{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:02:38Z","timestamp":1791273758037,"version":"4.1.0"},"reference-count":27,"publisher":"Royal Society of Chemistry (RSC)","issue":"9","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100006280","name":"Ministerio de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["PID2020-113351RA-I00\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["PID2020-113351RA-I00\/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100006280","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006280","name":"Ministerio de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["PID2022-137893OB-I00"],"award-info":[{"award-number":["PID2022-137893OB-I00"]}],"id":[{"id":"10.13039\/501100006280","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006280","name":"Ministerio de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["TED2021-130803B-I00 MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["TED2021-130803B-I00 MCIN\/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100006280","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<jats:p>\n                    (\n                    <jats:italic>R<\/jats:italic>\n                    )-Tamsulosin was stereoselectively synthesized\n                    <jats:italic>via<\/jats:italic>\n                    three different chemoenzymatic strategies. Alcohol dehydrogenases and transaminases were used to produce enantiopure alcohol and amine precursors, obtaining the desired drug in good overall yield.\n                  <\/jats:p>","DOI":"10.1039\/d4ob02047b","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T03:20:54Z","timestamp":1737688854000},"page":"2244-2253","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chemoenzymatic synthesis of Tamsulosin"],"prefix":"10.1039","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5594-0492","authenticated-orcid":false,"given":"Enol","family":"de Prado","sequence":"first","affiliation":[{"name":"Organic and Inorganic Chemistry Department, Instituto Universitario de Qu\u00edmica Organomet\u00e1lica \u201cEnrique Moles\u201d, University of Oviedo. Avenida Juli\u00e1n Claver\u00eda 8, 33006 Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3364-1512","authenticated-orcid":false,"given":"Juan","family":"Mangas-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Organic and Inorganic Chemistry Department, Instituto Universitario de Qu\u00edmica Organomet\u00e1lica \u201cEnrique Moles\u201d, University of Oviedo. Avenida Juli\u00e1n Claver\u00eda 8, 33006 Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9998-0656","authenticated-orcid":false,"given":"Vicente","family":"Gotor-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Organic and Inorganic Chemistry Department, Instituto Universitario de Qu\u00edmica Organomet\u00e1lica \u201cEnrique Moles\u201d, University of Oviedo. Avenida Juli\u00e1n Claver\u00eda 8, 33006 Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D4OB02047B\/cit1a\/1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s12010-020-03272-3","volume":"192","author":"Jiang","year":"2020","journal-title":"Appl. Biochem. Biotechnol."},{"key":"D4OB02047B\/cit1b\/1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3390\/catal12060595","volume":"12","author":"Zawodny","year":"2022","journal-title":"Catalysts"},{"key":"D4OB02047B\/cit1c\/1","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1021\/jacsau.2c00712","volume":"3","author":"France","year":"2023","journal-title":"JACS Au"},{"key":"D4OB02047B\/cit2a\/1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/s43586-021-00044-z","volume":"1","author":"Bell","year":"2021","journal-title":"Nat. Rev. Methods Primers"},{"key":"D4OB02047B\/cit2b\/1","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1039\/D1CS00100K","volume":"51","author":"Hanefeld","year":"2022","journal-title":"Chem. Soc. Rev."},{"key":"D4OB02047B\/cit2c\/1","doi-asserted-by":"crossref","first-page":"5571","DOI":"10.1021\/acscatal.3c00812","volume":"13","author":"Lewis","year":"2023","journal-title":"ACS Catal."},{"key":"D4OB02047B\/cit2d\/1","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1039\/D3CS00689A","volume":"53","author":"O'Connell","year":"2024","journal-title":"Chem. Soc. Rev."},{"key":"D4OB02047B\/cit3a\/1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.cbpa.2020.01.012","volume":"55","author":"Fryszkowska","year":"2020","journal-title":"Curr. Opin. Chem. Biol."},{"key":"D4OB02047B\/cit3b\/1","doi-asserted-by":"crossref","first-page":"e202102709","DOI":"10.1002\/cssc.202102709","volume":"15","author":"Alc\u00e1ntara","year":"2022","journal-title":"ChemSusChem"},{"key":"D4OB02047B\/cit3c\/1","doi-asserted-by":"crossref","first-page":"ead8615","DOI":"10.1126\/science.adh8615","volume":"382","author":"Buller","year":"2023","journal-title":"Science"},{"key":"D4OB02047B\/cit4\/1","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.bmc.2017.06.043","volume":"26","author":"Sun","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"D4OB02047B\/cit5a\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0090-4295(98)00048-X","volume":"51","author":"Holtgrewe","year":"1998","journal-title":"Urology"},{"key":"D4OB02047B\/cit5b\/1","doi-asserted-by":"crossref","first-page":"5800","DOI":"10.1016\/j.ejmech.2010.09.042","volume":"45","author":"Sagratini","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"D4OB02047B\/cit7a\/1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1248\/yakushi1947.115.10_773","volume":"115","author":"Tanenaka","year":"1995","journal-title":"Yakugaku Zasshi"},{"key":"D4OB02047B\/cit7d\/1","doi-asserted-by":"crossref","first-page":"6242","DOI":"10.1016\/j.bmc.2017.01.023","volume":"25","author":"Brenna","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"D4OB02047B\/cit9b\/1","doi-asserted-by":"crossref","first-page":"e202115643","DOI":"10.1002\/anie.202115643","volume":"61","author":"Saito","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4OB02047B\/cit11\/1","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1002\/chir.20544","volume":"20","author":"Gizur","year":"2008","journal-title":"Chirality"},{"key":"D4OB02047B\/cit13\/1","doi-asserted-by":"crossref","first-page":"9323","DOI":"10.1002\/anie.201301814","volume":"52","author":"Burda","year":"2013","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4OB02047B\/cit15\/1","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.tetasy.2007.01.012","volume":"18","author":"Acetti","year":"2007","journal-title":"Tetrahedron: Asymmetry"},{"key":"D4OB02047B\/cit16\/1","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1021\/acs.oprd.4c00236","volume":"28","author":"Malt\u00e1-Lak\u00f3","year":"2024","journal-title":"Org. Process Res. Dev."},{"key":"D4OB02047B\/cit17\/1","doi-asserted-by":"crossref","first-page":"3714","DOI":"10.1016\/j.bmcl.2014.07.015","volume":"24","author":"Keaney","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4OB02047B\/cit18\/1","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1021\/jo00008a016","volume":"56","author":"Kazlauskas","year":"1991","journal-title":"J. Org. Chem."},{"key":"D4OB02047B\/cit19a\/1","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/S0957-4166(02)00336-1","volume":"13","author":"Gonz\u00e1lez-Sab\u00edn","year":"2002","journal-title":"Tetrahedron: Asymmetry"},{"key":"D4OB02047B\/cit19b\/1","doi-asserted-by":"crossref","first-page":"8171","DOI":"10.1039\/c1ob06251d","volume":"9","author":"Mu\u00f1oz","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"D4OB02047B\/cit20\/1","doi-asserted-by":"crossref","first-page":"7294","DOI":"10.1021\/ja00389a064","volume":"104","author":"Chen","year":"1982","journal-title":"J. Am. Chem. Soc."},{"key":"D4OB02047B\/cit21\/1","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1002\/adsc.202100351","volume":"363","author":"Albarr\u00e1n-Velo","year":"2021","journal-title":"Adv. Synth. Catal."},{"key":"D4OB02047B\/cit22\/1","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1021\/ol070679c","volume":"9","author":"de Gonzalo","year":"2007","journal-title":"Org. Lett."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/OB\/D4OB02047B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:05:03Z","timestamp":1782965103000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/23\/9\/2244-2253\/861983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,2,26]]}},"URL":"https:\/\/doi.org\/10.1039\/d4ob02047b","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}