{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:52:43Z","timestamp":1783043563798,"version":"3.54.6"},"reference-count":58,"publisher":"Royal Society of Chemistry (RSC)","issue":"14","license":[{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"vor","delay-in-days":95,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100008432","name":"Consejer\u00eda de Educaci\u00f3n y Empleo, Junta de Extremadura","doi-asserted-by":"publisher","award":["IB20103"],"award-info":[{"award-number":["IB20103"]}],"id":[{"id":"10.13039\/501100008432","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2021-126193OB-I00"],"award-info":[{"award-number":["PID2021-126193OB-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["FPU18\/0177"],"award-info":[{"award-number":["FPU18\/0177"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>Pomegranate supplemetation decreased fat depots, counteracted the dyslipidemia caused by fructose and improved markers of liver injury. Microbial metabolites from pomegranate may be responsible for these health benefits.<\/jats:p>","DOI":"10.1039\/d4fo00688g","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T15:41:22Z","timestamp":1712331682000},"page":"7348-7363","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Pomegranate supplementation alleviates dyslipidemia and the onset of non-alcoholic fatty liver disease in Wistar rats by shifting microbiota and producing urolithin-like microbial metabolites"],"prefix":"10.1039","volume":"15","author":[{"given":"Guadalupe","family":"S\u00e1nchez-Terr\u00f3n","sequence":"first","affiliation":[{"name":"TECAL Research Group, Meat and Meat Products Research Institute (IPROCAR), Universidad de Extremadura (UEX, ROR-ID 0174shg90), C\u00e1ceres, 10003, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remigio","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Animal Health Department, Animal Health and Zoonoses Research Group (GISAZ), UIC Zoonosis and Emergent Diseases (ENZOEM Competitive Research Unit), Universidad of C\u00f3rdoba (UCO, ROR-ID 05yc77b46), C\u00f3rdoba, 14014, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Morcuende","sequence":"additional","affiliation":[{"name":"TECAL Research Group, Meat and Meat Products Research Institute (IPROCAR), Universidad de Extremadura (UEX, ROR-ID 0174shg90), C\u00e1ceres, 10003, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor","family":"Caballero","sequence":"additional","affiliation":[{"name":"TECAL Research Group, Meat and Meat Products Research Institute (IPROCAR), Universidad de Extremadura (UEX, ROR-ID 0174shg90), C\u00e1ceres, 10003, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8509-2789","authenticated-orcid":false,"given":"Mario","family":"Est\u00e9vez","sequence":"additional","affiliation":[{"name":"TECAL Research Group, Meat and Meat Products Research Institute (IPROCAR), Universidad de Extremadura (UEX, ROR-ID 0174shg90), C\u00e1ceres, 10003, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D4FO00688G\/cit1\/1","volume-title":"Guideline: Sugars Intake for Adults and Children","year":"2015","unstructured":"Guideline: Sugars Intake for Adults and Children , World Health Organization , Geneva , 2015"},{"issue":"1","key":"D4FO00688G\/cit2\/1","first-page":"1","volume":"12","author":"Merino","year":"2020","journal-title":"Nutrients"},{"issue":"12","key":"D4FO00688G\/cit3\/1","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/j.cmet.2021.09.010","volume":"33","author":"Herman","year":"2021","journal-title":"Cell Metab."},{"issue":"2","key":"D4FO00688G\/cit4\/1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.cmet.2017.12.016","volume":"27","author":"Jang","year":"2018","journal-title":"Cell Metab."},{"key":"D4FO00688G\/cit5\/1","doi-asserted-by":"publisher","first-page":"133805","DOI":"10.1016\/j.foodchem.2022.133805","volume":"397","author":"S\u00e1nchez-Terr\u00f3n","year":"2023","journal-title":"J. Agric. Food Chem."},{"issue":"22","key":"D4FO00688G\/cit6\/1","doi-asserted-by":"crossref","first-page":"14355","DOI":"10.3390\/ijms232214355","volume":"23","author":"Iametti","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"D4FO00688G\/cit7\/1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1172\/JCI96702","volume":"128","author":"Hannou","year":"2018","journal-title":"J. Clin. Invest."},{"issue":"8","key":"D4FO00688G\/cit8\/1","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1002\/jsfa.8042","volume":"97","author":"Noori","year":"2017","journal-title":"J. Sci. Food Agric."},{"issue":"1","key":"D4FO00688G\/cit9\/1","doi-asserted-by":"crossref","first-page":"102693","DOI":"10.1016\/j.dsx.2022.102693","volume":"17","author":"Jafarirad","year":"2023","journal-title":"Diabetes Metab. Syndr."},{"issue":"51","key":"D4FO00688G\/cit10\/1","doi-asserted-by":"crossref","first-page":"16273","DOI":"10.1021\/acs.jafc.2c06585","volume":"70","author":"Caballero","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"D4FO00688G\/cit11\/1","first-page":"1","volume":"2023","author":"Yin","year":"2023","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"issue":"1","key":"D4FO00688G\/cit12\/1","doi-asserted-by":"crossref","first-page":"1500901","DOI":"10.1002\/mnfr.201500901","volume":"61","author":"Tom\u00e1s-Barber\u00e1n","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"issue":"3","key":"D4FO00688G\/cit13\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antiox11030553","volume":"11","author":"Olvera-Sandoval","year":"2022","journal-title":"Antioxidants"},{"issue":"6","key":"D4FO00688G\/cit14\/1","doi-asserted-by":"publisher","first-page":"1228S","DOI":"10.3945\/jn.108.098277","volume":"139","author":"Marriott","year":"2009","journal-title":"J. Nutr."},{"key":"D4FO00688G\/cit15\/1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fnut.2016.00010","volume":"3","author":"Chusyd","year":"2016","journal-title":"Front. Nutr."},{"issue":"4","key":"D4FO00688G\/cit16\/1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.meatsci.2011.05.017","volume":"89","author":"Utrera","year":"2011","journal-title":"Meat Sci."},{"issue":"21","key":"D4FO00688G\/cit17\/1","doi-asserted-by":"crossref","first-page":"4650","DOI":"10.3390\/nu14214650","volume":"14","author":"S\u00e1nchez-Quintero","year":"2022","journal-title":"Nutrients"},{"issue":"8","key":"D4FO00688G\/cit18\/1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/o59-099","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Physiol."},{"key":"D4FO00688G\/cit19\/1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.chroma.2015.08.044","volume":"1428","author":"Garc\u00eda-Villalba","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"D4FO00688G\/cit20\/1","first-page":"21","volume-title":"Applied Spatial Data Analysis with R","author":"Wickham","year":"2008","unstructured":"H.Wickham , Elegant Graphics for Data Analysis: ggplot2 , in Applied Spatial Data Analysis with R , 2008 , pp. 21\u201354"},{"issue":"3","key":"D4FO00688G\/cit21\/1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11306-007-0082-2","volume":"3","author":"Sumner","year":"2007","journal-title":"Metabolomics"},{"issue":"5","key":"D4FO00688G\/cit22\/1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1080\/10408363.2019.1711360","volume":"57","author":"Softic","year":"2020","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"D4FO00688G\/cit23\/1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1097\/MOG.0b013e3282f3f4c4","volume":"24","author":"Miller","year":"2008","journal-title":"Curr. Opin. Gastroenterol."},{"key":"D4FO00688G\/cit24\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/490650","volume":"2011","author":"Bj\u00f8rndal","year":"2011","journal-title":"J. Obes."},{"issue":"2","key":"D4FO00688G\/cit25\/1","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1748-1716.2012.02409.x","volume":"205","author":"Wronska","year":"2012","journal-title":"Acta Physiol."},{"issue":"1","key":"D4FO00688G\/cit26\/1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41591-020-1126-7","volume":"27","author":"Becher","year":"2021","journal-title":"Nat. Med."},{"key":"D4FO00688G\/cit27\/1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.82200","volume-title":"Nonalcoholic Fat Liver Disease \u2013 An Update","author":"Mary Varghese","year":"2019","unstructured":"S.Mary Varghese and J.Thomas , The effect of M. latifolia leaf extract on high-fructose corn syrup (HFCS)-induced non-alcoholic fatty liver disease in rat models , in Nonalcoholic Fat Liver Disease \u2013 An Update , 2019 . 10.5772\/intechopen.82200"},{"issue":"1","key":"D4FO00688G\/cit28\/1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.pbb.2010.02.012","volume":"97","author":"Bocarsly","year":"2010","journal-title":"Pharmacol., Biochem. Behav."},{"issue":"1","key":"D4FO00688G\/cit29\/1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/MOL.0b013e3283346ca2","volume":"21","author":"Bray","year":"2010","journal-title":"Curr. Opin. Lipidol."},{"issue":"7","key":"D4FO00688G\/cit30\/1","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/oby.2005.136","volume":"13","author":"J\u00fcrgens","year":"2005","journal-title":"Obes. Res."},{"issue":"11","key":"D4FO00688G\/cit31\/1","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.jnutbio.2015.05.011","volume":"26","author":"Sellmann","year":"2015","journal-title":"J. Nutr. Biochem."},{"issue":"1","key":"D4FO00688G\/cit32\/1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1515\/jbcr-2015-0143","volume":"8","author":"Sandeva","year":"2015","journal-title":"J. Biomed. Clin. Res."},{"issue":"9","key":"D4FO00688G\/cit33\/1","doi-asserted-by":"crossref","first-page":"100742","DOI":"10.1016\/j.xcrm.2022.100742","volume":"3","author":"Richard","year":"2022","journal-title":"Cell Rep. Med."},{"key":"D4FO00688G\/cit34\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2022.898471","volume":"13","author":"Meneses","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"2","key":"D4FO00688G\/cit35\/1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41430-018-0323-7","volume":"73","author":"Bosy-Westphal","year":"2019","journal-title":"Eur. J. Clin. Nutr."},{"issue":"7","key":"D4FO00688G\/cit36\/1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0025-6196(24)00530-5","volume":"55","author":"Ludwig","year":"1980","journal-title":"Mayo Clin. Proc."},{"issue":"7800","key":"D4FO00688G\/cit37\/1","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41586-020-2101-7","volume":"579","author":"Zhao","year":"2020","journal-title":"Nature"},{"issue":"2","key":"D4FO00688G\/cit38\/1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1039\/C1FO10111K","volume":"3","author":"Janevski","year":"2012","journal-title":"Food Funct."},{"issue":"4","key":"D4FO00688G\/cit39\/1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.jfda.2016.03.005","volume":"24","author":"Hsieh","year":"2016","journal-title":"J. Food Drug Anal."},{"issue":"1","key":"D4FO00688G\/cit40\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-021-02269-w","volume":"4","author":"Paar","year":"2021","journal-title":"Commun. Biol."},{"issue":"0","key":"D4FO00688G\/cit41\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5455\/njppp.2023.13.02056202316022023","volume":"11","author":"Rajesh","year":"2020","journal-title":"Natl. J. Physiol., Pharm. Pharmacol."},{"key":"D4FO00688G\/cit42\/1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.toxrep.2021.12.001","volume":"9","author":"Thompson","year":"2022","journal-title":"Toxicol. Rep."},{"issue":"3","key":"D4FO00688G\/cit43\/1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1503\/cmaj.1040752","volume":"172","author":"Giannini","year":"2005","journal-title":"Can. Med. Assoc. J."},{"issue":"4","key":"D4FO00688G\/cit44\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu9040385","volume":"9","author":"Aragno","year":"2017","journal-title":"Nutrients"},{"key":"D4FO00688G\/cit45\/1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.freeradbiomed.2015.12.022","volume":"91","author":"Mastrocola","year":"2016","journal-title":"Free Radicals Biol. Med."},{"issue":"13","key":"D4FO00688G\/cit46\/1","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.3390\/ijms22136969","volume":"22","author":"Muriel","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"D4FO00688G\/cit47\/1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3390\/nu9040335","volume":"9","author":"Zhang","year":"2017","journal-title":"Nutrients"},{"issue":"2","key":"D4FO00688G\/cit48\/1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/liv.12442","volume":"35","author":"Kanuri","year":"2015","journal-title":"Liver Int."},{"issue":"5","key":"D4FO00688G\/cit49\/1","first-page":"600","volume":"25","author":"Yanpar","year":"2021","journal-title":"J. Res. Pharm."},{"issue":"16","key":"D4FO00688G\/cit50\/1","first-page":"1","volume":"63","author":"Hou","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"issue":"5","key":"D4FO00688G\/cit51\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu9050436","volume":"9","author":"Mandal","year":"2017","journal-title":"Nutrients"},{"key":"D4FO00688G\/cit52\/1","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.3389\/fimmu.2017.01159","volume":"8","author":"Lambertz","year":"2017","journal-title":"Front. Immunol."},{"issue":"6","key":"D4FO00688G\/cit53\/1","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1002\/hep.30652","volume":"73","author":"Cho","year":"2021","journal-title":"Hepatology"},{"issue":"24","key":"D4FO00688G\/cit54\/1","doi-asserted-by":"crossref","first-page":"6900","DOI":"10.1080\/10408398.2022.2036693","volume":"63","author":"Zhang","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"1","key":"D4FO00688G\/cit55\/1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41467-018-07859-7","volume":"10","author":"Singh","year":"2019","journal-title":"Nat. Commun."},{"issue":"21","key":"D4FO00688G\/cit56\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules25215136","volume":"25","author":"Adachi","year":"2020","journal-title":"Molecules"},{"key":"D4FO00688G\/cit57\/1","first-page":"100195","volume":"13","author":"Rodr\u00edguez-Romero","year":"2022","journal-title":"Food Chem.: X"},{"issue":"4","key":"D4FO00688G\/cit58\/1","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.cell.2016.10.020","volume":"167","author":"Schirmer","year":"2016","journal-title":"Cell"}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/FO\/D4FO00688G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:08:05Z","timestamp":1782882485000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/15\/14\/7348-7363\/850840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":58,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2024,7,15]]}},"URL":"https:\/\/doi.org\/10.1039\/d4fo00688g","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}