{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:48:25Z","timestamp":1782967705038,"version":"3.54.5"},"reference-count":40,"publisher":"Royal Society of Chemistry (RSC)","issue":"3","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/M506539\/1"],"award-info":[{"award-number":["EP\/M506539\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/M508056\/1"],"award-info":[{"award-number":["EP\/M508056\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/T517896\/1"],"award-info":[{"award-number":["EP\/T517896\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000853","name":"University of Glasgow","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000853","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/Y008944\/1"],"award-info":[{"award-number":["MR\/Y008944\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["221295\/Z\/20\/Z"],"award-info":[{"award-number":["221295\/Z\/20\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/19\/34\/34354"],"award-info":[{"award-number":["FS\/19\/34\/34354"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/16\/10\/32375"],"award-info":[{"award-number":["RG\/16\/10\/32375"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000848","name":"University of Edinburgh","doi-asserted-by":"publisher","award":["RE\/13\/3\/30183"],"award-info":[{"award-number":["RE\/13\/3\/30183"]}],"id":[{"id":"10.13039\/501100000848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020414","name":"Neurosciences Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020414","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000923","name":"Silicon Valley Community Foundation","doi-asserted-by":"publisher","award":["10.13039\/100014989"],"award-info":[{"award-number":["10.13039\/100014989"]}],"id":[{"id":"10.13039\/100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000923","name":"Silicon Valley Community Foundation","doi-asserted-by":"publisher","award":["DAF2021-225273"],"award-info":[{"award-number":["DAF2021-225273"]}],"id":[{"id":"10.13039\/100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>A series of fluorinated 6-arylaminobenzamides have been shown to be selective and potent agonists of the sphingosine-1-phosphate-5 receptor. Radiofluorination and PET imaging with the lead compound showed fast uptake in rat brain and spinal cord.<\/jats:p>","DOI":"10.1039\/d4md00929k","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T07:40:41Z","timestamp":1735890041000},"page":"1235-1249","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Synthesis and evaluation of 6-arylaminobenzamides as positron emission tomography imaging ligands for the sphingosine-1-phosphate-5 receptor"],"prefix":"10.1039","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0220-8879","authenticated-orcid":false,"given":"Timaeus E. F.","family":"Morgan","sequence":"first","affiliation":[{"name":"School of Chemistry, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK"},{"name":"Edinburgh Imaging, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma K.","family":"Grant","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Edinburgh Imaging, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK"},{"name":"University\/BHF Centre for Cardiovascular Sciences, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lachlan J. N.","family":"Waddell","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martyn C.","family":"Henry","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"McErlain","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos J.","family":"Alcaide-Corral","sequence":"additional","affiliation":[{"name":"Edinburgh Imaging, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally L.","family":"Pimlott","sequence":"additional","affiliation":[{"name":"West of Scotland PET Centre, Greater Glasgow and Clyde NHS Trust, Glasgow, G12 OYN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana A. S.","family":"Tavares","sequence":"additional","affiliation":[{"name":"Edinburgh Imaging, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK"},{"name":"University\/BHF Centre for Cardiovascular Sciences, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7907-5766","authenticated-orcid":false,"given":"Andrew","family":"Sutherland","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D4MD00929K\/cit1\/1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nrd2356","volume":"8","author":"Marsolais","year":"2009","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D4MD00929K\/cit2\/1","doi-asserted-by":"crossref","first-page":"eaar5551","DOI":"10.1126\/science.aar5551","volume":"366","author":"Cartier","year":"2019","journal-title":"Science"},{"key":"D4MD00929K\/cit3a\/1","doi-asserted-by":"crossref","first-page":"6299","DOI":"10.1021\/cr200273u","volume":"111","author":"Blaho","year":"2011","journal-title":"Chem. Rev."},{"key":"D4MD00929K\/cit3b\/1","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1194\/jlr.R046300","volume":"55","author":"Blaho","year":"2014","journal-title":"J. Lipid Res."},{"key":"D4MD00929K\/cit4\/1","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3389\/fphar.2019.00807","volume":"10","author":"Grassi","year":"2019","journal-title":"Front. Pharmacol."},{"key":"D4MD00929K\/cit5\/1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2165\/11596550-000000000-00000","volume":"51","author":"David","year":"2012","journal-title":"Clin. Pharmacokinet."},{"key":"D4MD00929K\/cit6\/1","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nrd3248","volume":"9","author":"Brinkmann","year":"2010","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D4MD00929K\/cit7\/1","doi-asserted-by":"crossref","first-page":"14053","DOI":"10.1021\/bi011606i","volume":"40","author":"Im","year":"2001","journal-title":"Biochemistry"},{"key":"D4MD00929K\/cit8\/1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/1742-2094-9-133","volume":"9","author":"Van Doorn","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"D4MD00929K\/cit9\/1","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1523\/JNEUROSCI.4645-04.2005","volume":"25","author":"Jaillard","year":"2005","journal-title":"J. Neurosci."},{"key":"D4MD00929K\/cit10a\/1","doi-asserted-by":"crossref","first-page":"6724","DOI":"10.1021\/jm200609t","volume":"54","author":"Demont","year":"2011","journal-title":"J. Med. Chem."},{"key":"D4MD00929K\/cit10b\/1","doi-asserted-by":"crossref","first-page":"9154","DOI":"10.1021\/acs.jmedchem.5b00928","volume":"58","author":"Hobson","year":"2015","journal-title":"J. Med. Chem."},{"key":"D4MD00929K\/cit11\/1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1021\/acsmedchemlett.0c00631","volume":"12","author":"Ma","year":"2021","journal-title":"ACS Med. Chem. Lett."},{"key":"D4MD00929K\/cit12\/1","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s40265-019-01140-x","volume":"79","author":"Al-Salama","year":"2019","journal-title":"Drugs"},{"key":"D4MD00929K\/cit13\/1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1039\/B922628C","volume":"40","author":"Pimlott","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"D4MD00929K\/cit14a\/1","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1039\/C6CS00492J","volume":"46","author":"van der Born","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"D4MD00929K\/cit14b\/1","doi-asserted-by":"crossref","first-page":"13873","DOI":"10.1021\/acs.joc.1c01474","volume":"86","author":"Halder","year":"2021","journal-title":"J. Org. Chem."},{"key":"D4MD00929K\/cit15a\/1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/cmdc.201000477","volume":"6","author":"Briard","year":"2011","journal-title":"ChemMedChem"},{"key":"D4MD00929K\/cit15b\/1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/jlcr.3055","volume":"56","author":"Rokka","year":"2013","journal-title":"J. Labelled Compd. Radiopharm."},{"key":"D4MD00929K\/cit15c\/1","doi-asserted-by":"crossref","first-page":"5168","DOI":"10.1016\/j.bmc.2014.08.009","volume":"22","author":"Prasad","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"D4MD00929K\/cit15d\/1","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1021\/jm502021d","volume":"58","author":"Shaikh","year":"2015","journal-title":"J. Med. Chem."},{"key":"D4MD00929K\/cit15e\/1","doi-asserted-by":"crossref","first-page":"9171","DOI":"10.1039\/C8OB02609B","volume":"16","author":"Luo","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"D4MD00929K\/cit15f\/1","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1021\/acschemneuro.1c00492","volume":"12","author":"Jiang","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"D4MD00929K\/cit15g\/1","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.1021\/acs.jmedchem.2c01752","volume":"66","author":"Qiu","year":"2023","journal-title":"J. Med. Chem."},{"key":"D4MD00929K\/cit15h\/1","doi-asserted-by":"crossref","first-page":"117697","DOI":"10.1016\/j.bmc.2024.117697","volume":"104","author":"Prasad","year":"2024","journal-title":"Bioorg. Med. Chem."},{"key":"D4MD00929K\/cit15i\/1","doi-asserted-by":"crossref","first-page":"5428","DOI":"10.1039\/D4OB00712C","volume":"22","author":"Qiu","year":"2024","journal-title":"Org. Biomol. Chem."},{"key":"D4MD00929K\/cit16\/1","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1002\/cmdc.201000253","volume":"5","author":"Mattes","year":"2010","journal-title":"ChemMedChem"},{"key":"D4MD00929K\/cit17\/1","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1021\/acs.joc.5b02761","volume":"81","author":"Racys","year":"2016","journal-title":"J. Org. Chem."},{"key":"D4MD00929K\/cit18\/1","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1039\/C3CS60289C","volume":"43","author":"Sambiagio","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"D4MD00929K\/cit19\/1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/1097-0282(2000)55:2<140::AID-BIP40>3.0.CO;2-B","volume":"55","author":"Kami\u00f1ski","year":"2000","journal-title":"Pept. Sci."},{"key":"D4MD00929K\/cit20a\/1","doi-asserted-by":"crossref","first-page":"4782","DOI":"10.1021\/acs.orglett.5b02345","volume":"17","author":"Racys","year":"2015","journal-title":"Org. Lett."},{"key":"D4MD00929K\/cit20b\/1","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/chem.201605671","volume":"23","author":"Mostafa","year":"2017","journal-title":"Chem. \u2013 Eur. J."},{"key":"D4MD00929K\/cit21\/1","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1021\/cr00039a007","volume":"95","author":"Miyaura","year":"1995","journal-title":"Chem. Rev."},{"key":"D4MD00929K\/cit23\/1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.nucmedbio.2011.06.011","volume":"39","author":"Tavares","year":"2012","journal-title":"Nucl. Med. Biol."},{"key":"D4MD00929K\/cit24\/1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.lfs.2003.07.005","volume":"74","author":"Harrison","year":"2003","journal-title":"Life Sci."},{"key":"D4MD00929K\/cit25\/1","first-page":"217","volume-title":"Assay Guidance Manual","author":"DeLapp","year":"2012","unstructured":"N. W.DeLapp ,  W. H.Gough ,  S. D.Kahl ,  A. C.Porter  and  T. R.Wiernicki , in  Assay Guidance Manual , ed.  G. S. Sittampalam ,  A. Grossman  and  K. Brimacombe ,  Eli Lilly & Company and The National Center for Advancing Translational Sciences ,  Bethesda ,  2012 ,  pp. 217\u2013228"},{"key":"D4MD00929K\/cit27\/1","doi-asserted-by":"crossref","first-page":"e2300387","DOI":"10.1002\/ardp.202300387","volume":"356","author":"Wunsch","year":"2023","journal-title":"Arch. Pharm."},{"key":"D4MD00929K\/cit28\/1","doi-asserted-by":"crossref","first-page":"4736","DOI":"10.1038\/s41467-022-32447-1","volume":"13","author":"Lyapina","year":"2022","journal-title":"Nat. Commun."},{"key":"D4MD00929K\/cit29\/1","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/s41422-021-00566-x","volume":"31","author":"Yuan","year":"2021","journal-title":"Cell Res."},{"key":"D4MD00929K\/cit31\/1","doi-asserted-by":"crossref","first-page":"871","DOI":"10.3389\/fnins.2020.00871","volume":"14","author":"Shaw","year":"2020","journal-title":"Front. Neurosci."}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/MD\/D4MD00929K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:45:20Z","timestamp":1782963920000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/16\/3\/1235-1249\/854762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3,19]]}},"URL":"https:\/\/doi.org\/10.1039\/d4md00929k","relation":{},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}