{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T19:52:37Z","timestamp":1792871557980,"version":"4.5.0"},"reference-count":69,"publisher":"Royal Society of Chemistry (RSC)","issue":"5","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":63,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001747","name":"Hong Kong Baptist University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000741","name":"University of Warwick","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000741","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>\n                    One peptidomimetic metallohelix architecture has a balance of charge and lipophilicity that favours selective cell entry in\n                    <jats:italic>E. coli<\/jats:italic>\n                    over mammalian cells, while a closely related structure is promiscuous and unselective.\n                  <\/jats:p>","DOI":"10.1039\/d4md00973h","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T02:21:11Z","timestamp":1741141271000},"page":"2249-2260","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Membrane lipid composition directs the cellular selectivity of antimicrobial metallohelices"],"prefix":"10.1039","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9604-5136","authenticated-orcid":false,"given":"Nicola J.","family":"Rogers","sequence":"first","affiliation":[{"name":"Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong"},{"name":"Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4933-3052","authenticated-orcid":false,"given":"Miles L.","family":"Postings","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5261-304X","authenticated-orcid":false,"given":"Ann M.","family":"Dixon","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Moat","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Warwick, Gibbet Hill Campus, Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Shreeve","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Stuart","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8044-7763","authenticated-orcid":false,"given":"Nicholas R.","family":"Waterfield","sequence":"additional","affiliation":[{"name":"Warwick Medical School, University of Warwick, Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5656-7060","authenticated-orcid":false,"given":"Peter","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D4MD00973H\/cit1\/1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1574-6968.2002.tb11000.x","volume":"206","author":"Hancock","year":"2002","journal-title":"FEMS Microbiol. Lett."},{"key":"D4MD00973H\/cit2\/1","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nrmicro1098","volume":"3","author":"Brogden","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"D4MD00973H\/cit3\/1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1124\/pr.55.1.2","volume":"55","author":"Yeaman","year":"2003","journal-title":"Pharmacol. Rev."},{"key":"D4MD00973H\/cit4\/1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1517\/17460440902992888","volume":"4","author":"Marcos","year":"2009","journal-title":"Expert Opin. Drug Discovery"},{"key":"D4MD00973H\/cit5\/1","doi-asserted-by":"crossref","first-page":"D1087","DOI":"10.1093\/nar\/gkv1278","volume":"44","author":"Wang","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"D4MD00973H\/cit6\/1","unstructured":"https:\/\/aps.unmc.edu\/"},{"key":"D4MD00973H\/cit7\/1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/415389a","volume":"415","author":"Zasloff","year":"2002","journal-title":"Nature"},{"key":"D4MD00973H\/cit8\/1","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S0140-6736(97)80051-7","volume":"349","author":"Hancock","year":"1997","journal-title":"Lancet"},{"key":"D4MD00973H\/cit9\/1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/(SICI)1097-0282(1998)47:6<451::AID-BIP4>3.0.CO;2-F","volume":"47","author":"Oren","year":"1998","journal-title":"Peptide Sci."},{"key":"D4MD00973H\/cit10\/1","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.peptides.2003.08.023","volume":"24","author":"Powers","year":"2003","journal-title":"Peptides"},{"key":"D4MD00973H\/cit11\/1","doi-asserted-by":"crossref","first-page":"35714","DOI":"10.1074\/jbc.M104925200","volume":"276","author":"Zhang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"D4MD00973H\/cit12\/1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/wrr.12211","volume":"22","author":"Gr\u00f6nberg","year":"2014","journal-title":"Wound Repair Regen."},{"key":"D4MD00973H\/cit13\/1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1128\/AAC.03513-14","volume":"59","author":"Nilsson","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"D4MD00973H\/cit14\/1","doi-asserted-by":"crossref","first-page":"4610","DOI":"10.2174\/0929867323666160825162435","volume":"23","author":"Azmi","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"D4MD00973H\/cit15\/1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/978-1-4419-7692-5_6","volume-title":"Prokaryotic Antimicrobial Peptides: From Genes to Applications","author":"Tossi","year":"2011","unstructured":"A.Tossi , in  Prokaryotic Antimicrobial Peptides: From Genes to Applications , ed.  D. Drider  and  S. Rebuffat ,  Springer New York ,  New York, NY ,  2011 ,  pp. 81\u201398"},{"key":"D4MD00973H\/cit16\/1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1021\/ar900036b","volume":"43","author":"Tew","year":"2010","journal-title":"Acc. Chem. Res."},{"key":"D4MD00973H\/cit17\/1","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/S1367-5931(02)00385-X","volume":"6","author":"Patch","year":"2002","journal-title":"Curr. Opin. Chem. Biol."},{"key":"D4MD00973H\/cit18\/1","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1002\/cbic.202100151","volume":"22","author":"Jayawant","year":"2021","journal-title":"ChemBioChem"},{"key":"D4MD00973H\/cit19\/1","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1039\/D0SC06412B","volume":"12","author":"Song","year":"2021","journal-title":"Chem. Sci."},{"key":"D4MD00973H\/cit20\/1","doi-asserted-by":"crossref","first-page":"10241","DOI":"10.1021\/acs.chemrev.9b00008","volume":"119","author":"Dougherty","year":"2019","journal-title":"Chem. Rev."},{"key":"D4MD00973H\/cit21\/1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/jps.21117","volume":"97","author":"Foerg","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"D4MD00973H\/cit22\/1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1074\/jbc.M209548200","volume":"278","author":"Richard","year":"2003","journal-title":"J. Biol. Chem."},{"key":"D4MD00973H\/cit23\/1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00249-011-0682-7","volume":"40","author":"Splith","year":"2011","journal-title":"Eur. Biophys. J."},{"key":"D4MD00973H\/cit24\/1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ejpb.2004.02.018","volume":"58","author":"Tr\u00e9hin","year":"2004","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"D4MD00973H\/cit25\/1","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.1021\/jm4011675","volume":"57","author":"Walensky","year":"2014","journal-title":"J. Med. Chem."},{"key":"D4MD00973H\/cit26\/1","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1039\/c3sc51731d","volume":"4","author":"Brabec","year":"2013","journal-title":"Chem. Sci."},{"key":"D4MD00973H\/cit27\/1","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1039\/C5SC03677A","volume":"7","author":"Kaner","year":"2016","journal-title":"Chem. Sci."},{"key":"D4MD00973H\/cit28\/1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nchem.2024","volume":"6","author":"Faulkner","year":"2014","journal-title":"Nat. Chem."},{"key":"D4MD00973H\/cit29\/1","doi-asserted-by":"crossref","first-page":"8547","DOI":"10.1039\/C9SC02651G","volume":"10","author":"Song","year":"2019","journal-title":"Chem. Sci."},{"key":"D4MD00973H\/cit30\/1","doi-asserted-by":"crossref","first-page":"14677","DOI":"10.1002\/anie.202006814","volume":"59","author":"Song","year":"2020","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4MD00973H\/cit31\/1","doi-asserted-by":"crossref","first-page":"6656","DOI":"10.1039\/D3DT00948C","volume":"52","author":"Coverdale","year":"2023","journal-title":"Dalton Trans."},{"key":"D4MD00973H\/cit32\/1","doi-asserted-by":"crossref","first-page":"11029","DOI":"10.1039\/D4SC02541E","volume":"15","author":"Song","year":"2024","journal-title":"Chem. Sci."},{"key":"D4MD00973H\/cit33\/1","doi-asserted-by":"crossref","first-page":"5297","DOI":"10.1093\/nar\/gkv438","volume":"43","author":"Malina","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"D4MD00973H\/cit34\/1","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1093\/nar\/gkx244","volume":"45","author":"Zhao","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"D4MD00973H\/cit35\/1","doi-asserted-by":"crossref","first-page":"15723","DOI":"10.1002\/anie.201809207","volume":"57","author":"Zhao","year":"2018","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4MD00973H\/cit36\/1","doi-asserted-by":"crossref","first-page":"2198678","DOI":"10.1080\/14756366.2023.2198678","volume":"38","author":"Malina","year":"2023","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D4MD00973H\/cit37\/1","doi-asserted-by":"crossref","first-page":"7174","DOI":"10.1093\/nar\/gkad536","volume":"51","author":"Malina","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"D4MD00973H\/cit38\/1","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1093\/nar\/gkab1277","volume":"50","author":"Malina","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"D4MD00973H\/cit39\/1","doi-asserted-by":"crossref","first-page":"16554","DOI":"10.1002\/chem.202004060","volume":"26","author":"Hrabina","year":"2020","journal-title":"Chem. \u2013 Eur. J."},{"key":"D4MD00973H\/cit40\/1","doi-asserted-by":"crossref","first-page":"14543","DOI":"10.1038\/s41598-020-71429-5","volume":"10","author":"Malina","year":"2020","journal-title":"Sci. Rep."},{"key":"D4MD00973H\/cit41\/1","doi-asserted-by":"crossref","first-page":"8435","DOI":"10.1002\/chem.202001107","volume":"26","author":"Malina","year":"2020","journal-title":"Chem. \u2013 Eur. J."},{"key":"D4MD00973H\/cit42\/1","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1021\/acs.inorgchem.0c00092","volume":"59","author":"Hrabina","year":"2020","journal-title":"Inorg. Chem."},{"key":"D4MD00973H\/cit43\/1","doi-asserted-by":"crossref","first-page":"14656","DOI":"10.1039\/C5DT02018B","volume":"44","author":"Malina","year":"2015","journal-title":"Dalton Trans."},{"key":"D4MD00973H\/cit44\/1","doi-asserted-by":"crossref","first-page":"11655","DOI":"10.1021\/ja502789e","volume":"136","author":"Li","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"D4MD00973H\/cit45\/1","doi-asserted-by":"crossref","first-page":"eaao6718","DOI":"10.1126\/sciadv.aao6718","volume":"4","author":"Guan","year":"2018","journal-title":"Sci. Adv."},{"key":"D4MD00973H\/cit46\/1","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1039\/D2SC05897A","volume":"14","author":"Du","year":"2023","journal-title":"Chem. Sci."},{"key":"D4MD00973H\/cit47\/1","doi-asserted-by":"crossref","first-page":"8141","DOI":"10.1021\/acsnano.2c11476","volume":"17","author":"Liu","year":"2023","journal-title":"ACS Nano"},{"key":"D4MD00973H\/cit48\/1","doi-asserted-by":"crossref","first-page":"9835","DOI":"10.1021\/jacs.7b05822","volume":"139","author":"Mitchell","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"D4MD00973H\/cit49\/1","doi-asserted-by":"crossref","first-page":"9708","DOI":"10.1039\/C9SC03532J","volume":"10","author":"Simpson","year":"2019","journal-title":"Chem. Sci."},{"key":"D4MD00973H\/cit50\/1","volume-title":"Exploring QSAR - Hydrophobic, Electronic, and Steric Constants","author":"Hansch","year":"1995","unstructured":"C.Hansch ,  A.Leo  and  D.Hoekman ,  Exploring QSAR - Hydrophobic, Electronic, and Steric Constants ,  American Chemical Society ,  USA ,  1995"},{"key":"D4MD00973H\/cit51\/1","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1086\/533452","volume":"197","author":"Rice","year":"2008","journal-title":"J. Infect. Dis."},{"key":"D4MD00973H\/cit52\/1","first-page":"3919","volume":"11","author":"Lei","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"D4MD00973H\/cit53\/1","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.drudis.2011.05.010","volume":"16","author":"Kell","year":"2011","journal-title":"Drug Discovery Today"},{"key":"D4MD00973H\/cit54\/1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrd2438","volume":"7","author":"Dobson","year":"2008","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D4MD00973H\/cit55\/1","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.drudis.2012.03.015","volume":"17","author":"Di","year":"2012","journal-title":"Drug Discovery Today"},{"key":"D4MD00973H\/cit56\/1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrd3187","volume":"9","author":"Sugano","year":"2010","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D4MD00973H\/cit57\/1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00294-021-01217-9","volume":"68","author":"Frimodt-M\u00f8ller","year":"2022","journal-title":"Curr. Genet."},{"key":"D4MD00973H\/cit58\/1","doi-asserted-by":"crossref","first-page":"15610","DOI":"10.1021\/bi048206q","volume":"43","author":"Kobayashi","year":"2004","journal-title":"Biochemistry"},{"key":"D4MD00973H\/cit59\/1","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/psc.1319","volume":"17","author":"Epand","year":"2011","journal-title":"J. Pept. Sci."},{"key":"D4MD00973H\/cit60\/1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jcis.2018.10.103","volume":"537","author":"Ciumac","year":"2019","journal-title":"J. Colloid Interface Sci."},{"key":"D4MD00973H\/cit61\/1","doi-asserted-by":"crossref","DOI":"10.1201\/b11018","volume-title":"The Structure of Biological Membranes","author":"Yeagle","year":"2011","unstructured":"P. L.Yeagle ,  The Structure of Biological Membranes ,  CRC Press ,  Boca Raton , 3rd edn,  2011"},{"key":"D4MD00973H\/cit62\/1","doi-asserted-by":"crossref","first-page":"6801","DOI":"10.1074\/jbc.271.12.6801","volume":"271","author":"Morein","year":"1996","journal-title":"J. Biol. Chem."},{"key":"D4MD00973H\/cit63\/1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0014-5793(98)00733-9","volume":"431","author":"van Klompenburg","year":"1998","journal-title":"FEBS Lett."},{"key":"D4MD00973H\/cit64\/1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1432-1033.1996.00207.x","volume":"235","author":"Van Raalte","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"D4MD00973H\/cit65\/1","doi-asserted-by":"crossref","first-page":"8657","DOI":"10.1021\/bi963151g","volume":"36","author":"Speelmans","year":"1997","journal-title":"Biochemistry"},{"key":"D4MD00973H\/cit66\/1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1365-2672.1992.tb04999.x","volume":"73","author":"Aluyi","year":"1992","journal-title":"J. Appl. Bacteriol."},{"key":"D4MD00973H\/cit67\/1","doi-asserted-by":"crossref","first-page":"182990","DOI":"10.1016\/j.bbamem.2019.05.012","volume":"1861","author":"Agrawal","year":"2019","journal-title":"Biochim. Biophys. Acta"},{"key":"D4MD00973H\/cit68\/1","doi-asserted-by":"crossref","first-page":"11682","DOI":"10.1002\/chem.202101388","volume":"27","author":"Malina","year":"2021","journal-title":"Chem. \u2013 Eur. J."},{"key":"D4MD00973H\/cit69\/1","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/s41557-021-00708-z","volume":"13","author":"Hu","year":"2021","journal-title":"Nat. Chem."}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/MD\/D4MD00973H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:55:21Z","timestamp":1782885321000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/16\/5\/2249-2260\/854780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":69,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5,22]]}},"URL":"https:\/\/doi.org\/10.1039\/d4md00973h","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D4MD00973H\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4MD00973H\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4MD00973H\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4MD00973H\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4MD00973H\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}