{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:11:27Z","timestamp":1783703487286,"version":"3.55.0"},"reference-count":26,"publisher":"Royal Society of Chemistry (RSC)","issue":"3","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"am","delay-in-days":382,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22377001"],"award-info":[{"award-number":["22377001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>An effective compound treatment of ALI by reducing oxidative stress and inflammatory response was discovered.<\/jats:p>","DOI":"10.1039\/d4md00858h","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T20:41:01Z","timestamp":1737146461000},"page":"1441-1458","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Discovery of a novel pyrimidine derivative for treatment of acute lung injury through reducing oxidative stress and inflammatory response"],"prefix":"10.1039","volume":"16","author":[{"given":"Yu Jie","family":"Jian","sequence":"first","affiliation":[{"name":"School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, 230032, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Lv","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, 230032, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leran","family":"Du","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, 230032, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cen Cen","family":"Lei","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, 230032, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Ping","family":"Zhi","sequence":"additional","affiliation":[{"name":"School of Health Management, Anhui Medical University Hefei, 230032, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7984-2977","authenticated-orcid":false,"given":"Xin Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, 230032, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D4MD00858H\/cit1\/1","doi-asserted-by":"crossref","first-page":"104736","DOI":"10.1016\/j.phrs.2020.104736","volume":"155","author":"Abedi","year":"2020","journal-title":"Pharmacol. Res."},{"key":"D4MD00858H\/cit2\/1","doi-asserted-by":"crossref","first-page":"154143","DOI":"10.1016\/j.phymed.2022.154143","volume":"101","author":"Hong","year":"2022","journal-title":"Phytomedicine"},{"key":"D4MD00858H\/cit3\/1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.5858\/arpa.2015-0519-RA","volume":"140","author":"Butt","year":"2016","journal-title":"Arch. Pathol. Lab. Med."},{"key":"D4MD00858H\/cit4\/1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molimm.2017.12.008","volume":"94","author":"Meng","year":"2018","journal-title":"Mol. Immunol."},{"key":"D4MD00858H\/cit5\/1","doi-asserted-by":"crossref","first-page":"105224","DOI":"10.1016\/j.phrs.2020.105224","volume":"163","author":"He","year":"2021","journal-title":"Pharmacol. Res."},{"key":"D4MD00858H\/cit6\/1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1055\/s-0033-1351119","volume":"34","author":"Sweeney","year":"2013","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"D4MD00858H\/cit7\/1","doi-asserted-by":"crossref","first-page":"109706","DOI":"10.1016\/j.biopha.2019.109706","volume":"122","author":"Ding","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"D4MD00858H\/cit8\/1","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1056\/NEJM199605303342201","volume":"334","author":"Anzueto","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"D4MD00858H\/cit9\/1","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1007\/s001340101077","volume":"27","author":"Vincent","year":"2001","journal-title":"Intensive Care Med."},{"key":"D4MD00858H\/cit10\/1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1164\/ajrccm\/138.1.62","volume":"138","author":"Luce","year":"1988","journal-title":"Am. Rev. Respir. Dis."},{"key":"D4MD00858H\/cit11\/1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1517\/14728214.12.3.461","volume":"12","author":"Bosma","year":"2007","journal-title":"Expert Opin. Emerging Drugs"},{"key":"D4MD00858H\/cit12\/1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1517\/14728214.2015.1000299","volume":"20","author":"Impellizzeri","year":"2015","journal-title":"Expert Opin. Emerging Drugs"},{"key":"D4MD00858H\/cit13\/1","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1001\/jama.2017.21907","volume":"319","author":"Fan","year":"2018","journal-title":"JAMA, J. Am. Med. Assoc."},{"key":"D4MD00858H\/cit14\/1","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1378\/chest.10-0014","volume":"138","author":"Stapleton","year":"2010","journal-title":"Chest"},{"key":"D4MD00858H\/cit15\/1","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1002\/cphy.c100068","volume":"1","author":"Sarma","year":"2011","journal-title":"Compr. Physiol."},{"key":"D4MD00858H\/cit16\/1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/med.21599","volume":"40","author":"Cinelli","year":"2020","journal-title":"Med. Res. Rev."},{"key":"D4MD00858H\/cit17\/1","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1093\/jnen\/63.9.901","volume":"63","author":"Minghetti","year":"2004","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"D4MD00858H\/cit18\/1","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.biopha.2017.02.081","volume":"89","author":"Zhang","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"D4MD00858H\/cit19\/1","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/ptr.5833","volume":"31","author":"Tao","year":"2017","journal-title":"Phytother. Res."},{"key":"D4MD00858H\/cit20\/1","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.intimp.2015.08.021","volume":"28","author":"Xu","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"D4MD00858H\/cit21\/1","doi-asserted-by":"crossref","first-page":"705080","DOI":"10.3389\/fimmu.2021.705080","volume":"12","author":"Shirey","year":"2021","journal-title":"Front. Immunol."},{"key":"D4MD00858H\/cit22\/1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cell.2008.02.043","volume":"133","author":"Imai","year":"2008","journal-title":"Cell"},{"key":"D4MD00858H\/cit23\/1","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.bbamcr.2018.02.010","volume":"1865","author":"Bellezza","year":"2018","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"key":"D4MD00858H\/cit24\/1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12967-021-02745-1","volume":"19","author":"Li","year":"2021","journal-title":"J. Transl. Med."},{"key":"D4MD00858H\/cit25\/1","doi-asserted-by":"crossref","first-page":"174748","DOI":"10.1016\/j.ejphar.2022.174748","volume":"917","author":"Zhang","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"D4MD00858H\/cit26\/1","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1007\/s00210-023-02813-x","volume":"397","author":"Zhao","year":"2024","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/MD\/D4MD00858H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:22:20Z","timestamp":1783448540000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/16\/3\/1441-1458\/854738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3,19]]}},"URL":"https:\/\/doi.org\/10.1039\/d4md00858h","relation":{},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}