{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T20:23:04Z","timestamp":1785788584541,"version":"3.56.0"},"reference-count":34,"publisher":"Royal Society of Chemistry (RSC)","issue":"37","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":235,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22201311"],"award-info":[{"award-number":["22201311"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A0505050100"],"award-info":[{"award-number":["2023A0505050100"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>A simple and chemo-selective dehydrogenative synthesis of \u03b1,\u03b2-conjugated secondary amides is developed without any external oxidant. The selectivity of this dehydrogenative transformation is controlled by a putative \u03b1-lactam intermediate.<\/jats:p>","DOI":"10.1039\/d4sc04419c","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T02:40:54Z","timestamp":1724380854000},"page":"15385-15390","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Catalytic dehydrogenative synthesis of \u03b1,\u03b2-unsaturated secondary amides without external oxidants"],"prefix":"10.1039","volume":"15","author":[{"given":"Shaokang","family":"An","sequence":"first","affiliation":[{"name":"School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyin","family":"Lai","sequence":"additional","affiliation":[{"name":"Guangzhou Flower Flavours & Fragrances Co., Ltd, Guangzhou 510442, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8442-2697","authenticated-orcid":false,"given":"Wenbo H.","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D4SC04419C\/cit1\/1","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1021\/acscatal.0c04712","volume":"11","author":"Gnaim","year":"2021","journal-title":"ACS Catal."},{"key":"D4SC04419C\/cit2\/1","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1021\/acs.accounts.0c00787","volume":"54","author":"Huang","year":"2021","journal-title":"Acc. Chem. Res."},{"key":"D4SC04419C\/cit3\/1","doi-asserted-by":"crossref","first-page":"5875","DOI":"10.1021\/jacs.5b02243","volume":"137","author":"Chen","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC04419C\/cit4\/1","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1021\/jacs.5b12924","volume":"138","author":"Chen","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC04419C\/cit5\/1","doi-asserted-by":"crossref","first-page":"5669","DOI":"10.1021\/jacs.9b02552","volume":"141","author":"Huang","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC04419C\/cit6\/1","doi-asserted-by":"crossref","first-page":"7757","DOI":"10.1021\/jacs.7b04722","volume":"139","author":"Chen","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC04419C\/cit7\/1","doi-asserted-by":"crossref","first-page":"16205","DOI":"10.1002\/anie.201811197","volume":"57","author":"Chen","year":"2018","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4SC04419C\/cit8\/1","doi-asserted-by":"crossref","first-page":"14889","DOI":"10.1021\/jacs.9b07932","volume":"141","author":"Chen","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC04419C\/cit9a\/1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/anie.201808794","volume":"58","author":"Teskey","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4SC04419C\/cit9b\/1","doi-asserted-by":"crossref","first-page":"9836","DOI":"10.1039\/C9SC03715B","volume":"10","author":"Bauer","year":"2019","journal-title":"Chem. Sci."},{"key":"D4SC04419C\/cit9c\/1","doi-asserted-by":"crossref","first-page":"8267","DOI":"10.1021\/acs.joc.9b00872","volume":"84","author":"Wang","year":"2019","journal-title":"J. Org. Chem."},{"key":"D4SC04419C\/cit10a\/1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1021\/jacs.7b11351","volume":"140","author":"Wang","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC04419C\/cit10b\/1","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1021\/om8000444","volume":"27","author":"Giri","year":"2008","journal-title":"Organometallics"},{"key":"D4SC04419C\/cit11\/1","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1021\/cr100280d","volume":"111","author":"Yeung","year":"2011","journal-title":"Chem. Rev."},{"key":"D4SC04419C\/cit12\/1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1021\/ar800164n","volume":"42","author":"Li","year":"2009","journal-title":"Acc. Chem. Res."},{"key":"D4SC04419C\/cit13\/1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/anie.201304268","volume":"53","author":"Girard","year":"2014","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4SC04419C\/cit14\/1","doi-asserted-by":"crossref","first-page":"6449","DOI":"10.1021\/ja201143v","volume":"133","author":"Guimond","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC04419C\/cit15\/1","doi-asserted-by":"crossref","first-page":"6908","DOI":"10.1021\/ja102571b","volume":"132","author":"Guimond","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC04419C\/cit16\/1","doi-asserted-by":"crossref","first-page":"15607","DOI":"10.1021\/ja5072702","volume":"136","author":"Fukui","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC04419C\/cit17\/1","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1021\/ja100676r","volume":"132","author":"Tan","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC04419C\/cit18\/1","doi-asserted-by":"crossref","first-page":"19592","DOI":"10.1021\/ja310153v","volume":"134","author":"Wang","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC04419C\/cit19\/1","doi-asserted-by":"crossref","first-page":"13888","DOI":"10.1021\/ja902762a","volume":"131","author":"Wu","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC04419C\/cit20\/1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41586-024-07341-z","volume":"629","author":"Zhou","year":"2024","journal-title":"Nature"},{"key":"D4SC04419C\/cit21a\/1","doi-asserted-by":"crossref","first-page":"6460","DOI":"10.1021\/acs.orglett.2c02594","volume":"24","author":"Yang","year":"2022","journal-title":"Org. Lett."},{"key":"D4SC04419C\/cit21b\/1","doi-asserted-by":"crossref","first-page":"7947","DOI":"10.1039\/D2SC02291E","volume":"13","author":"Yu","year":"2022","journal-title":"Chem. Sci."},{"key":"D4SC04419C\/cit21c\/1","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1039\/b613443m","volume":"37","author":"Zard","year":"2008","journal-title":"Chem. Soc. Rev."},{"key":"D4SC04419C\/cit22a\/1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/anie.196800251","volume":"7","author":"Lengyel","year":"1968","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4SC04419C\/cit22b\/1","doi-asserted-by":"crossref","first-page":"5031","DOI":"10.1021\/ja00065a011","volume":"115","author":"Hoffman","year":"1993","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC04419C\/cit23\/1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/anie.198002761","volume":"19","author":"L'Abb\u00e9","year":"1980","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4SC04419C\/cit24\/1","doi-asserted-by":"crossref","first-page":"5507","DOI":"10.1021\/jo00350a014","volume":"50","author":"Baumgarten","year":"1985","journal-title":"J. Org. Chem."},{"key":"D4SC04419C\/cit25\/1","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1021\/ja00883a069","volume":"84","author":"Baumgarten","year":"1962","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC04419C\/cit26\/1","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1021\/ja01061a018","volume":"86","author":"Sheehan","year":"1964","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC04419C\/cit27a\/1","doi-asserted-by":"crossref","first-page":"14232","DOI":"10.1021\/ja306323x","volume":"134","author":"Bissember","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC04419C\/cit28\/1","unstructured":"For the details about this drug, please see  https:\/\/www.drugs.com\/loperamide.html"}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/SC\/D4SC04419C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:35:58Z","timestamp":1782848158000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sc\/article\/15\/37\/15385-15390\/869659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":34,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2024,9,25]]}},"URL":"https:\/\/doi.org\/10.1039\/d4sc04419c","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D4SC04419C\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4SC04419C\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4SC04419C\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4SC04419C\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4SC04419C\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4SC04419C\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4SC04419C\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4SC04419C\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4SC04419C\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4SC04419C\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}