{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:53:50Z","timestamp":1790268830587,"version":"4.1.0"},"reference-count":100,"publisher":"Royal Society of Chemistry (RSC)","issue":"46","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":298,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>Fluorinated five-membered heterocycles have potent therapeutic activities including antiviral, anti-inflammatory, enzymatic inhibitory, and antimalarial.<\/jats:p>","DOI":"10.1039\/d4ra05697c","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T04:06:46Z","timestamp":1729829206000},"page":"33864-33905","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Recent progress in therapeutic applications of fluorinated five-membered heterocycles and their benzo-fused systems"],"prefix":"10.1039","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7061-9907","authenticated-orcid":false,"given":"Ashraf A.","family":"Abbas","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9620-8548","authenticated-orcid":false,"given":"Thoraya A.","family":"Farghaly","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt"},{"name":"Department of Chemistry, Faculty of Science, Umm Al-Qura University, Makkah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1351-9886","authenticated-orcid":false,"given":"Kamal M.","family":"Dawood","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D4RA05697C\/cit1\/1","doi-asserted-by":"crossref","first-page":"44247","DOI":"10.1039\/D0RA09198G","volume":"10","author":"Heravi","year":"2020","journal-title":"RSC Adv."},{"key":"D4RA05697C\/cit2\/1","first-page":"281","volume":"17","author":"Henary","year":"2024","journal-title":"Pharm."},{"key":"D4RA05697C\/cit3\/1","doi-asserted-by":"crossref","first-page":"10633","DOI":"10.1021\/acsomega.0c00830","volume":"5","author":"Inoue","year":"2020","journal-title":"ACS Omega"},{"key":"D4RA05697C\/cit4\/1","doi-asserted-by":"crossref","first-page":"18206","DOI":"10.1021\/acsomega.2c01121","volume":"7","author":"Zhang","year":"2022","journal-title":"ACS Omega"},{"key":"D4RA05697C\/cit5\/1","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1021\/ja01634a101","volume":"76","author":"Fried","year":"1954","journal-title":"J. Am. Chem. Soc."},{"key":"D4RA05697C\/cit6\/1","first-page":"1071","volume":"131","author":"O'Hagan","year":"2010","journal-title":"Chem"},{"key":"D4RA05697C\/cit7\/1","doi-asserted-by":"crossref","first-page":"10633","DOI":"10.1021\/acsomega.0c00830","volume":"5","author":"Inoue","year":"2020","journal-title":"ACS Omega"},{"key":"D4RA05697C\/cit8\/1","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.cclet.2021.08.043","volume":"33","author":"Simur","year":"2022","journal-title":"Chin. Chem. Lett."},{"issue":"2","key":"D4RA05697C\/cit9\/1","volume-title":"Fluorine in Heterocyclic Chemistry","volume":"1","year":"2014","unstructured":"Fluorine in Heterocyclic Chemistry , ed.  V. Nenajdenko ,  Springer ,  2014 ,  vol. 1 ,  2"},{"key":"D4RA05697C\/cit10\/1","volume-title":"Fluorinated Heterocyclic Compounds: Synthesis, Chemistry and Applications","year":"2009","unstructured":"Fluorinated Heterocyclic Compounds: Synthesis, Chemistry and Applications , ed.  V. A. Petrov ,  Wiley ,  New York ,  2009"},{"key":"D4RA05697C\/cit11\/1","volume-title":"Fluorinated Heterocycles","year":"2009","unstructured":"Fluorinated Heterocycles , ed.  A. Gakh  and  K. L. Kirk ,  ACS ,  Washington ,  2009"},{"key":"D4RA05697C\/cit12\/1","first-page":"265","volume-title":"Chapter 9, Organofluorine Compounds as Anticancer Agents","author":"Reddy","year":"2015","unstructured":"V. P.Reddy ,  Organofluorine compounds in biology and medicine , Chapter 9, Organofluorine Compounds as Anticancer Agents ,  Elsevier ,  2015 ,  pp. 265\u2013300"},{"key":"D4RA05697C\/cit13\/1","doi-asserted-by":"crossref","first-page":"5822","DOI":"10.1021\/acs.jmedchem.7b01788","volume":"61","author":"Meanwell","year":"2018","journal-title":"J. Med. Chem."},{"key":"D4RA05697C\/cit14\/1","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1039\/B610213C","volume":"37","author":"Purser","year":"2008","journal-title":"Chem. Soc. Rev."},{"key":"D4RA05697C\/cit15\/1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/cbic.200301023","volume":"5","author":"Bohm","year":"2004","journal-title":"ChemBioChem"},{"key":"D4RA05697C\/cit16\/1","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.3762\/bjoc.9.306","volume":"9","author":"Hu","year":"2013","journal-title":"Beilstein J. Org. Chem."},{"key":"D4RA05697C\/cit17\/1","doi-asserted-by":"crossref","first-page":"115758","DOI":"10.1016\/j.ejmech.2023.115758","volume":"260","author":"Sheikhi","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"D4RA05697C\/cit18\/1","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1021\/jm800219f","volume":"51","author":"Hagman","year":"2008","journal-title":"J. Med. Chem."},{"key":"D4RA05697C\/cit19\/1","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/cbic.200300907","volume":"5","author":"Olsen","year":"2004","journal-title":"ChemBioChem"},{"key":"D4RA05697C\/cit20\/1","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1002\/anie.200351268","volume":"42","author":"Olsen","year":"2003","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4RA05697C\/cit21\/1","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1126\/science.1131943","volume":"317","author":"Muller","year":"2007","journal-title":"Science"},{"key":"D4RA05697C\/cit22\/1","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1021\/ci9002393","volume":"49","author":"Zhou","year":"2009","journal-title":"J. Chem. Inf. Model."},{"key":"D4RA05697C\/cit23\/1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/cpt.1844","volume":"108","author":"Du","year":"2020","journal-title":"Clin. Pharmacol. Ther."},{"key":"D4RA05697C\/cit24\/1","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jhep.2009.04.019","volume":"51","author":"Kim","year":"2009","journal-title":"J. Hepatol."},{"key":"D4RA05697C\/cit25\/1","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.intimp.2005.08.027","volume":"6","author":"Fernandez-Calotti","year":"2006","journal-title":"Int. Immunopharmacol."},{"key":"D4RA05697C\/cit26\/1","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1517\/13543776.2016.1088832","volume":"25","author":"Meng","year":"2015","journal-title":"Expert Opin. Ther. Pat."},{"key":"D4RA05697C\/cit27\/1","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1021\/acs.accounts.6b00274","volume":"49","author":"Liotta","year":"2016","journal-title":"Acc. Chem. Res."},{"key":"D4RA05697C\/cit28\/1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/17460441.2023.2157401","volume":"18","author":"Ding","year":"2023","journal-title":"Expert Opin. Drug Discovery"},{"issue":"3","key":"D4RA05697C\/cit29\/1","first-page":"261","volume-title":"International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 62","volume":"23","author":"World Health Organization","year":"2009","unstructured":"World Health Organization , \" International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 62 \",  WHO Drug Information ,  2009 ,  23 ,  3 ,  p. 261"},{"key":"D4RA05697C\/cit30\/1","first-page":"434","volume-title":"Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition","author":"Hamilton","year":"2015","unstructured":"R. J.Hamilton ,  Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition ,  Jones & Bartlett Learning ,  2015 ,  pp. 434\u2013435"},{"key":"D4RA05697C\/cit31\/1","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1089\/aid.2004.20.1173","volume":"20","author":"Wang","year":"2004","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"D4RA05697C\/cit32\/1","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1096\/fasebj.13.12.1511","volume":"13","author":"Feng","year":"1999","journal-title":"FASEB J."},{"key":"D4RA05697C\/cit33\/1","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1016\/j.bmcl.2009.02.040","volume":"19","author":"Meanwell","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4RA05697C\/cit34\/1","doi-asserted-by":"crossref","DOI":"10.1002\/9780470281895","volume-title":"Bioorganic and Medicinal Chemistry of Fluorine","author":"Begue","year":"2008","unstructured":"J. P.Begue  and  D.Bonnet-Delpon ,  Bioorganic and Medicinal Chemistry of Fluorine ,  Wiley ,  Hoboken .  2008"},{"key":"D4RA05697C\/cit35\/1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.bmcl.2007.10.074","volume":"18","author":"Kitas","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4RA05697C\/cit36\/1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.2174\/1385272827666230516100739","volume":"27","author":"Kalar","year":"2023","journal-title":"Curr. Org. Chem."},{"key":"D4RA05697C\/cit37\/1","first-page":"110133","volume":"268","author":"Chatterjee","year":"2023","journal-title":"Chem"},{"key":"D4RA05697C\/cit38\/1","doi-asserted-by":"crossref","first-page":"14824","DOI":"10.1002\/anie.201814457","volume":"58","author":"Szpera","year":"2019","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"D4RA05697C\/cit39\/1","doi-asserted-by":"crossref","first-page":"5786","DOI":"10.1039\/C7CS00619E","volume":"47","author":"Markus","year":"2018","journal-title":"Chem. Soc. Rev."},{"key":"D4RA05697C\/cit40\/1","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.tet.2003.11.017","volume":"60","author":"Dawood","year":"2004","journal-title":"Tetrahedron"},{"key":"D4RA05697C\/cit41\/1","doi-asserted-by":"crossref","first-page":"5302","DOI":"10.1021\/jo035871g","volume":"69","author":"Dawood","year":"2004","journal-title":"J. Org. Chem."},{"key":"D4RA05697C\/cit42\/1","doi-asserted-by":"crossref","first-page":"7691","DOI":"10.1021\/jo0105437","volume":"66","author":"Dawood","year":"2001","journal-title":"J. Org. Chem."},{"key":"D4RA05697C\/cit43\/1","doi-asserted-by":"crossref","first-page":"7030","DOI":"10.1021\/jo0104936","volume":"66","author":"Dawood","year":"2001","journal-title":"J. Org. Chem."},{"key":"D4RA05697C\/cit44\/1","first-page":"67","volume":"19","author":"Fuchigami","year":"1999","journal-title":"Rev. Heteroatom Chem."},{"key":"D4RA05697C\/cit45\/1","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1021\/op400349g","volume":"18","author":"Campbell","year":"2014","journal-title":"Org. Process Res. Dev."},{"key":"D4RA05697C\/cit46\/1","doi-asserted-by":"crossref","first-page":"19752","DOI":"10.1039\/D4RA01387E","volume":"14","author":"Abbas","year":"2024","journal-title":"RSC Adv."},{"key":"D4RA05697C\/cit47\/1","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1080\/17460441.2023.2157400","volume":"17","author":"Abbas","year":"2022","journal-title":"Expert Opin. Drug Discovery"},{"key":"D4RA05697C\/cit48\/1","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.2174\/1570179417999200628035124","volume":"24","author":"Dawood","year":"2020","journal-title":"Curr. Org. Chem."},{"key":"D4RA05697C\/cit49\/1","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1080\/13543776.2020.1798402","volume":"30","author":"Dawood","year":"2020","journal-title":"Expert Opin. Ther. Pat."},{"key":"D4RA05697C\/cit50\/1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/13543776.2018.1389898","volume":"28","author":"Behbehani","year":"2018","journal-title":"Expert Opin. Ther. Pat."},{"key":"D4RA05697C\/cit51\/1","doi-asserted-by":"crossref","first-page":"24992","DOI":"10.1039\/D4RA05091F","volume":"14","author":"Mohamed","year":"2024","journal-title":"RSC Adv."},{"key":"D4RA05697C\/cit52\/1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.ejmech.2013.02.042","volume":"63","author":"Wu","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"D4RA05697C\/cit53\/1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ejmech.2017.11.028","volume":"143","author":"Liu","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"D4RA05697C\/cit54\/1","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1021\/jm801595c","volume":"52","author":"Smith","year":"2009","journal-title":"J. Med. Chem."},{"key":"D4RA05697C\/cit55\/1","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1055\/s-0036-1588625","volume":"49","author":"Kharitonova","year":"2017","journal-title":"Synthesis"},{"key":"D4RA05697C\/cit56\/1","doi-asserted-by":"crossref","first-page":"6885","DOI":"10.1016\/j.bmc.2012.09.026","volume":"20","author":"Mart\u00ednez-Montero","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"D4RA05697C\/cit57\/1","doi-asserted-by":"crossref","first-page":"30223","DOI":"10.1039\/D0RA06148D","volume":"10","author":"Das","year":"2020","journal-title":"RSC Adv."},{"key":"D4RA05697C\/cit60\/1","doi-asserted-by":"crossref","first-page":"6437","DOI":"10.1016\/j.bmcl.2008.10.066","volume":"18","author":"Roberts","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4RA05697C\/cit61\/1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1021\/jm801322h","volume":"52","author":"Jones","year":"2009","journal-title":"J. Med. Chem."},{"key":"D4RA05697C\/cit63\/1","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1021\/jm801470b","volume":"52","author":"Piscitelli","year":"2009","journal-title":"J. Med. Chem."},{"key":"D4RA05697C\/cit64\/1","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1021\/jm101614j","volume":"54","author":"La Regina","year":"2011","journal-title":"J. Med. Chem."},{"key":"D4RA05697C\/cit65\/1","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.1021\/jm070488f","volume":"50","author":"La Regina","year":"2007","journal-title":"J. Med. Chem."},{"key":"D4RA05697C\/cit66\/1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bmcl.2012.10.115","volume":"23","author":"Yeung","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4RA05697C\/cit67\/1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bmcl.2012.10.117","volume":"23","author":"Yeung","year":"2013","journal-title":"Med. Chem. Lett."},{"key":"D4RA05697C\/cit68\/1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bmcl.2012.10.125","volume":"23","author":"Yeung","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4RA05697C\/cit69\/1","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1021\/jm401621g","volume":"57","author":"Zhang","year":"2014","journal-title":"J. Med. Chem."},{"key":"D4RA05697C\/cit70\/1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.bmc.2015.12.008","volume":"24","author":"Cihan-\u00dcst\u00fcnda\u011f","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"D4RA05697C\/cit71\/1","doi-asserted-by":"crossref","first-page":"5462","DOI":"10.1016\/j.bmcl.2016.10.030","volume":"26","author":"Randolph","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4RA05697C\/cit72\/1","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.1021\/jm051292n","volume":"50","author":"Dressen","year":"2017","journal-title":"J. Med. Chem."},{"key":"D4RA05697C\/cit79\/1","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1021\/jm401986p","volume":"57","author":"Rooney","year":"2014","journal-title":"J. Med. Chem."},{"key":"D4RA05697C\/cit80\/1","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1021\/acs.jmedchem.2c01943","volume":"66","author":"Nan","year":"2023","journal-title":"J. Med. Chem."},{"key":"D4RA05697C\/cit81\/1","doi-asserted-by":"crossref","first-page":"6259","DOI":"10.1021\/jm400742j","volume":"56","author":"Crocetti","year":"2013","journal-title":"J. Med. Chem."},{"key":"D4RA05697C\/cit83\/1","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1021\/jm301720p","volume":"56","author":"Padilla","year":"2013","journal-title":"J. Med. Chem."},{"key":"D4RA05697C\/cit87\/1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1021\/jm0609014","volume":"50","author":"Goodman","year":"2007","journal-title":"J. Med. Chem."},{"key":"D4RA05697C\/cit89\/1","doi-asserted-by":"crossref","first-page":"6631","DOI":"10.1021\/jm8005096","volume":"51","author":"Sehon","year":"2008","journal-title":"J. Med. Chem."},{"key":"D4RA05697C\/cit93\/1","first-page":"220","volume":"3","author":"Sathe","year":"2011","journal-title":"Int. J. Pharm. Sci."},{"key":"D4RA05697C\/cit94\/1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.5530\/ijpi.2021.2.34","volume":"11","author":"Varpe","year":"2021","journal-title":"Int. J. Pharm. Invest."},{"key":"D4RA05697C\/cit95\/1","doi-asserted-by":"crossref","first-page":"10399","DOI":"10.3390\/ijms241210399","volume":"24","author":"Ayoub","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D4RA05697C\/cit96\/1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/10426509708545540","volume":"120","author":"Fuchigami","year":"1997","journal-title":"Phosphorus, Sulfur Relat. Elem."},{"key":"D4RA05697C\/cit97\/1","doi-asserted-by":"crossref","first-page":"114025","DOI":"10.1016\/j.ejmech.2021.114025","volume":"228","author":"Wang","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"D4RA05697C\/cit98\/1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.ejmech.2013.04.011","volume":"64","author":"Limpachayaporn","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"D4RA05697C\/cit99\/1","doi-asserted-by":"crossref","first-page":"5334","DOI":"10.1002\/adsc.201900814","volume":"361","author":"Wang","year":"2019","journal-title":"Adv. Synth. Catal."},{"key":"D4RA05697C\/cit101\/1","first-page":"203","volume":"156","author":"Chochkova","year":"2013","journal-title":"Chem"},{"key":"D4RA05697C\/cit102\/1","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1016\/j.bmcl.2012.02.083","volume":"22","author":"Meng","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4RA05697C\/cit103\/1","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.bmc.2014.01.028","volume":"22","author":"Sato","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"D4RA05697C\/cit104\/1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1021\/ml400339b","volume":"5","author":"Nomura","year":"2014","journal-title":"ACS Med. Chem. Lett."},{"key":"D4RA05697C\/cit118\/1","doi-asserted-by":"crossref","first-page":"6180","DOI":"10.1016\/j.bmc.2009.07.067","volume":"17","author":"Claramunt","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"D4RA05697C\/cit124\/1","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.ejmech.2011.01.027","volume":"46","author":"Claramunt","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"D4RA05697C\/cit125\/1","doi-asserted-by":"crossref","first-page":"134116","DOI":"10.1016\/j.molstruc.2022.134116","volume":"1271","author":"Kousaxidis","year":"2023","journal-title":"J. Mol. Struct."},{"key":"D4RA05697C\/cit126\/1","first-page":"22","volume":"22","author":"Mallia","year":"2023","journal-title":"Chem. Res."},{"key":"D4RA05697C\/cit127\/1","doi-asserted-by":"crossref","first-page":"114855","DOI":"10.1016\/j.ejmech.2022.114855","volume":"246","author":"Short","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"D4RA05697C\/cit128\/1","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1016\/j.bmcl.2016.03.102","volume":"26","author":"Witt","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4RA05697C\/cit129\/1","doi-asserted-by":"crossref","first-page":"6819","DOI":"10.1021\/acs.jmedchem.5b00585","volume":"58","author":"Mistry","year":"2015","journal-title":"J. Med. Chem."},{"key":"D4RA05697C\/cit130\/1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.ejmech.2016.08.059","volume":"124","author":"Marcinkowska","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"D4RA05697C\/cit131\/1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/17415993.2014.896363","volume":"35","author":"Ali","year":"2014","journal-title":"J. Sulfur Chem."},{"key":"D4RA05697C\/cit132\/1","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1039\/c2md20136d","volume":"3","author":"Ge","year":"2012","journal-title":"MedChemComm"},{"key":"D4RA05697C\/cit133\/1","doi-asserted-by":"crossref","first-page":"5032","DOI":"10.1016\/j.bmcl.2008.08.008","volume":"18","author":"Aslanian","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4RA05697C\/cit134\/1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/ardp.201300321","volume":"347","author":"Ojeda-G\u00f3mez","year":"2014","journal-title":"Arch. Pharm."},{"key":"D4RA05697C\/cit143\/1","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1021\/jm301572h","volume":"56","author":"Procopiou","year":"2013","journal-title":"J. Med. Chem."},{"key":"D4RA05697C\/cit146\/1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1021\/jm701217r","volume":"51","author":"Lee","year":"2008","journal-title":"J. Med. Chem."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/RA\/D4RA05697C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:38:19Z","timestamp":1782970699000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/14\/46\/33864-33905\/867141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":100,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2024,10,23]]}},"URL":"https:\/\/doi.org\/10.1039\/d4ra05697c","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}