{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T14:49:16Z","timestamp":1789742956230,"version":"4.0.1"},"reference-count":45,"publisher":"Royal Society of Chemistry (RSC)","issue":"45","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":296,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["328933"],"award-info":[{"award-number":["328933"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["347897"],"award-info":[{"award-number":["347897"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["336355"],"award-info":[{"award-number":["336355"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["337531"],"award-info":[{"award-number":["337531"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003126","name":"Opetus- ja Kulttuuriministeri\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003126","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<jats:p>In this study, our innovative Mito@ZiF-8 system enhances the functionality of isolated mitochondria and reprograms M2 macrophage metabolism upon delivery, ultimately, reducing the tumorigenic potential of breast cancer cells.<\/jats:p>","DOI":"10.1039\/d4nr02471k","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T02:02:05Z","timestamp":1729648925000},"page":"20925-20939","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Encapsulated mitochondria to reprogram the metabolism of M2-type macrophages for anti-tumor therapy"],"prefix":"10.1039","volume":"16","author":[{"given":"Yonghui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Organ Transplantation Center, The First Hospital of Jilin University, Changchun, China"},{"name":"Pharmaceutical Sciences Laboratory, \u00c5bo Akademi University, Turku 20520, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Laboratory, \u00c5bo Akademi University, Turku 20520, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Ma","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Laboratory, \u00c5bo Akademi University, Turku 20520, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Filppula","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Laboratory, \u00c5bo Akademi University, Turku 20520, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youbin","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Organ Transplantation Center, The First Hospital of Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangbin","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1071-4416","authenticated-orcid":false,"given":"Hongbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Organ Transplantation Center, The First Hospital of Jilin University, Changchun, China"},{"name":"Pharmaceutical Sciences Laboratory, \u00c5bo Akademi University, Turku 20520, Finland"},{"name":"Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, Turku 20520, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D4NR02471K\/cit1\/1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.molcel.2016.02.011","volume":"61","author":"Zong","year":"2016","journal-title":"Mol. Cell"},{"key":"D4NR02471K\/cit2\/1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/cr.2017.155","volume":"28","author":"Porporato","year":"2018","journal-title":"Cell Res."},{"key":"D4NR02471K\/cit3\/1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1126\/science.2814477","volume":"246","author":"King","year":"1989","journal-title":"Science"},{"key":"D4NR02471K\/cit4\/1","doi-asserted-by":"crossref","first-page":"108875","DOI":"10.1016\/j.clim.2021.108875","volume":"232","author":"Goswami","year":"2021","journal-title":"Clin. Immunol."},{"key":"D4NR02471K\/cit5\/1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/s41423-023-01061-6","volume":"20","author":"Bied","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"D4NR02471K\/cit6\/1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1101\/gad.1756509","volume":"23","author":"Jones","year":"2009","journal-title":"Genes Dev."},{"key":"D4NR02471K\/cit7\/1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12943-023-01725-x","volume":"22","author":"Zhang","year":"2023","journal-title":"Mol. Cancer"},{"key":"D4NR02471K\/cit8\/1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jconrel.2022.01.025","volume":"343","author":"Huang","year":"2022","journal-title":"J. Controlled Release"},{"key":"D4NR02471K\/cit9\/1","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.apsb.2022.10.008","volume":"13","author":"Zhang","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"D4NR02471K\/cit10\/1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.pathol.4.110807.092314","volume":"5","author":"Wallace","year":"2010","journal-title":"Annu. Rev. Pathol.: Mech. Dis."},{"key":"D4NR02471K\/cit11\/1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1186\/s12967-023-04203-6","volume":"21","author":"Sun","year":"2023","journal-title":"J. Transl. Med."},{"key":"D4NR02471K\/cit12\/1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10549-012-2283-2","volume":"136","author":"Elliott","year":"2012","journal-title":"Breast Cancer Res. Treat."},{"key":"D4NR02471K\/cit13\/1","doi-asserted-by":"crossref","first-page":"5949","DOI":"10.2174\/0929867326666190618152518","volume":"27","author":"Cao","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"D4NR02471K\/cit14\/1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1021\/acsnano.7b08056","volume":"12","author":"Ricco","year":"2018","journal-title":"ACS Nano"},{"key":"D4NR02471K\/cit15\/1","doi-asserted-by":"crossref","first-page":"7240","DOI":"10.1038\/ncomms8240","volume":"6","author":"Liang","year":"2015","journal-title":"Nat. Commun."},{"key":"D4NR02471K\/cit16\/1","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1021\/acs.accounts.7b00090","volume":"50","author":"Doonan","year":"2017","journal-title":"Acc. Chem. Res."},{"key":"D4NR02471K\/cit17\/1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.cell.2020.02.051","volume":"181","author":"Russell","year":"2020","journal-title":"Cell"},{"key":"D4NR02471K\/cit18\/1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrm.2017.66","volume":"19","author":"Suomalainen","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"D4NR02471K\/cit19\/1","doi-asserted-by":"crossref","first-page":"1601406","DOI":"10.1002\/adhm.201601406","volume":"6","author":"Zhang","year":"2017","journal-title":"Adv. Healthc. Mater."},{"key":"D4NR02471K\/cit20\/1","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1158\/0008-5472.CAN-20-2990","volume":"81","author":"Anderson","year":"2021","journal-title":"Cancer Res."},{"key":"D4NR02471K\/cit21\/1","doi-asserted-by":"crossref","first-page":"175229","DOI":"10.1016\/j.ejphar.2022.175229","volume":"931","author":"Zhang","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"D4NR02471K\/cit22\/1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12943-021-01313-x","volume":"20","author":"Mohapatra","year":"2021","journal-title":"Mol. Cancer"},{"key":"D4NR02471K\/cit23\/1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3109\/08830185.2014.969421","volume":"34","author":"Zhu","year":"2015","journal-title":"Int. Rev. Immunol."},{"key":"D4NR02471K\/cit24\/1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13045-023-01478-6","volume":"16","author":"Li","year":"2023","journal-title":"J. Hematol. Oncol."},{"key":"D4NR02471K\/cit25\/1","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.trecan.2019.10.007","volume":"5","author":"Mehla","year":"2019","journal-title":"Trends Cancer"},{"key":"D4NR02471K\/cit26\/1","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.cmet.2020.05.004","volume":"31","author":"Zhang","year":"2020","journal-title":"Cell Metab."},{"key":"D4NR02471K\/cit27\/1","doi-asserted-by":"crossref","first-page":"12032","DOI":"10.3390\/ijms241512032","volume":"24","author":"Vassiliou","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D4NR02471K\/cit28\/1","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.tcb.2020.07.003","volume":"30","author":"Bakir","year":"2020","journal-title":"Trends Cell Biol."},{"key":"D4NR02471K\/cit29\/1","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.trecan.2020.06.005","volume":"6","author":"Ramesh","year":"2020","journal-title":"Trends Cancer"},{"key":"D4NR02471K\/cit30\/1","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.3892\/or.2013.2943","volume":"31","author":"Camerlingo","year":"2014","journal-title":"Oncol. Rep."},{"key":"D4NR02471K\/cit31\/1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13046-019-1028-z","volume":"38","author":"Chang","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"D4NR02471K\/cit32\/1","doi-asserted-by":"crossref","first-page":"e22898","DOI":"10.1002\/jbt.22898","volume":"35","author":"Kubat","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"D4NR02471K\/cit33\/1","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1128\/jb.142.2.414-423.1980","volume":"142","author":"Scott","year":"1980","journal-title":"J. Bacteriol."},{"key":"D4NR02471K\/cit34\/1","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1021\/ja1100189","volume":"133","author":"Yang","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"D4NR02471K\/cit35\/1","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.7150\/thno.33100","volume":"9","author":"Sun","year":"2019","journal-title":"Theranostics"},{"key":"D4NR02471K\/cit36\/1","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/s41586-024-07340-0","volume":"629","author":"Lin","year":"2024","journal-title":"Nature"},{"key":"D4NR02471K\/cit37\/1","doi-asserted-by":"crossref","first-page":"14669","DOI":"10.1038\/s41598-017-14868-x","volume":"7","author":"Yang","year":"2017","journal-title":"Sci. Rep."},{"key":"D4NR02471K\/cit38\/1","doi-asserted-by":"crossref","first-page":"1437S","DOI":"10.1093\/jn\/130.5.1437S","volume":"130","author":"McCall","year":"2000","journal-title":"J. Nutr."},{"key":"D4NR02471K\/cit39\/1","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s10534-014-9773-0","volume":"27","author":"Liuzzi","year":"2014","journal-title":"BioMetals"},{"key":"D4NR02471K\/cit40\/1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/ijc.34679","volume":"154","author":"Bendellaa","year":"2024","journal-title":"Int. J. Cancer"},{"key":"D4NR02471K\/cit41\/1","doi-asserted-by":"crossref","first-page":"H966","DOI":"10.1152\/ajpcell.00261.2012","volume":"304","author":"Masuzawa","year":"2013","journal-title":"Am. J. Physiol.: Heart Circ. Physiol."},{"key":"D4NR02471K\/cit42\/1","doi-asserted-by":"crossref","first-page":"115518","DOI":"10.1016\/j.biopha.2023.115518","volume":"167","author":"Martinez-Ruiz","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"D4NR02471K\/cit43\/1","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1038\/s41467-023-40015-4","volume":"14","author":"Setyawati","year":"2023","journal-title":"Nat. Commun."},{"key":"D4NR02471K\/cit44\/1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/s41467-024-44814-1","volume":"15","author":"Li","year":"2024","journal-title":"Nat. Commun."},{"key":"D4NR02471K\/cit45\/1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.mito.2017.03.004","volume":"34","author":"McCully","year":"2017","journal-title":"Mitochondrion"}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/NR\/D4NR02471K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T18:23:58Z","timestamp":1783275838000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/16\/45\/20925-20939\/859648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":45,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2024,11,21]]}},"URL":"https:\/\/doi.org\/10.1039\/d4nr02471k","relation":{},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}