{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T21:28:20Z","timestamp":1785792500606,"version":"3.56.0"},"reference-count":177,"publisher":"Royal Society of Chemistry (RSC)","issue":"10","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"am","delay-in-days":356,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32101153"],"award-info":[{"award-number":["32101153"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005085","name":"Beijing Institute of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Commun."],"abstract":"<jats:p>This review explores the synthesis, drug loading, and surface modifications of metal\u2013organic frameworks (MOFs), highlighting their role in improving cancer immunotherapy and paving the way for safer and more effective treatments.<\/jats:p>","DOI":"10.1039\/d4cc06510g","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T02:01:59Z","timestamp":1734919319000},"page":"1962-1977","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":118,"title":["Immunoadjuvant-functionalized metal\u2013organic frameworks: synthesis and applications in tumor immune modulation"],"prefix":"10.1039","volume":"61","author":[{"given":"Chen","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Song","sequence":"additional","affiliation":[{"name":"Xuanwu Hospital Capital Medical University, Beijing, 100037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medical Technology, the Qiushi College, Beijing Institute of Technology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenqi","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D4CC06510G\/cit1\/1","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nature09781","volume":"469","author":"Visvader","year":"2011","journal-title":"Nature"},{"key":"D4CC06510G\/cit2\/1","doi-asserted-by":"crossref","first-page":"2304249","DOI":"10.1002\/adma.202304249","volume":"36","author":"Yan","year":"2024","journal-title":"Adv. Mater."},{"key":"D4CC06510G\/cit3\/1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41571-023-00782-x","volume":"20","author":"Galluzzi","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"D4CC06510G\/cit4\/1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/s41571-022-00697-z","volume":"19","author":"Vozenin","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"D4CC06510G\/cit5\/1","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1056\/NEJMoa2214122","volume":"388","author":"Hamdy","year":"2023","journal-title":"New Engl. J. Med."},{"key":"D4CC06510G\/cit6\/1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature10673","volume":"480","author":"Mellman","year":"2011","journal-title":"Nature"},{"key":"D4CC06510G\/cit7\/1","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.3390\/cancers14102569","volume":"14","author":"Smolarz","year":"2022","journal-title":"Cancers"},{"key":"D4CC06510G\/cit8\/1","doi-asserted-by":"crossref","first-page":"5730","DOI":"10.3390\/molecules27175730","volume":"27","author":"Sekhoacha","year":"2022","journal-title":"Molecules"},{"key":"D4CC06510G\/cit9\/1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13046-022-02251-2","volume":"41","author":"Bausart","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"D4CC06510G\/cit10\/1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41571-019-0272-7","volume":"17","author":"Kepp","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"D4CC06510G\/cit11\/1","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/nature13954","volume":"515","author":"Tumeh","year":"2014","journal-title":"Nature"},{"key":"D4CC06510G\/cit12\/1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s40264-018-0774-8","volume":"42","author":"Baraibar","year":"2019","journal-title":"Drug Saf."},{"key":"D4CC06510G\/cit13\/1","doi-asserted-by":"crossref","first-page":"114308","DOI":"10.1016\/j.addr.2022.114308","volume":"185","author":"Shang","year":"2022","journal-title":"Adv. Drug Delivery Rev."},{"key":"D4CC06510G\/cit14\/1","doi-asserted-by":"crossref","first-page":"2000129","DOI":"10.1002\/adtp.202000129","volume":"3","author":"Pacifici","year":"2020","journal-title":"Adv. Ther."},{"key":"D4CC06510G\/cit15\/1","doi-asserted-by":"crossref","first-page":"0022","DOI":"10.34133\/cbsystems.0022","volume":"4","author":"Zhao","year":"2023","journal-title":"Cyborg Bionic Syst."},{"key":"D4CC06510G\/cit16\/1","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.3390\/ijms23031923","volume":"23","author":"Jiang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"D4CC06510G\/cit17\/1","doi-asserted-by":"crossref","first-page":"2201995","DOI":"10.1002\/adhm.202201995","volume":"12","author":"Zhao","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"D4CC06510G\/cit18\/1","doi-asserted-by":"crossref","first-page":"5962","DOI":"10.1021\/ja00197a079","volume":"111","author":"Hoskins","year":"1989","journal-title":"J. Am. Chem. Soc."},{"key":"D4CC06510G\/cit19\/1","doi-asserted-by":"crossref","first-page":"213968","DOI":"10.1016\/j.ccr.2021.213968","volume":"443","author":"Fan","year":"2021","journal-title":"Coord. Chem. Rev."},{"key":"D4CC06510G\/cit20\/1","doi-asserted-by":"crossref","first-page":"6116","DOI":"10.1039\/C4CS00159A","volume":"43","author":"Qiu","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"D4CC06510G\/cit21\/1","doi-asserted-by":"crossref","first-page":"2007442","DOI":"10.1002\/adma.202007442","volume":"33","author":"Shen","year":"2021","journal-title":"Adv. Mater."},{"key":"D4CC06510G\/cit22\/1","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jcis.2020.12.028","volume":"587","author":"Tian","year":"2021","journal-title":"J. Colloid Interface Sci."},{"key":"D4CC06510G\/cit23\/1","doi-asserted-by":"crossref","first-page":"2100333","DOI":"10.1002\/adma.202100333","volume":"33","author":"Liang","year":"2021","journal-title":"Adv. Mater."},{"key":"D4CC06510G\/cit24\/1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.jcis.2022.04.077","volume":"621","author":"Han","year":"2022","journal-title":"J. Colloid Interface Sci."},{"key":"D4CC06510G\/cit25\/1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41551-018-0203-4","volume":"2","author":"Lu","year":"2018","journal-title":"Nat. Biomed. Eng."},{"key":"D4CC06510G\/cit26\/1","doi-asserted-by":"crossref","first-page":"2210440","DOI":"10.1002\/adma.202210440","volume":"35","author":"Chen","year":"2023","journal-title":"Adv. Mater."},{"key":"D4CC06510G\/cit27\/1","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.3390\/polym15061490","volume":"15","author":"Fernandes","year":"2023","journal-title":"Polymers"},{"key":"D4CC06510G\/cit28\/1","doi-asserted-by":"crossref","first-page":"113009","DOI":"10.1016\/j.ccr.2019.07.006","volume":"398","author":"Zhu","year":"2019","journal-title":"Coord. Chem. Rev."},{"key":"D4CC06510G\/cit29\/1","first-page":"e1877","volume":"15","author":"Pena","year":"2023","journal-title":"Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol."},{"key":"D4CC06510G\/cit30\/1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jconrel.2022.05.003","volume":"347","author":"Li","year":"2022","journal-title":"J. Controlled Release"},{"key":"D4CC06510G\/cit31\/1","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1007\/s10904-021-02011-3","volume":"31","author":"Harvey","year":"2021","journal-title":"J. Inorg. Organomet. Polym. Mater."},{"key":"D4CC06510G\/cit32\/1","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1039\/D0CS00178C","volume":"50","author":"Liu","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"D4CC06510G\/cit33\/1","doi-asserted-by":"crossref","first-page":"2307299","DOI":"10.1002\/smll.202307299","volume":"20","author":"Zhang","year":"2024","journal-title":"Small"},{"key":"D4CC06510G\/cit34\/1","doi-asserted-by":"crossref","first-page":"31519","DOI":"10.1021\/acsami.7b09583","volume":"9","author":"Zhang","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D4CC06510G\/cit35\/1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jconrel.2019.02.035","volume":"300","author":"Zhong","year":"2019","journal-title":"J. Controlled Release"},{"key":"D4CC06510G\/cit36\/1","doi-asserted-by":"crossref","first-page":"47407","DOI":"10.1021\/acsami.1c16154","volume":"13","author":"Zhou","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D4CC06510G\/cit37\/1","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.1002\/jcp.29358","volume":"235","author":"Lei","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"D4CC06510G\/cit38\/1","doi-asserted-by":"crossref","first-page":"6454","DOI":"10.1002\/adfm.201600650","volume":"26","author":"Zhang","year":"2016","journal-title":"Adv. Funct. Mater."},{"key":"D4CC06510G\/cit39\/1","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1039\/D1SC04112F","volume":"13","author":"Hidalgo","year":"2022","journal-title":"Chem. Sci."},{"key":"D4CC06510G\/cit40\/1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.jconrel.2022.11.054","volume":"353","author":"Wang","year":"2023","journal-title":"J. Controlled Release"},{"key":"D4CC06510G\/cit41\/1","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1038\/s41467-020-17637-z","volume":"11","author":"Li","year":"2020","journal-title":"Nat. Commun."},{"key":"D4CC06510G\/cit42\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-020-00755-7","volume":"19","author":"Zhang","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"D4CC06510G\/cit43\/1","doi-asserted-by":"crossref","first-page":"147932","DOI":"10.1016\/j.cej.2023.147932","volume":"479","author":"Bai","year":"2024","journal-title":"Chem. Eng. J."},{"key":"D4CC06510G\/cit44\/1","doi-asserted-by":"crossref","first-page":"102102","DOI":"10.1016\/j.nantod.2023.102102","volume":"54","author":"Huang","year":"2024","journal-title":"Nano Today"},{"key":"D4CC06510G\/cit45\/1","doi-asserted-by":"crossref","first-page":"121120","DOI":"10.1016\/j.biomaterials.2021.121120","volume":"277","author":"Xiao","year":"2021","journal-title":"Biomaterials"},{"key":"D4CC06510G\/cit46\/1","doi-asserted-by":"crossref","first-page":"eabe7174","DOI":"10.1126\/sciadv.abe7174","volume":"7","author":"Alsaiari","year":"2021","journal-title":"Sci. Adv."},{"key":"D4CC06510G\/cit47\/1","doi-asserted-by":"crossref","first-page":"2305131","DOI":"10.1002\/smll.202305131","volume":"20","author":"Liu","year":"2024","journal-title":"Small"},{"key":"D4CC06510G\/cit48\/1","doi-asserted-by":"crossref","first-page":"105221","DOI":"10.1016\/j.mtcomm.2022.105221","volume":"34","author":"Wang","year":"2023","journal-title":"Mater. Today Commun."},{"key":"D4CC06510G\/cit49\/1","doi-asserted-by":"crossref","first-page":"2100616","DOI":"10.1002\/adma.202100616","volume":"33","author":"Zhao","year":"2021","journal-title":"Adv. Mater."},{"key":"D4CC06510G\/cit50\/1","doi-asserted-by":"crossref","first-page":"2101174","DOI":"10.1002\/adhm.202101174","volume":"10","author":"Zhao","year":"2021","journal-title":"Adv. Healthcare Mater."},{"key":"D4CC06510G\/cit51\/1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3390\/pharmaceutics14030527","volume":"14","author":"Yalamandala","year":"2022","journal-title":"Pharmaceutics"},{"key":"D4CC06510G\/cit52\/1","doi-asserted-by":"crossref","first-page":"12502","DOI":"10.1021\/jacs.6b06663","volume":"138","author":"Lu","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"D4CC06510G\/cit53\/1","doi-asserted-by":"crossref","first-page":"2003764","DOI":"10.1002\/adfm.202003764","volume":"30","author":"Chen","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"D4CC06510G\/cit54\/1","doi-asserted-by":"crossref","first-page":"13850","DOI":"10.1021\/ja8057953","volume":"130","author":"Cavka","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"D4CC06510G\/cit55\/1","doi-asserted-by":"crossref","first-page":"5808","DOI":"10.1021\/acsnano.2c12313","volume":"17","author":"Wei","year":"2023","journal-title":"ACS Nano"},{"key":"D4CC06510G\/cit56\/1","doi-asserted-by":"crossref","first-page":"213676","DOI":"10.1016\/j.ccr.2020.213676","volume":"431","author":"Ren","year":"2021","journal-title":"Coord. Chem. Rev."},{"key":"D4CC06510G\/cit57\/1","doi-asserted-by":"crossref","first-page":"4678","DOI":"10.1039\/D0TB02652B","volume":"9","author":"Ren","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"D4CC06510G\/cit58\/1","doi-asserted-by":"crossref","first-page":"15784","DOI":"10.1021\/jacs.7b07895","volume":"139","author":"Wang","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"D4CC06510G\/cit59\/1","doi-asserted-by":"crossref","first-page":"2102188","DOI":"10.1002\/adma.202102188","volume":"33","author":"Ding","year":"2021","journal-title":"Adv. Mater."},{"key":"D4CC06510G\/cit60\/1","doi-asserted-by":"crossref","first-page":"1900996","DOI":"10.1002\/adhm.201900996","volume":"9","author":"Cai","year":"2020","journal-title":"Adv. Healthcare Mater."},{"key":"D4CC06510G\/cit61\/1","doi-asserted-by":"crossref","first-page":"1900996","DOI":"10.1002\/adhm.201900996","volume":"9","author":"Cai","year":"2020","journal-title":"Adv. Healthcare Mater."},{"key":"D4CC06510G\/cit62\/1","doi-asserted-by":"crossref","first-page":"135370","DOI":"10.1016\/j.cej.2022.135370","volume":"437","author":"Li","year":"2022","journal-title":"Chem. Eng. J."},{"key":"D4CC06510G\/cit63\/1","doi-asserted-by":"crossref","first-page":"135680","DOI":"10.1016\/j.chemosphere.2022.135680","volume":"307","author":"Hao","year":"2022","journal-title":"Chemosphere"},{"key":"D4CC06510G\/cit64\/1","doi-asserted-by":"crossref","first-page":"102678","DOI":"10.1016\/j.nano.2023.102678","volume":"50","author":"Tian","year":"2023","journal-title":"Nanomedicine"},{"key":"D4CC06510G\/cit65\/1","doi-asserted-by":"crossref","first-page":"4630","DOI":"10.1021\/acsnano.8b01186","volume":"12","author":"Zeng","year":"2018","journal-title":"ACS Nano"},{"key":"D4CC06510G\/cit66\/1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.aca.2020.07.052","volume":"1131","author":"Li","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"D4CC06510G\/cit67\/1","doi-asserted-by":"crossref","first-page":"2000411","DOI":"10.1002\/advs.202000411","volume":"7","author":"Chen","year":"2020","journal-title":"Adv. Sci."},{"key":"D4CC06510G\/cit68\/1","doi-asserted-by":"crossref","first-page":"2201441","DOI":"10.1002\/adhm.202201441","volume":"11","author":"Guo","year":"2022","journal-title":"Adv. Healthcare Mater."},{"key":"D4CC06510G\/cit69\/1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s40820-022-00801-z","volume":"14","author":"Li","year":"2022","journal-title":"Nano-Micro Lett."},{"key":"D4CC06510G\/cit70\/1","doi-asserted-by":"crossref","first-page":"1907267","DOI":"10.1002\/adma.201907267","volume":"32","author":"Ploetz","year":"2020","journal-title":"Adv. Mater."},{"key":"D4CC06510G\/cit71\/1","doi-asserted-by":"crossref","first-page":"17470","DOI":"10.1021\/acsami.2c21005","volume":"15","author":"Xu","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D4CC06510G\/cit72\/1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jconrel.2023.06.033","volume":"360","author":"Chiang","year":"2023","journal-title":"J. Controlled Release"},{"key":"D4CC06510G\/cit73\/1","doi-asserted-by":"crossref","first-page":"6296","DOI":"10.1002\/anie.200460592","volume":"43","author":"F\u00e9rey","year":"2004","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4CC06510G\/cit74\/1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.actbio.2022.03.023","volume":"144","author":"Liu","year":"2022","journal-title":"Acta Biomater."},{"key":"D4CC06510G\/cit75\/1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/nmat2608","volume":"9","author":"Horcajada","year":"2010","journal-title":"Nat. Mater."},{"key":"D4CC06510G\/cit76\/1","doi-asserted-by":"crossref","first-page":"100701","DOI":"10.1016\/j.apmt.2020.100701","volume":"20","author":"Zhao","year":"2020","journal-title":"Appl. Mater. Today"},{"key":"D4CC06510G\/cit77\/1","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.3390\/nano9081103","volume":"9","author":"Cutrone","year":"2019","journal-title":"Nanomaterials"},{"key":"D4CC06510G\/cit78\/1","doi-asserted-by":"crossref","first-page":"7796","DOI":"10.1021\/acs.nanolett.1c02782","volume":"21","author":"Ni","year":"2021","journal-title":"Nano Lett."},{"key":"D4CC06510G\/cit79\/1","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1039\/C6CC09280B","volume":"53","author":"Zhang","year":"2017","journal-title":"Chem. Commun."},{"key":"D4CC06510G\/cit80\/1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1021\/acsami.2c19904","volume":"15","author":"Ge","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D4CC06510G\/cit81\/1","doi-asserted-by":"crossref","first-page":"12463","DOI":"10.1021\/acsami.8b01680","volume":"10","author":"Yang","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D4CC06510G\/cit82\/1","first-page":"312","volume":"6","author":"Fan","year":"2021","journal-title":"Bioact. Mater."},{"key":"D4CC06510G\/cit83\/1","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1021\/jacs.8b01072","volume":"140","author":"Lan","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"D4CC06510G\/cit84\/1","doi-asserted-by":"crossref","first-page":"2210644","DOI":"10.1002\/adfm.202210644","volume":"33","author":"Yalamandala","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"D4CC06510G\/cit85\/1","doi-asserted-by":"crossref","first-page":"2102271","DOI":"10.1002\/adma.202102271","volume":"33","author":"Liang","year":"2021","journal-title":"Adv. Mater."},{"key":"D4CC06510G\/cit86\/1","doi-asserted-by":"crossref","first-page":"133847","DOI":"10.1016\/j.cej.2021.133847","volume":"433","author":"Wei","year":"2022","journal-title":"Chem. Eng. J."},{"key":"D4CC06510G\/cit87\/1","doi-asserted-by":"crossref","first-page":"2302333","DOI":"10.1002\/adhm.202302333","volume":"13","author":"Hu","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"D4CC06510G\/cit88\/1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12645-023-00200-y","volume":"14","author":"Huang","year":"2023","journal-title":"Cancer Nanotechnol."},{"key":"D4CC06510G\/cit89\/1","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1038\/s41467-018-04703-w","volume":"9","author":"Ni","year":"2018","journal-title":"Nat. Commun."},{"key":"D4CC06510G\/cit90\/1","doi-asserted-by":"crossref","first-page":"7641","DOI":"10.1039\/D0SC01949F","volume":"11","author":"Ni","year":"2020","journal-title":"Chem. Sci."},{"key":"D4CC06510G\/cit91\/1","doi-asserted-by":"crossref","first-page":"2305440","DOI":"10.1002\/smll.202305440","volume":"19","author":"Zhen","year":"2023","journal-title":"Small"},{"key":"D4CC06510G\/cit92\/1","doi-asserted-by":"crossref","first-page":"2202830","DOI":"10.1002\/adhm.202202830","volume":"12","author":"Choi","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"D4CC06510G\/cit93\/1","doi-asserted-by":"crossref","first-page":"2204932","DOI":"10.1002\/advs.202204932","volume":"10","author":"Li","year":"2023","journal-title":"Adv. Sci."},{"key":"D4CC06510G\/cit94\/1","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1002\/adma.201104714","volume":"24","author":"Zhang","year":"2012","journal-title":"Adv. Mater."},{"key":"D4CC06510G\/cit95\/1","doi-asserted-by":"crossref","first-page":"121261","DOI":"10.1016\/j.biomaterials.2021.121261","volume":"280","author":"Dai","year":"2022","journal-title":"Biomaterials"},{"key":"D4CC06510G\/cit96\/1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.actbio.2023.09.052","volume":"172","author":"Wang","year":"2023","journal-title":"Acta Biomater."},{"key":"D4CC06510G\/cit97\/1","doi-asserted-by":"crossref","first-page":"9633","DOI":"10.1007\/s12274-023-5477-5","volume":"16","author":"Jiang","year":"2023","journal-title":"Nano Res."},{"key":"D4CC06510G\/cit98\/1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.biomaterials.2017.01.017","volume":"122","author":"Duan","year":"2017","journal-title":"Biomaterials"},{"key":"D4CC06510G\/cit99\/1","doi-asserted-by":"crossref","first-page":"13398","DOI":"10.1021\/acsanm.1c02908","volume":"4","author":"Duan","year":"2021","journal-title":"ACS Appl. Nano Mater."},{"key":"D4CC06510G\/cit100\/1","first-page":"532","volume":"33","author":"Cui","year":"2024","journal-title":"Bioact. Mater."},{"key":"D4CC06510G\/cit101\/1","doi-asserted-by":"crossref","first-page":"15905","DOI":"10.1021\/acsnano.3c03962","volume":"17","author":"Zheng","year":"2023","journal-title":"ACS Nano"},{"key":"D4CC06510G\/cit102\/1","doi-asserted-by":"crossref","first-page":"2312919","DOI":"10.1002\/adfm.202312919","volume":"34","author":"Xiong","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"D4CC06510G\/cit103\/1","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1038\/s41467-022-30436-y","volume":"13","author":"Dai","year":"2022","journal-title":"Nat. Commun."},{"key":"D4CC06510G\/cit104\/1","doi-asserted-by":"crossref","first-page":"101195","DOI":"10.1016\/j.nantod.2021.101195","volume":"38","author":"Zhan","year":"2021","journal-title":"Nano Today"},{"key":"D4CC06510G\/cit105\/1","doi-asserted-by":"crossref","first-page":"102112","DOI":"10.1016\/j.nantod.2023.102112","volume":"54","author":"Liu","year":"2024","journal-title":"Nano Today"},{"key":"D4CC06510G\/cit106\/1","doi-asserted-by":"crossref","first-page":"25575","DOI":"10.1021\/acsnano.3c09734","volume":"17","author":"Wu","year":"2023","journal-title":"ACS Nano"},{"key":"D4CC06510G\/cit107\/1","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1080\/1061186X.2022.2077949","volume":"30","author":"Wang","year":"2022","journal-title":"J. Drug Targeting"},{"key":"D4CC06510G\/cit108\/1","doi-asserted-by":"crossref","first-page":"44199","DOI":"10.1021\/acsami.2c12990","volume":"14","author":"Chen","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D4CC06510G\/cit109\/1","doi-asserted-by":"crossref","first-page":"2301519","DOI":"10.1002\/smll.202301519","volume":"19","author":"Li","year":"2023","journal-title":"Small"},{"key":"D4CC06510G\/cit110\/1","doi-asserted-by":"crossref","first-page":"6442","DOI":"10.1021\/acsami.2c19476","volume":"15","author":"Wang","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D4CC06510G\/cit111\/1","first-page":"115117","volume":"669","author":"Yang","year":"2023","journal-title":"Anbio Biotechnol."},{"key":"D4CC06510G\/cit112\/1","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1080\/10717544.2021.2012306","volume":"28","author":"Li","year":"2021","journal-title":"Drug Delivery"},{"key":"D4CC06510G\/cit113\/1","doi-asserted-by":"crossref","first-page":"110774","DOI":"10.1016\/j.msec.2020.110774","volume":"111","author":"Kritskiy","year":"2020","journal-title":"Mater. Sci. Eng., C"},{"key":"D4CC06510G\/cit114\/1","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/anie.201911429","volume":"59","author":"Ni","year":"2020","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4CC06510G\/cit115\/1","doi-asserted-by":"crossref","first-page":"2206779","DOI":"10.1002\/advs.202206779","volume":"10","author":"Li","year":"2023","journal-title":"Adv. Sci."},{"key":"D4CC06510G\/cit116\/1","doi-asserted-by":"crossref","first-page":"145764","DOI":"10.1016\/j.cej.2023.145764","volume":"474","author":"Yang","year":"2023","journal-title":"Chem. Eng. J."},{"key":"D4CC06510G\/cit117\/1","doi-asserted-by":"crossref","first-page":"2102188","DOI":"10.1002\/adma.202102188","volume":"33","author":"Ding","year":"2021","journal-title":"Adv. Mater."},{"key":"D4CC06510G\/cit118\/1","doi-asserted-by":"crossref","first-page":"102678","DOI":"10.1016\/j.nano.2023.102678","volume":"50","author":"Tian","year":"2023","journal-title":"Nanomedicine"},{"key":"D4CC06510G\/cit119\/1","doi-asserted-by":"crossref","first-page":"100701","DOI":"10.1016\/j.apmt.2020.100701","volume":"20","author":"Zhao","year":"2020","journal-title":"Appl. Mater. Today"},{"key":"D4CC06510G\/cit120\/1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41551-018-0203-4","volume":"2","author":"Lu","year":"2018","journal-title":"Nat. Biomed. Eng."},{"key":"D4CC06510G\/cit121\/1","doi-asserted-by":"crossref","first-page":"101195","DOI":"10.1016\/j.nantod.2021.101195","volume":"38","author":"Zhan","year":"2021","journal-title":"Nano Today"},{"key":"D4CC06510G\/cit122\/1","doi-asserted-by":"crossref","first-page":"2301519","DOI":"10.1002\/smll.202301519","volume":"19","author":"Li","year":"2023","journal-title":"Small"},{"key":"D4CC06510G\/cit123\/1","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/anie.201911429","volume":"59","author":"Ni","year":"2020","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4CC06510G\/cit124\/1","doi-asserted-by":"crossref","first-page":"2206779","DOI":"10.1002\/advs.202206779","volume":"10","author":"Li","year":"2023","journal-title":"Adv. Sci."},{"key":"D4CC06510G\/cit125\/1","doi-asserted-by":"crossref","first-page":"145764","DOI":"10.1016\/j.cej.2023.145764","volume":"474","author":"Yang","year":"2023","journal-title":"Chem. Eng. J."},{"key":"D4CC06510G\/cit126\/1","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1016\/j.apsb.2022.02.023","volume":"12","author":"Zeng","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"D4CC06510G\/cit127\/1","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.2217\/nnm-2023-0164","volume":"18","author":"Duan","year":"2023","journal-title":"Nanomedicine"},{"key":"D4CC06510G\/cit128\/1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3390\/cancers13010077","volume":"13","author":"Gong","year":"2021","journal-title":"Cancers"},{"key":"D4CC06510G\/cit129\/1","doi-asserted-by":"crossref","first-page":"113607","DOI":"10.1016\/j.colsurfb.2023.113607","volume":"232","author":"Ding","year":"2023","journal-title":"Colloids Surf., B"},{"key":"D4CC06510G\/cit130\/1","doi-asserted-by":"crossref","first-page":"6995","DOI":"10.3390\/ijms22136995","volume":"22","author":"Boutilier","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"D4CC06510G\/cit131\/1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0923-2494(99)80039-X","volume":"149","author":"Gordon","year":"1998","journal-title":"Res. Immunol."},{"key":"D4CC06510G\/cit132\/1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/imr.12266","volume":"264","author":"Weiss","year":"2015","journal-title":"Immunol. Rev."},{"key":"D4CC06510G\/cit133\/1","first-page":"1","volume":"6","author":"Sang","year":"2015","journal-title":"J. Clin. Cell. Immunol."},{"key":"D4CC06510G\/cit134\/1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41577-019-0124-9","volume":"19","author":"Russell","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"D4CC06510G\/cit135\/1","doi-asserted-by":"crossref","first-page":"7882","DOI":"10.1021\/acs.nanolett.2c02560","volume":"22","author":"Cao","year":"2022","journal-title":"Nano Lett."},{"key":"D4CC06510G\/cit136\/1","doi-asserted-by":"crossref","first-page":"6358","DOI":"10.1021\/acsami.1c21700","volume":"14","author":"Ma","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D4CC06510G\/cit137\/1","doi-asserted-by":"crossref","first-page":"148069","DOI":"10.1016\/j.cej.2023.148069","volume":"480","author":"Yao","year":"2024","journal-title":"Chem. Eng. J."},{"key":"D4CC06510G\/cit138\/1","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.1038\/s41467-022-32349-2","volume":"13","author":"Cheng","year":"2022","journal-title":"Nat. Commun."},{"key":"D4CC06510G\/cit139\/1","doi-asserted-by":"crossref","first-page":"120029","DOI":"10.1016\/j.biomaterials.2020.120029","volume":"248","author":"Zhang","year":"2020","journal-title":"Biomaterials"},{"key":"D4CC06510G\/cit140\/1","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1038\/s41467-019-11157-1","volume":"10","author":"Liu","year":"2019","journal-title":"Nat. Commun."},{"key":"D4CC06510G\/cit141\/1","doi-asserted-by":"crossref","first-page":"7862","DOI":"10.1039\/D1BM01396C","volume":"9","author":"Cheng","year":"2021","journal-title":"Biomaterials Science"},{"key":"D4CC06510G\/cit142\/1","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1182\/blood-2018-11-844548","volume":"133","author":"Giese","year":"2019","journal-title":"Blood"},{"key":"D4CC06510G\/cit143\/1","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/s41590-018-0229-5","volume":"19","author":"Patel","year":"2018","journal-title":"Nat. Immunol."},{"key":"D4CC06510G\/cit144\/1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/cvr\/cvv159","volume":"107","author":"M\u00f3csai","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"D4CC06510G\/cit145\/1","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1158\/0008-5472.CAN-11-2393","volume":"72","author":"Spicer","year":"2012","journal-title":"Cancer Res."},{"key":"D4CC06510G\/cit146\/1","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/ijc.25987","volume":"129","author":"Tazzyman","year":"2011","journal-title":"Int. J. Cancer"},{"key":"D4CC06510G\/cit147\/1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s13277-011-0236-8","volume":"33","author":"Fridlender","year":"2012","journal-title":"Tumor Biol."},{"key":"D4CC06510G\/cit148\/1","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1038\/s41467-023-37580-z","volume":"14","author":"Cui","year":"2023","journal-title":"Nat. Commun."},{"key":"D4CC06510G\/cit149\/1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nature06175","volume":"449","author":"Steinman","year":"2007","journal-title":"Nature"},{"key":"D4CC06510G\/cit150\/1","doi-asserted-by":"crossref","first-page":"7325","DOI":"10.3390\/ijms23137325","volume":"23","author":"Kang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"D4CC06510G\/cit151\/1","doi-asserted-by":"crossref","first-page":"1903301","DOI":"10.1002\/advs.201903301","volume":"7","author":"Cheng","year":"2020","journal-title":"Adv. Sci."},{"key":"D4CC06510G\/cit152\/1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/bit.28304","volume":"120","author":"Li","year":"2023","journal-title":"Biotechnol. Bioeng."},{"key":"D4CC06510G\/cit153\/1","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.2217\/imt.15.73","volume":"7","author":"Kajihara","year":"2015","journal-title":"Immunotherapy"},{"key":"D4CC06510G\/cit154\/1","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1021\/acsnano.2c09033","volume":"17","author":"Ma","year":"2023","journal-title":"ACS Nano"},{"key":"D4CC06510G\/cit155\/1","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.3390\/pharmaceutics15071821","volume":"15","author":"Hu","year":"2023","journal-title":"Pharmaceutics"},{"key":"D4CC06510G\/cit156\/1","doi-asserted-by":"crossref","first-page":"e202203115","DOI":"10.1002\/ange.202203115","volume":"134","author":"Wang","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4CC06510G\/cit157\/1","doi-asserted-by":"crossref","first-page":"2005935","DOI":"10.1002\/adfm.202005935","volume":"31","author":"Guo","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"D4CC06510G\/cit158\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-020-00755-7","volume":"19","author":"Huang","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"D4CC06510G\/cit159\/1","doi-asserted-by":"crossref","first-page":"11795549241236896","DOI":"10.1177\/11795549241236896","volume":"18","author":"Zhang","year":"2024","journal-title":"Clin. Med. Insights: Oncol."},{"key":"D4CC06510G\/cit160\/1","first-page":"1","volume":"19","author":"Peng","year":"2023","journal-title":"Bioact. Mater."},{"key":"D4CC06510G\/cit161\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-018-0433-3","volume":"17","author":"Wang","year":"2019","journal-title":"J. Nanobiotechnol."},{"key":"D4CC06510G\/cit162\/1","doi-asserted-by":"crossref","first-page":"2309366","DOI":"10.1002\/smll.202309366","volume":"20","author":"Shi","year":"2024","journal-title":"Small"},{"key":"D4CC06510G\/cit163\/1","doi-asserted-by":"crossref","first-page":"eaaz6108","DOI":"10.1126\/sciadv.aaz6108","volume":"6","author":"Zhuang","year":"2020","journal-title":"Sci. Adv."},{"key":"D4CC06510G\/cit164\/1","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1021\/acs.molpharmaceut.4c00307","volume":"21","author":"Liu","year":"2024","journal-title":"Mol. Pharmaceutics"},{"key":"D4CC06510G\/cit165\/1","doi-asserted-by":"crossref","first-page":"23829","DOI":"10.1021\/acsnano.3c07885","volume":"17","author":"Guo","year":"2023","journal-title":"ACS Nano"},{"key":"D4CC06510G\/cit166\/1","doi-asserted-by":"crossref","first-page":"114321","DOI":"10.1016\/j.addr.2022.114321","volume":"186","author":"Long","year":"2022","journal-title":"Adv. Drug Delivery Rev."},{"key":"D4CC06510G\/cit167\/1","doi-asserted-by":"crossref","first-page":"114294","DOI":"10.1016\/j.addr.2022.114294","volume":"185","author":"Krishnan","year":"2022","journal-title":"Adv. Drug Delivery Rev."},{"key":"D4CC06510G\/cit168\/1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41467-017-00729-8","volume":"8","author":"Kim","year":"2017","journal-title":"Nat. Commun."},{"key":"D4CC06510G\/cit169\/1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1039\/D3NJ03511E","volume":"48","author":"Zhang","year":"2023","journal-title":"New J. Chem."},{"key":"D4CC06510G\/cit170\/1","doi-asserted-by":"crossref","first-page":"1909806","DOI":"10.1002\/adfm.201909806","volume":"30","author":"Chen","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"D4CC06510G\/cit171\/1","doi-asserted-by":"crossref","first-page":"eabb5223","DOI":"10.1126\/sciadv.abb5223","volume":"6","author":"Ni","year":"2020","journal-title":"Sci. Adv."},{"key":"D4CC06510G\/cit172\/1","doi-asserted-by":"crossref","first-page":"119983","DOI":"10.1016\/j.biomaterials.2020.119983","volume":"245","author":"Zhang","year":"2020","journal-title":"Biomaterials"},{"key":"D4CC06510G\/cit173\/1","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"key":"D4CC06510G\/cit174\/1","doi-asserted-by":"crossref","first-page":"2301429","DOI":"10.1002\/adhm.202301429","volume":"12","author":"Yu","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"D4CC06510G\/cit175\/1","doi-asserted-by":"crossref","first-page":"101911","DOI":"10.1016\/j.nantod.2023.101911","volume":"51","author":"Huang","year":"2023","journal-title":"Nano Today"},{"key":"D4CC06510G\/cit176\/1","doi-asserted-by":"crossref","first-page":"122333","DOI":"10.1016\/j.biomaterials.2023.122333","volume":"302","author":"Feng","year":"2023","journal-title":"Biomaterials"},{"key":"D4CC06510G\/cit177\/1","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jcis.2024.02.055","volume":"662","author":"An","year":"2024","journal-title":"J. Colloid Interface Sci."}],"container-title":["Chemical Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/CC\/D4CC06510G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:09:28Z","timestamp":1782878968000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cc\/article\/61\/10\/1962-1977\/840999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":177,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,1,28]]}},"URL":"https:\/\/doi.org\/10.1039\/d4cc06510g","relation":{},"ISSN":["1359-7345","1364-548X"],"issn-type":[{"value":"1359-7345","type":"print"},{"value":"1364-548X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}