{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:54:38Z","timestamp":1790258078613,"version":"4.1.0"},"reference-count":57,"publisher":"Royal Society of Chemistry (RSC)","issue":"7","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"am","delay-in-days":435,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>\n                    The synbiotic combination of 2\u2032-Fucosyllactose and\u00a0\n                    <jats:italic>Bifidobacterium animalis subsp. lactis BB-12<\/jats:italic>\n                    supports gut microbiota homeostasis, enhances fecal SCFA levels, and mitigates neurodevelopmental abnormalities in ASD mice.\n                  <\/jats:p>","DOI":"10.1039\/d4fo06234e","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T23:41:07Z","timestamp":1741736467000},"page":"2703-2717","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Synbiotic combination of 2\u2032-fucosyllactose and\n                    <i>Bifidobacterium<\/i>\n                    mitigates neurodevelopmental disorders and ASD-like behaviors induced by valproic acid"],"prefix":"10.1039","volume":"16","author":[{"given":"Ying","family":"He","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xin","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiu","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China"},{"name":"Research and Development Center, Xi'an Yinqiao Dairy (Group) Co., Ltd, Xi'an, Shaanxi 710075, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbo","family":"She","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China"},{"name":"Northwest A&F University Shenzhen Research Institute, Shenzhen, Guangdong, 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gengjie","family":"Jia","sequence":"additional","affiliation":[{"name":"Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Wu","sequence":"additional","affiliation":[{"name":"Research and Development Center, Xi'an Yinqiao Dairy (Group) Co., Ltd, Xi'an, Shaanxi 710075, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6863-6561","authenticated-orcid":false,"given":"Zhigang","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China"},{"name":"Northwest A&F University Shenzhen Research Institute, Shenzhen, Guangdong, 518000, China"},{"name":"Shaanxi Precision Nutrition and Health Research Institute, Xian 710300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D4FO06234E\/cit1\/1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/35081509","volume":"2","author":"Johnson","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"D4FO06234E\/cit2\/1","doi-asserted-by":"crossref","DOI":"10.2307\/j.ctv1pncndb","volume-title":"The Fundamentals of Brain Development","author":"Stiles","year":"2008","unstructured":"J.Stiles ,  The Fundamentals of Brain Development ,  2008"},{"key":"D4FO06234E\/cit3\/1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1186\/s12916-024-03617-3","volume":"22","author":"Love","year":"2024","journal-title":"BMC Med."},{"key":"D4FO06234E\/cit4\/1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41398-022-02009-6","volume":"12","author":"Qiu","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"D4FO06234E\/cit5\/1","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1186\/s12888-024-05729-9","volume":"24","author":"Jiang","year":"2024","journal-title":"BMC Psychiatry"},{"key":"D4FO06234E\/cit6\/1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41398-019-0608-1","volume":"9","author":"Zhao","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"D4FO06234E\/cit7\/1","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/s41372-020-00871-0","volume":"41","author":"Tong","year":"2021","journal-title":"J. Perinatol."},{"key":"D4FO06234E\/cit8\/1","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1002\/aur.2499","volume":"14","author":"Tioleco","year":"2021","journal-title":"Autism Res."},{"key":"D4FO06234E\/cit9\/1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41398-023-02391-9","volume":"13","author":"Guerra","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"D4FO06234E\/cit10\/1","doi-asserted-by":"crossref","first-page":"111322","DOI":"10.1016\/j.biopha.2021.111322","volume":"137","author":"Taleb","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"D4FO06234E\/cit11\/1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s40168-023-01656-1","volume":"11","author":"Wang","year":"2023","journal-title":"Microbiome"},{"key":"D4FO06234E\/cit12\/1","doi-asserted-by":"crossref","first-page":"383s","DOI":"10.3945\/an.111.001404","volume":"3","author":"Bode","year":"2012","journal-title":"Adv. Nutr."},{"issue":"10","key":"D4FO06234E\/cit13\/1","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.3390\/nu12103052","volume":"12","author":"Nolan","year":"2020","journal-title":"Nutrients"},{"issue":"1","key":"D4FO06234E\/cit14\/1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3390\/nu12010266","volume":"12","author":"Wici\u0144ski","year":"2020","journal-title":"Nutrients"},{"issue":"10","key":"D4FO06234E\/cit15\/1","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.3390\/nu13103364","volume":"13","author":"Hill","year":"2021","journal-title":"Nutrients"},{"key":"D4FO06234E\/cit16\/1","doi-asserted-by":"crossref","first-page":"113293","DOI":"10.1016\/j.foodres.2023.113293","volume":"173","author":"Zhang","year":"2023","journal-title":"Food Res. Int."},{"key":"D4FO06234E\/cit17\/1","doi-asserted-by":"crossref","first-page":"1054431","DOI":"10.3389\/fnut.2022.1054431","volume":"9","author":"Xie","year":"2022","journal-title":"Front. Nutr."},{"key":"D4FO06234E\/cit18\/1","doi-asserted-by":"crossref","first-page":"e0228323","DOI":"10.1371\/journal.pone.0228323","volume":"15","author":"Berger","year":"2020","journal-title":"PLoS One"},{"key":"D4FO06234E\/cit19\/1","first-page":"E617","volume":"317","author":"Cerd\u00f3","year":"2019","journal-title":"Am. J. Physiol.: Endocrinol. Metab."},{"key":"D4FO06234E\/cit20\/1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fendo.2020.00025","volume":"11","author":"Silva","year":"2020","journal-title":"Front. Endocrinol."},{"key":"D4FO06234E\/cit21\/1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.molmed.2014.05.002","volume":"20","author":"Borre","year":"2014","journal-title":"Trends Mol. Med."},{"key":"D4FO06234E\/cit22\/1","doi-asserted-by":"crossref","first-page":"e34092","DOI":"10.1016\/j.heliyon.2024.e34092","volume":"10","author":"Ashique","year":"2024","journal-title":"Heliyon"},{"issue":"3","key":"D4FO06234E\/cit23\/1","doi-asserted-by":"crossref","first-page":"938","DOI":"10.3390\/nu13030938","volume":"13","author":"Ryan","year":"2021","journal-title":"Nutrients"},{"key":"D4FO06234E\/cit24\/1","doi-asserted-by":"crossref","first-page":"7983","DOI":"10.1038\/s41598-019-43780-9","volume":"9","author":"Zabel","year":"2019","journal-title":"Sci. Rep."},{"key":"D4FO06234E\/cit25\/1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-024-03552-2","author":"Wang","year":"2024","journal-title":"Pediatr. Res."},{"key":"D4FO06234E\/cit26\/1","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/s41564-021-00970-4","volume":"6","author":"Laursen","year":"2021","journal-title":"Nat. Microbiol."},{"key":"D4FO06234E\/cit27\/1","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1007\/s11010-022-04471-8","volume":"477","author":"Dong","year":"2022","journal-title":"Mol. Cell. Biochem."},{"key":"D4FO06234E\/cit28\/1","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.3389\/fmicb.2017.01067","volume":"8","author":"Succi","year":"2017","journal-title":"Front. Microbiol."},{"key":"D4FO06234E\/cit29\/1","doi-asserted-by":"crossref","first-page":"7461","DOI":"10.3168\/jds.2023-23367","volume":"106","author":"Luo","year":"2023","journal-title":"J. Dairy Sci."},{"key":"D4FO06234E\/cit30\/1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1039\/D3FO02663A","volume":"15","author":"Wang","year":"2024","journal-title":"Food Funct."},{"key":"D4FO06234E\/cit31\/1","doi-asserted-by":"crossref","first-page":"7865","DOI":"10.1039\/D4FO00886C","volume":"15","author":"Li","year":"2024","journal-title":"Food Funct."},{"issue":"3","key":"D4FO06234E\/cit32\/1","doi-asserted-by":"crossref","first-page":"719","DOI":"10.3390\/nu15030719","volume":"15","author":"Berger","year":"2023","journal-title":"Nutrients"},{"key":"D4FO06234E\/cit33\/1","doi-asserted-by":"crossref","first-page":"822020","DOI":"10.3389\/fnut.2022.822020","volume":"9","author":"Yao","year":"2022","journal-title":"Front. Nutr."},{"issue":"8","key":"D4FO06234E\/cit34\/1","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.3390\/nu15081845","volume":"15","author":"Kim","year":"2023","journal-title":"Nutrients"},{"key":"D4FO06234E\/cit35\/1","doi-asserted-by":"crossref","first-page":"10924","DOI":"10.1039\/D3FO03272H","volume":"14","author":"Kou","year":"2023","journal-title":"Food Funct."},{"key":"D4FO06234E\/cit36\/1","doi-asserted-by":"crossref","first-page":"112072","DOI":"10.1016\/j.foodres.2022.112072","volume":"162","author":"Liu","year":"2022","journal-title":"Food Res. Int."},{"key":"D4FO06234E\/cit37\/1","doi-asserted-by":"crossref","first-page":"104162","DOI":"10.1016\/j.fbio.2024.104162","volume":"59","author":"Chen","year":"2024","journal-title":"Food Biosci."},{"key":"D4FO06234E\/cit38\/1","first-page":"2565","volume":"4","author":"Oliveros","year":"2021","journal-title":"Nutr. Food Sci."},{"key":"D4FO06234E\/cit39\/1","doi-asserted-by":"crossref","first-page":"1054431","DOI":"10.3389\/fnut.2022.1054431","volume":"9","author":"Xie","year":"2022","journal-title":"Front. Nutr."},{"key":"D4FO06234E\/cit40\/1","doi-asserted-by":"crossref","first-page":"118738","DOI":"10.1016\/j.carbpol.2021.118738","volume":"276","author":"Zhang","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"D4FO06234E\/cit41\/1","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.3168\/jds.2019-17645","volume":"103","author":"Quinn","year":"2020","journal-title":"J. Dairy Sci."},{"issue":"11","key":"D4FO06234E\/cit42\/1","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.3390\/microorganisms11112659","volume":"11","author":"Nogacka","year":"2023","journal-title":"Microorganisms"},{"issue":"24","key":"D4FO06234E\/cit43\/1","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.3390\/nu14245392","volume":"14","author":"Mao","year":"2022","journal-title":"Nutrients"},{"key":"D4FO06234E\/cit44\/1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1186\/s12866-016-0867-4","volume":"16","author":"Bunesova","year":"2016","journal-title":"BMC Microbiol."},{"key":"D4FO06234E\/cit45\/1","doi-asserted-by":"crossref","first-page":"eadj3502","DOI":"10.1126\/science.adj3502","volume":"382","author":"Spragge","year":"2023","journal-title":"Science"},{"key":"D4FO06234E\/cit46\/1","doi-asserted-by":"crossref","first-page":"eadd6617","DOI":"10.1126\/sciimmunol.add6617","volume":"7","author":"Clark","year":"2022","journal-title":"Sci. Immunol."},{"key":"D4FO06234E\/cit47\/1","doi-asserted-by":"crossref","first-page":"24760","DOI":"10.1073\/pnas.1908128116","volume":"116","author":"Bostick","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D4FO06234E\/cit48\/1","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1038\/s41396-021-00937-7","volume":"15","author":"Tsukuda","year":"2021","journal-title":"ISME J."},{"key":"D4FO06234E\/cit49\/1","doi-asserted-by":"crossref","first-page":"11939","DOI":"10.1038\/ncomms11939","volume":"7","author":"Matsuki","year":"2016","journal-title":"Nat. Commun."},{"issue":"3","key":"D4FO06234E\/cit50\/1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3390\/microorganisms6030075","volume":"6","author":"Geerlings","year":"2018","journal-title":"Microorganisms"},{"key":"D4FO06234E\/cit51\/1","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1136\/gutjnl-2020-322260","volume":"69","author":"Paone","year":"2020","journal-title":"Gut"},{"key":"D4FO06234E\/cit52\/1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.nutres.2022.07.007","volume":"106","author":"Yadav","year":"2022","journal-title":"Nutr. Res."},{"issue":"4","key":"D4FO06234E\/cit53\/1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3390\/cells12040657","volume":"12","author":"Fock","year":"2023","journal-title":"Cells"},{"key":"D4FO06234E\/cit54\/1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s40168-019-0713-7","volume":"7","author":"Li","year":"2019","journal-title":"Microbiome"},{"key":"D4FO06234E\/cit55\/1","doi-asserted-by":"crossref","first-page":"e15795","DOI":"10.15252\/emmm.202215795","volume":"14","author":"Liu","year":"2022","journal-title":"EMBO Mol. Med."},{"key":"D4FO06234E\/cit56\/1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuropharm.2015.11.003","volume":"102","author":"Kratsman","year":"2016","journal-title":"Neuropharmacology"},{"key":"D4FO06234E\/cit57\/1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41575-019-0157-3","volume":"16","author":"Dalile","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/FO\/D4FO06234E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:28:13Z","timestamp":1782941293000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/16\/7\/2703-2717\/851456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":57,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,3,31]]}},"URL":"https:\/\/doi.org\/10.1039\/d4fo06234e","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}