{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:44:37Z","timestamp":1792853077417,"version":"4.5.0"},"reference-count":58,"publisher":"Royal Society of Chemistry (RSC)","issue":"45","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":302,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["EMR\/2016\/005414"],"award-info":[{"award-number":["EMR\/2016\/005414"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["WEA\/2020\/000032"],"award-info":[{"award-number":["WEA\/2020\/000032"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1142750"],"award-info":[{"award-number":["APP1142750"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["ID2011990"],"award-info":[{"award-number":["ID2011990"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>\n                    Current treatments for tuberculosis primarily target\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    (\n                    <jats:italic>Mtb<\/jats:italic>\n                    ) infections, often neglecting the emerging issue of latent tuberculosis infection (LTBI) which are characterized by reduced susceptibility to antibiotics.\n                  <\/jats:p>","DOI":"10.1039\/d4sc06618a","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T07:46:41Z","timestamp":1730188001000},"page":"19084-19093","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Decoding the role of mycobacterial lipid remodelling and membrane dynamics in antibiotic tolerance"],"prefix":"10.1039","volume":"15","author":[{"given":"Anjana P.","family":"Menon","sequence":"first","affiliation":[{"name":"Department of Chemistry, Indian Institute of Technology Bombay, Mumbai 400076, India"},{"name":"IITB-Monash Research Academy, Indian Institute of Technology Bombay, Mumbai 400076, India"},{"name":"Department of Biochemistry & Molecular Biology, Monash University, Clayton, VIC 3800, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzong-Hsien","family":"Lee","sequence":"additional","affiliation":[{"name":"IITB-Monash Research Academy, Indian Institute of Technology Bombay, Mumbai 400076, India"},{"name":"Department of Biochemistry & Molecular Biology, Monash University, Clayton, VIC 3800, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0234-4064","authenticated-orcid":false,"given":"Marie-Isabel","family":"Aguilar","sequence":"additional","affiliation":[{"name":"IITB-Monash Research Academy, Indian Institute of Technology Bombay, Mumbai 400076, India"},{"name":"Department of Biochemistry & Molecular Biology, Monash University, Clayton, VIC 3800, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3684-4312","authenticated-orcid":false,"given":"Shobhna","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Indian Institute of Technology Bombay, Mumbai 400076, India"},{"name":"IITB-Monash Research Academy, Indian Institute of Technology Bombay, Mumbai 400076, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D4SC06618A\/cit1\/1","volume-title":"Global tuberculosis report 2023","year":"2023","unstructured":"Global tuberculosis report 2023 ,  Geneva: World Health Organization ,  2023 , Licence: CC BY-NC-SA 3.0 IGO"},{"key":"D4SC06618A\/cit2\/1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1146\/annurev-pathol-042120-032916","volume":"16","author":"Kinsella","year":"2021","journal-title":"Annu. Rev. Pathol.: Mech. Dis."},{"key":"D4SC06618A\/cit3\/1","volume-title":"MMWR Morbidity and Mortality Weekly Report","volume":"72","author":"Schildknecht","year":"2023","unstructured":"K. R.Schildknecht ,  Tuberculosis\u2014United States, 2022 ,  MMWR Morbidity and Mortality Weekly Report ,  2023 , vol.  72"},{"issue":"2","key":"D4SC06618A\/cit4\/1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4046\/trd.2015.78.2.56","volume":"78","author":"Lee","year":"2015","journal-title":"Tuberc. Respir. Dis."},{"issue":"6","key":"D4SC06618A\/cit5\/1","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.bpj.2020.01.027","volume":"118","author":"Adhyapak","year":"2020","journal-title":"Biophys. J."},{"issue":"4","key":"D4SC06618A\/cit6\/1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1128\/microbiolspec.GPP3-0027-2018","volume":"7","author":"Daff\u00e9","year":"2019","journal-title":"Microbiol. Spectrum"},{"issue":"1","key":"D4SC06618A\/cit7\/1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41579-019-0273-7","volume":"18","author":"Dulberger","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"issue":"10","key":"D4SC06618A\/cit8\/1","doi-asserted-by":"crossref","first-page":"a021105","DOI":"10.1101\/cshperspect.a021105","volume":"4","author":"Jackson","year":"2014","journal-title":"Cold Spring Harbor Perspect. Med."},{"issue":"4","key":"D4SC06618A\/cit9\/1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1021\/acsbiomedchemau.2c00010","volume":"2","author":"Menon","year":"2022","journal-title":"ACS Bio Med Chem Au"},{"key":"D4SC06618A\/cit10\/1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cbpa.2019.05.025","volume":"52","author":"Lee","year":"2019","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"10","key":"D4SC06618A\/cit11\/1","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1039\/D3SC04523D","volume":"15","author":"Lee","year":"2024","journal-title":"Chem. Sci."},{"key":"D4SC06618A\/cit12\/1","first-page":"578","volume":"360","author":"Mishra","year":"2023","journal-title":"J. Ophthalmol. Clin. Res."},{"issue":"11","key":"D4SC06618A\/cit13\/1","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/s41429-020-0320-7","volume":"73","author":"Lelovic","year":"2020","journal-title":"J. Antibiot."},{"key":"D4SC06618A\/cit14\/1","doi-asserted-by":"crossref","first-page":"804838","DOI":"10.3389\/fneur.2022.804838","volume":"13","author":"Sholeye","year":"2022","journal-title":"Front. Neurol."},{"issue":"13\u201314","key":"D4SC06618A\/cit15\/1","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/j.addr.2013.09.004","volume":"65","author":"Peetla","year":"2013","journal-title":"Adv. Drug Delivery Rev."},{"issue":"6","key":"D4SC06618A\/cit16\/1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.2323\/jgam.53.333","volume":"53","author":"Chaturvedi","year":"2007","journal-title":"J. Gen. Appl. Microbiol."},{"key":"D4SC06618A\/cit17\/1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jconrel.2021.11.023","volume":"342","author":"Herman","year":"2022","journal-title":"J. Controlled Release"},{"issue":"12","key":"D4SC06618A\/cit18\/1","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.3390\/molecules22122267","volume":"22","author":"Ramirez","year":"2017","journal-title":"Molecules"},{"key":"D4SC06618A\/cit19\/1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0099-5428(08)60691-7","volume-title":"Clarithromycin. Analytical Profiles of Drug Substances and Excipients","volume":"24","author":"Salem","year":"1996","unstructured":"I. I.Salem ,  Clarithromycin. Analytical Profiles of Drug Substances and Excipients ,  Elsevier ,  1996 , vol.  24 ,  p. 45\u201385"},{"issue":"1","key":"D4SC06618A\/cit20\/1","doi-asserted-by":"publisher","DOI":"10.1128\/ecosalplus.ESP-0017-2019","volume":"9","author":"Mosaei","year":"2020","journal-title":"EcoSal Plus"},{"issue":"1","key":"D4SC06618A\/cit21\/1","doi-asserted-by":"crossref","first-page":"10048","DOI":"10.1038\/ncomms10048","volume":"6","author":"Chan","year":"2015","journal-title":"Nat. Commun."},{"key":"D4SC06618A\/cit22\/1","doi-asserted-by":"crossref","first-page":"101574","DOI":"10.1016\/j.cimid.2020.101574","volume":"74","author":"Khawbung","year":"2021","journal-title":"Comp. Immunol., Microbiol. Infect. Dis."},{"key":"D4SC06618A\/cit23\/1","first-page":"341","volume-title":"Molecular genetics of Mycobacteria","author":"Layre","year":"2014","unstructured":"E.Layre ,  R.Al-Mubarak ,  J. T.Belisle  and  D. B.Moody ,  Mycobacterial lipidomics ,  Molecular genetics of Mycobacteria ,  2014 ,  pp. 341\u2013360"},{"issue":"11","key":"D4SC06618A\/cit24\/1","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.bbalip.2016.10.007","volume":"1862","author":"L\u00f3pez-Lara","year":"2017","journal-title":"Biochim. Biophys. Acta, Mol. Cell Biol. Lipids"},{"issue":"10","key":"D4SC06618A\/cit25\/1","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1099\/00221287-148-10-3089","volume":"148","author":"Etienne","year":"2002","journal-title":"Microbiology"},{"issue":"26","key":"D4SC06618A\/cit26\/1","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.1002\/anie.200806121","volume":"48","author":"Hertweck","year":"2009","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4SC06618A\/cit27\/1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.biochi.2017.06.015","volume":"141","author":"Yao","year":"2017","journal-title":"Biochimie"},{"key":"D4SC06618A\/cit28\/1","volume-title":"Lipid intermediates in the biosynthesis of bacterial cell-wall components","author":"Baddiley","year":"1973","unstructured":"J.Baddiley ,  Lipid intermediates in the biosynthesis of bacterial cell-wall components ,  Portland Press Ltd ,  1973"},{"issue":"2","key":"D4SC06618A\/cit29\/1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1073\/pnas.88.2.444","volume":"88","author":"Kumar","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"D4SC06618A\/cit30\/1","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.tcb.2006.08.009","volume":"16","author":"Janmey","year":"2006","journal-title":"Trends Cell Biol."},{"key":"D4SC06618A\/cit31\/1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cis.2013.10.028","volume":"205","author":"Pomorski","year":"2014","journal-title":"Adv. Colloid Interface Sci."},{"issue":"10","key":"D4SC06618A\/cit32\/1","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1529\/biophysj.106.084590","volume":"91","author":"Seu","year":"2006","journal-title":"Biophys. J."},{"key":"D4SC06618A\/cit33\/1","doi-asserted-by":"crossref","first-page":"600221","DOI":"10.3389\/fmicb.2020.600221","volume":"11","author":"Mozaheb","year":"2020","journal-title":"Front. Microbiol."},{"issue":"1","key":"D4SC06618A\/cit34\/1","doi-asserted-by":"crossref","first-page":"6694","DOI":"10.1038\/s41467-023-42478-x","volume":"14","author":"Angala","year":"2023","journal-title":"Nat. Commun."},{"issue":"22","key":"D4SC06618A\/cit35\/1","doi-asserted-by":"crossref","first-page":"10044","DOI":"10.1073\/pnas.0914680107","volume":"107","author":"Gold","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"D4SC06618A\/cit36\/1","doi-asserted-by":"crossref","first-page":"104589","DOI":"10.1016\/j.jbc.2023.104589","volume":"299","author":"Sengupta","year":"2023","journal-title":"J. Biol. Chem."},{"key":"D4SC06618A\/cit37\/1","first-page":"75","volume-title":"The mycobacterial cell envelope","author":"Gilleron","year":"2008","unstructured":"M.Gilleron ,  M.Jackson ,  J.Nigou  and  G.Puzo ,  Structure, Biosynthesis, and Activities of the Phosphatidyl-myo-Inositol-Based Lipoglycans ,  The mycobacterial cell envelope ,  2008 ,  pp. 75\u2013105"},{"issue":"8","key":"D4SC06618A\/cit38\/1","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1002\/jcb.24515","volume":"114","author":"Pang","year":"2013","journal-title":"J. Cell. Biochem."},{"key":"D4SC06618A\/cit39\/1","volume-title":"Synthesis and Biological Evaluation of Trehalose Glycolipids","author":"Khan","year":"2012","unstructured":"A. A.Khan ,  Synthesis and Biological Evaluation of Trehalose Glycolipids ,  Open Access Te Herenga Waka-Victoria University of Wellington ,  2012"},{"key":"D4SC06618A\/cit40\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000365423","volume-title":"Intravenous Lipid Emulsions","volume":"112","author":"Burdge","year":"2015","unstructured":"G. C.Burdge  and  P. C.Calder ,  Introduction to fatty acids and lipids .  Intravenous Lipid Emulsions ,  2015 ,  112 ,  1\u201316"},{"key":"D4SC06618A\/cit41\/1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.tube.2016.05.006","volume":"99","author":"Lipworth","year":"2016","journal-title":"Tuberculosis"},{"key":"D4SC06618A\/cit42\/1","doi-asserted-by":"crossref","first-page":"107028","DOI":"10.1016\/j.mimet.2024.107028","author":"Opperman","year":"2024","journal-title":"J. Microbiol. Methods"},{"key":"D4SC06618A\/cit43\/1","doi-asserted-by":"crossref","first-page":"509337","DOI":"10.3389\/fmicb.2019.03026","volume":"10","author":"Nagakubo","year":"2020","journal-title":"Front. Microbiol."},{"key":"D4SC06618A\/cit44\/1","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.ejmech.2018.08.030","volume":"157","author":"Patel","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"D4SC06618A\/cit45\/1","doi-asserted-by":"crossref","first-page":"876667","DOI":"10.3389\/fcimb.2022.876667","volume":"12","author":"Rodriguez","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"16","key":"D4SC06618A\/cit46\/1","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1089\/ars.2013.5789","volume":"21","author":"Horwitz","year":"2014","journal-title":"Antioxid. Redox Signaling"},{"issue":"11","key":"D4SC06618A\/cit47\/1","doi-asserted-by":"crossref","first-page":"148259","DOI":"10.1016\/j.bbabio.2020.148259","volume":"1861","author":"Abby","year":"2020","journal-title":"Biochim. Biophys. Acta, Bioenerg."},{"key":"D4SC06618A\/cit48\/1","first-page":"119","volume":"6","author":"Crellin","year":"2013","journal-title":"Lipid Metab."},{"key":"D4SC06618A\/cit49\/1","first-page":"1007","volume-title":"Modern research and educational topics in microscopy","volume":"2","author":"S\u00e1nchez","year":"2007","unstructured":"S. A.S\u00e1nchez ,  M.Tricerri ,  G.Gunther  and  E.Gratton ,  Laurdan generalized polarization: from cuvette to microscope ,  Modern research and educational topics in microscopy ,  2007 ,  2 ,  1007\u20131014"},{"issue":"6","key":"D4SC06618A\/cit50\/1","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.bbamem.2019.04.004","volume":"1861","author":"Dadhich","year":"2019","journal-title":"Biochim. Biophys. Acta, Biomembr.|"},{"issue":"5","key":"D4SC06618A\/cit51\/1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/00365518809085746","volume":"48","author":"Hagve","year":"1988","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"D4SC06618A\/cit52\/1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.chemphyslip.2013.12.004","volume":"180","author":"Groenewald","year":"2014","journal-title":"Chem. Phys. Lipids"},{"issue":"4","key":"D4SC06618A\/cit53\/1","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1039\/C5MD00503E","volume":"7","author":"Mingeot-Leclercq","year":"2016","journal-title":"MedChemComm"},{"issue":"2","key":"D4SC06618A\/cit54\/1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1021\/jm301116j","volume":"56","author":"Pinheiro","year":"2013","journal-title":"J. Med. Chem."},{"issue":"12","key":"D4SC06618A\/cit55\/1","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1002\/cphc.201300262","volume":"14","author":"Pinheiro","year":"2013","journal-title":"ChemPhysChem"},{"issue":"2","key":"D4SC06618A\/cit56\/1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1021\/jm301116j","volume":"56","author":"Pinheiro","year":"2013","journal-title":"J. Med. Chem."},{"issue":"11","key":"D4SC06618A\/cit57\/1","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1128\/AAC.00653-06","volume":"50","author":"Prasad","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"issue":"2","key":"D4SC06618A\/cit58\/1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1093\/jac\/dkt364","volume":"69","author":"McGrath","year":"2014","journal-title":"J. Antimicrob. Chemother."}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/SC\/D4SC06618A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:07:57Z","timestamp":1782929277000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sc\/article\/15\/45\/19084-19093\/870159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":58,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2024,11,20]]}},"URL":"https:\/\/doi.org\/10.1039\/d4sc06618a","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}