{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:25:51Z","timestamp":1793107551206,"version":"4.5.0"},"reference-count":51,"publisher":"Royal Society of Chemistry (RSC)","issue":"21","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"am","delay-in-days":626,"URL":"http:\/\/rsc.li\/journals-terms-of-use#chorus"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["IIP2122712"],"award-info":[{"award-number":["IIP2122712"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CHE2216473"],"award-info":[{"award-number":["CHE2216473"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP210165"],"award-info":[{"award-number":["RP210165"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R41AI162477"],"award-info":[{"award-number":["R41AI162477"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI107415"],"award-info":[{"award-number":["R21AI107415"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Lab Chip"],"abstract":"<jats:p>A reusable and cost-effective paper-in-polymer-pond (PiPP) hybrid microfluidic microplate with unique features for ultrasensitive and high-throughput multiplexed detection of disease biomarkers within an hour without using specialized instruments.<\/jats:p>","DOI":"10.1039\/d4lc00485j","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T07:59:27Z","timestamp":1726646367000},"page":"4962-4973","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A paper-in-polymer-pond (PiPP) hybrid microfluidic microplate for multiplexed ultrasensitive detection of cancer biomarkers"],"prefix":"10.1039","volume":"24","author":[{"given":"Sanjay S.","family":"Timilsina","sequence":"first","affiliation":[{"name":"Department of Chemistry & Biochemistry, University of Texas at El Paso, 500 W University Ave, El Paso, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7954-0717","authenticated-orcid":false,"given":"XiuJun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemistry & Biochemistry, University of Texas at El Paso, 500 W University Ave, El Paso, TX, USA"},{"name":"Forensic Science & Environmental Science and Engineering, 500 W University Ave, El Paso, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D4LC00485J\/cit1\/1","doi-asserted-by":"crossref","first-page":"811044","DOI":"10.3389\/fpubh.2022.811044","volume":"10","author":"Wang","year":"2022","journal-title":"Front. Public Health"},{"key":"D4LC00485J\/cit2\/1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"Bray","year":"2018","journal-title":"Ca-Cancer J. Clin."},{"key":"D4LC00485J\/cit3\/1","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Cancer"},{"key":"D4LC00485J\/cit4\/1","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0140-6736(03)12713-4","volume":"361","author":"Gr\u00f6nberg","year":"2003","journal-title":"Lancet"},{"key":"D4LC00485J\/cit5\/1","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Cancer"},{"key":"D4LC00485J\/cit6\/1","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1097\/CM9.0000000000001619","volume":"134","author":"Lu","year":"2021","journal-title":"Chin. Med. J."},{"key":"D4LC00485J\/cit7\/1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.5306\/wjco.v5.i3.465","volume":"5","author":"Unger-Salda\u00f1a","year":"2014","journal-title":"World J. Clin. Oncol."},{"key":"D4LC00485J\/cit8\/1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"Sung","year":"2021","journal-title":"Ca-Cancer J. Clin."},{"key":"D4LC00485J\/cit9\/1","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1200\/JCO.2013.49.1241","volume":"31","author":"Guy Jr","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"D4LC00485J\/cit10\/1","volume-title":"The global economic burden of noncommunicable diseases","author":"Bloom","year":"2012","unstructured":"D. E.Bloom ,  E.Cafiero ,  E.Jan\u00e9-Llopis ,  S.Abrahams-Gessel ,  L. R.Bloom ,  S.Fathima ,  A. B.Feigl ,  T.Gaziano ,  A.Hamandi  and  M.Mowafi ,  The global economic burden of noncommunicable diseases , Program on the Global Demography of Aging,  2012"},{"issue":"4","key":"D4LC00485J\/cit11\/1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1136\/gutjnl-2015-310912","volume":"66","author":"Arnold","year":"2016","journal-title":"Gut"},{"key":"D4LC00485J\/cit12\/1","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.1007\/s00216-012-6656-5","volume":"405","author":"Sardesai","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"D4LC00485J\/cit13\/1","volume-title":"A Genetic Link Between Prostate Cancer and Colon Cancer","author":"Pomakov","year":"2024","unstructured":"O.Pomakov ,  A Genetic Link Between Prostate Cancer and Colon Cancer ,  https:\/\/drcatalona.com\/quest\/a-genetic-link-between-prostate-cancer-and-colon-cancer\/ , (accessed May 7,  2024 )"},{"key":"D4LC00485J\/cit14\/1","doi-asserted-by":"crossref","first-page":"5930","DOI":"10.1021\/acs.analchem.8b00842","volume":"90","author":"Fu","year":"2018","journal-title":"Anal. Chem."},{"key":"D4LC00485J\/cit15\/1","doi-asserted-by":"crossref","first-page":"7062","DOI":"10.1039\/C5AN00780A","volume":"140","author":"Sanjay","year":"2015","journal-title":"Analyst"},{"key":"D4LC00485J\/cit16\/1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.talanta.2015.04.068","volume":"145","author":"Dou","year":"2015","journal-title":"Talanta"},{"key":"D4LC00485J\/cit17\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2017.09.013","volume":"128","author":"Sanjay","year":"2018","journal-title":"Adv. Drug Delivery Rev."},{"key":"D4LC00485J\/cit18\/1","doi-asserted-by":"crossref","DOI":"10.1533\/9780857097040","volume-title":"Microfluidic devices for biomedical applications","author":"Li","year":"2013","unstructured":"X. J.Li  and  Y.Zhou ,  Microfluidic devices for biomedical applications ,  Elsevier ,  2013"},{"key":"D4LC00485J\/cit19\/1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2144\/05383RV02","volume":"38","author":"Fiorini","year":"2005","journal-title":"BioTechniques"},{"key":"D4LC00485J\/cit20\/1","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.bios.2016.09.033","volume":"87","author":"Dou","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"D4LC00485J\/cit21\/1","doi-asserted-by":"crossref","first-page":"772","DOI":"10.2174\/1389201017666160127110440","volume":"17","author":"Sanjay","year":"2016","journal-title":"Curr. Pharm. Biotechnol."},{"key":"D4LC00485J\/cit22\/1","doi-asserted-by":"crossref","first-page":"114365","DOI":"10.1016\/j.addr.2022.114365","volume":"187","author":"Zhang","year":"2022","journal-title":"Adv. Drug Delivery Rev."},{"key":"D4LC00485J\/cit23\/1","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1021\/acs.accounts.1c00382","volume":"54","author":"Timilsina","year":"2021","journal-title":"Acc. Chem. Res."},{"key":"D4LC00485J\/cit24\/1","doi-asserted-by":"crossref","first-page":"117809","DOI":"10.1016\/j.trac.2024.117809","volume":"177","author":"Li","year":"2024","journal-title":"TrAC, Trends Anal. Chem."},{"key":"D4LC00485J\/cit25\/1","doi-asserted-by":"crossref","first-page":"30474","DOI":"10.1038\/srep30474","volume":"6","author":"Sanjay","year":"2016","journal-title":"Sci. Rep."},{"key":"D4LC00485J\/cit26\/1","doi-asserted-by":"crossref","first-page":"5422","DOI":"10.1039\/C5NR09051B","volume":"8","author":"Fu","year":"2016","journal-title":"Nanoscale"},{"key":"D4LC00485J\/cit27\/1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.suronc.2008.05.008","volume":"18","author":"Tan","year":"2009","journal-title":"Surg. Oncol."},{"key":"D4LC00485J\/cit28\/1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bios.2013.11.065","volume":"55","author":"Zhou","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"D4LC00485J\/cit29\/1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bios.2017.10.027","volume":"101","author":"Zhou","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"D4LC00485J\/cit30\/1","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1007\/s12668-016-0390-y","volume":"7","author":"Barbosa","year":"2017","journal-title":"Bionanoscience"},{"key":"D4LC00485J\/cit31\/1","doi-asserted-by":"crossref","first-page":"20196","DOI":"10.1039\/C8NR06367B","volume":"10","author":"Chen","year":"2018","journal-title":"Nanoscale"},{"key":"D4LC00485J\/cit32\/1","doi-asserted-by":"crossref","first-page":"5707","DOI":"10.1021\/acs.analchem.7b00726","volume":"89","author":"Li","year":"2017","journal-title":"Anal. Chem."},{"key":"D4LC00485J\/cit33\/1","doi-asserted-by":"crossref","first-page":"5152","DOI":"10.1021\/acs.analchem.7b00989","volume":"89","author":"Qiu","year":"2017","journal-title":"Anal. Chem."},{"key":"D4LC00485J\/cit34\/1","doi-asserted-by":"crossref","first-page":"15105","DOI":"10.1021\/acs.analchem.1c03387","volume":"93","author":"Fu","year":"2021","journal-title":"Anal. Chem."},{"key":"D4LC00485J\/cit35\/1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.bios.2015.03.006","volume":"70","author":"Barbosa","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"D4LC00485J\/cit36\/1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41378-020-0143-5","volume":"6","author":"Sanjay","year":"2020","journal-title":"Microsyst. Nanoeng."},{"key":"D4LC00485J\/cit37\/1","first-page":"127516","author":"Prasad","year":"2019","journal-title":"Sens. Actuators, B"},{"key":"D4LC00485J\/cit38\/1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.tibtech.2017.01.001","volume":"35","author":"Walsh III","year":"2017","journal-title":"Trends Biotechnol."},{"key":"D4LC00485J\/cit39\/1","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1080\/15583724.2015.1031377","volume":"55","author":"Ali","year":"2015","journal-title":"Polym. Rev."},{"key":"D4LC00485J\/cit40\/1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/elps.201100482","volume":"33","author":"Zhou","year":"2012","journal-title":"Electrophoresis"},{"key":"D4LC00485J\/cit41\/1","doi-asserted-by":"crossref","first-page":"7978","DOI":"10.1021\/ac5021694","volume":"86","author":"Dou","year":"2014","journal-title":"Anal. Chem."},{"key":"D4LC00485J\/cit42\/1","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.1039\/c3lc50654a","volume":"13","author":"Zuo","year":"2013","journal-title":"Lab Chip"},{"key":"D4LC00485J\/cit43\/1","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1039\/D2LC00834C","volume":"22","author":"Tavakoli","year":"2022","journal-title":"Lab Chip"},{"key":"D4LC00485J\/cit44\/1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.aca.2017.02.040","volume":"969","author":"Jia","year":"2017","journal-title":"Anal. Chim. Acta"},{"key":"D4LC00485J\/cit45\/1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.snb.2017.12.197","volume":"260","author":"Chen","year":"2018","journal-title":"Sens. Actuators, B"},{"key":"D4LC00485J\/cit46\/1","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1039\/C0LC00398K","volume":"11","author":"Fragoso","year":"2011","journal-title":"Lab Chip"},{"key":"D4LC00485J\/cit47\/1","doi-asserted-by":"crossref","first-page":"3883","DOI":"10.1039\/C6AN00254D","volume":"141","author":"Fu","year":"2016","journal-title":"Analyst"},{"key":"D4LC00485J\/cit48\/1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/cgt.2016.42","volume":"23","author":"Jazayeri","year":"2016","journal-title":"Cancer Gene Ther."},{"key":"D4LC00485J\/cit49\/1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.snb.2014.11.115","volume":"209","author":"Han","year":"2015","journal-title":"Sens. Actuators, B"},{"key":"D4LC00485J\/cit50\/1","doi-asserted-by":"crossref","first-page":"645","DOI":"10.4155\/bio.13.19","volume":"5","author":"van Amsterdam","year":"2013","journal-title":"Bioanalysis"},{"key":"D4LC00485J\/cit51\/1","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/elps.201800449","volume":"40","author":"Xu","year":"2019","journal-title":"Electrophoresis"}],"container-title":["Lab on a Chip"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/LC\/D4LC00485J","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/LC\/D4LC00485J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:15:09Z","timestamp":1782879309000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/lc\/article\/24\/21\/4962-4973\/853075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":51,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2024,10,22]]}},"URL":"https:\/\/doi.org\/10.1039\/d4lc00485j","relation":{},"ISSN":["1473-0197","1473-0189"],"issn-type":[{"value":"1473-0197","type":"print"},{"value":"1473-0189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}