{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:34:36Z","timestamp":1791830076415,"version":"4.3.4"},"reference-count":85,"publisher":"Royal Society of Chemistry (RSC)","issue":"16","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":92,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>The power of pyrrole: a 1,6-self-immolative spacer designed on the pyrrole structure enables direct late-stage functionalisation of drugs and their traceless release under enzymatic or reductive micellar catalysis in water.<\/jats:p>","DOI":"10.1039\/d4sc01576b","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T11:43:07Z","timestamp":1712058187000},"page":"6168-6177","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A novel bioresponsive self-immolative spacer based on aza-quinone methide reactivity for the controlled release of thiols, phenols, amines, sulfonamides or amides"],"prefix":"10.1039","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6506-5049","authenticated-orcid":false,"given":"Elena","family":"Ermini","sequence":"first","affiliation":[{"name":"Dipartimento di Biotecnologie, Chimica e Farmacia, Universit\u00e0 degli Studi di Siena, Via A. Moro 2, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6395-9348","authenticated-orcid":false,"given":"Annalaura","family":"Brai","sequence":"additional","affiliation":[{"name":"Dipartimento di Biotecnologie, Chimica e Farmacia, Universit\u00e0 degli Studi di Siena, Via A. Moro 2, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4420-8930","authenticated-orcid":false,"given":"Elena","family":"Cini","sequence":"additional","affiliation":[{"name":"Dipartimento di Biotecnologie, Chimica e Farmacia, Universit\u00e0 degli Studi di Siena, Via A. Moro 2, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Finetti","sequence":"additional","affiliation":[{"name":"Dipartimento di Biotecnologie, Chimica e Farmacia, Universit\u00e0 degli Studi di Siena, Via A. Moro 2, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Giannini","sequence":"additional","affiliation":[{"name":"Translational Medicine & Clinical Pharmacology Corporate R&D \u2013 Alfasigma SpA, Via Pontina, km 30400, 00071 Pomezia (Roma), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7171-7928","authenticated-orcid":false,"given":"Daniele","family":"Padula","sequence":"additional","affiliation":[{"name":"Dipartimento di Biotecnologie, Chimica e Farmacia, Universit\u00e0 degli Studi di Siena, Via A. Moro 2, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucrezia","family":"Paradisi","sequence":"additional","affiliation":[{"name":"Dipartimento di Biotecnologie, Chimica e Farmacia, Universit\u00e0 degli Studi di Siena, Via A. Moro 2, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Poggialini","sequence":"additional","affiliation":[{"name":"Dipartimento di Biotecnologie, Chimica e Farmacia, Universit\u00e0 degli Studi di Siena, Via A. Moro 2, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Trabalzini","sequence":"additional","affiliation":[{"name":"Dipartimento di Biotecnologie, Chimica e Farmacia, Universit\u00e0 degli Studi di Siena, Via A. Moro 2, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Tolu","sequence":"additional","affiliation":[{"name":"Dipartimento di Biotecnologie, Chimica e Farmacia, Universit\u00e0 degli Studi di Siena, Via A. Moro 2, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8660-7580","authenticated-orcid":false,"given":"Maurizio","family":"Taddei","sequence":"additional","affiliation":[{"name":"Dipartimento di Biotecnologie, Chimica e Farmacia, Universit\u00e0 degli Studi di Siena, Via A. Moro 2, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D4SC01576B\/cit1\/1","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.3390\/molecules27175709","volume":"27","author":"Trovato","year":"2022","journal-title":"Molecules"},{"key":"D4SC01576B\/cit2\/1","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.chempr.2023.04.014","volume":"9","author":"Wang","year":"2023","journal-title":"Chem"},{"key":"D4SC01576B\/cit3\/1","doi-asserted-by":"crossref","first-page":"214918","DOI":"10.1016\/j.ccr.2022.214918","volume":"475","author":"Zhao","year":"2023","journal-title":"Coord. Chem. Rev."},{"key":"D4SC01576B\/cit4\/1","doi-asserted-by":"crossref","first-page":"7631","DOI":"10.1039\/D2CS00317A","volume":"51","author":"Dong","year":"2022","journal-title":"Chem. Soc. Rev."},{"key":"D4SC01576B\/cit5a\/1","doi-asserted-by":"crossref","first-page":"5136","DOI":"10.1039\/D2CS00247G","volume":"51","author":"Ma","year":"2022","journal-title":"Chem. Soc. Rev."},{"key":"D4SC01576B\/cit5b\/1","first-page":"22103877","volume":"33","author":"Li","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"D4SC01576B\/cit5c\/1","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.3390\/ijms24032757","volume":"23","author":"Das","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D4SC01576B\/cit5d\/1","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1039\/D2TB02248F","volume":"11","author":"Yu","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"D4SC01576B\/cit6a\/1","first-page":"180030","volume":"1","author":"Taresco","year":"2018","journal-title":"Adv. Ther."},{"key":"D4SC01576B\/cit6b\/1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.4155\/fmc-2018-0249","volume":"11","author":"Benchekroun","year":"2019","journal-title":"Future Med. Chem."},{"key":"D4SC01576B\/cit6c\/1","doi-asserted-by":"crossref","first-page":"e1664","DOI":"10.1002\/wnan.1664","volume":"13","author":"Devnarain","year":"2021","journal-title":"WIREs Nanomedicine and Nanobiotechnology"},{"key":"D4SC01576B\/cit7a\/1","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1021\/ar500179y","volume":"47","author":"Gnaim","year":"2014","journal-title":"Acc. Chem. Res."},{"key":"D4SC01576B\/cit7b\/1","doi-asserted-by":"crossref","first-page":"116281","DOI":"10.1016\/j.bmc.2021.116281","volume":"44","author":"Abe","year":"2021","journal-title":"Bioorg. Med. Chem."},{"key":"D4SC01576B\/cit8\/1","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1016\/j.xphs.2020.08.014","volume":"109","author":"Gonzaga","year":"2020","journal-title":"J. Pharm. Sci."},{"key":"D4SC01576B\/cit9\/1","doi-asserted-by":"crossref","first-page":"7492","DOI":"10.1002\/anie.201500088","volume":"54","author":"Alouane","year":"2015","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4SC01576B\/cit10\/1","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1021\/jo400105m","volume":"78","author":"Robbins","year":"2013","journal-title":"J. Org. Chem."},{"key":"D4SC01576B\/cit11a\/1","doi-asserted-by":"crossref","first-page":"7778","DOI":"10.1039\/D1CC02895B","volume":"57","author":"Dal Corso","year":"2021","journal-title":"Chem. Commun."},{"key":"D4SC01576B\/cit11b\/1","doi-asserted-by":"crossref","first-page":"e202200279","DOI":"10.1002\/cmdc.202200279","volume":"17","author":"Dal Corso","year":"2022","journal-title":"ChemMedChem"},{"key":"D4SC01576B\/cit11c\/1","doi-asserted-by":"crossref","first-page":"7240","DOI":"10.1039\/D3CC01596C","volume":"59","author":"Grier","year":"2023","journal-title":"Chem. Commun."},{"key":"D4SC01576B\/cit12a\/1","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1039\/D0SC00532K","volume":"11","author":"Roberts","year":"2020","journal-title":"Chem. Sci."},{"key":"D4SC01576B\/cit12b\/1","doi-asserted-by":"crossref","first-page":"4872","DOI":"10.1039\/D0CS01061H","volume":"50","author":"Xue","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"D4SC01576B\/cit13a\/1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/s41557-022-00964-7","volume":"14","author":"Dunsmore","year":"2022","journal-title":"Nat. Chem."},{"key":"D4SC01576B\/cit13b\/1","first-page":"e2022100","volume":"61","author":"Gong","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4SC01576B\/cit14a\/1","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1021\/jo300400q","volume":"77","author":"Schmid","year":"2012","journal-title":"J. Org. Chem."},{"key":"D4SC01576B\/cit14b\/1","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/poc.3129","volume":"26","author":"Schmid","year":"2013","journal-title":"J. Phys. Org. Chem."},{"key":"D4SC01576B\/cit15\/1","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1021\/jm0001020","volume":"43","author":"Borch","year":"2000","journal-title":"J. Med. Chem."},{"key":"D4SC01576B\/cit16a\/1","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.1021\/jm030308b","volume":"46","author":"Hay","year":"2003","journal-title":"J. Med. Chem."},{"key":"D4SC01576B\/cit16b\/1","doi-asserted-by":"crossref","first-page":"103975","DOI":"10.1016\/j.bioorg.2020.103975","volume":"101","author":"Huang","year":"2020","journal-title":"Bioorg. Chem."},{"key":"D4SC01576B\/cit16c\/1","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.3390\/molecules25102347","volume":"25","author":"Anduran","year":"2020","journal-title":"Molecules"},{"key":"D4SC01576B\/cit17\/1","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.bmcl.2016.11.093","volume":"27","author":"Chaplin","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4SC01576B\/cit18\/1","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1021\/jm010202l","volume":"44","author":"Tercel","year":"2001","journal-title":"J. Med. Chem."},{"key":"D4SC01576B\/cit19a\/1","doi-asserted-by":"crossref","first-page":"9447","DOI":"10.1021\/jacs.0c02774","volume":"142","author":"Kim","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC01576B\/cit19b\/1","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1021\/acscentsci.1c00460","volume":"7","author":"Hu","year":"2021","journal-title":"ACS Cent. Sci."},{"key":"D4SC01576B\/cit20a\/1","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1021\/cb400088q","volume":"8","author":"Chowdhury","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"D4SC01576B\/cit20b\/1","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.bmcl.2016.11.093","volume":"27","author":"Winn","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4SC01576B\/cit20c\/1","doi-asserted-by":"crossref","first-page":"103975","DOI":"10.1016\/j.bioorg.2020.103975","volume":"101","author":"Huang","year":"2020","journal-title":"Bioorg. Chem."},{"key":"D4SC01576B\/cit20d\/1","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1039\/a607202j","author":"Berry","year":"1997","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"D4SC01576B\/cit21a\/1","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.1021\/jm501844d","volume":"58","author":"Klingler","year":"2015","journal-title":"J. Med. Chem."},{"key":"D4SC01576B\/cit21b\/1","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1021\/acs.chemrev.8b00201","volume":"119","author":"Chen","year":"2019","journal-title":"Chem. Rev."},{"key":"D4SC01576B\/cit21c\/1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.2174\/1389557519666191119144100","volume":"20","author":"Pfaff","year":"2020","journal-title":"Mini-Rev. Med. Chem."},{"key":"D4SC01576B\/cit22a\/1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ejmech.2015.12.027","volume":"109","author":"Frost","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"D4SC01576B\/cit22b\/1","doi-asserted-by":"crossref","first-page":"15832","DOI":"10.1002\/anie.201811338","volume":"57","author":"Sun","year":"2018","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4SC01576B\/cit22c\/1","doi-asserted-by":"crossref","first-page":"12780","DOI":"10.1002\/anie.201807582","volume":"57","author":"Bakthavatsalam","year":"2018","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4SC01576B\/cit23\/1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/bmc.256","volume":"17","author":"Srinivas","year":"2003","journal-title":"Biomed. Chromatogr."},{"key":"D4SC01576B\/cit24a\/1","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.3390\/ph3092751","volume":"3","author":"Subramanian","year":"2010","journal-title":"Pharmaceuticals"},{"key":"D4SC01576B\/cit24b\/1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0169-409X(02)00179-5","volume":"55","author":"Saito","year":"2003","journal-title":"Adv. Drug Delivery Rev."},{"key":"D4SC01576B\/cit24c\/1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/1871520616666160817110310","volume":"17","author":"Dalzoppo","year":"2017","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"D4SC01576B\/cit25\/1","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1039\/a607202j","author":"Berry","year":"1997","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"D4SC01576B\/cit26a\/1","doi-asserted-by":"crossref","first-page":"8979","DOI":"10.1002\/anie.201604026","volume":"55","author":"Feng","year":"2016","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4SC01576B\/cit26b\/1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1021\/ol403079x","volume":"16","author":"Kelly","year":"2014","journal-title":"Org. Lett."},{"key":"D4SC01576B\/cit27a\/1","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1021\/cr0306790","volume":"104","author":"Balaban","year":"2004","journal-title":"Chem. Rev."},{"key":"D4SC01576B\/cit27b\/1","doi-asserted-by":"crossref","first-page":"9261","DOI":"10.1016\/0040-4039(95)02019-L","volume":"51","author":"De Rosa","year":"1995","journal-title":"Tetrahedron Lett."},{"key":"D4SC01576B\/cit27c\/1","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1039\/a900762h","author":"De Rosa","year":"1999","journal-title":"J. Chem. Soc., Perkin Trans. 2"},{"key":"D4SC01576B\/cit28\/1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jopr.2013.02.014","volume":"7","author":"Thulam","year":"2013","journal-title":"J. Pharma Res."},{"key":"D4SC01576B\/cit29\/1","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1039\/D1QO00212K","volume":"8","author":"Song","year":"2021","journal-title":"Org. Chem. Front."},{"key":"D4SC01576B\/cit30a\/1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/978-0-387-49785-3_23","volume-title":"Prodrugs: Challenges and Rewards, Part 2","volume":"V","author":"Guarino","year":"2007","unstructured":"V.Guarino  and  V.Stella , in  Prodrugs: Challenges and Rewards, Part 2 ,  2007 ,  vol. V ,  p. 833"},{"key":"D4SC01576B\/cit30b\/1","volume-title":"The Organic Chemistry of Drug Design and Drug Action","author":"Silverman","year":"2015","unstructured":"R. B.Silverman  and  M. W.Holladay ,  The Organic Chemistry of Drug Design and Drug Action ,  Academic Press ,  London , 3rd edn,  2015"},{"key":"D4SC01576B\/cit31\/1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1021\/acsmedchemlett.2c00492","volume":"14","author":"Kostyo","year":"2023","journal-title":"ACS Med. Chem. Lett."},{"key":"D4SC01576B\/cit32\/1","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/nchem.2635","volume":"8","author":"Staben","year":"2016","journal-title":"Nat. Chem."},{"key":"D4SC01576B\/cit33\/1","volume-title":"Amides 648 entries|DrugBank Online","unstructured":"Amides 648 entries|DrugBank Online ,  https:\/\/go.drugbank.com\/categories\/DBCAT000494 , accessed 30 October 2022"},{"key":"D4SC01576B\/cit34a\/1","doi-asserted-by":"crossref","first-page":"4873","DOI":"10.1039\/c0ob01065k","volume":"9","author":"Rannoux","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"D4SC01576B\/cit34b\/1","doi-asserted-by":"crossref","first-page":"6321","DOI":"10.1016\/j.bmcl.2013.09.067","volume":"23","author":"Bourbon","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4SC01576B\/cit34c\/1","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.3390\/molecules28062445","volume":"28","author":"Petrini","year":"2023","journal-title":"Molecules"},{"key":"D4SC01576B\/cit35\/1","doi-asserted-by":"crossref","first-page":"6050","DOI":"10.1021\/jacs.2c01136","volume":"144","author":"Rose","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC01576B\/cit36b\/1","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1002\/jcc.21759","volume":"32","author":"Grimme","year":"2011","journal-title":"J. Comput. Chem."},{"key":"D4SC01576B\/cit37\/1","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1021\/cr9904009","volume":"105","author":"Tomasi","year":"2005","journal-title":"Chem. Rev."},{"key":"D4SC01576B\/cit38a\/1","doi-asserted-by":"crossref","first-page":"8358","DOI":"10.1021\/jm5008209","volume":"57","author":"Giannini","year":"2014","journal-title":"J. Med. Chem."},{"key":"D4SC01576B\/cit38b\/1","doi-asserted-by":"crossref","first-page":"5735","DOI":"10.18632\/oncotarget.3240","volume":"6","author":"Vesci","year":"2015","journal-title":"Oncotarget"},{"key":"D4SC01576B\/cit38c\/1","doi-asserted-by":"crossref","first-page":"6490","DOI":"10.1039\/C7SC05266A","volume":"9","author":"Cini","year":"2018","journal-title":"Chem. Sci."},{"key":"D4SC01576B\/cit39\/1","doi-asserted-by":"crossref","first-page":"9974","DOI":"10.1021\/acs.jmedchem.6b01426","volume":"59","author":"Rubio-Ruiz","year":"2016","journal-title":"J. Med. Chem."},{"key":"D4SC01576B\/cit40a\/1","doi-asserted-by":"crossref","first-page":"131170","DOI":"10.1016\/j.tet.2020.131170","volume":"76","author":"Calder","year":"2020","journal-title":"Tetrahedron"},{"key":"D4SC01576B\/cit40b\/1","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.chembiol.2021.04.004","volume":"28","author":"Skwarska","year":"2021","journal-title":"Cell Chem. Biol."},{"key":"D4SC01576B\/cit41\/1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1021\/jm070821f","volume":"51","author":"Szab\u00f3","year":"2008","journal-title":"J. Med. Chem."},{"key":"D4SC01576B\/cit42a\/1","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.1111\/bph.13331","volume":"172","author":"O'Callaghan","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"D4SC01576B\/cit42b\/1","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.3390\/cancers15082374","volume":"15","author":"Finetti","year":"2023","journal-title":"Cancers"},{"key":"D4SC01576B\/cit43a\/1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1021\/acsmedchemlett.5b00146","volume":"6","author":"Ji","year":"2015","journal-title":"ACS Med. Chem. Lett."},{"key":"D4SC01576B\/cit43b\/1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1021\/acs.bioconjchem.8b00887","volume":"30","author":"Pardeshi","year":"2019","journal-title":"Bioconjugate Chem."},{"key":"D4SC01576B\/cit44\/1","doi-asserted-by":"crossref","first-page":"10618","DOI":"10.1021\/acs.jmedchem.0c00222","volume":"63","author":"Gracheva","year":"2020","journal-title":"J. Med. Chem."},{"key":"D4SC01576B\/cit45\/1","doi-asserted-by":"crossref","first-page":"111788","DOI":"10.1016\/j.ejmech.2019.111788","volume":"185","author":"Ghawanmeh","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"D4SC01576B\/cit46\/1","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1039\/C8CS00304A","volume":"48","author":"Sharma","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"D4SC01576B\/cit47\/1","first-page":"62","volume":"15","author":"Spiegelberg","year":"2019","journal-title":"Clin. Transl. Radiat. Oncol."},{"key":"D4SC01576B\/cit48\/1","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1574-6976.2008.00107.x","volume":"32","author":"Rold\u00e1n","year":"2008","journal-title":"FEMS Microbiol. Rev."},{"key":"D4SC01576B\/cit49a\/1","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1073\/pnas.93.6.2528","volume":"93","author":"Beyer","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"D4SC01576B\/cit49b\/1","first-page":"442","volume":"39","author":"Wohlleben","year":"2018","journal-title":"Oncol. Rep."},{"key":"D4SC01576B\/cit50\/1","doi-asserted-by":"crossref","first-page":"686","DOI":"10.3390\/cells11040686","volume":"11","author":"Godet","year":"2022","journal-title":"Cells"}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/SC\/D4SC01576B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:56:22Z","timestamp":1782964582000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sc\/article\/15\/16\/6168-6177\/869017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":85,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2024,4,24]]}},"URL":"https:\/\/doi.org\/10.1039\/d4sc01576b","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}