{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:17:20Z","timestamp":1782890240563,"version":"3.54.5"},"reference-count":34,"publisher":"Royal Society of Chemistry (RSC)","issue":"4","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":72,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/100008102","name":"University of Cincinnati","doi-asserted-by":"publisher","award":["G402226"],"award-info":[{"award-number":["G402226"]}],"id":[{"id":"10.13039\/100008102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Sens. Diagn."],"abstract":"<jats:p>A sample-to-answer polystyrene lab-on-a-chip for chemiluminescence immunoassay. Platform features on-chip reagent lyophilization and autonomous sequential dual flow control for sensitive and rapid detection of biomarkers at point-of-care.<\/jats:p>","DOI":"10.1039\/d4sd00352g","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T06:19:26Z","timestamp":1741933166000},"page":"320-335","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A new sequential dual flow lab-on-a-chip with a lyophilized one-component chemiluminescence substrate for high-sensitive microchannel lateral flow assay (mLFA)"],"prefix":"10.1039","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6228-8454","authenticated-orcid":false,"given":"Supreeth","family":"Setty","sequence":"first","affiliation":[{"name":"MicroSystems and BioMEMS Laboratory, Department of Electrical and Computer Engineering, University of Cincinnati, Cincinnati, OH 45221, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4043-1587","authenticated-orcid":false,"given":"Heeyeong","family":"Jang","sequence":"additional","affiliation":[{"name":"MicroSystems and BioMEMS Laboratory, Department of Electrical and Computer Engineering, University of Cincinnati, Cincinnati, OH 45221, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5165-1051","authenticated-orcid":false,"given":"Jungyoup","family":"Han","sequence":"additional","affiliation":[{"name":"MiCo BioMed USA Inc., Skillman, NJ 08558, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8375-0178","authenticated-orcid":false,"given":"Joo Youn","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nogi","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun Seok","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1006-7204","authenticated-orcid":false,"given":"Chong","family":"Ahn","sequence":"additional","affiliation":[{"name":"MicroSystems and BioMEMS Laboratory, Department of Electrical and Computer Engineering, University of Cincinnati, Cincinnati, OH 45221, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D4SD00352G\/cit1\/1","volume-title":"World Health Organization","author":"Kettler","year":"2004","unstructured":"H.Kettler ,  K.White  and  S.Hawkes ,  World Health Organization ,  2004"},{"key":"D4SD00352G\/cit2\/1","doi-asserted-by":"crossref","first-page":"979398","DOI":"10.3389\/frlct.2022.979398","volume":"1","author":"Cooper","year":"2022","journal-title":"Front. Lab. Chip. Technol."},{"key":"D4SD00352G\/cit3\/1","volume-title":"StatPearls","author":"Shreffler","year":"2023","unstructured":"J.Shreffler  and  M. R.Huecker ,  StatPearls ,  2023"},{"key":"D4SD00352G\/cit4\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11886-020-01350-w","volume":"22","author":"Mullins","year":"2020","journal-title":"Curr. Cardiol. Rep."},{"key":"D4SD00352G\/cit5\/1","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1039\/b906523g","volume":"9","author":"Gervais","year":"2009","journal-title":"Lab Chip"},{"key":"D4SD00352G\/cit6\/1","doi-asserted-by":"crossref","first-page":"3750","DOI":"10.1039\/D0AN02286A","volume":"146","author":"Castillo-Le\u00f3n","year":"2021","journal-title":"Analyst"},{"key":"D4SD00352G\/cit7\/1","author":"World Health Organization","unstructured":"World Health Organization ,  https:\/\/www.who.int\/news-room\/questions-and-answers\/item\/simple-rapid-tests , (accessed June 2024)"},{"key":"D4SD00352G\/cit8\/1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3390\/bios11060191","volume":"11","author":"Kim","year":"2021","journal-title":"Biosensors"},{"key":"D4SD00352G\/cit9\/1","doi-asserted-by":"crossref","first-page":"14848","DOI":"10.1038\/srep14848","volume":"5","author":"Lim","year":"2015","journal-title":"Sci. Rep."},{"key":"D4SD00352G\/cit10\/1","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1007\/s10096-013-1910-0","volume":"32","author":"Xiang","year":"2013","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"D4SD00352G\/cit11\/1","doi-asserted-by":"crossref","first-page":"9132","DOI":"10.1021\/acs.analchem.8b01543","volume":"90","author":"Deng","year":"2018","journal-title":"Anal. Chem."},{"key":"D4SD00352G\/cit12\/1","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1039\/C8AN01899E","volume":"144","author":"Ghosh","year":"2019","journal-title":"Analyst"},{"key":"D4SD00352G\/cit13\/1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41378-019-0108-8","volume":"6","author":"Ghosh","year":"2020","journal-title":"Microsyst. Nanoeng."},{"key":"D4SD00352G\/cit14\/1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0003-2670(01)93732-8","volume":"118","author":"Fritsche","year":"1980","journal-title":"Anal. Chim. Acta"},{"key":"D4SD00352G\/cit15\/1","volume-title":"U.S. Pat.","author":"Lee","year":"2020","unstructured":"C. Y.Lee  and  C. W.Lien ,  U.S. Pat. , No. 10711185,  2020"},{"key":"D4SD00352G\/cit16\/1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/bio.2544","volume":"29","author":"Tao","year":"2014","journal-title":"Luminescence"},{"key":"D4SD00352G\/cit17\/1","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1039\/D2LC00878E","volume":"23","author":"Parandakh","year":"2023","journal-title":"Lab Chip"},{"key":"D4SD00352G\/cit18\/1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41579-021-00630-8","volume":"19","author":"Yang","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"D4SD00352G\/cit19\/1","doi-asserted-by":"crossref","first-page":"e24479","DOI":"10.1002\/jcla.24479","volume":"36","author":"Feng","year":"2022","journal-title":"J. Clin. Lab. Anal."},{"key":"D4SD00352G\/cit20\/1","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.3390\/v13061115","volume":"13","author":"Bai","year":"2021","journal-title":"Viruses"},{"key":"D4SD00352G\/cit21\/1","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1039\/c2lc40585g","volume":"12","author":"Kai","year":"2012","journal-title":"Lab Chip"},{"key":"D4SD00352G\/cit22\/1","first-page":"H151","volume":"23","author":"Gervais","year":"2011","journal-title":"Adv. Mater."},{"key":"D4SD00352G\/cit23\/1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1039\/b305892a","volume":"4","author":"Hong","year":"2004","journal-title":"Lab Chip"},{"key":"D4SD00352G\/cit24\/1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s10404-023-02683-y","volume":"27","author":"Ahn","year":"2023","journal-title":"Microfluid. Nanofluid."},{"key":"D4SD00352G\/cit25\/1","doi-asserted-by":"crossref","first-page":"6652","DOI":"10.1021\/acs.analchem.9b00582","volume":"91","author":"Upaassana","year":"2019","journal-title":"Anal. Chem."},{"key":"D4SD00352G\/cit26\/1","doi-asserted-by":"crossref","first-page":"5202","DOI":"10.1002\/chem.201805918","volume":"25","author":"Giussani","year":"2019","journal-title":"Chem. - Eur. J."},{"key":"D4SD00352G\/cit27\/1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s12010-007-8011-4","volume":"144","author":"Lin","year":"2008","journal-title":"Appl. Biochem. Biotechnol."},{"key":"D4SD00352G\/cit28\/1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s12010-014-0850-1","volume":"173","author":"Khan","year":"2014","journal-title":"Appl. Biochem. Biotechnol."},{"key":"D4SD00352G\/cit29\/1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0076-6879(00)05500-2","volume":"305","author":"Kricka","year":"2000","journal-title":"Methods Enzymol."},{"key":"D4SD00352G\/cit30\/1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.trac.2017.04.001","volume":"91","author":"Zarei","year":"2017","journal-title":"TrAC, Trends Anal. Chem."},{"key":"D4SD00352G\/cit31\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1479-5876-7-99","volume":"7","author":"Shahzad","year":"2009","journal-title":"J. Transl. Med."},{"key":"D4SD00352G\/cit32\/1","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1039\/C5LC01562F","volume":"16","author":"Tian","year":"2016","journal-title":"Lab Chip"},{"key":"D4SD00352G\/cit33\/1","doi-asserted-by":"crossref","first-page":"17966","DOI":"10.1038\/s41598-022-22921-7","volume":"12","author":"Cruz-Cardenas","year":"2022","journal-title":"Sci. Rep."},{"key":"D4SD00352G\/cit34\/1","unstructured":"MiCo BioMed Co., Ltd. ,  https:\/\/micobiomed-usa.com\/optimiser_platform_technology\/optimiser-quick-reference-guide\/ , (accessed June 2024)"}],"container-title":["Sensors &amp; Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/SD\/D4SD00352G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:38:07Z","timestamp":1782884287000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sd\/article\/4\/4\/320-335\/870952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4,10]]}},"URL":"https:\/\/doi.org\/10.1039\/d4sd00352g","relation":{},"ISSN":["2635-0998"],"issn-type":[{"value":"2635-0998","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}