00122B\/cit7\/1","doi-asserted-by":"crossref","first-page":"6664","DOI":"10.1039\/D1FO00851J","volume":"12","author":"Zang","year":"2021","journal-title":"Food Funct."},{"key":"D4CC00122B\/cit8\/1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jconrel.2016.06.017","volume":"235","author":"Bhattacharjee","year":"2016","journal-title":"J. Controlled Release"},{"key":"D4CC00122B\/cit9\/1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00418-011-0869-0","volume":"137","author":"Klappan","year":"2012","journal-title":"Histochem. Cell Biol."},{"issue":"118","key":"D4CC00122B\/cit10\/1","doi-asserted-by":"crossref","first-page":"97547","DOI":"10.1039\/C5RA18896B","volume":"5","author":"Mukhopadhyay","year":"2015","journal-title":"RSC Adv."},{"issue":"1","key":"D4CC00122B\/cit11\/1","doi-asserted-by":"crossref","first-page":"11701","DOI":"10.1038\/s41598-021-90754-x","volume":"11","author":"Semlali","year":"2021","journal-title":"Sci. Rep."},{"issue":"4","key":"D4CC00122B\/cit12\/1","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/cctc.201701825","volume":"10","author":"Oozeerally","year":"2018","journal-title":"ChemCatChem"},{"key":"D4CC00122B\/cit13\/1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ultramic.2017.07.001","volume":"182","author":"Eaton","year":"2017","journal-title":"Ultramicroscopy"},{"key":"D4CC00122B\/cit14\/1","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s11947-013-1160-2","volume":"7","author":"Souza","year":"2014","journal-title":"Food Bioprocess Technol."},{"key":"D4CC00122B\/cit15\/1","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1007\/s10876-020-01913-5","volume":"32","author":"Selvaraj","year":"2021","journal-title":"J. Cluster Sci."},{"key":"D4CC00122B\/cit16\/1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3390\/cryst8060250","volume":"8","author":"Zhan","year":"2018","journal-title":"Crystals"},{"key":"D4CC00122B\/cit17\/1","doi-asserted-by":"crossref","first-page":"129193","DOI":"10.1016\/j.cej.2021.129193","volume":"416","author":"Guo","year":"2021","journal-title":"Chem. Eng. J."},{"key":"D4CC00122B\/cit18\/1","doi-asserted-by":"crossref","first-page":"e4221","DOI":"10.1002\/aoc.4221","volume":"32","author":"Molavi","year":"2018","journal-title":"Appl. Organomet. Chem."},{"key":"D4CC00122B\/cit19\/1","doi-asserted-by":"crossref","first-page":"7940","DOI":"10.1021\/acs.analchem.0c01335","volume":"92","author":"Geng","year":"2020","journal-title":"Anal. Chem."},{"key":"D4CC00122B\/cit20\/1","first-page":"2013","author":"Kim","year":"2013","journal-title":"Oxid. Med. Cell.\nLongevity"},{"key":"D4CC00122B\/cit21\/1","doi-asserted-by":"crossref","first-page":"468","DOI":"10.2174\/1568009618666181016164920","volume":"19","author":"Ning","year":"2019","journal-title":"Curr. Cancer Drug Targets"},{"key":"D4CC00122B\/cit22\/1","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/15548627.2018.1474314","volume":"14","author":"Mauthe","year":"2018","journal-title":"Autophagy"},{"key":"D4CC00122B\/cit23\/1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.14348\/molcells.2017.0115","volume":"40","author":"Ji","year":"2017","journal-title":"Mol. Cells"}],"container-title":["Chemical Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/CC\/D4CC00122B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:05:01Z","timestamp":1782965101000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cc\/article\/60\/42\/5514-5517\/838512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":23,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2024,5,21]]}},"URL":"https:\/\/doi.org\/10.1039\/d4cc00122b","relation":{},"ISSN":["1359-7345","1364-548X"],"issn-type":[{"value":"1359-7345","type":"print"},{"value":"1364-548X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}