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Biomol. Chem."],"abstract":"<jats:p>\n                    This study focuses on the exploration of a novel synthetic route for the KRAS\n                    <jats:sup>G12C<\/jats:sup>\n                    inhibitor. The approach avoids the formation of regioselective by-products and eliminates the need for high temperatures and nitric acid.\n                  <\/jats:p>","DOI":"10.1039\/d4ob02104e","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T02:41:06Z","timestamp":1740451266000},"page":"3194-3198","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Stereoselective synthesis of a KRAS\n                    <sup>G12C<\/sup>\n                    inhibitor with a quinoline-piperazine scaffold"],"prefix":"10.1039","volume":"23","author":[{"given":"Ying","family":"Hu","sequence":"first","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China"},{"name":"College of Chemistry and Material Science, Sichuan Normal University, Chengdu, Sichuan 610066, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin-Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Yi","family":"Pu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3755-7262","authenticated-orcid":false,"given":"Yan-Jun","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Material Science, Sichuan Normal University, Chengdu, Sichuan 610066, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8004-821X","authenticated-orcid":false,"given":"Lin","family":"Dong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D4OB02104E\/cit1\/1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.cell.2018.03.035","volume":"173","author":"Sanchez-Vega","year":"2018","journal-title":"Cell"},{"key":"D4OB02104E\/cit2\/1","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1158\/0008-5472.CAN-11-2612","volume":"72","author":"Prior","year":"2012","journal-title":"Cancer Res."},{"key":"D4OB02104E\/cit3\/1","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/s41401-020-00542-y","volume":"42","author":"Wang","year":"2021","journal-title":"Acta Pharmacol. 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