{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:41:24Z","timestamp":1792456884342,"version":"4.5.0"},"reference-count":68,"publisher":"Royal Society of Chemistry (RSC)","issue":"14","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/100007699","name":"University of Georgia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007699","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007698","name":"University of Florida","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007698","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM153272"],"award-info":[{"award-number":["R35GM153272"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM136583"],"award-info":[{"award-number":["T32GM136583"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00AI163295"],"award-info":[{"award-number":["R00AI163295"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32GM136583"],"award-info":[{"award-number":["T32GM136583"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10 OD021758-01A1"],"award-info":[{"award-number":["S10 OD021758-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<jats:p>6,8-Ditrifluoromethyl halogenated phenazine potently eradicates Gram-positive bacterial biofilm communities that demonstrate innate tolerance to all classes of conventional antibiotics.<\/jats:p>","DOI":"10.1039\/d4ob02011a","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T02:41:43Z","timestamp":1736131303000},"page":"3342-3357","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Identification of 6,8-ditrifluoromethyl halogenated phenazine as a potent bacterial biofilm-eradicating agent"],"prefix":"10.1039","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5043-9669","authenticated-orcid":false,"given":"Qiwen","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical & Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia 30602, USA"},{"name":"Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Sheiber","sequence":"additional","affiliation":[{"name":"Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32827, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1643-0422","authenticated-orcid":false,"given":"Priscila Cristina","family":"Bartolomeu Halicki","sequence":"additional","affiliation":[{"name":"Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32827, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6827-6706","authenticated-orcid":false,"given":"Ke","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Blanco","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8718-9275","authenticated-orcid":false,"given":"Sadie","family":"Milhous","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouguang","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, Florida 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-3238","authenticated-orcid":false,"given":"Kyle H.","family":"Rohde","sequence":"additional","affiliation":[{"name":"Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32827, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7103-461X","authenticated-orcid":false,"given":"Renee M.","family":"Fleeman","sequence":"additional","affiliation":[{"name":"Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32827, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3811-2721","authenticated-orcid":false,"given":"Robert W.","family":"Huigens III","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical & Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia 30602, USA"},{"name":"Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA"},{"name":"Department of Chemistry, Franklin College of Arts and Sciences, University of Georgia, Athens, Georgia 30602, USA"},{"name":"Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D4OB02011A\/cit1\/1","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/s41579-024-01054-w","volume":"22","author":"Miller","year":"2024","journal-title":"Nat. Rev. Microbiol."},{"key":"D4OB02011A\/cit2\/1","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s41579-022-00682-4","volume":"20","author":"Ciofu","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"D4OB02011A\/cit3\/1","doi-asserted-by":"crossref","first-page":"7618","DOI":"10.1021\/acs.jmedchem.9b00370","volume":"62","author":"Abouelhassan","year":"2019","journal-title":"J. Med. Chem."},{"key":"D4OB02011A\/cit4\/1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41579-022-00820-y","volume":"21","author":"Darby","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"D4OB02011A\/cit5\/1","doi-asserted-by":"crossref","first-page":"VMBF-0016-2015","DOI":"10.1128\/microbiolspec.VMBF-0016-2015","volume":"4","author":"Munita","year":"2016","journal-title":"Microbiol. Spectrum"},{"key":"D4OB02011A\/cit6\/1","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1039\/c0cc05111j","volume":"47","author":"Wright","year":"2011","journal-title":"Chem. Commun."},{"key":"D4OB02011A\/cit7\/1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-micro-042922-122020","volume":"76","author":"Bridges","year":"2022","journal-title":"Annu. Rev. Microbiol."},{"key":"D4OB02011A\/cit8\/1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/978-3-642-28951-4_8","volume":"211","author":"Lewis","year":"2012","journal-title":"Handb. Exp. Pharmacol."},{"key":"D4OB02011A\/cit9\/1","doi-asserted-by":"crossref","first-page":"e00026","DOI":"10.1128\/MMBR.00026-19","volume":"84","author":"Schilcher","year":"2020","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"D4OB02011A\/cit10\/1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41392-024-01866-5","volume":"9","author":"Niu","year":"2024","journal-title":"Signal Transduction Targeted Ther."},{"key":"D4OB02011A\/cit11\/1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.chom.2019.06.002","volume":"26","author":"Yan","year":"2019","journal-title":"Cell Host Microbe"},{"key":"D4OB02011A\/cit12\/1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.tibtech.2018.10.011","volume":"37","author":"Wu","year":"2019","journal-title":"Trends Biotechnol."},{"key":"D4OB02011A\/cit13\/1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cell.2020.02.056","volume":"181","author":"Lewis","year":"2020","journal-title":"Cell"},{"key":"D4OB02011A\/cit14\/1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41586-024-07530-w","volume":"632","author":"Lewis","year":"2024","journal-title":"Nature"},{"key":"D4OB02011A\/cit15\/1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/nyas.14930","volume":"1519","author":"Lluka","year":"2023","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"D4OB02011A\/cit16\/1","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/s41573-023-00791-6","volume":"22","author":"Theuretzbacher","year":"2023","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D4OB02011A\/cit17\/1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nature12790","volume":"503","author":"Conlon","year":"2013","journal-title":"Nature"},{"key":"D4OB02011A\/cit18\/1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature14098","volume":"517","author":"Ling","year":"2015","journal-title":"Nature"},{"key":"D4OB02011A\/cit19\/1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41586-019-1791-1","volume":"576","author":"Imai","year":"2019","journal-title":"Nature"},{"key":"D4OB02011A\/cit20\/1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1126\/science.1109755","volume":"308","author":"Charest","year":"2005","journal-title":"Science"},{"key":"D4OB02011A\/cit21\/1","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1021\/ol071377d","volume":"9","author":"Brubaker","year":"2007","journal-title":"Org. Lett."},{"key":"D4OB02011A\/cit22\/1","doi-asserted-by":"crossref","first-page":"17913","DOI":"10.1021\/ja806629e","volume":"130","author":"Sun","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"D4OB02011A\/cit23\/1","doi-asserted-by":"crossref","first-page":"8840","DOI":"10.1002\/anie.201310843","volume":"53","author":"Wright","year":"2014","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4OB02011A\/cit24\/1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.cbpa.2016.03.011","volume":"32","author":"Liu","year":"2016","journal-title":"Curr. Opin. Chem. Biol."},{"key":"D4OB02011A\/cit25\/1","first-page":"57","author":"Seiple","year":"2015","journal-title":"Synlett"},{"key":"D4OB02011A\/cit26\/1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/anie.201507357","volume":"55","author":"Zhang","year":"2016","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4OB02011A\/cit27\/1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nature17967","volume":"533","author":"Seiple","year":"2016","journal-title":"Nature"},{"key":"D4OB02011A\/cit28\/1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/ja.2017.116","volume":"71","author":"Hogan","year":"2018","journal-title":"J. Antibiot."},{"key":"D4OB02011A\/cit29\/1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41586-021-04045-6","volume":"599","author":"Mitcheltree","year":"2021","journal-title":"Nature"},{"key":"D4OB02011A\/cit30\/1","doi-asserted-by":"crossref","first-page":"13946","DOI":"10.1021\/ja207142h","volume":"133","author":"Xie","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"D4OB02011A\/cit31\/1","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1021\/ja209937s","volume":"134","author":"Xie","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"D4OB02011A\/cit32\/1","doi-asserted-by":"crossref","first-page":"13522","DOI":"10.1021\/ja507009a","volume":"136","author":"Okano","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"D4OB02011A\/cit33\/1","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1021\/jacs.5b01008","volume":"137","author":"Okano","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"D4OB02011A\/cit34\/1","doi-asserted-by":"crossref","first-page":"E5052","DOI":"10.1073\/pnas.1704125114","volume":"114","author":"Okano","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D4OB02011A\/cit35\/1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nature22308","volume":"545","author":"Richter","year":"2017","journal-title":"Nature"},{"key":"D4OB02011A\/cit36\/1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/nyas.13598","volume":"1435","author":"Richter","year":"2019","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"D4OB02011A\/cit37\/1","doi-asserted-by":"crossref","first-page":"10856","DOI":"10.1021\/jacs.0c04427","volume":"142","author":"Motika","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"D4OB02011A\/cit38\/1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41564-019-0604-5","volume":"5","author":"Parker","year":"2020","journal-title":"Nat. Microbiol."},{"key":"D4OB02011A\/cit39\/1","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1021\/acs.accounts.0c00895","volume":"54","author":"Munoz","year":"2021","journal-title":"Acc. Chem. Res."},{"key":"D4OB02011A\/cit40\/1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41586-023-06760-8","volume":"624","author":"Geddes","year":"2023","journal-title":"Nature"},{"key":"D4OB02011A\/cit41\/1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/s41586-024-07502-0","volume":"630","author":"Mu\u00f1oz","year":"2024","journal-title":"Nature"},{"key":"D4OB02011A\/cit42\/1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/s41586-018-0483-6","volume":"561","author":"Smith","year":"2018","journal-title":"Nature"},{"key":"D4OB02011A\/cit43\/1","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1021\/cr020473j","volume":"104","author":"Laursen","year":"2004","journal-title":"Chem. Rev."},{"key":"D4OB02011A\/cit44\/1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nchembio764","volume":"2","author":"Price-Whelan","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"D4OB02011A\/cit45\/1","doi-asserted-by":"crossref","first-page":"6149","DOI":"10.1016\/j.bmc.2017.01.002","volume":"25","author":"Guttenberger","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"D4OB02011A\/cit46\/1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1099\/00222615-34-4-213","volume":"34","author":"Machan","year":"1991","journal-title":"J. Med. Microbiol."},{"key":"D4OB02011A\/cit47\/1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1039\/C3OB42416B","volume":"12","author":"Borrero","year":"2014","journal-title":"Org. Biomol. Chem."},{"key":"D4OB02011A\/cit48\/1","doi-asserted-by":"crossref","first-page":"14819","DOI":"10.1002\/anie.201508155","volume":"54","author":"Garrison","year":"2015","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4OB02011A\/cit49\/1","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.1021\/acs.jmedchem.5b02004","volume":"59","author":"Garrison","year":"2016","journal-title":"J. Med. Chem."},{"key":"D4OB02011A\/cit50\/1","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1038\/s41598-017-01045-3","volume":"7","author":"Yang","year":"2017","journal-title":"Sci. Rep."},{"key":"D4OB02011A\/cit51\/1","doi-asserted-by":"crossref","first-page":"15523","DOI":"10.1002\/anie.201809785","volume":"57","author":"Abouelhassan","year":"2018","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4OB02011A\/cit52\/1","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.1021\/acs.jmedchem.7b01903","volume":"61","author":"Garrison","year":"2018","journal-title":"J. Med. Chem."},{"key":"D4OB02011A\/cit53\/1","doi-asserted-by":"crossref","first-page":"7275","DOI":"10.1021\/acs.jmedchem.1c00168","volume":"64","author":"Yang","year":"2021","journal-title":"J. Med. Chem."},{"key":"D4OB02011A\/cit54\/1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1021\/acsinfecdis.1c00402","volume":"8","author":"Liu","year":"2022","journal-title":"ACS Infect. Dis."},{"key":"D4OB02011A\/cit55\/1","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1021\/acsinfecdis.2c00558","volume":"9","author":"Xiao","year":"2023","journal-title":"ACS Infect. Dis."},{"key":"D4OB02011A\/cit56\/1","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1021\/acsinfecdis.0c00837","volume":"7","author":"Fu","year":"2021","journal-title":"ACS Infect. Dis."},{"key":"D4OB02011A\/cit57\/1","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1055\/s-2007-982534","author":"Wr\u00f3bel","year":"2007","journal-title":"Synlett"},{"key":"D4OB02011A\/cit58\/1","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1055\/s-0030-1258230","author":"Wr\u00f3bel","year":"2010","journal-title":"Synthesis"},{"key":"D4OB02011A\/cit59\/1","doi-asserted-by":"crossref","first-page":"6484","DOI":"10.1016\/j.tetlet.2011.09.113","volume":"52","author":"Kwast","year":"2011","journal-title":"Tetrahedron Lett."},{"key":"D4OB02011A\/cit60\/1","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1016\/j.tet.2017.04.046","volume":"73","author":"Wr\u00f3bel","year":"2017","journal-title":"Tetrahedron"},{"key":"D4OB02011A\/cit61\/1","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1039\/D3MD00204G","volume":"14","author":"Liu","year":"2023","journal-title":"RSC Med. Chem."},{"key":"D4OB02011A\/cit62\/1","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1128\/JCM.37.6.1771-1776.1999","volume":"37","author":"Ceri","year":"1999","journal-title":"J. Clin. Microbiol."},{"key":"D4OB02011A\/cit63\/1","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/nprot.2010.71","volume":"5","author":"Harrison","year":"2010","journal-title":"Nat. Protoc."},{"key":"D4OB02011A\/cit64\/1","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1002\/cbic.201402254","volume":"15","author":"Jennings","year":"2014","journal-title":"ChemBioChem"},{"key":"D4OB02011A\/cit65\/1","volume-title":"Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standards","year":"2009","unstructured":"Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standards ,  Clinical and Laboratory Standards Institute ,  Wayne, PA , 8th edn (M7\u2013M8),  2009"},{"key":"D4OB02011A\/cit66\/1","first-page":"e00743","volume":"61","author":"Rodrigues","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"D4OB02011A\/cit67\/1","doi-asserted-by":"crossref","first-page":"e6077","DOI":"10.1371\/journal.pone.0006077","volume":"4","author":"Deb","year":"2009","journal-title":"PLoS One"},{"key":"D4OB02011A\/cit68\/1","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1159\/000319855","volume":"2","author":"Pang","year":"2010","journal-title":"J. Innate Immun."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/OB\/D4OB02011A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:16:14Z","timestamp":1782965774000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/23\/14\/3342-3357\/861964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":68,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2025,4,2]]}},"URL":"https:\/\/doi.org\/10.1039\/d4ob02011a","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}