{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:36:02Z","timestamp":1790562962389,"version":"4.1.0"},"reference-count":60,"publisher":"Royal Society of Chemistry (RSC)","issue":"12","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"am","delay-in-days":687,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nat. Prod. Rep."],"abstract":"<jats:p>A highlight on the discovery of the antifungal enfumafungin, its biosynthesis, activity profile and mode of action that led to the development program of ibrexafungerp, the first oral antifungal agent approved in more than 20 years.<\/jats:p>","DOI":"10.1039\/d4np00044g","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T03:24:42Z","timestamp":1731900282000},"page":"1835-1845","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Fungerps: discovery of the glucan synthase inhibitor enfumafungin and development of a new class of antifungal triterpene glycosides"],"prefix":"10.1039","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3198-9205","authenticated-orcid":false,"given":"Francisca","family":"Vicente","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Avda Conocimiento 34, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1607-5106","authenticated-orcid":false,"given":"Fernando","family":"Reyes","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Avda Conocimiento 34, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4202-1219","authenticated-orcid":false,"given":"Olga","family":"Genilloud","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Avda Conocimiento 34, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D4NP00044G\/cit1\/1","doi-asserted-by":"crossref","first-page":"732223","DOI":"10.3389\/fcimb.2021.732223","volume":"11","author":"McCarty","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"D4NP00044G\/cit2\/1","volume-title":"WHO fungal priority pathogens list to guide research, development and public health action","year":"2022","unstructured":"WHO fungal priority pathogens list to guide research, development and public health action ,  Geneva ,  World Health Organization ,  2022"},{"key":"D4NP00044G\/cit3\/1","doi-asserted-by":"crossref","first-page":"4882","DOI":"10.1021\/ja9944296","volume":"122","author":"Schwartz","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"D4NP00044G\/cit4\/1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0723-2020(00)80062-4","volume":"23","author":"Pel\u00e1ez","year":"2000","journal-title":"Syst. Appl. Microbiol."},{"key":"D4NP00044G\/cit5\/1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s101230100020","volume":"4","author":"Cabello","year":"2001","journal-title":"Int. Microbiol."},{"key":"D4NP00044G\/cit6\/1","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1046\/j.1365-2672.2001.01447.x","volume":"91","author":"Vicente","year":"2001","journal-title":"J. Appl. Microbiol."},{"key":"D4NP00044G\/cit7\/1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1128\/AAC.44.2.368-377.2000","volume":"44","author":"Onishi","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"D4NP00044G\/cit8\/1","doi-asserted-by":"crossref","first-page":"334","DOI":"10.7164\/antibiotics.50.334","volume":"50","author":"Onishi","year":"1997","journal-title":"Antibiotics"},{"key":"D4NP00044G\/cit9\/1","doi-asserted-by":"crossref","first-page":"32709","DOI":"10.1074\/jbc.272.51.32709","volume":"272","author":"Mandala","year":"1997","journal-title":"J. Biol. Chem."},{"key":"D4NP00044G\/cit10\/1","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1128\/AAC.36.8.1648","volume":"36","author":"Bartizal","year":"1992","journal-title":"Antimicrob. Agents Chemother."},{"key":"D4NP00044G\/cit11\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1002870","volume":"8","author":"Butts","year":"2012","journal-title":"PLoS Pathog."},{"key":"D4NP00044G\/cit12\/1","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1128\/AAC.00710-17","volume":"61","author":"Moreno-Vel\u00e1squez","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"D4NP00044G\/cit13\/1","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1128\/AAC.38.12.2750","volume":"38","author":"Kurtz","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"D4NP00044G\/cit14\/1","doi-asserted-by":"crossref","first-page":"127661","DOI":"10.1016\/j.bmcl.2020.127661","volume":"32","author":"Apgar","year":"2021","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4NP00044G\/cit15\/1","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1021\/np300412h","volume":"75","author":"R\u00edos","year":"2012","journal-title":"J. Nat. Prod."},{"key":"D4NP00044G\/cit16\/1","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1021\/np50126a034","volume":"58","author":"Gamble","year":"1995","journal-title":"J. Nat. Prod."},{"issue":"48","key":"D4NP00044G\/cit17\/1","first-page":"736","volume":"199","author":"Van der Pyl","year":"1995","journal-title":"J. Antibiot."},{"key":"D4NP00044G\/cit18\/1","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1039\/D2OB02158G","volume":"21","author":"Li","year":"2023","journal-title":"Org. Biomol. Chem."},{"key":"D4NP00044G\/cit19\/1","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1111\/1462-2920.14333","volume":"20","author":"Kuhnert","year":"2018","journal-title":"Environ. Microbiol."},{"key":"D4NP00044G\/cit20\/1","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1021\/acs.jnatprod.3c00562","volume":"86","author":"Cheng","year":"2023","journal-title":"J. Nat. Prod."},{"key":"D4NP00044G\/cit21\/1","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1016\/j.tetlet.2006.04.113","volume":"47","author":"Zorn","year":"2006","journal-title":"Tetrahedron Lett."},{"key":"D4NP00044G\/cit22\/1","doi-asserted-by":"crossref","first-page":"4838","DOI":"10.1016\/j.tetlet.2016.09.057","volume":"57","author":"Fujitani","year":"2016","journal-title":"Tetrahedron Lett."},{"key":"D4NP00044G\/cit27\/1","doi-asserted-by":"crossref","first-page":"6811","DOI":"10.1016\/j.bmcl.2012.05.031","volume":"22","author":"Heasley","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4NP00044G\/cit28\/1","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.1016\/j.bmcl.2015.10.011","volume":"25","author":"Apgar","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4NP00044G\/cit29\/1","first-page":"9","volume":"65","author":"Chu","year":"2021","journal-title":"Antimicrob. Agents Chemother."},{"key":"D4NP00044G\/cit30\/1","doi-asserted-by":"crossref","first-page":"127357","DOI":"10.1016\/j.bmcl.2020.127357","volume":"30","author":"Apgar","year":"2020","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4NP00044G\/cit31\/1","doi-asserted-by":"crossref","first-page":"127661","DOI":"10.1016\/j.bmcl.2020.127661","volume":"32","author":"Apgar","year":"2021","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4NP00044G\/cit32\/1","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1093\/jac\/dks466","volume":"68","author":"Pfaller","year":"2013","journal-title":"Antimicrob. Chemother."},{"key":"D4NP00044G\/cit33\/1","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1007\/s40265-021-01571-5","volume":"81","author":"Lee","year":"2021","journal-title":"Drugs"},{"key":"D4NP00044G\/cit34\/1","first-page":"7","volume":"61","author":"Schell","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"D4NP00044G\/cit35\/1","first-page":"2","volume":"61","author":"Schell","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"D4NP00044G\/cit36\/1","volume-title":"Proceedings of the ASM Microbe","author":"Ghannoum","year":"2020","unstructured":"M. L. L.Ghannoum ,  L.Long ,  R.Sherif ,  F. Z.Abidi ,  K.Borroto-Esoda ,  S.Barat , D.Angulo  and  N.Wiederhold ,  Proceedings of the ASM Microbe ,  Chicago, IL, USA ,  2020"},{"key":"D4NP00044G\/cit37\/1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1128\/AAC.02396-16","volume":"61","author":"Larkin","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"D4NP00044G\/cit38\/1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1128\/AAC.01692-19","volume":"63","author":"Nunnally","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"D4NP00044G\/cit39\/1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1128\/AAC.00244-18","volume":"62","author":"Ghannoum","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"D4NP00044G\/cit40\/1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3390\/jof7030232","volume":"7","author":"Rivero-Menendez","year":"2021","journal-title":"J. Fungi"},{"key":"D4NP00044G\/cit41\/1","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1128\/AAC.01588-12","volume":"57","author":"Pfaller","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"D4NP00044G\/cit42\/1","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1128\/AAC.02145-13","volume":"58","author":"Jim\u00e9nez-Ortigosa","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"D4NP00044G\/cit43\/1","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1128\/AAC.00234-15","volume":"59","author":"Lamoth","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"D4NP00044G\/cit44\/1","doi-asserted-by":"crossref","first-page":"e01510","DOI":"10.1128\/AAC.01510-19","volume":"63","author":"Ghannoum","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"D4NP00044G\/cit45\/1","first-page":"8","volume":"64","author":"Lee","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"D4NP00044G\/cit46\/1","doi-asserted-by":"crossref","first-page":"S472","DOI":"10.1093\/ofid\/ofx163.1207","volume":"4","author":"Borroto-Esoda","year":"2017","journal-title":"Open Forum Infect. Dis."},{"key":"D4NP00044G\/cit47\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1128\/AAC.02429-19","volume":"64","author":"Petraitis","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"D4NP00044G\/cit48\/1","volume-title":"29th European Congress of Clinical Microbiology and Infectious Diseases","author":"Barat","year":"2019","unstructured":"S.Barat ,  K.Borroto-Esoda ,  D.Angulo ,  A.Ashbaugh  and  M.CushionIn ,  29th European Congress of Clinical Microbiology and Infectious Diseases ,  Amsterdam, Netherlands ,  2019 , O0733"},{"key":"D4NP00044G\/cit49\/1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1128\/AAC.02068-16","volume":"61","author":"Wring","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"D4NP00044G\/cit50\/1","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1001\/jama.2022.6375","volume":"327","author":"Leclair","year":"2022","journal-title":"JAMA"},{"key":"D4NP00044G\/cit51\/1","doi-asserted-by":"crossref","first-page":"S445","DOI":"10.1093\/infdis\/jix131","volume":"216","author":"Arendrup","year":"2017","journal-title":"J. Infect. Dis."},{"key":"D4NP00044G\/cit52\/1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3390\/jof7030163","volume":"7","author":"Jallow","year":"2021","journal-title":"J. Fungi"},{"key":"D4NP00044G\/cit53\/1","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1093\/jac\/dkz277","volume":"74","author":"Spec","year":"2019","journal-title":"J. Antimicrob. Chemother."},{"key":"D4NP00044G\/cit54\/1","doi-asserted-by":"crossref","first-page":"e28776","DOI":"10.1016\/j.heliyon.2024.e28776","volume":"10","author":"He","year":"2024","journal-title":"Heliyon"},{"key":"D4NP00044G\/cit55\/1","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/cid\/ciab841","volume":"74","author":"Nyirjesy","year":"2022","journal-title":"Clin. Infect. Dis."},{"key":"D4NP00044G\/cit56\/1","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.3390\/jof8111121","volume":"8","author":"Angulo","year":"2022","journal-title":"J. Fungi"},{"key":"D4NP00044G\/cit57\/1","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/1471-0528.16972","volume":"129","author":"Sobel","year":"2022","journal-title":"BJOG"},{"key":"D4NP00044G\/cit58\/1","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1093\/cid\/ciab750","volume":"74","author":"Schwebke","year":"2022","journal-title":"Clin. Infect. Dis."},{"key":"D4NP00044G\/cit59\/1","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1007\/s40265-021-01611-0","volume":"81","author":"Hoenigl","year":"2021","journal-title":"Drugs"},{"key":"D4NP00044G\/cit60\/1","volume-title":"29th European Congress of Clinical Microbiology and Infectious Diseases","author":"Juneja","year":"2019","unstructured":"D.Juneja ,  O.Singh ,  B.Tarai  and  D.Angulo , In  29th European Congress of Clinical Microbiology and Infectious Diseases ,  Amsterdam, Netherlands ,  2019 ,  p. L0028"},{"key":"D4NP00044G\/cit61\/1","unstructured":"https:\/\/d1io3yog0oux5.cloudfront.net\/_7da6ffa8256e21a01d1cf6a17e9e8734\/scynexis\/news\/2021-06-02_SCYNEXIS_Announces_FDA_Approval_of_BREXAFEMME_240.pdf"},{"key":"D4NP00044G\/cit62\/1","unstructured":"https:\/\/d1io3yog0oux5.cloudfront.net\/_7da6ffa8256e21a01d1cf6a17e9e8734\/scynexis\/news\/2022-12-01_SCYNEXIS_Announces_FDA_Approval_of_Second_314.pdf"},{"key":"D4NP00044G\/cit63\/1","volume-title":"Oral Communication O0581","author":"Wiederhold","year":"2024","unstructured":"N.Wiederhold ,  L.Najvar ,  R.Jaramillo ,  M.Olivo ,  H.Patterson , and  T.Patterson ,  Oral Communication O0581 ,  ESCMID Global, ECCMID ,  Barcelona, Spain ,  2024"},{"key":"D4NP00044G\/cit64\/1","unstructured":"https:\/\/d1io3yog0oux5.cloudfront.net\/_7da6ffa8256e21a01d1cf6a17e9e8734\/scynexis\/news\/2024-05-08_SCYNEXIS_Reports_First_Quarter_2024_Financial_335.pdf"}],"container-title":["Natural Product Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/NP\/D4NP00044G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:36:14Z","timestamp":1782941774000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/np\/article\/41\/12\/1835-1845\/858794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":60,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12,11]]}},"URL":"https:\/\/doi.org\/10.1039\/d4np00044g","relation":{},"ISSN":["0265-0568","1460-4752"],"issn-type":[{"value":"0265-0568","type":"print"},{"value":"1460-4752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}