{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:19:58Z","timestamp":1783163998762,"version":"3.54.6"},"reference-count":59,"publisher":"Royal Society of Chemistry (RSC)","issue":"28","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":165,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20524"],"award-info":[{"award-number":["U23A20524"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22271126"],"award-info":[{"award-number":["22271126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22307052"],"award-info":[{"award-number":["22307052"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2019-I2M-5-074"],"award-info":[{"award-number":["2019-I2M-5-074"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2021-I2M-1-026"],"award-info":[{"award-number":["2021-I2M-1-026"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2021-I2M-3-001"],"award-info":[{"award-number":["2021-I2M-3-001"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["IRT_15R27"],"award-info":[{"award-number":["IRT_15R27"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>An unprecedented tertiary amine catalyzed peptide allylation between Trp and MBH carbonates was disclosed, to enable late-stage peptide functionalization and macrocyclization both in traditional homogeneous phase and on-resins in SPPS.<\/jats:p>","DOI":"10.1039\/d4sc01244e","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T02:41:37Z","timestamp":1718332897000},"page":"11099-11107","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Late-stage peptide modification and macrocyclization enabled by tertiary amine catalyzed tryptophan allylation"],"prefix":"10.1039","volume":"15","author":[{"given":"Yuyang","family":"Liu","sequence":"first","affiliation":[{"name":"Research Unit of Peptide Science (2019RU066), Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China"},{"name":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China"},{"name":"School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7528-2036","authenticated-orcid":false,"given":"Guofeng","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangjun","family":"Bao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyuan","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7663-6249","authenticated-orcid":false,"given":"Zhaoqing","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4719-9921","authenticated-orcid":false,"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Unit of Peptide Science (2019RU066), Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China"},{"name":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China"},{"name":"School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5277-3329","authenticated-orcid":false,"given":"Wangsheng","family":"Sun","sequence":"additional","affiliation":[{"name":"Research Unit of Peptide Science (2019RU066), Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China"},{"name":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D4SC01244E\/cit1\/1","doi-asserted-by":"crossref","first-page":"14015","DOI":"10.1021\/acs.chemrev.7b00522","volume":"117","author":"Hamley","year":"2017","journal-title":"Chem. Rev."},{"key":"D4SC01244E\/cit2\/1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41573-020-00135-8","volume":"20","author":"Muttenthaler","year":"2021","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D4SC01244E\/cit3\/1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41392-022-00904-4","volume":"7","author":"Wang","year":"2022","journal-title":"Signal Transduction Targeted Ther."},{"key":"D4SC01244E\/cit4\/1","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1039\/C5NP00083A","volume":"33","author":"Charron","year":"2016","journal-title":"Nat. Prod. Rep."},{"key":"D4SC01244E\/cit5\/1","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1039\/D0CS00556H","volume":"50","author":"Cooper","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"D4SC01244E\/cit6\/1","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1021\/acs.jmedchem.7b00318","volume":"61","author":"Henninot","year":"2018","journal-title":"J. Med. Chem."},{"key":"D4SC01244E\/cit7\/1","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1016\/j.bmc.2018.01.012","volume":"26","author":"Erak","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"D4SC01244E\/cit8\/1","doi-asserted-by":"crossref","first-page":"9836","DOI":"10.1021\/acs.chemrev.8b00744","volume":"119","author":"Reguera","year":"2019","journal-title":"Chem. Rev."},{"key":"D4SC01244E\/cit9\/1","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1021\/jacs.8b13178","volume":"141","author":"Vinogradov","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC01244E\/cit10\/1","doi-asserted-by":"crossref","first-page":"115896","DOI":"10.1016\/j.bmc.2020.115896","volume":"29","author":"Berdan","year":"2021","journal-title":"Bioorg. Med. Chem."},{"key":"D4SC01244E\/cit11\/1","doi-asserted-by":"crossref","first-page":"5673","DOI":"10.1021\/acs.jmedchem.8b01153","volume":"62","author":"Gehringer","year":"2019","journal-title":"J. Med. Chem."},{"key":"D4SC01244E\/cit12\/1","doi-asserted-by":"crossref","first-page":"8775","DOI":"10.1021\/cr500200x","volume":"114","author":"Noisier","year":"2014","journal-title":"Chem. Rev."},{"key":"D4SC01244E\/cit13\/1","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1021\/acs.biochem.7b00536","volume":"56","author":"deGruyter","year":"2017","journal-title":"Biochemistry"},{"key":"D4SC01244E\/cit14\/1","doi-asserted-by":"crossref","first-page":"4810","DOI":"10.1002\/anie.201806009","volume":"58","author":"Zhang","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4SC01244E\/cit15\/1","first-page":"1797","volume":"2","author":"Tong","year":"2020","journal-title":"CCS Chem."},{"key":"D4SC01244E\/cit16\/1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1021\/jacs.1c11185","volume":"144","author":"Mackay","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC01244E\/cit17\/1","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1021\/acs.chemrev.1c00357","volume":"122","author":"Lechner","year":"2022","journal-title":"Chem. Rev."},{"key":"D4SC01244E\/cit18\/1","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1021\/acs.accounts.3c00260","volume":"56","author":"Wang","year":"2023","journal-title":"Acc. Chem. Res."},{"key":"D4SC01244E\/cit19\/1","doi-asserted-by":"crossref","first-page":"research0049.1","DOI":"10.1186\/gb-2001-2-11-research0049","volume":"2","author":"Gilis","year":"2001","journal-title":"Genome Biol."},{"key":"D4SC01244E\/cit20\/1","doi-asserted-by":"crossref","first-page":"e3286","DOI":"10.1002\/psc.3286","volume":"27","author":"Hu","year":"2021","journal-title":"J. Pept. Sci."},{"key":"D4SC01244E\/cit21\/1","doi-asserted-by":"crossref","first-page":"5328","DOI":"10.1002\/chem.201903756","volume":"26","author":"Gru\u00df","year":"2020","journal-title":"Chem.\u2013Eur. J."},{"key":"D4SC01244E\/cit22\/1","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1016\/j.chempr.2020.10.026","volume":"6","author":"Wang","year":"2020","journal-title":"Chem"},{"key":"D4SC01244E\/cit23\/1","doi-asserted-by":"crossref","first-page":"eabe6202","DOI":"10.1126\/sciadv.abe6202","volume":"7","author":"Kaplaneris","year":"2021","journal-title":"Sci. Adv."},{"key":"D4SC01244E\/cit24\/1","doi-asserted-by":"crossref","first-page":"e202216661","DOI":"10.1002\/anie.202216661","volume":"62","author":"Kaplaneris","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4SC01244E\/cit25\/1","doi-asserted-by":"crossref","first-page":"14686","DOI":"10.1002\/anie.202007226","volume":"59","author":"Bai","year":"2020","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4SC01244E\/cit26\/1","doi-asserted-by":"crossref","first-page":"e202206177","DOI":"10.1002\/anie.202206177","volume":"61","author":"Liu","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4SC01244E\/cit27\/1","doi-asserted-by":"crossref","first-page":"11661","DOI":"10.1039\/D1CC04202E","volume":"57","author":"Liu","year":"2021","journal-title":"Chem. Commun."},{"key":"D4SC01244E\/cit28\/1","doi-asserted-by":"crossref","first-page":"3973","DOI":"10.1038\/s41467-023-39703-y","volume":"14","author":"Wang","year":"2023","journal-title":"Nat. Commun."},{"key":"D4SC01244E\/cit29\/1","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1039\/D2CC06371A","volume":"59","author":"Li","year":"2023","journal-title":"Chem. Commun."},{"key":"D4SC01244E\/cit30\/1","doi-asserted-by":"crossref","first-page":"6773","DOI":"10.1021\/jacs.3c13447","volume":"146","author":"Nuruzzaman","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC01244E\/cit31\/1","doi-asserted-by":"crossref","first-page":"9112","DOI":"10.1021\/jacs.0c03039","volume":"142","author":"Tower","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC01244E\/cit32\/1","doi-asserted-by":"crossref","first-page":"6227","DOI":"10.1021\/jacs.1c10536","volume":"144","author":"Hoopes","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC01244E\/cit33\/1","doi-asserted-by":"crossref","first-page":"e2022006","DOI":"10.1002\/cmdc.202200651","volume":"18","author":"Yu","year":"2023","journal-title":"ChemMedChem"},{"key":"D4SC01244E\/cit34\/1","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1021\/jacs.9b11709","volume":"142","author":"Kee","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC01244E\/cit35\/1","doi-asserted-by":"crossref","first-page":"22878","DOI":"10.1021\/jacs.3c08098","volume":"145","author":"Kuehl","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC01244E\/cit36\/1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1021\/acs.orglett.0c03735","volume":"23","author":"Laroche","year":"2021","journal-title":"Org. Lett."},{"key":"D4SC01244E\/cit37\/1","doi-asserted-by":"crossref","first-page":"5758","DOI":"10.1039\/D1CC01822A","volume":"57","author":"Lima","year":"2021","journal-title":"Chem. Commun."},{"key":"D4SC01244E\/cit38\/1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1039\/C3SC51497H","volume":"5","author":"Malins","year":"2014","journal-title":"Chem. Sci."},{"key":"D4SC01244E\/cit39\/1","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.31635\/ccschem.023.202303130","volume":"6","author":"Bao","year":"2024","journal-title":"CCS Chem."},{"key":"D4SC01244E\/cit40\/1","doi-asserted-by":"crossref","first-page":"5815","DOI":"10.1002\/ejoc.202000667","author":"Le Roch","year":"2020","journal-title":"Eur. J. Org Chem."},{"key":"D4SC01244E\/cit41\/1","doi-asserted-by":"crossref","first-page":"26452","DOI":"10.1021\/jacs.3c10792","volume":"145","author":"Dolgado","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC01244E\/cit42\/1","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.1039\/D0OB00795A","volume":"18","author":"Yang","year":"2020","journal-title":"Org. Biomol. Chem."},{"key":"D4SC01244E\/cit43\/1","doi-asserted-by":"crossref","first-page":"15392","DOI":"10.1002\/chem.202102749","volume":"27","author":"Reimler","year":"2021","journal-title":"Chem.\u2013Eur. J."},{"key":"D4SC01244E\/cit44\/1","doi-asserted-by":"crossref","first-page":"e202307782","DOI":"10.1002\/anie.202307782","volume":"62","author":"Krajcovicova","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4SC01244E\/cit45\/1","doi-asserted-by":"crossref","first-page":"5331","DOI":"10.1002\/anie.202012523","volume":"60","author":"Bao","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4SC01244E\/cit46\/1","doi-asserted-by":"crossref","first-page":"9248","DOI":"10.1021\/acs.orglett.2c03813","volume":"24","author":"Liu","year":"2022","journal-title":"Org. Lett."},{"key":"D4SC01244E\/cit47\/1","doi-asserted-by":"crossref","first-page":"8338","DOI":"10.1021\/acs.orglett.3c03453","volume":"25","author":"Bao","year":"2023","journal-title":"Org. Lett."},{"key":"D4SC01244E\/cit48\/1","doi-asserted-by":"crossref","first-page":"2308491","DOI":"10.1002\/advs.202308491","volume":"11","author":"Zuo","year":"2024","journal-title":"Adv. Sci."},{"key":"D4SC01244E\/cit49\/1","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1021\/acs.orglett.4c01567","volume":"26","author":"Yu","year":"2024","journal-title":"Org. Lett."},{"key":"D4SC01244E\/cit50\/1","doi-asserted-by":"crossref","first-page":"5332","DOI":"10.1002\/anie.201700494","volume":"56","author":"Zhu","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4SC01244E\/cit51\/1","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/anie.201911420","volume":"59","author":"Yang","year":"2020","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4SC01244E\/cit52\/1","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1021\/ol101601d","volume":"12","author":"Sun","year":"2010","journal-title":"Org. Lett."},{"key":"D4SC01244E\/cit53\/1","doi-asserted-by":"crossref","first-page":"7826","DOI":"10.1021\/jo2011522","volume":"76","author":"Sun","year":"2011","journal-title":"J. Org. Chem."},{"key":"D4SC01244E\/cit54\/1","doi-asserted-by":"crossref","first-page":"7882","DOI":"10.1039\/C6CC03246J","volume":"52","author":"Zhu","year":"2016","journal-title":"Chem. Commun."},{"key":"D4SC01244E\/cit55\/1","doi-asserted-by":"crossref","first-page":"5737","DOI":"10.1002\/anie.200902093","volume":"48","author":"Cui","year":"2009","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4SC01244E\/cit56\/1","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1002\/anie.201812705","volume":"58","author":"Kaplaneris","year":"2018","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4SC01244E\/cit57\/1","doi-asserted-by":"crossref","first-page":"10241","DOI":"10.1021\/acs.chemrev.9b00008","volume":"119","author":"Dougherty","year":"2019","journal-title":"Chem. Rev."},{"key":"D4SC01244E\/cit58\/1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1039\/C4CS00246F","volume":"44","author":"Lau","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"D4SC01244E\/cit59\/1","doi-asserted-by":"crossref","first-page":"10079","DOI":"10.1021\/acs.chemrev.0c00532","volume":"120","author":"Li","year":"2020","journal-title":"Chem. Rev."}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/SC\/D4SC01244E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:28:16Z","timestamp":1782887296000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sc\/article\/15\/28\/11099-11107\/868938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":59,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2024,7,17]]}},"URL":"https:\/\/doi.org\/10.1039\/d4sc01244e","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}