{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:07:41Z","timestamp":1787004461949,"version":"build-2736575974"},"reference-count":30,"publisher":"Royal Society of Chemistry (RSC)","issue":"39","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"am","delay-in-days":604,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371908"],"award-info":[{"award-number":["82371908"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271938"],"award-info":[{"award-number":["82271938"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971574"],"award-info":[{"award-number":["81971574"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515220060"],"award-info":[{"award-number":["2021A1515220060"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515011350"],"award-info":[{"award-number":["2021A1515011350"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515012177"],"award-info":[{"award-number":["2024A1515012177"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["202102010025"],"award-info":[{"award-number":["202102010025"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["A2024637"],"award-info":[{"award-number":["A2024637"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["J. Mater. Chem. B"],"abstract":"<jats:p>The co-release of Len and BMS-202 from iRGD-modified liposomes induced a synergistic antitumor immunotherapy, with early therapeutic monitoring by IVIM-MRI.<\/jats:p>","DOI":"10.1039\/d4tb00081a","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T04:36:21Z","timestamp":1724733381000},"page":"9963-9978","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["iRGD-mediated liposomal nanoplatforms for improving hepatocellular carcinoma targeted combination immunotherapy and monitoring tumor response\n                    <i>via<\/i>\n                    IVIM-MRI"],"prefix":"10.1039","volume":"12","author":[{"given":"Jiamin","family":"Li","sequence":"first","affiliation":[{"name":"School of Medicine, South China University of Technology, Guangzhou, 510006, China"},{"name":"Department of Radiology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruili","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Medicine, South China University of Technology, Guangzhou, 510006, China"},{"name":"Department of Radiology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Medicine, South China University of Technology, Guangzhou, 510006, China"},{"name":"Department of Radiology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrui","family":"Pang","sequence":"additional","affiliation":[{"name":"School of Medicine, South China University of Technology, Guangzhou, 510006, China"},{"name":"Department of Radiology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiangxi Road, Guangzhou, 510120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengsheng","family":"Lai","sequence":"additional","affiliation":[{"name":"School of Medical Equipment, Guangdong Food and Drug Vocational College, Guangzhou, Guangdong, 510520, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2784-3780","authenticated-orcid":false,"given":"Youyong","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, 511442, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6154-676X","authenticated-orcid":false,"given":"Xinqing","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Medicine, South China University of Technology, Guangzhou, 510006, China"},{"name":"Department of Radiology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2768-9429","authenticated-orcid":false,"given":"Ruimeng","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Medicine, South China University of Technology, Guangzhou, 510006, China"},{"name":"Department of Radiology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D4TB00081A\/cit1\/1","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1111\/liv.12818","volume":"35","author":"Park","year":"2015","journal-title":"Liver Int."},{"key":"D4TB00081A\/cit2\/1","doi-asserted-by":"crossref","first-page":"17588359211018026","DOI":"10.1177\/17588359211018026","volume":"13","author":"Liu","year":"2021","journal-title":"Ther. Adv. Med. Oncol."},{"key":"D4TB00081A\/cit3\/1","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.3390\/cancers11101554","volume":"11","author":"Macek Jilkova","year":"2019","journal-title":"Cancers"},{"key":"D4TB00081A\/cit4\/1","first-page":"e190031","volume":"1","author":"Wu","year":"2019","journal-title":"Radiology"},{"key":"D4TB00081A\/cit5\/1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/s41392-020-00264-x","volume":"5","author":"Huang","year":"2020","journal-title":"Signal Transduction Targeted Ther."},{"key":"D4TB00081A\/cit6\/1","doi-asserted-by":"crossref","first-page":"42473","DOI":"10.1021\/acsami.1c11763","volume":"13","author":"Liu","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D4TB00081A\/cit7\/1","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.actbio.2022.10.032","volume":"154","author":"Luo","year":"2022","journal-title":"Acta Biomater."},{"key":"D4TB00081A\/cit8\/1","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1002\/hep.31921","volume":"74","author":"Yi","year":"2021","journal-title":"Hepatology"},{"key":"D4TB00081A\/cit9\/1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1158\/0008-5472.CAN-20-2426","volume":"82","author":"Adachi","year":"2022","journal-title":"Cancer Res."},{"key":"D4TB00081A\/cit10\/1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.actbio.2021.08.013","volume":"135","author":"Shen","year":"2021","journal-title":"Acta Biomater."},{"key":"D4TB00081A\/cit11\/1","doi-asserted-by":"crossref","first-page":"140437","DOI":"10.1016\/j.cej.2022.140437","volume":"454","author":"Du","year":"2023","journal-title":"Chem. Eng. J."},{"key":"D4TB00081A\/cit12\/1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12951-022-01309-9","volume":"20","author":"Mahmoud","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"D4TB00081A\/cit13\/1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12964-021-00796-x","volume":"20","author":"Yang","year":"2022","journal-title":"Cell Commun. Signalling"},{"key":"D4TB00081A\/cit14\/1","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.3390\/polym12091906","volume":"12","author":"Kang","year":"2020","journal-title":"Polymers"},{"key":"D4TB00081A\/cit15\/1","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.ccr.2009.10.013","volume":"16","author":"Sugahara","year":"2009","journal-title":"Cancer Cell"},{"key":"D4TB00081A\/cit16\/1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.ajps.2022.07.006","volume":"17","author":"Zhang","year":"2022","journal-title":"Asian J. Pharm. Sci."},{"key":"D4TB00081A\/cit17\/1","doi-asserted-by":"crossref","first-page":"1800025","DOI":"10.1002\/adfm.201800025","volume":"28","author":"Kuang","year":"2018","journal-title":"Adv. Funct. Mater."},{"key":"D4TB00081A\/cit18\/1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neuroimage.2017.12.062","volume":"187","author":"Le Bihan","year":"2019","journal-title":"NeuroImage"},{"key":"D4TB00081A\/cit19\/1","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1177\/0284185116683576","volume":"58","author":"Lee","year":"2017","journal-title":"Acta Radiol."},{"key":"D4TB00081A\/cit20\/1","doi-asserted-by":"crossref","first-page":"39003","DOI":"10.1021\/acsami.1c08290","volume":"13","author":"Tu","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D4TB00081A\/cit21\/1","doi-asserted-by":"crossref","first-page":"e2207786","DOI":"10.1002\/smll.202207786","volume":"19","author":"Zhang","year":"2023","journal-title":"Small"},{"key":"D4TB00081A\/cit22\/1","doi-asserted-by":"crossref","first-page":"e0212513","DOI":"10.1371\/journal.pone.0212513","volume":"14","author":"Mattei","year":"2019","journal-title":"PLoS One"},{"key":"D4TB00081A\/cit23\/1","first-page":"1","author":"Suzuki","year":"2023","journal-title":"Hepatol. Int."},{"key":"D4TB00081A\/cit24\/1","doi-asserted-by":"crossref","first-page":"105829","DOI":"10.1016\/j.phrs.2021.105829","volume":"174","author":"Lu","year":"2021","journal-title":"Pharmacol. Res."},{"key":"D4TB00081A\/cit25\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2045-824X-6-18","volume":"6","author":"Yamamoto","year":"2014","journal-title":"Vascular cell"},{"key":"D4TB00081A\/cit26\/1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jconrel.2021.10.016","volume":"340","author":"Deng","year":"2021","journal-title":"J. Controlled Release"},{"key":"D4TB00081A\/cit27\/1","doi-asserted-by":"crossref","first-page":"e2209785","DOI":"10.1002\/adma.202209785","volume":"35","author":"Xu","year":"2023","journal-title":"Adv. Mater."},{"key":"D4TB00081A\/cit28\/1","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.acra.2023.08.021","volume":"31","author":"Duan","year":"2024","journal-title":"Acad. Radiol."},{"key":"D4TB00081A\/cit29\/1","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1158\/0008-5472.CAN-16-2499","volume":"77","author":"Shi","year":"2017","journal-title":"Cancer Res."},{"key":"D4TB00081A\/cit30\/1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.jconrel.2022.07.015","volume":"349","author":"Shen","year":"2022","journal-title":"J. Controlled Release"}],"container-title":["Journal of Materials Chemistry B"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/TB\/D4TB00081A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T22:09:25Z","timestamp":1782943765000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/tb\/article\/12\/39\/9963-9978\/876023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":30,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2024,10,9]]}},"URL":"https:\/\/doi.org\/10.1039\/d4tb00081a","relation":{},"ISSN":["2050-750X","2050-7518"],"issn-type":[{"value":"2050-750X","type":"print"},{"value":"2050-7518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}