{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:04:58Z","timestamp":1782889498058,"version":"3.54.5"},"reference-count":49,"publisher":"Royal Society of Chemistry (RSC)","issue":"1","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"am","delay-in-days":287,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100024589","name":"Institute of Advanced Study in Science and Technology","doi-asserted-by":"publisher","award":["IASST\/R&D\/LSD\/IHP-4\/2023-24\/1275-1283"],"award-info":[{"award-number":["IASST\/R&D\/LSD\/IHP-4\/2023-24\/1275-1283"]}],"id":[{"id":"10.13039\/501100024589","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>Virtual screening and synthetic modification of natural product-derived steroidal precursors as potential SGLT2 inhibitors for the treatment of diabetic nephropathy.<\/jats:p>","DOI":"10.1039\/d4md00645c","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T23:01:17Z","timestamp":1728946877000},"page":"296-311","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Breaking boundaries in diabetic nephropathy treatment: design and synthesis of novel steroidal SGLT2 inhibitors"],"prefix":"10.1039","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4683-6810","authenticated-orcid":false,"given":"Geetmani Singh","family":"Nongthombam","sequence":"first","affiliation":[{"name":"Chemical Biology Laboratory, Life Sciences Division, Institute of Advanced Study in Science and Technology, Guwahati-781035, Assam, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semim Akhtar","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Chemical Biology Laboratory, Life Sciences Division, Institute of Advanced Study in Science and Technology, Guwahati-781035, Assam, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangkon","family":"Saikia","sequence":"additional","affiliation":[{"name":"Chemical Biology Laboratory, Life Sciences Division, Institute of Advanced Study in Science and Technology, Guwahati-781035, Assam, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2821-3628","authenticated-orcid":false,"given":"Sanjib","family":"Gogoi","sequence":"additional","affiliation":[{"name":"Applied Organic Chemistry, Chemical Sciences & Technology Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6876-2659","authenticated-orcid":false,"given":"Jagat Chandra","family":"Borah","sequence":"additional","affiliation":[{"name":"Chemical Biology Laboratory, Life Sciences Division, Institute of Advanced Study in Science and Technology, Guwahati-781035, Assam, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India"},{"name":"Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Guwahati 781101, Assam, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D4MD00645C\/cit1\/1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.pathol.4.110807.092150","volume":"6","author":"Kanwar","year":"2011","journal-title":"Annu. Rev. Pathol.: Mech. Dis."},{"key":"D4MD00645C\/cit2\/1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3390\/life13020539","volume":"13","author":"Wu","year":"2023","journal-title":"Life"},{"key":"D4MD00645C\/cit3\/1","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.2522\/ptj.20080008","volume":"88","author":"Cade","year":"2008","journal-title":"Phys. Ther."},{"key":"D4MD00645C\/cit4\/1","doi-asserted-by":"crossref","first-page":"044","DOI":"10.29328\/journal.jcn.1001058","volume":"4","author":"Jorge","year":"2020","journal-title":"J. Clin. Nephrol."},{"key":"D4MD00645C\/cit5\/1","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1007\/s00125-018-4654-7","volume":"61","author":"Rieg","year":"2018","journal-title":"Diabetologia"},{"key":"D4MD00645C\/cit6\/1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nrd3180","volume":"9","author":"Chao","year":"2010","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D4MD00645C\/cit7\/1","volume-title":"Sodium-Glucose Transport Protein 2 (SGLT2) Inhibitors","author":"Padda","year":"2022","unstructured":"I. S.Padda ,  A. U.Mahtani  and  M.Parmar ,  Sodium-Glucose Transport Protein 2 (SGLT2) Inhibitors ,  2022"},{"key":"D4MD00645C\/cit8\/1","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.3390\/ijms18051083","volume":"18","author":"Kawanami","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"D4MD00645C\/cit9\/1","doi-asserted-by":"crossref","first-page":"109526","DOI":"10.1016\/j.biopha.2019.109526","volume":"120","author":"Yaribeygi","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"D4MD00645C\/cit10\/1","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.2337\/db16-0058","volume":"65","author":"Hawley","year":"2016","journal-title":"Diabetes"},{"key":"D4MD00645C\/cit11\/1","doi-asserted-by":"crossref","first-page":"e0240517","DOI":"10.1371\/journal.pone.0240517","volume":"15","author":"Moore","year":"2020","journal-title":"PLoS One"},{"key":"D4MD00645C\/cit12\/1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1089\/ars.2016.6664","volume":"25","author":"Jha","year":"2016","journal-title":"Antioxid. Redox Signaling"},{"key":"D4MD00645C\/cit13\/1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.14348\/molcells.2015.0010","volume":"38","author":"Gorin","year":"2015","journal-title":"Mol. Cells"},{"key":"D4MD00645C\/cit14\/1","doi-asserted-by":"crossref","first-page":"8406","DOI":"10.1021\/acs.jmedchem.4c00676","volume":"67","author":"Li","year":"2024","journal-title":"J. Med. Chem."},{"key":"D4MD00645C\/cit15\/1","doi-asserted-by":"crossref","first-page":"120437","DOI":"10.1016\/j.jlumin.2024.120437","volume":"269","author":"Min","year":"2024","journal-title":"J. Lumin."},{"key":"D4MD00645C\/cit16\/1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.kint.2016.02.043","volume":"90","author":"Coughlan","year":"2016","journal-title":"Kidney Int."},{"key":"D4MD00645C\/cit17\/1","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3390\/jcm9020458","volume":"9","author":"Donate-Correa","year":"2020","journal-title":"J. Clin. Med."},{"key":"D4MD00645C\/cit18\/1","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/s10787-021-00818-7","volume":"29","author":"El-Rous","year":"2021","journal-title":"Inflammopharmacology"},{"key":"D4MD00645C\/cit19\/1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13578-015-0056-4","volume":"5","author":"Zhang","year":"2015","journal-title":"Cell Biosci."},{"key":"D4MD00645C\/cit20\/1","first-page":"1","volume":"8","author":"Su","year":"2017","journal-title":"Front. Immunol."},{"key":"D4MD00645C\/cit21\/1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1369\/0022155419849388","volume":"67","author":"B\u00fclow","year":"2019","journal-title":"J. Histochem. Cytochem."},{"key":"D4MD00645C\/cit22\/1","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.biopha.2018.10.026","volume":"108","author":"Fan","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"D4MD00645C\/cit23\/1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1021\/acscombsci.8b00140","volume":"21","author":"Nongthombam","year":"2019","journal-title":"ACS Comb. Sci."},{"key":"D4MD00645C\/cit24\/1","doi-asserted-by":"crossref","first-page":"152893","DOI":"10.1016\/j.tetlet.2021.152893","volume":"67","author":"Nongthombam","year":"2021","journal-title":"Tetrahedron Lett."},{"key":"D4MD00645C\/cit25\/1","doi-asserted-by":"crossref","first-page":"138311","DOI":"10.1016\/j.molstruc.2024.138311","volume":"1310","author":"Feng","year":"2024","journal-title":"J. Mol. Struct."},{"key":"D4MD00645C\/cit26\/1","doi-asserted-by":"crossref","first-page":"6897","DOI":"10.1021\/acs.jmedchem.4c00906","volume":"67","author":"Lang","year":"2024","journal-title":"J. Med. Chem."},{"key":"D4MD00645C\/cit27\/1","doi-asserted-by":"crossref","first-page":"135279","DOI":"10.1016\/j.molstruc.2023.135279","volume":"1283","author":"Lin","year":"2023","journal-title":"J. Mol. Struct."},{"key":"D4MD00645C\/cit28\/1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3987\/REV-18-898","volume":"98","author":"Nongthombam","year":"2019","journal-title":"Heterocycles"},{"key":"D4MD00645C\/cit29\/1","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1080\/00397911.2021.1955930","volume":"51","author":"Nongthombam","year":"2021","journal-title":"Synth. Commun."},{"key":"D4MD00645C\/cit30\/1","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1039\/C4NJ02372B","volume":"39","author":"Singh","year":"2015","journal-title":"New J. Chem."},{"key":"D4MD00645C\/cit31\/1","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.2337\/dc12-1503","volume":"36","author":"Ferrannini","year":"2013","journal-title":"Diabetes Care"},{"key":"D4MD00645C\/cit32\/1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1113\/EP086478","volume":"103","author":"Chonlaket","year":"2018","journal-title":"Exp. Physiol."},{"key":"D4MD00645C\/cit33\/1","doi-asserted-by":"crossref","first-page":"110684","DOI":"10.1016\/j.biopha.2020.110684","volume":"131","author":"Guo","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"D4MD00645C\/cit34\/1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1464-5491.2009.02894.x","volume":"27","author":"Gerich","year":"2010","journal-title":"Diabetic Med."},{"key":"D4MD00645C\/cit35\/1","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.3390\/antiox10081166","volume":"10","author":"Tsai","year":"2021","journal-title":"Antioxidants"},{"key":"D4MD00645C\/cit36\/1","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.freeradbiomed.2018.06.042","volume":"124","author":"Yang","year":"2018","journal-title":"Free Radical Biol. Med."},{"key":"D4MD00645C\/cit37\/1","doi-asserted-by":"crossref","first-page":"7881","DOI":"10.3390\/ijms22157881","volume":"22","author":"Wang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"D4MD00645C\/cit38\/1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ddtec.2004.11.007","volume":"1","author":"Lipinski","year":"2004","journal-title":"Drug Discovery Today: Technol."},{"key":"D4MD00645C\/cit39\/1","doi-asserted-by":"crossref","first-page":"5560","DOI":"10.1016\/j.bmcl.2009.08.045","volume":"19","author":"Johnson","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4MD00645C\/cit40\/1","doi-asserted-by":"crossref","first-page":"5.6.1","DOI":"10.1002\/cpbi.3","volume":"54","author":"Webb","year":"2016","journal-title":"Curr. Protoc. Bioinf."},{"key":"D4MD00645C\/cit41\/1","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1063\/1.463137","volume":"97","author":"Tuckerman","year":"1992","journal-title":"J. Chem. Phys."},{"key":"D4MD00645C\/cit42\/1","first-page":"1","author":"Fu","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"D4MD00645C\/cit43\/1","doi-asserted-by":"crossref","first-page":"110347","DOI":"10.1016\/j.cbi.2023.110347","volume":"371","author":"Ahmed","year":"2023","journal-title":"Chem.-Biol. Interact."},{"key":"D4MD00645C\/cit44\/1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s13659-018-0188-4","volume":"9","author":"Lu","year":"2019","journal-title":"Nat. Prod. Bioprospect."},{"key":"D4MD00645C\/cit45\/1","doi-asserted-by":"crossref","first-page":"105803","DOI":"10.1016\/j.fitote.2023.105803","volume":"173","author":"Swargiary","year":"2024","journal-title":"Fitoterapia"},{"key":"D4MD00645C\/cit46\/1","doi-asserted-by":"crossref","first-page":"e1003696","DOI":"10.1371\/journal.pgen.1003696","volume":"9","author":"Tiao","year":"2013","journal-title":"PLoS Genet."},{"key":"D4MD00645C\/cit47\/1","doi-asserted-by":"crossref","first-page":"115936","DOI":"10.1016\/j.jep.2022.115936","volume":"303","author":"Gurumayum","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"D4MD00645C\/cit48\/1","doi-asserted-by":"crossref","first-page":"173840","DOI":"10.1016\/j.ejphar.2020.173840","volume":"893","author":"Xu","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"D4MD00645C\/cit49\/1","doi-asserted-by":"crossref","first-page":"153309","DOI":"10.1016\/j.phymed.2020.153309","volume":"78","author":"Chen","year":"2020","journal-title":"Phytomedicine"}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/MD\/D4MD00645C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:29:23Z","timestamp":1782883763000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/16\/1\/296-311\/854671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,23]]}},"URL":"https:\/\/doi.org\/10.1039\/d4md00645c","relation":{},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}