{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:39:52Z","timestamp":1787503192152,"version":"build-2736575974"},"reference-count":84,"publisher":"Royal Society of Chemistry (RSC)","issue":"19","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":115,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>An anticancer proligand, with AIEE features, demonstrates exceptional binding efficiencies with DNA and SARS-CoV-2 and offers as a promising bioprobe.<\/jats:p>","DOI":"10.1039\/d4ra00554f","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T06:08:30Z","timestamp":1714025310000},"page":"13654-13668","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Aminoguanidine-based bioactive proligand as AIEE probe for anticancer and anticovid studies"],"prefix":"10.1039","volume":"14","author":[{"given":"K. K.","family":"Mohammed Hashim","sequence":"first","affiliation":[{"name":"Department of Applied Chemistry, Cochin University of Science and Technology, Kochi, Kerala, 682 022, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5005-9180","authenticated-orcid":false,"given":"E.","family":"Manoj","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, Cochin University of Science and Technology, Kochi, Kerala, 682 022, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D4RA00554F\/cit1\/1","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1039\/C7CC00170C","volume":"53","author":"Mou","year":"2017","journal-title":"Chem. Commun."},{"key":"D4RA00554F\/cit2\/1","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1039\/c4sc00721b","volume":"5","author":"Zhang","year":"2014","journal-title":"Chem. Sci."},{"key":"D4RA00554F\/cit3\/1","doi-asserted-by":"crossref","first-page":"13730","DOI":"10.1039\/C8DT03179G","volume":"47","author":"Kang","year":"2018","journal-title":"Dalt. Trans."},{"key":"D4RA00554F\/cit4\/1","doi-asserted-by":"crossref","first-page":"7314","DOI":"10.1039\/c3tc31562b","volume":"1","author":"Han","year":"2013","journal-title":"J. Mater. Chem. C"},{"key":"D4RA00554F\/cit5\/1","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1021\/acsabm.8b00600","volume":"1","author":"Zhu","year":"2018","journal-title":"ACS Appl. Bio Mater."},{"key":"D4RA00554F\/cit6\/1","doi-asserted-by":"crossref","first-page":"4332","DOI":"10.1039\/b904665h","author":"Hong","year":"2009","journal-title":"Chem. Commun."},{"key":"D4RA00554F\/cit7\/1","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.dyepig.2018.05.076","volume":"158","author":"Reddy","year":"2018","journal-title":"Dye Pigment."},{"key":"D4RA00554F\/cit8\/1","doi-asserted-by":"crossref","first-page":"e202201229","DOI":"10.1002\/slct.202201229","volume":"7","author":"Hashim","year":"2022","journal-title":"ChemistrySelect"},{"key":"D4RA00554F\/cit9\/1","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.1021\/acs.inorgchem.9b00195","volume":"58","author":"Li","year":"2019","journal-title":"Inorg. Chem."},{"key":"D4RA00554F\/cit10\/1","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1039\/C5CC10423H","volume":"52","author":"Feng","year":"2016","journal-title":"Chem. Commun."},{"key":"D4RA00554F\/cit11\/1","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.1039\/c1cs15113d","volume":"40","author":"Hong","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"D4RA00554F\/cit12\/1","doi-asserted-by":"crossref","first-page":"9885","DOI":"10.1039\/D1SC02069B","volume":"12","author":"Yao","year":"2021","journal-title":"Chem. Sci."},{"key":"D4RA00554F\/cit13\/1","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1039\/D3SD00110E","volume":"2","author":"Afrin","year":"2023","journal-title":"Sens. Diagn."},{"key":"D4RA00554F\/cit14\/1","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1039\/D2CS00497F","volume":"52","author":"Li","year":"2023","journal-title":"Chem. Soc. Rev."},{"key":"D4RA00554F\/cit15\/1","doi-asserted-by":"crossref","first-page":"9243","DOI":"10.1021\/acs.chemrev.0c01176","volume":"121","author":"Algar","year":"2021","journal-title":"Chem. Rev."},{"key":"D4RA00554F\/cit16\/1","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1007\/s00216-022-03995-8","author":"Ma","year":"2022","journal-title":"Anal. Bioanal. Chem."},{"key":"D4RA00554F\/cit17\/1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nprot.2013.166","volume":"9","author":"Redy-keisar","year":"2014","journal-title":"Nat. Protoc."},{"key":"D4RA00554F\/cit18\/1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s41061-022-00376-8","volume":"380","author":"Li","year":"2022","journal-title":"Top. Curr. Chem."},{"key":"D4RA00554F\/cit19\/1","doi-asserted-by":"crossref","first-page":"e321","DOI":"10.1002\/agt2.321","volume":"4","author":"Jiang","year":"2023","journal-title":"Aggregate"},{"key":"D4RA00554F\/cit20\/1","doi-asserted-by":"crossref","first-page":"e443","DOI":"10.1002\/agt2.443","volume":"5","author":"Liu","year":"2024","journal-title":"Aggregate"},{"key":"D4RA00554F\/cit21\/1","doi-asserted-by":"crossref","first-page":"16733","DOI":"10.1039\/C5CC06439B","volume":"51","author":"Xu","year":"2015","journal-title":"Chem. Commun."},{"key":"D4RA00554F\/cit22\/1","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.cmi.2020.06.009","volume":"26","author":"Ben-Ami","year":"2020","journal-title":"Clin. Microbiol. Infect."},{"key":"D4RA00554F\/cit23\/1","doi-asserted-by":"crossref","first-page":"4208","DOI":"10.1039\/D3NJ04949C","volume":"48","author":"Liu","year":"2024","journal-title":"New J. Chem."},{"key":"D4RA00554F\/cit24\/1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/agt2.195","volume":"4","author":"Zhang","year":"2023","journal-title":"Aggregate"},{"key":"D4RA00554F\/cit25\/1","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1039\/D2DT03554E","volume":"52","author":"Gupta","year":"2023","journal-title":"Dalt. Trans."},{"key":"D4RA00554F\/cit26\/1","doi-asserted-by":"crossref","first-page":"8996","DOI":"10.1021\/acsnano.1c01932","volume":"15","author":"Chen","year":"2021","journal-title":"ACS Nano"},{"key":"D4RA00554F\/cit27\/1","first-page":"1","volume":"10","author":"Ju","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"D4RA00554F\/cit28\/1","doi-asserted-by":"crossref","first-page":"635558","DOI":"10.3389\/fimmu.2021.635558","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Immunol."},{"key":"D4RA00554F\/cit29\/1","doi-asserted-by":"crossref","first-page":"36007","DOI":"10.1039\/C7RA05064J","volume":"7","author":"Pan","year":"2017","journal-title":"RSC Adv."},{"key":"D4RA00554F\/cit30\/1","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/bio.3477","volume":"33","author":"Densil","year":"2018","journal-title":"Luminescence"},{"key":"D4RA00554F\/cit31\/1","doi-asserted-by":"crossref","first-page":"115554","DOI":"10.1016\/j.poly.2021.115554","volume":"211","author":"Chakraborty","year":"2022","journal-title":"Polyhedron"},{"key":"D4RA00554F\/cit32\/1","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1021\/acsinfecdis.1c00001","volume":"7","author":"Krollenbrock","year":"2021","journal-title":"ACS Infect. Dis."},{"key":"D4RA00554F\/cit34\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053229614024218","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Crystallogr. Sect., C Struct. Chem."},{"key":"D4RA00554F\/cit35\/1","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1107\/S0021889812029111","volume":"45","author":"Farrugia","year":"2012","journal-title":"J. Appl. Crystallogr."},{"key":"D4RA00554F\/cit36\/1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1107\/S0021889802022112","volume":"36","author":"Spek","year":"2003","journal-title":"J. Appl. Crystallogr."},{"key":"D4RA00554F\/cit37\/1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1107\/S002188980600731X","volume":"39","author":"Macrae","year":"2006","journal-title":"J. Appl. Crystallogr."},{"key":"D4RA00554F\/cit40\/1","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1063\/1.464913","volume":"98","author":"Becke","year":"1993","journal-title":"J. Chem. Phys."},{"key":"D4RA00554F\/cit41\/1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1103\/PhysRevB.37.785","volume":"37","author":"Lee","year":"1988","journal-title":"Phys. Rev. B: Condens. Matter Mater. Phys."},{"key":"D4RA00554F\/cit42\/1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jphotochem.2018.03.039","volume":"359","author":"Chakraborty","year":"2018","journal-title":"J. Photochem. Photobiol. A Chem."},{"key":"D4RA00554F\/cit43\/1","doi-asserted-by":"crossref","first-page":"11182","DOI":"10.1021\/acs.jpcc.2c02170","volume":"126","author":"Sebastian","year":"2022","journal-title":"J. Phys. Chem. C"},{"key":"D4RA00554F\/cit44\/1","doi-asserted-by":"crossref","first-page":"10757","DOI":"10.1021\/acs.jpcc.6b01334","volume":"120","author":"Paramasivam","year":"2016","journal-title":"J. Phys. Chem. C"},{"key":"D4RA00554F\/cit45\/1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.jlumin.2012.07.017","volume":"134","author":"Shahabadi","year":"2013","journal-title":"J. Lumin."},{"key":"D4RA00554F\/cit46\/1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0022-2836(61)80047-8","volume":"3","author":"Marmur","year":"1961","journal-title":"J. Mol. Biol."},{"key":"D4RA00554F\/cit47\/1","doi-asserted-by":"crossref","first-page":"6392","DOI":"10.1021\/bi00394a013","volume":"26","author":"Wolfe","year":"1987","journal-title":"Biochem."},{"key":"D4RA00554F\/cit48\/1","doi-asserted-by":"crossref","first-page":"17109","DOI":"10.1021\/acs.inorgchem.0c02373","volume":"59","author":"Haribabu","year":"2020","journal-title":"Inorg. Chem."},{"key":"D4RA00554F\/cit49\/1","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1021\/acs.inorgchem.6b02419","volume":"56","author":"Villarreal","year":"2017","journal-title":"Inorg. Chem."},{"key":"D4RA00554F\/cit50\/1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/jcc.21600","volume":"32","author":"Allouche","year":"2012","journal-title":"J. Comput. Chem."},{"key":"D4RA00554F\/cit51\/1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.abb3405","volume":"368","author":"Zhang","year":"2020","journal-title":"Science"},{"key":"D4RA00554F\/cit52\/1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41586-020-2180-5","volume":"581","author":"Lan","year":"2020","journal-title":"Nature"},{"key":"D4RA00554F\/cit53\/1","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1073\/pnas.78.4.2179","volume":"78","author":"Drew","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D4RA00554F\/cit54\/1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"D4RA00554F\/cit56\/1","volume-title":"The PyMOL Molecular Graphics System","author":"DeLano","year":"2002","unstructured":"W. L.DeLano ,  The PyMOL Molecular Graphics System ,  De-Lano Scientific ,  San Carlos, CA .,  2002"},{"key":"D4RA00554F\/cit57\/1","doi-asserted-by":"crossref","first-page":"100681","DOI":"10.1016\/j.cdc.2021.100681","volume":"33","author":"Rapheal","year":"2021","journal-title":"Chem. Data Collect."},{"key":"D4RA00554F\/cit58\/1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1039\/B818330A","volume":"11","author":"Spackman","year":"2009","journal-title":"CrystEngComm"},{"key":"D4RA00554F\/cit59\/1","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1107\/S0108768104020300","volume":"60","author":"McKinnon","year":"2004","journal-title":"Acta Crystallogr. Sect., B Struct. Sci."},{"key":"D4RA00554F\/cit61\/1","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1039\/B203191B","volume":"4","author":"Spackman","year":"2002","journal-title":"CrystEngComm"},{"key":"D4RA00554F\/cit62\/1","doi-asserted-by":"crossref","first-page":"131125","DOI":"10.1016\/j.molstruc.2021.131125","volume":"1246","author":"Hashim","year":"2021","journal-title":"J. Mol. Struct."},{"key":"D4RA00554F\/cit63\/1","first-page":"1","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat. Commun."},{"key":"D4RA00554F\/cit64\/1","doi-asserted-by":"crossref","first-page":"4726","DOI":"10.1039\/D3NJ05828J","author":"Cao","year":"2024","journal-title":"New J. Chem."},{"key":"D4RA00554F\/cit65\/1","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1039\/C3TC32591A","volume":"2","author":"Liu","year":"2014","journal-title":"J. Mater. Chem. C"},{"key":"D4RA00554F\/cit66\/1","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1039\/C8QM00096D","volume":"2","author":"Peng","year":"2018","journal-title":"Mater. Chem. Front."},{"key":"D4RA00554F\/cit67\/1","doi-asserted-by":"crossref","first-page":"114894","DOI":"10.1016\/j.jphotochem.2023.114894","volume":"443","author":"Sebastian","year":"2023","journal-title":"J. Photochem. Photobiol. A Chem."},{"key":"D4RA00554F\/cit68\/1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0031-8914(34)90011-2","volume":"1","author":"Koopmans","year":"1934","journal-title":"Physica"},{"key":"D4RA00554F\/cit69\/1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/wcms.19","volume":"1","author":"Murray","year":"2011","journal-title":"Wiley Interdiscip. Rev. Comput. Mol. Sci."},{"key":"D4RA00554F\/cit70\/1","doi-asserted-by":"crossref","first-page":"116583","DOI":"10.1016\/j.poly.2023.116583","volume":"244","author":"Sooraj","year":"2023","journal-title":"Polyhedron"},{"key":"D4RA00554F\/cit71\/1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1380-7323(96)80044-6","volume":"3","author":"Orozco","year":"1996","journal-title":"Theor. Comput. Chem."},{"key":"D4RA00554F\/cit72\/1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1039\/C8MD00472B","volume":"10","author":"Guan","year":"2019","journal-title":"Medchemcomm"},{"key":"D4RA00554F\/cit73\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep42717","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"D4RA00554F\/cit74\/1","first-page":"418","volume-title":"The PreADME Approach: Web-based program for rapid prediction of physico-chemical, drug absorption and drug-like properties","author":"Lee","year":"2003","unstructured":"S. K.Lee ,  I. H.Lee ,  H. J.Kim ,  G. S.Chang ,  J. E.Chung  and  K. T.No ,  The PreADME Approach: Web-based program for rapid prediction of physico-chemical, drug absorption and drug-like properties ,  Blackwell Publishing ,  Massachusetts, USA ,  2003 ,  pp. 418\u2013420"},{"key":"D4RA00554F\/cit75\/1","doi-asserted-by":"crossref","first-page":"20715","DOI":"10.1039\/D0NJ04295A","volume":"44","author":"Ngoc Toan","year":"2020","journal-title":"New J. Chem."},{"key":"D4RA00554F\/cit76\/1","doi-asserted-by":"crossref","first-page":"13580","DOI":"10.1039\/D2RA00719C","volume":"12","author":"Goudarziafshar","year":"2022","journal-title":"RSC Adv."},{"key":"D4RA00554F\/cit77\/1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jphotobiol.2012.09.015","volume":"117","author":"Niroomand","year":"2012","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"D4RA00554F\/cit78\/1","doi-asserted-by":"crossref","first-page":"9780","DOI":"10.1039\/C6OB01850E","volume":"14","author":"Kopsida","year":"2016","journal-title":"Org. Biomol. Chem."},{"key":"D4RA00554F\/cit79\/1","doi-asserted-by":"crossref","first-page":"9333","DOI":"10.1039\/D3RA00395G","volume":"13","author":"Al-Rashdi","year":"2023","journal-title":"RSC Adv."},{"key":"D4RA00554F\/cit80\/1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jpba.2017.10.016","volume":"149","author":"Qais","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"D4RA00554F\/cit81\/1","doi-asserted-by":"crossref","first-page":"31257","DOI":"10.1074\/jbc.M502577200","volume":"280","author":"Hsu","year":"2005","journal-title":"J. Biol. Chem."},{"key":"D4RA00554F\/cit82\/1","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.1021\/acs.jproteome.0c00683","volume":"19","author":"Achutha","year":"2020","journal-title":"J. Proteome Res."},{"key":"D4RA00554F\/cit83\/1","doi-asserted-by":"crossref","first-page":"129454","DOI":"10.1016\/j.molstruc.2020.129454","volume":"1228","author":"Al-Janabi","year":"2021","journal-title":"J. Mol. Struct."},{"key":"D4RA00554F\/cit84\/1","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1126\/science.1085658","volume":"300","author":"Anand","year":"2003","journal-title":"Science"},{"key":"D4RA00554F\/cit85\/1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41467-020-16954-7","volume":"11","author":"Kneller","year":"2020","journal-title":"Nat. Commun."},{"key":"D4RA00554F\/cit86\/1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/pro.2201","volume":"22","author":"Scholfield","year":"2013","journal-title":"Protein Sci."},{"key":"D4RA00554F\/cit87\/1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cossms.2009.05.001","volume":"13","author":"Fourmigu\u00e9","year":"2009","journal-title":"Curr. Opin. Solid State Mater. Sci."},{"key":"D4RA00554F\/cit88\/1","doi-asserted-by":"crossref","first-page":"16789","DOI":"10.1073\/pnas.0407607101","volume":"101","author":"Auffinger","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D4RA00554F\/cit89\/1","doi-asserted-by":"crossref","first-page":"111326","DOI":"10.1016\/j.inoche.2023.111326","volume":"157","author":"Hashim","year":"2023","journal-title":"Inorg. Chem. Commun."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/RA\/D4RA00554F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T18:15:22Z","timestamp":1783275322000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/14\/19\/13654-13668\/865252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":84,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2024,4,22]]}},"URL":"https:\/\/doi.org\/10.1039\/d4ra00554f","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}