{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:00:33Z","timestamp":1787313633509,"version":"build-2736575974"},"reference-count":69,"publisher":"Royal Society of Chemistry (RSC)","issue":"19","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":114,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","award":["cstc2021ycjh-bgzxm0064"],"award-info":[{"award-number":["cstc2021ycjh-bgzxm0064"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<jats:p>Topical administration of CPI NPs alleviates alkali burn-induced CRNV in rats, accompanied by downregulation of FTO expression and increased RNA m6A modification, with reductions in IL-6, TNF-\u03b1, VEGF, and CD31 levels. Created by Figdraw.<\/jats:p>","DOI":"10.1039\/d4nr05507a","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T11:06:27Z","timestamp":1745579187000},"page":"12323-12339","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Topical application of insulin encapsulated by chitosan-modified PLGA nanoparticles to alleviate alkali burn-induced corneal neovascularization"],"prefix":"10.1039","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0053-6806","authenticated-orcid":false,"given":"Yuqing","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"},{"name":"Chongqing Key Laboratory of Ultrasound Molecular Imaging, Institute of Ultrasound Imaging, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"},{"name":"State Key Laboratory of Ultrasound in Medicine and Engineering, Chongqing Medical University, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangrui","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Li","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Ultrasound Molecular Imaging, Institute of Ultrasound Imaging, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D4NR05507A\/cit1\/1","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.jtos.2020.09.002","volume":"18","author":"Cho","year":"2020","journal-title":"Ocul. Surf."},{"key":"D4NR05507A\/cit2\/1","doi-asserted-by":"crossref","first-page":"100456","DOI":"10.1016\/j.mtbio.2022.100456","volume":"17","author":"Huang","year":"2022","journal-title":"Mater. Today Bio"},{"key":"D4NR05507A\/cit3\/1","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jtos.2018.06.004","volume":"16","author":"Roshandel","year":"2018","journal-title":"Ocul. Surf."},{"key":"D4NR05507A\/cit4\/1","doi-asserted-by":"crossref","first-page":"e10276","DOI":"10.1002\/btm2.10276","volume":"7","author":"Wang","year":"2021","journal-title":"Bioeng. Transl. Med."},{"key":"D4NR05507A\/cit5\/1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.advms.2015.10.003","volume":"61","author":"Bakunowicz-\u0141azarczyk","year":"2016","journal-title":"Adv. Med. Sci."},{"key":"D4NR05507A\/cit6\/1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1056\/NEJMoa0905955","volume":"363","author":"Rama","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"D4NR05507A\/cit7\/1","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.2147\/OPTH.S235873","volume":"14","author":"Soleimani","year":"2020","journal-title":"Clin. Ophthalmol."},{"key":"D4NR05507A\/cit8\/1","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.jconrel.2023.09.019","volume":"362","author":"Zhang","year":"2023","journal-title":"J. Controlled Release"},{"key":"D4NR05507A\/cit9\/1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jtos.2012.01.005","volume":"10","author":"Stevenson","year":"2012","journal-title":"Ocul. Surf."},{"key":"D4NR05507A\/cit10\/1","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/j.ajpath.2020.08.006","volume":"190","author":"Yang","year":"2020","journal-title":"Am. J. Pathol."},{"key":"D4NR05507A\/cit11\/1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1076\/ceyr.21.5.833.5535","volume":"21","author":"Rocha","year":"2000","journal-title":"Curr. Eye Res."},{"key":"D4NR05507A\/cit12\/1","first-page":"2105","volume":"34","author":"Feldman","year":"1993","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"D4NR05507A\/cit13\/1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1136\/bjo.29.7.361","volume":"29","author":"Aynsley","year":"1945","journal-title":"Br. J. Ophthalmol."},{"key":"D4NR05507A\/cit14\/1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/pharmaceutics16010015","volume":"16","author":"Jaworski","year":"2023","journal-title":"Pharmaceutics"},{"key":"D4NR05507A\/cit15\/1","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1097\/ICO.0000000000003145","volume":"42","author":"Balal","year":"2023","journal-title":"Cornea"},{"key":"D4NR05507A\/cit16\/1","doi-asserted-by":"crossref","first-page":"e912","DOI":"10.1111\/aos.14997","volume":"100","author":"Diaz-Valle","year":"2022","journal-title":"Acta Ophthalmol."},{"key":"D4NR05507A\/cit17\/1","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.biopha.2018.04.097","volume":"104","author":"Song","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"D4NR05507A\/cit18\/1","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1097\/ICO.0000000000003308","volume":"42","author":"Dasrilsyah","year":"2023","journal-title":"Cornea"},{"key":"D4NR05507A\/cit19\/1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.addr.2017.04.001","volume":"122","author":"Janagam","year":"2017","journal-title":"Adv. Drug Delivery Rev."},{"key":"D4NR05507A\/cit20\/1","doi-asserted-by":"crossref","first-page":"114770","DOI":"10.1016\/j.addr.2023.114770","volume":"196","author":"Han","year":"2023","journal-title":"Adv. Drug Delivery Rev."},{"key":"D4NR05507A\/cit21\/1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.actbio.2020.01.008","volume":"104","author":"Wang","year":"2020","journal-title":"Acta Biomater."},{"key":"D4NR05507A\/cit22\/1","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.2174\/1381612822666151216145900","volume":"22","author":"Fangueiro","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"D4NR05507A\/cit23\/1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jconrel.2012.01.043","volume":"161","author":"Danhier","year":"2012","journal-title":"J. Controlled Release"},{"key":"D4NR05507A\/cit24\/1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2174\/1570159X19666210823103020","volume":"20","author":"Shahbaz","year":"2022","journal-title":"Curr. Neuropharmacol."},{"key":"D4NR05507A\/cit25\/1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jconrel.2024.01.053","volume":"367","author":"Xu","year":"2024","journal-title":"J. Controlled Release"},{"key":"D4NR05507A\/cit26\/1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1208\/s12249-019-1526-5","volume":"21","author":"Zhu","year":"2019","journal-title":"AAPS PharmSciTech"},{"key":"D4NR05507A\/cit27\/1","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.3390\/polym16182606","volume":"16","author":"Yang","year":"2024","journal-title":"Polymers"},{"key":"D4NR05507A\/cit28\/1","doi-asserted-by":"crossref","first-page":"114326","DOI":"10.1016\/j.ejpb.2024.114326","volume":"200","author":"Ramalho","year":"2024","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"D4NR05507A\/cit29\/1","doi-asserted-by":"crossref","first-page":"658","DOI":"10.3390\/molecules29030658","volume":"29","author":"Qin","year":"2024","journal-title":"Molecules"},{"key":"D4NR05507A\/cit30\/1","doi-asserted-by":"crossref","first-page":"e2302327","DOI":"10.1002\/adhm.202302327","volume":"13","author":"Bai","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"D4NR05507A\/cit31\/1","doi-asserted-by":"crossref","first-page":"5889","DOI":"10.3390\/ijms20235889","volume":"20","author":"Matica","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"D4NR05507A\/cit32\/1","first-page":"291","volume":"14","author":"Zali","year":"2015","journal-title":"Iran. J. Pharm. Res."},{"key":"D4NR05507A\/cit33\/1","first-page":"51159","author":"Anderson","year":"2014","journal-title":"J. Visualized Exp."},{"key":"D4NR05507A\/cit34\/1","doi-asserted-by":"crossref","first-page":"e15905","DOI":"10.1371\/journal.pone.0015905","volume":"6","author":"Bhattacharjee","year":"2011","journal-title":"PLoS One"},{"key":"D4NR05507A\/cit35\/1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1080\/10717544.2021.1872739","volume":"28","author":"Li","year":"2021","journal-title":"Drug Delivery"},{"key":"D4NR05507A\/cit36\/1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.ijbiomac.2021.09.069","volume":"191","author":"Suri","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"D4NR05507A\/cit37\/1","first-page":"150","volume":"14","author":"Amrite","year":"2008","journal-title":"Mol. Vision"},{"key":"D4NR05507A\/cit38\/1","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.actbio.2023.05.021","volume":"166","author":"Yao","year":"2023","journal-title":"Acta Biomater."},{"key":"D4NR05507A\/cit39\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2017.04.008","volume":"400","author":"Taghavi","year":"2017","journal-title":"Cancer Lett."},{"key":"D4NR05507A\/cit40\/1","doi-asserted-by":"crossref","first-page":"5397","DOI":"10.1039\/D0CS01127D","volume":"50","author":"Sousa de Almeida","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"D4NR05507A\/cit41\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40123-020-00257-7","volume":"9","author":"Meza-Rios","year":"2020","journal-title":"Ophthalmol. Ther."},{"key":"D4NR05507A\/cit42\/1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3390\/nano14080669","volume":"14","author":"Coco","year":"2024","journal-title":"Nanomaterials"},{"key":"D4NR05507A\/cit43\/1","doi-asserted-by":"crossref","first-page":"7861","DOI":"10.2147\/IJN.S269004","volume":"15","author":"Bin-Jumah","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"D4NR05507A\/cit44\/1","doi-asserted-by":"crossref","first-page":"7738","DOI":"10.1073\/pnas.0802857105","volume":"105","author":"Wang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D4NR05507A\/cit45\/1","doi-asserted-by":"crossref","first-page":"100251","DOI":"10.1016\/j.jhepr.2021.100251","volume":"3","author":"Mariotti","year":"2021","journal-title":"Jhep Rep."},{"key":"D4NR05507A\/cit46\/1","doi-asserted-by":"crossref","first-page":"5281","DOI":"10.3390\/ijms20215281","volume":"20","author":"Wang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"D4NR05507A\/cit47\/1","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1080\/10717544.2022.2048134","volume":"29","author":"Luo","year":"2022","journal-title":"Drug Delivery"},{"key":"D4NR05507A\/cit48\/1","doi-asserted-by":"crossref","first-page":"e10499","DOI":"10.1002\/btm2.10499","volume":"8","author":"Xiong","year":"2023","journal-title":"Bioeng. Transl. Med."},{"key":"D4NR05507A\/cit49\/1","doi-asserted-by":"crossref","first-page":"9596","DOI":"10.1038\/s41598-019-46116-9","volume":"9","author":"Shimizu","year":"2019","journal-title":"Sci. Rep."},{"key":"D4NR05507A\/cit50\/1","doi-asserted-by":"crossref","first-page":"7371","DOI":"10.1038\/s41467-022-35241-1","volume":"13","author":"Li","year":"2022","journal-title":"Nat. Commun."},{"key":"D4NR05507A\/cit51\/1","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1097\/ICO.0000000000002106","volume":"38","author":"Dohlman","year":"2019","journal-title":"Cornea"},{"key":"D4NR05507A\/cit52\/1","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.2217\/nnm-2017-0305","volume":"14","author":"Ibrahim Al-Mashahedah","year":"2019","journal-title":"Nanomedicine"},{"key":"D4NR05507A\/cit53\/1","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.1111\/jcmm.16501","volume":"25","author":"Nieto-Nicolau","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"D4NR05507A\/cit54\/1","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/s41419-018-0790-8","volume":"9","author":"Li","year":"2018","journal-title":"Cell Death Dis."},{"key":"D4NR05507A\/cit55\/1","doi-asserted-by":"crossref","first-page":"e2103317","DOI":"10.1002\/advs.202103317","volume":"9","author":"Ma","year":"2022","journal-title":"Adv. Sci."},{"key":"D4NR05507A\/cit56\/1","doi-asserted-by":"crossref","first-page":"zqab051","DOI":"10.1093\/function\/zqab051","volume":"2","author":"Ali","year":"2021","journal-title":"Function"},{"key":"D4NR05507A\/cit57\/1","doi-asserted-by":"crossref","first-page":"687381","DOI":"10.3389\/fphys.2021.687381","volume":"12","author":"Bayarri","year":"2021","journal-title":"Front. Physiol."},{"key":"D4NR05507A\/cit58\/1","doi-asserted-by":"crossref","first-page":"7757","DOI":"10.1002\/jcp.29382","volume":"235","author":"Chen","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"D4NR05507A\/cit59\/1","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/s41419-023-06200-5","volume":"14","author":"Cui","year":"2023","journal-title":"Cell Death Dis."},{"key":"D4NR05507A\/cit60\/1","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.7150\/ijbs.70292","volume":"18","author":"Wang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"D4NR05507A\/cit61\/1","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.molcel.2019.04.025","volume":"74","author":"Shi","year":"2019","journal-title":"Mol. Cell"},{"key":"D4NR05507A\/cit62\/1","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nchembio.687","volume":"7","author":"Jia","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"D4NR05507A\/cit63\/1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.gendis.2021.01.005","volume":"9","author":"Yang","year":"2021","journal-title":"Genes Dis."},{"key":"D4NR05507A\/cit64\/1","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.trecan.2022.02.010","volume":"8","author":"Li","year":"2022","journal-title":"Trends Cancer"},{"key":"D4NR05507A\/cit65\/1","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.numecd.2010.01.006","volume":"21","author":"Lappalainen","year":"2011","journal-title":"Nutr., Metab. Cardiovasc. Dis."},{"key":"D4NR05507A\/cit66\/1","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1161\/CIRCULATIONAHA.118.033794","volume":"139","author":"Mathiyalagan","year":"2019","journal-title":"Circulation"},{"key":"D4NR05507A\/cit67\/1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3389\/fonc.2019.00369","volume":"9","author":"Rong","year":"2019","journal-title":"Front. Oncol."},{"key":"D4NR05507A\/cit68\/1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/s44321-024-00025-1","volume":"16","author":"Chen","year":"2024","journal-title":"EMBO Mol. Med."},{"key":"D4NR05507A\/cit69\/1","doi-asserted-by":"crossref","first-page":"31431","DOI":"10.1021\/acsami.1c05405","volume":"13","author":"Bossi","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/NR\/D4NR05507A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:28:01Z","timestamp":1782883681000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/17\/19\/12323-12339\/860770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":69,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2025,5,15]]}},"URL":"https:\/\/doi.org\/10.1039\/d4nr05507a","relation":{},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}