{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:57:50Z","timestamp":1792634270281,"version":"4.5.0"},"reference-count":61,"publisher":"Royal Society of Chemistry (RSC)","issue":"46","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":302,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100010954","name":"Qingdao National Laboratory for Marine Science and Technology","doi-asserted-by":"publisher","award":["2022QNLM0003-2"],"award-info":[{"award-number":["2022QNLM0003-2"]}],"id":[{"id":"10.13039\/501100010954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104120"],"award-info":[{"award-number":["82104120"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023YQ013"],"award-info":[{"award-number":["ZR2023YQ013"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["2022HWYQ069"],"award-info":[{"award-number":["2022HWYQ069"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004195","name":"Ocean University of China","doi-asserted-by":"publisher","award":["202262015"],"award-info":[{"award-number":["202262015"]}],"id":[{"id":"10.13039\/501100004195","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>Glutathione peroxidase 4 (GPX4) plays a crucial role in the ferroptosis pathway, emerging as a potential drug target in the treatment of refractory tumors.<\/jats:p>","DOI":"10.1039\/d4sc05448b","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T10:01:09Z","timestamp":1730196069000},"page":"19420-19431","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A potent and selective anti-glutathione peroxidase 4 nanobody as a ferroptosis inducer"],"prefix":"10.1039","volume":"15","author":[{"given":"Xinyu","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Marine Drug, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China"},{"name":"Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou, 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7002-206X","authenticated-orcid":false,"given":"Aowei","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, Ocean University of China, Qingdao 266003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenglin","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drug, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China"},{"name":"Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drug, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China"},{"name":"Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drug, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China"},{"name":"Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2125-7345","authenticated-orcid":false,"given":"Ximing","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drug, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China"},{"name":"Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China"},{"name":"Marine Biomedical Research Institute of Qingdao, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266071, Shandong, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlin","family":"Xu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou, 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3222-0211","authenticated-orcid":false,"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drug, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China"},{"name":"Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0635-6801","authenticated-orcid":false,"given":"Xue","family":"Qiu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drug, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China"},{"name":"Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"issue":"5","key":"D4SC05448B\/cit1\/1","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"14","key":"D4SC05448B\/cit2\/1","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"issue":"7679","key":"D4SC05448B\/cit3\/1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature24297","volume":"551","author":"Hangauer","year":"2017","journal-title":"Nature"},{"issue":"7664","key":"D4SC05448B\/cit4\/1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nature23007","volume":"547","author":"Viswanathan","year":"2017","journal-title":"Nature"},{"issue":"3","key":"D4SC05448B\/cit5\/1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1021\/acscentsci.7b00589","volume":"4","author":"Shah","year":"2018","journal-title":"ACS Cent. Sci."},{"issue":"7","key":"D4SC05448B\/cit6\/1","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1073\/pnas.1821022116","volume":"116","author":"Fang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"D4SC05448B\/cit7\/1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41589-020-00734-x","volume":"17","author":"Sun","year":"2021","journal-title":"Nat. Chem. Biol."},{"issue":"1","key":"D4SC05448B\/cit8\/1","doi-asserted-by":"crossref","first-page":"5933","DOI":"10.1038\/s41467-023-41626-7","volume":"14","author":"Lv","year":"2023","journal-title":"Nat. Commun."},{"issue":"3","key":"D4SC05448B\/cit9\/1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cell.2017.11.048","volume":"172","author":"Ingold","year":"2018","journal-title":"Cell"},{"issue":"18","key":"D4SC05448B\/cit10\/1","doi-asserted-by":"crossref","first-page":"1800311","DOI":"10.1002\/pmic.201800311","volume":"19","author":"Forcina","year":"2019","journal-title":"Proteomics"},{"issue":"31","key":"D4SC05448B\/cit11\/1","doi-asserted-by":"crossref","first-page":"9041","DOI":"10.1021\/bi700840d","volume":"46","author":"Scheerer","year":"2007","journal-title":"Biochemistry"},{"issue":"2","key":"D4SC05448B\/cit12\/1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bbrc.2016.11.035","volume":"482","author":"Sakamoto","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"9","key":"D4SC05448B\/cit13\/1","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.bbalip.2018.06.006","volume":"1863","author":"Borchert","year":"2018","journal-title":"Biochim. Biophys. Acta, Mol. Cell Biol. Lipids"},{"issue":"5","key":"D4SC05448B\/cit14\/1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/s41589-020-0501-5","volume":"16","author":"Eaton","year":"2020","journal-title":"Nat. Chem. Biol."},{"issue":"12","key":"D4SC05448B\/cit15\/1","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.chembiol.2022.11.003","volume":"29","author":"Liu","year":"2022","journal-title":"Cell Chem. Biol."},{"issue":"8","key":"D4SC05448B\/cit16\/1","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1021\/acschembio.7b00424","volume":"12","author":"Allimuthu","year":"2017","journal-title":"ACS Chem. Biol."},{"issue":"51","key":"D4SC05448B\/cit17\/1","doi-asserted-by":"crossref","first-page":"20407","DOI":"10.1021\/jacs.9b10769","volume":"141","author":"Eaton","year":"2019","journal-title":"J. Am. Chem. Soc."},{"issue":"27","key":"D4SC05448B\/cit18\/1","doi-asserted-by":"crossref","first-page":"10477","DOI":"10.1039\/D4SC02002B","volume":"15","author":"Li","year":"2024","journal-title":"Chem. Sci."},{"issue":"23","key":"D4SC05448B\/cit19\/1","doi-asserted-by":"crossref","first-page":"127538","DOI":"10.1016\/j.bmcl.2020.127538","volume":"30","author":"Eaton","year":"2020","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"6428","key":"D4SC05448B\/cit20\/1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/363446a0","volume":"363","author":"Hamerscasterman","year":"1993","journal-title":"Nature"},{"issue":"7","key":"D4SC05448B\/cit21\/1","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1111\/febs.15515","volume":"288","author":"Muyldermans","year":"2021","journal-title":"FEBS J."},{"issue":"9","key":"D4SC05448B\/cit22\/1","doi-asserted-by":"crossref","first-page":"5009","DOI":"10.3390\/ijms23095009","volume":"23","author":"Arbabi-Ghahroudi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"D4SC05448B\/cit23\/1","doi-asserted-by":"crossref","first-page":"794","DOI":"10.3390\/ph16060794","volume":"16","author":"Castrignano","year":"2023","journal-title":"Pharmaceuticals"},{"issue":"4","key":"D4SC05448B\/cit24\/1","doi-asserted-by":"crossref","first-page":"4176","DOI":"10.3390\/ijms24044176","volume":"24","author":"Tang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"13","key":"D4SC05448B\/cit25\/1","first-page":"3512","volume":"17","author":"Lauwereys","year":"1998","journal-title":"FEBS J."},{"issue":"1","key":"D4SC05448B\/cit26\/1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1021\/bi0009082","volume":"40","author":"Perez","year":"2001","journal-title":"Biochemistry"},{"issue":"3","key":"D4SC05448B\/cit27\/1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1110\/ps.34602","volume":"11","author":"Dumoulin","year":"2002","journal-title":"Protein Sci."},{"issue":"11","key":"D4SC05448B\/cit28\/1","doi-asserted-by":"crossref","first-page":"e28218","DOI":"10.1371\/journal.pone.0028218","volume":"6","author":"Hussack","year":"2011","journal-title":"PLoS One"},{"issue":"11","key":"D4SC05448B\/cit29\/1","first-page":"1212","volume":"10","author":"Van Bockstaele","year":"2009","journal-title":"Curr. Opin. Invest. Drugs"},{"issue":"6","key":"D4SC05448B\/cit30\/1","doi-asserted-by":"crossref","first-page":"5994","DOI":"10.3390\/ijms24065994","volume":"24","author":"Jin","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D4SC05448B\/cit31\/1","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.2147\/IJN.S297631","volume":"16","author":"Sun","year":"2021","journal-title":"Int. J. Nanomed."},{"issue":"7","key":"D4SC05448B\/cit32\/1","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1021\/acscentsci.1c01265","volume":"8","author":"Maza","year":"2022","journal-title":"ACS Cent. Sci."},{"key":"D4SC05448B\/cit33\/1","doi-asserted-by":"crossref","first-page":"1012841","DOI":"10.3389\/fimmu.2023.1012841","volume":"14","author":"Maali","year":"2023","journal-title":"Front. Immunol."},{"issue":"7","key":"D4SC05448B\/cit34\/1","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1007\/s10072-021-05234-x","volume":"42","author":"Asefy","year":"2021","journal-title":"Neurol. Sci."},{"issue":"6","key":"D4SC05448B\/cit35\/1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3390\/ph16060863","volume":"16","author":"Bocancia-Mateescu","year":"2023","journal-title":"Pharmaceuticals"},{"key":"D4SC05448B\/cit36\/1","doi-asserted-by":"crossref","first-page":"1014377","DOI":"10.3389\/fimmu.2022.1014377","volume":"13","author":"Qin","year":"2022","journal-title":"Front. Immunol."},{"key":"D4SC05448B\/cit37\/1","doi-asserted-by":"crossref","first-page":"106760","DOI":"10.1016\/j.intimp.2020.106760","volume":"86","author":"Ahangarzadeh","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"D4SC05448B\/cit38\/1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1056\/NEJMoa1806311","volume":"380","author":"Scully","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"21","key":"D4SC05448B\/cit39\/1","doi-asserted-by":"crossref","first-page":"12886","DOI":"10.1021\/acs.analchem.8b03509","volume":"90","author":"Zhang","year":"2018","journal-title":"Anal. Chem."},{"issue":"17","key":"D4SC05448B\/cit40\/1","doi-asserted-by":"crossref","first-page":"11935","DOI":"10.1021\/acs.analchem.0c02338","volume":"92","author":"Wang","year":"2020","journal-title":"Anal. Chem."},{"issue":"9","key":"D4SC05448B\/cit41\/1","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/s41592-019-0530-8","volume":"16","author":"Algar","year":"2019","journal-title":"Nat. Methods"},{"issue":"2","key":"D4SC05448B\/cit42\/1","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1021\/acs.chemrev.6b00030","volume":"117","author":"Hildebrandt","year":"2017","journal-title":"Chem. Rev."},{"issue":"12","key":"D4SC05448B\/cit43\/1","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1021\/acscentsci.2c00998","volume":"8","author":"Shen","year":"2022","journal-title":"ACS Cent. Sci."},{"issue":"45","key":"D4SC05448B\/cit44\/1","first-page":"24785","volume":"145","author":"He","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC05448B\/cit45\/1","author":"Evans","year":"2021","unstructured":"R.Evans ,  M.O'Neill ,  A.Pritzel ,  N.Antropova ,  A.Senior ,  T.Green ,  A.Z\u00eddek ,  R.Bates ,  S.Blackwell ,  J.Yim ,  O.Ronneberger ,  S.Bodenstein ,  M.Zielinski ,  A.Bridgland ,  A.Potapenko ,  A.Cowie ,  K.Tunyasuvunakool ,  R.Jain ,  E.Clancy ,  P.Kohli ,  J. M.Jumper , and  D.Hassabis , Protein complex prediction with AlphaFold-Multimer,  bioRxiv ,  2021 , preprint, DOI: 10.1101\/2021.10.04.463034"},{"issue":"6","key":"D4SC05448B\/cit46\/1","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41592-022-01488-1","volume":"19","author":"Mirdita","year":"2022","journal-title":"Nat. Methods"},{"issue":"1","key":"D4SC05448B\/cit47\/1","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/s41467-022-28865-w","volume":"13","author":"Bryant","year":"2022","journal-title":"Nat. Commun."},{"issue":"5","key":"D4SC05448B\/cit49\/1","first-page":"15","volume":"14","author":"Li","year":"2024","journal-title":"Biosensors-Basel"},{"issue":"11","key":"D4SC05448B\/cit50\/1","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/s41589-021-00877-5","volume":"17","author":"Payne","year":"2021","journal-title":"Nat. Chem. Biol."},{"issue":"11","key":"D4SC05448B\/cit51\/1","first-page":"1121","volume":"3","author":"Joliot","year":"1991","journal-title":"New Biol."},{"issue":"14","key":"D4SC05448B\/cit52\/1","doi-asserted-by":"crossref","first-page":"10444","DOI":"10.1016\/S0021-9258(17)34080-2","volume":"269","author":"Derossi","year":"1994","journal-title":"J. Biol. Chem."},{"key":"D4SC05448B\/cit53\/1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jconrel.2013.11.020","volume":"174","author":"Wang","year":"2014","journal-title":"J. Controlled Release"},{"issue":"4","key":"D4SC05448B\/cit54\/1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.tips.2017.01.003","volume":"38","author":"Guidotti","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"issue":"2","key":"D4SC05448B\/cit55\/1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3390\/molecules23020295","volume":"23","author":"Borrelli","year":"2018","journal-title":"Molecules"},{"issue":"8","key":"D4SC05448B\/cit56\/1","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nchem.2811","volume":"9","author":"Herce","year":"2017","journal-title":"Nat. Chem."},{"issue":"40","key":"D4SC05448B\/cit57\/1","doi-asserted-by":"crossref","first-page":"22075","DOI":"10.1002\/anie.202103068","volume":"60","author":"Schneider","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"issue":"45","key":"D4SC05448B\/cit58\/1","first-page":"24535","volume":"145","author":"Arafiles","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"D4SC05448B\/cit59\/1","author":"Franz","year":"2024","unstructured":"L.Franz ,  T.Rubil ,  A.Bal\u00e1zs ,  M.Overtus ,  K.Kemnitz-Hassanin ,  C.Govaerts ,  M. A.Mall , and  C. P. R.Hackenberger , A cell-permeable nanobody to restore F508del cystic fibrosis transmembrane conductance regulator activity,  bioRxiv ,  2024 , preprint, DOI: 10.1101\/2024.04.26.591242"},{"issue":"6","key":"D4SC05448B\/cit60\/1","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/s41557-021-00661-x","volume":"13","author":"Schneider","year":"2021","journal-title":"Nat. Chem."},{"key":"D4SC05448B\/cit61\/1","doi-asserted-by":"crossref","first-page":"101328","DOI":"10.1016\/j.redox.2019.101328","volume":"28","author":"Miotto","year":"2020","journal-title":"Redox Biol."},{"issue":"9","key":"D4SC05448B\/cit62\/1","first-page":"1687","volume":"144","author":"Rong","year":"2017","journal-title":"Development"}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/SC\/D4SC05448B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:27:42Z","timestamp":1782887262000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sc\/article\/15\/46\/19420-19431\/869913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":61,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2024,11,27]]}},"URL":"https:\/\/doi.org\/10.1039\/d4sc05448b","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}