{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:20:12Z","timestamp":1787062812338,"version":"build-2736575974"},"reference-count":28,"publisher":"Royal Society of Chemistry (RSC)","issue":"55","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":163,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100018959","name":"EPSRC Centre for Doctoral Training in Technology Enhanced Chemical Synthesis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018959","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["0170-00001B"],"award-info":[{"award-number":["0170-00001B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Commun."],"abstract":"<jats:p>We describe a versatile and tuneable thiol responsive linker system using thiovinylketones, that relies on the conjugate addition\u2013elimination mechanism of Michael acceptors for the traceless release of therapeutics.<\/jats:p>","DOI":"10.1039\/d4cc01558d","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T03:41:15Z","timestamp":1718163675000},"page":"7025-7028","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs"],"prefix":"10.1039","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9833-6703","authenticated-orcid":false,"given":"Raoul","family":"Walther","sequence":"first","affiliation":[{"name":"Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3973-6026","authenticated-orcid":false,"given":"Mahri","family":"Park","sequence":"additional","affiliation":[{"name":"Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4907-058X","authenticated-orcid":false,"given":"Nicola","family":"Ashman","sequence":"additional","affiliation":[{"name":"Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Welch","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Cambridge, CB2 1QW Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3643-0080","authenticated-orcid":false,"given":"Jason S.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Cancer Research UK Cambridge Institute, Robinson Way, CB2 0RE Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7355-2824","authenticated-orcid":false,"given":"David R.","family":"Spring","sequence":"additional","affiliation":[{"name":"Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D4CC01558D\/cit1\/1","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1039\/C8CS00676H","volume":"48","author":"Bargh","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"D4CC01558D\/cit2\/1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.addr.2017.06.013","volume":"118","author":"Walther","year":"2017","journal-title":"Adv. Drug Delivery Rev."},{"key":"D4CC01558D\/cit3\/1","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1002\/anie.201106334","volume":"51","author":"Wirth","year":"2012","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4CC01558D\/cit4\/1","doi-asserted-by":"crossref","first-page":"6271","DOI":"10.1021\/ja901304n","volume":"131","author":"Staub","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"D4CC01558D\/cit5\/1","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1128\/AAC.04552-14","volume":"59","author":"Kocaoglu","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"D4CC01558D\/cit6\/1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/1074-5521(95)90120-5","volume":"2","author":"Tomasz","year":"1995","journal-title":"Chem. Biol."},{"key":"D4CC01558D\/cit7\/1","doi-asserted-by":"crossref","first-page":"11918","DOI":"10.1002\/anie.201907520","volume":"58","author":"W\u00f8rmer","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4CC01558D\/cit8\/1","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1002\/anie.201814073","volume":"58","author":"Hansen","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4CC01558D\/cit9\/1","doi-asserted-by":"crossref","first-page":"11783","DOI":"10.1002\/anie.201405924","volume":"53","author":"Asano","year":"2014","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4CC01558D\/cit10\/1","doi-asserted-by":"crossref","first-page":"18522","DOI":"10.1021\/jacs.0c07490","volume":"142","author":"Tokunaga","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"D4CC01558D\/cit11\/1","doi-asserted-by":"crossref","first-page":"20095","DOI":"10.1021\/jacs.1c06167","volume":"143","author":"Reddi","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"D4CC01558D\/cit12\/1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/anie.201707972","volume":"57","author":"Matsuo","year":"2018","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4CC01558D\/cit13\/1","doi-asserted-by":"crossref","first-page":"17205","DOI":"10.1016\/S0021-9258(19)77815-6","volume":"263","author":"Meister","year":"1988","journal-title":"J. Biol. Chem."},{"key":"D4CC01558D\/cit14\/1","doi-asserted-by":"crossref","first-page":"20095","DOI":"10.1021\/jacs.1c06167","volume":"143","author":"Reddi","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"D4CC01558D\/cit15\/1","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1039\/C9SC05841A","volume":"11","author":"Zhuang","year":"2020","journal-title":"Chem. Sci."},{"key":"D4CC01558D\/cit16\/1","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1021\/jacs.9b12122","volume":"142","author":"Sun","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"D4CC01558D\/cit17\/1","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/nchem.2601","volume":"8","author":"Diehl","year":"2016","journal-title":"Nat. Chem."},{"key":"D4CC01558D\/cit18\/1","doi-asserted-by":"crossref","first-page":"12324","DOI":"10.1021\/acs.jmedchem.3c00845","volume":"66","author":"Morese","year":"2023","journal-title":"J. Med. Chem."},{"key":"D4CC01558D\/cit19\/1","doi-asserted-by":"publisher","DOI":"10.26434\/chemrxiv-2024-kd6sg","volume-title":"ChemRxiv","author":"Eelkema","year":"2024","unstructured":"R.Eelkema ,  B.Klemm ,  M.Tavasso ,  I.Piergentili ,  M.Satijn ,  T.Breve  and  B.Pouyan ,  ChemRxiv ,  2024 , preprint 10.26434\/chemrxiv-2024-kd6sg"},{"key":"D4CC01558D\/cit20\/1","doi-asserted-by":"crossref","first-page":"11174","DOI":"10.1039\/D3CC02126B","volume":"59","author":"Spitzbarth","year":"2023","journal-title":"Chem. Commun."},{"key":"D4CC01558D\/cit21\/1","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1002\/chem.200800669","volume":"15","author":"Shiu","year":"2009","journal-title":"Chem. \u2013 Eur. J."},{"key":"D4CC01558D\/cit22\/1","doi-asserted-by":"crossref","first-page":"4714","DOI":"10.1021\/ol301781u","volume":"14","author":"Joshi","year":"2012","journal-title":"Org. Lett."},{"key":"D4CC01558D\/cit23\/1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1039\/C6SC01831A","volume":"8","author":"Pillow","year":"2017","journal-title":"Chem. Sci."},{"key":"D4CC01558D\/cit24\/1","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1002\/anie.201310709","volume":"53","author":"Krall","year":"2014","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4CC01558D\/cit25\/1","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/anie.201106527","volume":"51","author":"Bernardes","year":"2012","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4CC01558D\/cit26\/1","doi-asserted-by":"crossref","first-page":"eaaz6606","DOI":"10.1126\/scitranslmed.aaz6606","volume":"12","author":"Lu","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"D4CC01558D\/cit27\/1","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1021\/acschembio.7b00424","volume":"12","author":"Allimuthu","year":"2017","journal-title":"ACS Chem. Biol."},{"key":"D4CC01558D\/cit28\/1","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1039\/C8SC04645J","volume":"10","author":"Walsh","year":"2019","journal-title":"Chem. Sci."}],"container-title":["Chemical Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/CC\/D4CC01558D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:13:39Z","timestamp":1782875619000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cc\/article\/60\/55\/7025-7028\/839017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":28,"journal-issue":{"issue":"55","published-print":{"date-parts":[[2024,7,4]]}},"URL":"https:\/\/doi.org\/10.1039\/d4cc01558d","relation":{},"ISSN":["1359-7345","1364-548X"],"issn-type":[{"value":"1359-7345","type":"print"},{"value":"1364-548X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}