{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T21:54:03Z","timestamp":1782856443681,"version":"3.54.5"},"reference-count":48,"publisher":"Royal Society of Chemistry (RSC)","issue":"7","license":[{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["101019280"],"award-info":[{"award-number":["101019280"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>We report on the development of inhibitors of human RNA ligase 1 (Rlig1).<\/jats:p>","DOI":"10.1039\/d4sc06542e","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T06:00:58Z","timestamp":1737180058000},"page":"3313-3322","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Potent inhibitors of the human RNA ligase Rlig1 highlights its role in RNA integrity maintenance under oxidative cellular stress"],"prefix":"10.1039","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6639-4781","authenticated-orcid":false,"given":"Lisa A.","family":"Schlor","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Konstanz, Universit\u00e4tsstra\u00dfe 10, 78457 Konstanz, Germany"},{"name":"Konstanz Research School Chemical Biology, University of Konstanz, Universit\u00e4tsstra\u00dfe 10, 78457 Konstanz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Peu\u00dfner","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Konstanz, Universit\u00e4tsstra\u00dfe 10, 78457 Konstanz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Konstanz, Universit\u00e4tsstra\u00dfe 10, 78457 Konstanz, Germany"},{"name":"Screening Center, University of Konstanz, Universit\u00e4tsstra\u00dfe 10, 78457 Konstanz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6471-3689","authenticated-orcid":false,"given":"Andreas","family":"Marx","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Konstanz, Universit\u00e4tsstra\u00dfe 10, 78457 Konstanz, Germany"},{"name":"Konstanz Research School Chemical Biology, University of Konstanz, Universit\u00e4tsstra\u00dfe 10, 78457 Konstanz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D4SC06542E\/cit1\/1","first-page":"757","volume":"14","author":"Shuman","year":"2004","journal-title":"Curr. Opin. Chem. Biol."},{"key":"D4SC06542E\/cit2\/1","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1007\/s00018-012-0944-2","volume":"69","author":"Popow","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"D4SC06542E\/cit3\/1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1146\/annurev-genet-071719-021856","volume":"57","author":"Shuman","year":"2023","journal-title":"Annu. Rev. Genet."},{"key":"D4SC06542E\/cit4\/1","doi-asserted-by":"crossref","first-page":"6072","DOI":"10.1073\/pnas.1201207109","volume":"109","author":"Chakravarty","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D4SC06542E\/cit5\/1","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/s41467-023-36451-x","volume":"14","author":"Yuan","year":"2023","journal-title":"Nat. Commun."},{"key":"D4SC06542E\/cit6\/1","doi-asserted-by":"crossref","first-page":"e2408249121","DOI":"10.1073\/pnas.2408249121","volume":"121","author":"Hu","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D4SC06542E\/cit7\/1","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.3390\/cells10051075","volume":"10","author":"Goffart","year":"2021","journal-title":"Cells"},{"key":"D4SC06542E\/cit8\/1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1039\/D4CB00125G","author":"Stumpf","year":"2024","journal-title":"RSC Chem. Biol."},{"key":"D4SC06542E\/cit9\/1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"D4SC06542E\/cit10\/1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cotox.2017.11.002","volume":"7","author":"Lingappan","year":"2018","journal-title":"Curr. Opin. Toxicol."},{"key":"D4SC06542E\/cit11\/1","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.3390\/ijms22094642","volume":"22","author":"Juan","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"D4SC06542E\/cit12\/1","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1093\/nar\/gkx1308","volume":"46","author":"Willi","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"D4SC06542E\/cit13\/1","doi-asserted-by":"crossref","first-page":"20689","DOI":"10.1073\/pnas.2011511117","volume":"117","author":"Liu","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"D4SC06542E\/cit14\/1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41392-021-00648-7","volume":"6","author":"Huang","year":"2021","journal-title":"Signal Transduction Targeted Ther."},{"key":"D4SC06542E\/cit15\/1","doi-asserted-by":"crossref","first-page":"15158","DOI":"10.1074\/jbc.REV119.006513","author":"Yan","year":"2019","journal-title":"J. Biol. Chem."},{"key":"D4SC06542E\/cit16\/1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1080\/15216540600946456","volume":"58","author":"Li","year":"2006","journal-title":"IUBMB Life"},{"key":"D4SC06542E\/cit17\/1","doi-asserted-by":"crossref","first-page":"44670","DOI":"10.1074\/jbc.M204379200","volume":"277","author":"Maynard","year":"2002","journal-title":"J. Biol. Chem."},{"key":"D4SC06542E\/cit18\/1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.mito.2013.10.007","volume":"16","author":"Mantha","year":"2014","journal-title":"Mitochondrion"},{"key":"D4SC06542E\/cit19\/1","doi-asserted-by":"crossref","first-page":"16697","DOI":"10.1074\/jbc.M117.787739","volume":"292","author":"Xiao","year":"2017","journal-title":"J. Biol. Chem."},{"key":"D4SC06542E\/cit20\/1","doi-asserted-by":"crossref","first-page":"5022","DOI":"10.3390\/ijms21145022","volume":"21","author":"Liu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"D4SC06542E\/cit21\/1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41531-022-00402-y","volume":"8","author":"Xiao","year":"2022","journal-title":"npj Parkinson's Dis."},{"key":"D4SC06542E\/cit22\/1","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.12659\/MSM.916835","volume":"25","author":"Zhu","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"D4SC06542E\/cit23\/1","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.stem.2013.04.006","volume":"12","author":"Myant","year":"2013","journal-title":"Cell Stem Cell"},{"key":"D4SC06542E\/cit24\/1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.20892\/j.issn.2095-3941.2018.0253","volume":"16","author":"Jin","year":"2019","journal-title":"Cancer Biol. Med."},{"key":"D4SC06542E\/cit25\/1","first-page":"8148510","volume":"2019","author":"Shao","year":"2019","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"D4SC06542E\/cit26\/1","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1038\/s41467-018-06841-7","volume":"9","author":"Liu","year":"2018","journal-title":"Nat. Commun."},{"key":"D4SC06542E\/cit27\/1","doi-asserted-by":"crossref","first-page":"D941","DOI":"10.1093\/nar\/gky1015","volume":"47","author":"Tate","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"D4SC06542E\/cit28\/1","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/ng.3076","volume":"46","author":"Gao","year":"2014","journal-title":"Nat. Genet."},{"key":"D4SC06542E\/cit29\/1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nature10166","volume":"474","author":"C. G. A. R. Network","year":"2011","journal-title":"Nature"},{"key":"D4SC06542E\/cit30\/1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/cbic.200400211","volume":"6","author":"Ahsen","year":"2005","journal-title":"Chembiochem"},{"key":"D4SC06542E\/cit31\/1","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1021\/acschembio.5b00398","volume":"10","author":"Alexander","year":"2015","journal-title":"ACS Chem. Biol."},{"key":"D4SC06542E\/cit32\/1","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1021\/jm4012627","volume":"57","author":"Valente","year":"2014","journal-title":"J. Med. Chem."},{"key":"D4SC06542E\/cit33\/1","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1021\/acschembio.7b00708","volume":"12","author":"Fern\u00e1ndez-Montalv\u00e1n","year":"2017","journal-title":"ACS Chem. Biol."},{"key":"D4SC06542E\/cit34\/1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/ja.2010.4","volume":"63","author":"Gotoh","year":"2010","journal-title":"J. Antibiot."},{"key":"D4SC06542E\/cit35\/1","doi-asserted-by":"crossref","first-page":"6352","DOI":"10.1021\/jm400568p","volume":"56","author":"Raoof","year":"2013","journal-title":"J. Med. Chem."},{"key":"D4SC06542E\/cit36\/1","doi-asserted-by":"crossref","first-page":"e62152","DOI":"10.1371\/journal.pone.0062152","volume":"8","author":"Yoo","year":"2013","journal-title":"PLoS One"},{"key":"D4SC06542E\/cit37\/1","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/cmdc.201300420","volume":"9","author":"Rilova","year":"2014","journal-title":"ChemMedChem"},{"key":"D4SC06542E\/cit38\/1","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.bmcl.2013.01.085","volume":"23","author":"Garc\u00eda-Dom\u00ednguez","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4SC06542E\/cit39\/1","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/j.freeradbiomed.2010.09.021","volume":"49","author":"Loor","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"D4SC06542E\/cit40\/1","doi-asserted-by":"crossref","first-page":"26056","DOI":"10.1074\/jbc.272.41.26056","volume":"272","author":"Wen","year":"1997","journal-title":"J. Biol. Chem."},{"key":"D4SC06542E\/cit41\/1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.5487\/TR.2009.25.3.113","volume":"25","author":"Sa","year":"2009","journal-title":"Toxicol. Res."},{"key":"D4SC06542E\/cit42\/1","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1093\/nar\/gni054","volume":"33","author":"Imbeaud","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"D4SC06542E\/cit43\/1","doi-asserted-by":"crossref","first-page":"4303","DOI":"10.1128\/MCB.15.8.4303","volume":"15","author":"Petrini","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"D4SC06542E\/cit44\/1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0092-8674(92)90450-Q","volume":"69","author":"Barnes","year":"1992","journal-title":"Cell"},{"key":"D4SC06542E\/cit45\/1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0092-8674(92)90450-Q","volume":"69","author":"Deborah","year":"1992","journal-title":"Cell"},{"key":"D4SC06542E\/cit46\/1","doi-asserted-by":"crossref","first-page":"26003","DOI":"10.1039\/C5RA25853G","volume":"6","author":"Mandalapu","year":"2016","journal-title":"RSC Adv."},{"key":"D4SC06542E\/cit47\/1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nature03082","volume":"432","author":"Pascal","year":"2004","journal-title":"Nature"},{"key":"D4SC06542E\/cit48\/1","doi-asserted-by":"crossref","first-page":"23054","DOI":"10.1074\/jbc.M111.248831","volume":"286","author":"Taylor","year":"2011","journal-title":"J. Biol. Chem."}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/SC\/D4SC06542E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:44:21Z","timestamp":1782852261000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sc\/article\/16\/7\/3313-3322\/870143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,2,12]]}},"URL":"https:\/\/doi.org\/10.1039\/d4sc06542e","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D4SC06542E\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4SC06542E\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4SC06542E\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4SC06542E\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4SC06542E\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4SC06542E\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}