{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:10:19Z","timestamp":1783537819044,"version":"3.55.0"},"reference-count":63,"publisher":"Royal Society of Chemistry (RSC)","issue":"6","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":63,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100024250","name":"Israel Innovation Authority","doi-asserted-by":"publisher","award":["75044"],"award-info":[{"award-number":["75044"]}],"id":[{"id":"10.13039\/501100024250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003289","name":"Ministry of Aliyah and Integration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006245","name":"Ministry of Science and Technology, Israel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["670\/20"],"award-info":[{"award-number":["670\/20"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>From metal-catalyzed to metal-free DNA cleavage.<\/jats:p>","DOI":"10.1039\/d4md00984c","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T02:21:06Z","timestamp":1741141266000},"page":"2576-2591","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Towards catalytic fluoroquinolones: from metal-catalyzed to metal-free DNA cleavage"],"prefix":"10.1039","volume":"16","author":[{"given":"Moshe N.","family":"Goldmeier","sequence":"first","affiliation":[{"name":"Edith and Joseph Fischer Enzyme Inhibitors Laboratory, Schulich Faculty of Chemistry, Technion \u2013 Israel Institute of Technology, Haifa 3200003, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Khononov","sequence":"additional","affiliation":[{"name":"Edith and Joseph Fischer Enzyme Inhibitors Laboratory, Schulich Faculty of Chemistry, Technion \u2013 Israel Institute of Technology, Haifa 3200003, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Pie\u0144ko","sequence":"additional","affiliation":[{"name":"Edith and Joseph Fischer Enzyme Inhibitors Laboratory, Schulich Faculty of Chemistry, Technion \u2013 Israel Institute of Technology, Haifa 3200003, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valery","family":"Belakhov","sequence":"additional","affiliation":[{"name":"Edith and Joseph Fischer Enzyme Inhibitors Laboratory, Schulich Faculty of Chemistry, Technion \u2013 Israel Institute of Technology, Haifa 3200003, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Chun","family":"Yen","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology and Food Engineering, Technion \u2013 Israel Institute of Technology, Haifa 3200003, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limor","family":"Baruch","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology and Food Engineering, Technion \u2013 Israel Institute of Technology, Haifa 3200003, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelle","family":"Machluf","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology and Food Engineering, Technion \u2013 Israel Institute of Technology, Haifa 3200003, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1427-2619","authenticated-orcid":false,"given":"Timor","family":"Baasov","sequence":"additional","affiliation":[{"name":"Edith and Joseph Fischer Enzyme Inhibitors Laboratory, Schulich Faculty of Chemistry, Technion \u2013 Israel Institute of Technology, Haifa 3200003, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D4MD00984C\/cit1\/1","doi-asserted-by":"publisher","DOI":"10.1038\/nature.2014.15135","author":"Reardon","year":"2014","journal-title":"Nature"},{"key":"D4MD00984C\/cit2\/1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1126\/science.abl5997","volume":"373","author":"Kwon","year":"2021","journal-title":"Science"},{"key":"D4MD00984C\/cit3\/1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3390\/antibiotics11020200","volume":"11","author":"Murugaiyan","year":"2022","journal-title":"Antibiotics"},{"key":"D4MD00984C\/cit4\/1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3390\/antibiotics12010067","volume":"12","author":"Ye","year":"2023","journal-title":"Antibiotics"},{"key":"D4MD00984C\/cit5\/1","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.3390\/molecules26092671","volume":"26","author":"Terreni","year":"2021","journal-title":"Molecules"},{"key":"D4MD00984C\/cit6\/1","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.3390\/antibiotics11091237","volume":"11","author":"Stennett","year":"2022","journal-title":"Antibiotics"},{"key":"D4MD00984C\/cit7\/1","doi-asserted-by":"crossref","first-page":"14113","DOI":"10.1002\/chem.201701714","volume":"23","author":"Yu","year":"2017","journal-title":"Chem. \u2013 Eur. J."},{"key":"D4MD00984C\/cit8\/1","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1021\/acsinfecdis.0c00777","volume":"7","author":"Goldmeier","year":"2021","journal-title":"ACS Infect. Dis."},{"key":"D4MD00984C\/cit9\/1","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1039\/c3cc38977d","volume":"49","author":"Joyner","year":"2013","journal-title":"Chem. Commun."},{"key":"D4MD00984C\/cit10\/1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1021\/acschembio.8b01087","volume":"14","author":"Alexander","year":"2019","journal-title":"ACS Chem. Biol."},{"key":"D4MD00984C\/cit11\/1","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1021\/acsinfecdis.8b00171","volume":"4","author":"Libardo","year":"2018","journal-title":"ACS Infect. Dis."},{"key":"D4MD00984C\/cit12\/1","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1111\/febs.14263","volume":"284","author":"Libardo","year":"2017","journal-title":"FEBS J."},{"key":"D4MD00984C\/cit13\/1","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.1021\/acs.biochem.9b00440","volume":"58","author":"Agbale","year":"2019","journal-title":"Biochemistry"},{"key":"D4MD00984C\/cit14\/1","doi-asserted-by":"crossref","first-page":"1137947","DOI":"10.3389\/fcimb.2023.1137947","volume":"13","author":"Zhao","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"D4MD00984C\/cit15\/1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/cbic.201800549","volume":"20","author":"Smolkin","year":"2019","journal-title":"ChemBioChem"},{"key":"D4MD00984C\/cit16\/1","doi-asserted-by":"crossref","first-page":"14049","DOI":"10.1021\/acs.jmedchem.2c01302","volume":"65","author":"Goldmeier","year":"2022","journal-title":"J. Med. Chem."},{"key":"D4MD00984C\/cit17\/1","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1021\/acsinfecdis.4c00128","volume":"10","author":"Collins","year":"2024","journal-title":"ACS Infect. Dis."},{"key":"D4MD00984C\/cit18\/1","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1021\/acsinfecdis.3c00346","volume":"10","author":"Oviatt","year":"2024","journal-title":"ACS Infect. Dis."},{"key":"D4MD00984C\/cit19\/1","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1021\/ic2019814","volume":"51","author":"Tjioe","year":"2012","journal-title":"Inorg. Chem."},{"key":"D4MD00984C\/cit20\/1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/ardp.19953280415","volume":"328","author":"Mahboobi","year":"1995","journal-title":"Arch. Pharm."},{"key":"D4MD00984C\/cit21\/1","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1073\/pnas.68.8.1678","volume":"68","author":"Page","year":"1971","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D4MD00984C\/cit22\/1","doi-asserted-by":"crossref","first-page":"15613","DOI":"10.1021\/ja2052599","volume":"133","author":"Joyner","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"D4MD00984C\/cit23\/1","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1039\/c0nj00347f","volume":"34","author":"Xu","year":"2010","journal-title":"New J. Chem."},{"key":"D4MD00984C\/cit24\/1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/cjoc.201300699","volume":"32","author":"Fang","year":"2014","journal-title":"Chin. J. Chem."},{"key":"D4MD00984C\/cit25\/1","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1021\/jm900028n","volume":"52","author":"Pokrovskaya","year":"2009","journal-title":"J. Med. Chem."},{"key":"D4MD00984C\/cit26\/1","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1021\/acs.jctc.8b01176","volume":"15","author":"Bannwarth","year":"2019","journal-title":"J. Chem. Theory Comput."},{"key":"D4MD00984C\/cit27\/1","doi-asserted-by":"crossref","first-page":"7169","DOI":"10.1039\/C9CP06869D","volume":"22","author":"Pracht","year":"2020","journal-title":"Phys. Chem. Chem. Phys."},{"key":"D4MD00984C\/cit28\/1","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1021\/acs.jpca.1c00971","volume":"125","author":"Grimme","year":"2021","journal-title":"J. Phys. Chem. A"},{"key":"D4MD00984C\/cit29\/1","first-page":"e1606","volume":"12","author":"Neese","year":"2022","journal-title":"Wiley Interdiscip. Rev.: Comput. Mol. Sci."},{"key":"D4MD00984C\/cit30\/1","doi-asserted-by":"crossref","first-page":"113472","DOI":"10.1016\/j.fluid.2022.113472","volume":"560","author":"Gerlach","year":"2022","journal-title":"Fluid Phase Equilib."},{"key":"D4MD00984C\/cit31\/1","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/pro.2647","volume":"24","author":"Fitch","year":"2015","journal-title":"Protein Sci."},{"key":"D4MD00984C\/cit32\/1","doi-asserted-by":"crossref","first-page":"20634","DOI":"10.1021\/acs.inorgchem.3c01417","volume":"62","author":"Marlin","year":"2023","journal-title":"Inorg. Chem."},{"key":"D4MD00984C\/cit33\/1","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/zaac.202100107","volume":"647","author":"Pazderov\u00e1","year":"2021","journal-title":"Z. Anorg. Allg. Chem."},{"key":"D4MD00984C\/cit34\/1","doi-asserted-by":"crossref","first-page":"6183","DOI":"10.1021\/acs.jcim.3c01153","volume":"63","author":"Case","year":"2023","journal-title":"J. Chem. Inf. Model."},{"key":"D4MD00984C\/cit35\/1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.cbpa.2008.01.012","volume":"12","author":"Dupureur","year":"2008","journal-title":"Curr. Opin. Chem. Biol."},{"key":"D4MD00984C\/cit36\/1","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1002\/jcc.23905","volume":"36","author":"Allen","year":"2015","journal-title":"J. Comput. Chem."},{"key":"D4MD00984C\/cit37\/1","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/nsmb.1892","volume":"17","author":"Wohlkonig","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"D4MD00984C\/cit38\/1","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1021\/jp4125099","volume":"118","author":"Roe","year":"2014","journal-title":"J. Phys. Chem. B"},{"key":"D4MD00984C\/cit39\/1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graphics"},{"key":"D4MD00984C\/cit40\/1","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1021\/jz501780a","volume":"5","author":"Izadi","year":"2014","journal-title":"J. Phys. Chem. Lett."},{"key":"D4MD00984C\/cit41\/1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1021\/acs.jcim.0c01390","volume":"61","author":"Sengupta","year":"2021","journal-title":"J. Chem. Inf. Model."},{"key":"D4MD00984C\/cit42\/1","doi-asserted-by":"crossref","first-page":"6292","DOI":"10.1021\/acs.jctc.1c00697","volume":"17","author":"Zgarbov\u00e1","year":"2021","journal-title":"J. Chem. Theory Comput."},{"key":"D4MD00984C\/cit43\/1","doi-asserted-by":"crossref","first-page":"074501","DOI":"10.1063\/1.4960175","volume":"145","author":"Izadi","year":"2016","journal-title":"J. Chem. Phys."},{"key":"D4MD00984C\/cit44\/1","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/jcc.20035","volume":"25","author":"Wang","year":"2004","journal-title":"J. Comput. Chem."},{"key":"D4MD00984C\/cit45\/1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/jcc.23775","volume":"36","author":"Betz","year":"2015","journal-title":"J. Comput. Chem."},{"key":"D4MD00984C\/cit46\/1","doi-asserted-by":"crossref","first-page":"224104","DOI":"10.1063\/5.0211276","volume":"160","author":"Tao","year":"2024","journal-title":"J. Chem. Phys."},{"key":"D4MD00984C\/cit47\/1","doi-asserted-by":"crossref","first-page":"154122","DOI":"10.1063\/1.5090222","volume":"150","author":"Caldeweyher","year":"2019","journal-title":"J. Chem. Phys."},{"key":"D4MD00984C\/cit48\/1","doi-asserted-by":"crossref","first-page":"124101","DOI":"10.1063\/1.5143190","volume":"152","author":"Hourahine","year":"2020","journal-title":"J. Chem. Phys."},{"key":"D4MD00984C\/cit49\/1","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S0968-0896(97)00051-5","volume":"5","author":"Perreault","year":"1997","journal-title":"Bioorg. Med. Chem."},{"key":"D4MD00984C\/cit50\/1","doi-asserted-by":"crossref","first-page":"127813","DOI":"10.1016\/j.molstruc.2020.127813","volume":"1207","author":"Kondratenko","year":"2020","journal-title":"J. Mol. Struct."},{"key":"D4MD00984C\/cit51\/1","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1002\/cbic.201100022","volume":"12","author":"Ullrich","year":"2011","journal-title":"ChemBioChem"},{"key":"D4MD00984C\/cit52\/1","doi-asserted-by":"crossref","first-page":"9012","DOI":"10.1021\/acs.joc.6b01643","volume":"81","author":"Salvio","year":"2016","journal-title":"J. Org. Chem."},{"key":"D4MD00984C\/cit53\/1","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/cbic.201500566","volume":"17","author":"Wirth-Hamdoune","year":"2016","journal-title":"ChemBioChem"},{"key":"D4MD00984C\/cit54\/1","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1021\/bc900543b","volume":"21","author":"Alkhader","year":"2010","journal-title":"Bioconjugate Chem."},{"key":"D4MD00984C\/cit55\/1","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.279.5356.1504","volume":"279","author":"Redinbo","year":"1998","journal-title":"Science"},{"key":"D4MD00984C\/cit56\/1","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1016\/j.bmcl.2006.01.106","volume":"16","author":"Wan","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4MD00984C\/cit57\/1","doi-asserted-by":"crossref","first-page":"5090","DOI":"10.1016\/j.ejmech.2009.06.030","volume":"44","author":"Li","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"D4MD00984C\/cit58\/1","doi-asserted-by":"crossref","first-page":"11059","DOI":"10.1039\/c1cc14185f","volume":"47","author":"Wang","year":"2011","journal-title":"Chem. Commun."},{"key":"D4MD00984C\/cit59\/1","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1021\/jo0624041","volume":"72","author":"Sheng","year":"2007","journal-title":"J. Org. Chem."},{"key":"D4MD00984C\/cit60\/1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/hlca.201300308","volume":"97","author":"G\u00f6bel","year":"2014","journal-title":"Helv. Chim. Acta"},{"key":"D4MD00984C\/cit61\/1","doi-asserted-by":"crossref","first-page":"5638","DOI":"10.1021\/ja964319o","volume":"119","author":"Hettich","year":"1997","journal-title":"J. Am. Chem. Soc."},{"key":"D4MD00984C\/cit62\/1","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"D4MD00984C\/cit63\/1","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing. 29th Ed. CLSI supplement M100","author":"CLSI","year":"2019","unstructured":"CLSI ,  Performance Standards for Antimicrobial Susceptibility Testing. 29th Ed. CLSI supplement M100 ,  Clinical and Laboratory Standards Institute ,  Wayne PA ,  2019"}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/MD\/D4MD00984C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:46:50Z","timestamp":1783532810000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/16\/6\/2576-2591\/854782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":63,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6,18]]}},"URL":"https:\/\/doi.org\/10.1039\/d4md00984c","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D4MD00984C\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4MD00984C\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4MD00984C\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4MD00984C\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4MD00984C\/v1\/review2","asserted-by":"object"}]},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}