{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:21:34Z","timestamp":1792066894322,"version":"4.4.0"},"reference-count":13,"publisher":"Royal Society of Chemistry (RSC)","issue":"16","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"am","delay-in-days":391,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2023YFB3810400"],"award-info":[{"award-number":["2023YFB3810400"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52473328"],"award-info":[{"award-number":["52473328"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52303369"],"award-info":[{"award-number":["52303369"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["22hytd12"],"award-info":[{"award-number":["22hytd12"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Commun."],"abstract":"<jats:p>ROS-responsive PBAE nanoparticles was designed to target splenic APCs, enhance mRNA expression, and induce a Th1-skewed immune response, advancing mRNA vaccine efficacy.<\/jats:p>","DOI":"10.1039\/d4cc06064d","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T02:02:24Z","timestamp":1737943344000},"page":"3371-3374","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["ROS-responsive poly(\u03b2-amino ester) nanoparticles enable targeted delivery of mRNA vaccine to splenic antigen-presenting cells"],"prefix":"10.1039","volume":"61","author":[{"given":"Meng","family":"Jiang","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China"},{"name":"Guangzhou Key Laboratory of Medical Nanomaterials, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China"},{"name":"ChinaNanhai Translational Innovation Center of Precision Immunology, Sun Yat-Sen Memorial Hospital, Foshan 528200, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjian","family":"Yan","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China"},{"name":"Department of Stomatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zeng","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China"},{"name":"Guangzhou Key Laboratory of Medical Nanomaterials, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China"},{"name":"ChinaNanhai Translational Innovation Center of Precision Immunology, Sun Yat-Sen Memorial Hospital, Foshan 528200, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingseng","family":"Tang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China"},{"name":"Guangzhou Key Laboratory of Medical Nanomaterials, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China"},{"name":"ChinaNanhai Translational Innovation Center of Precision Immunology, Sun Yat-Sen Memorial Hospital, Foshan 528200, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China"},{"name":"Guangzhou Key Laboratory of Medical Nanomaterials, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China"},{"name":"ChinaNanhai Translational Innovation Center of Precision Immunology, Sun Yat-Sen Memorial Hospital, Foshan 528200, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baihua","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China"},{"name":"Guangzhou Key Laboratory of Medical Nanomaterials, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China"},{"name":"ChinaNanhai Translational Innovation Center of Precision Immunology, Sun Yat-Sen Memorial Hospital, Foshan 528200, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Qiu","sequence":"additional","affiliation":[{"name":"Human Phenome Institute, Fudan University, Shanghai 201203, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3386-5321","authenticated-orcid":false,"given":"Jinjin","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China"},{"name":"Guangzhou Key Laboratory of Medical Nanomaterials, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China"},{"name":"ChinaNanhai Translational Innovation Center of Precision Immunology, Sun Yat-Sen Memorial Hospital, Foshan 528200, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D4CC06064D\/cit1\/1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nature18300","volume":"534","author":"Kranz","year":"2016","journal-title":"Nature"},{"key":"D4CC06064D\/cit2\/1","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1093\/cid\/ciab707","volume":"74","author":"Li","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"D4CC06064D\/cit3\/1","doi-asserted-by":"crossref","first-page":"e2301606120","DOI":"10.1073\/pnas.2301606120","volume":"120","author":"Ben-Akiva","year":"2023","journal-title":"Proc. Natl. Acad. Sci."},{"key":"D4CC06064D\/cit4\/1","doi-asserted-by":"publisher","first-page":"110118","DOI":"10.1016\/j.cclet.2024.110118","author":"Liu","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"D4CC06064D\/cit5\/1","doi-asserted-by":"crossref","first-page":"1800249","DOI":"10.1002\/adhm.201800249","volume":"7","author":"Capasso Palmiero","year":"2018","journal-title":"Adv. Healthcare Mater."},{"key":"D4CC06064D\/cit6\/1","doi-asserted-by":"crossref","first-page":"122753","DOI":"10.1016\/j.biomaterials.2024.122753","volume":"313","author":"Kavanagh","year":"2025","journal-title":"Biomaterials"},{"key":"D4CC06064D\/cit7\/1","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.4049\/jimmunol.171.6.3010","volume":"171","author":"Matsue","year":"2003","journal-title":"J. Immunol."},{"key":"D4CC06064D\/cit8\/1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.yexcr.2011.11.013","volume":"318","author":"Arana","year":"2012","journal-title":"Exp. Cell Res."},{"key":"D4CC06064D\/cit9\/1","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1080\/17425247.2020.1796628","volume":"17","author":"Karlsson","year":"2020","journal-title":"Expert Opin. Drug Delivery"},{"key":"D4CC06064D\/cit10\/1","doi-asserted-by":"crossref","first-page":"e2207841119","DOI":"10.1073\/pnas.2207841119","volume":"119","author":"Chen","year":"2022","journal-title":"Proc. Natl. Acad. Sci."},{"key":"D4CC06064D\/cit11\/1","doi-asserted-by":"crossref","first-page":"e2218324120","DOI":"10.1073\/pnas.2218324120","volume":"120","author":"Baessler","year":"2023","journal-title":"Proc. Natl. Acad. Sci."},{"key":"D4CC06064D\/cit12\/1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1021\/acs.bioconjchem.8b00732","volume":"30","author":"Smith","year":"2019","journal-title":"Bioconjugate Chem."},{"key":"D4CC06064D\/cit13\/1","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.xphs.2021.11.004","volume":"111","author":"Larson","year":"2022","journal-title":"J. Pharm. Sci."}],"container-title":["Chemical Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/CC\/D4CC06064D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:20:57Z","timestamp":1782879657000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cc\/article\/61\/16\/3371-3374\/840828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":13,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2025,2,18]]}},"URL":"https:\/\/doi.org\/10.1039\/d4cc06064d","relation":{},"ISSN":["1359-7345","1364-548X"],"issn-type":[{"value":"1359-7345","type":"print"},{"value":"1364-548X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}