{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:01:31Z","timestamp":1782946891878,"version":"3.54.5"},"reference-count":26,"publisher":"Royal Society of Chemistry (RSC)","issue":"23","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"am","delay-in-days":485,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703332"],"award-info":[{"award-number":["81703332"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["J. Mater. Chem. B"],"abstract":"<jats:p>PD-E2 was capable of simultaneously blocking bone loss and downregulating the expression of ALP in the serum, which made serum ALP a potential biomarker for monitoring the bone health of menopause women clinically.<\/jats:p>","DOI":"10.1039\/d4tb02764g","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T12:44:53Z","timestamp":1746103493000},"page":"6679-6688","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["PD-E2: a nano-scaled delivery for estradiol to decrease uterus damage and increase bone mineral density"],"prefix":"10.1039","volume":"13","author":[{"given":"Qiqi","family":"Feng","sequence":"first","affiliation":[{"name":"Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Gong","sequence":"additional","affiliation":[{"name":"Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2828-6878","authenticated-orcid":false,"given":"Haimei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaonan","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9416-8952","authenticated-orcid":false,"given":"Jianhui","family":"Wu","sequence":"additional","affiliation":[{"name":"Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2669-6715","authenticated-orcid":false,"given":"Shiqi","family":"Peng","sequence":"additional","affiliation":[{"name":"Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D4TB02764G\/cit1\/1","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.yhbeh.2014.08.011","volume":"66","author":"Luine","year":"2014","journal-title":"Horm. Behav."},{"key":"D4TB02764G\/cit2\/1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s13311-019-00766-9","volume":"16","author":"Russell","year":"2019","journal-title":"Neurotherapeutics"},{"key":"D4TB02764G\/cit3\/1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.toxlet.2014.11.012","volume":"232","author":"Turdi","year":"2015","journal-title":"Toxicol. Lett."},{"key":"D4TB02764G\/cit4\/1","first-page":"973","volume":"20","author":"Lohrasbi","year":"2022","journal-title":"Int. J. Reprod. Biomed."},{"key":"D4TB02764G\/cit5\/1","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1161\/HYPERTENSIONAHA.122.20836","volume":"80","author":"Dutta","year":"2023","journal-title":"Hypertension"},{"key":"D4TB02764G\/cit6\/1","doi-asserted-by":"crossref","first-page":"122066","DOI":"10.1016\/j.biomaterials.2023.122066","volume":"296","author":"Lei","year":"2023","journal-title":"Biomaterials"},{"key":"D4TB02764G\/cit7\/1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1080\/13697137.2024.2368486","volume":"27","author":"Palacios","year":"2024","journal-title":"Climacteric"},{"key":"D4TB02764G\/cit8\/1","doi-asserted-by":"crossref","first-page":"1310432","DOI":"10.3389\/fendo.2023.1310432","volume":"14","author":"Prokai-Tatrai","year":"2024","journal-title":"Front in Endocrinology"},{"key":"D4TB02764G\/cit9\/1","doi-asserted-by":"crossref","first-page":"1350318","DOI":"10.3389\/fendo.2024.1350318","volume":"15","author":"Andy","year":"2024","journal-title":"Front in Endocrinology"},{"key":"D4TB02764G\/cit10\/1","doi-asserted-by":"crossref","first-page":"114866","DOI":"10.1016\/j.bbr.2024.114866","volume":"462","author":"Esperan\u00e7a","year":"2024","journal-title":"Behav. Brain Res."},{"key":"D4TB02764G\/cit11\/1","doi-asserted-by":"crossref","first-page":"S763","DOI":"10.1016\/j.ibneur.2023.08.1565","volume":"15","author":"Ladouceur","year":"2023","journal-title":"IBRO Neuroscience Reports"},{"key":"D4TB02764G\/cit12\/1","doi-asserted-by":"crossref","first-page":"e230116","DOI":"10.1530\/JOE-23-0116","volume":"259","author":"Lu","year":"2023","journal-title":"J. Endocrinol."},{"key":"D4TB02764G\/cit13\/1","doi-asserted-by":"crossref","first-page":"e14117","DOI":"10.1111\/apha.14117","volume":"240","author":"Kleis-Olsen","year":"2024","journal-title":"Acta Physiol."},{"key":"D4TB02764G\/cit14\/1","first-page":"1097","volume":"10","author":"Yang","year":"2024","journal-title":"Menopause"},{"key":"D4TB02764G\/cit15\/1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.maturitas.2023.04.271","volume":"174","author":"Stute","year":"2023","journal-title":"Maturitas"},{"key":"D4TB02764G\/cit16\/1","doi-asserted-by":"crossref","first-page":"825","DOI":"10.2147\/IJWH.S379808","author":"Madsen","year":"2023","journal-title":"Int. J. Women\u2019s Health"},{"key":"D4TB02764G\/cit17\/1","doi-asserted-by":"crossref","first-page":"eFPS02","DOI":"10.61622\/rbgo\/2024FPS02","volume":"46","author":"Barros","year":"2024","journal-title":"Rev. Bras. Ginecol. Obstet."},{"key":"D4TB02764G\/cit18\/1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.mce.2015.10.004","volume":"419","author":"Garcia","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"D4TB02764G\/cit19\/1","first-page":"149","volume":"42","author":"Egarter","year":"2021","journal-title":"Horm. Mol. Biol. Clin. Invest."},{"key":"D4TB02764G\/cit20\/1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.maturitas.2020.05.002","volume":"139","author":"Tsiligiannis","year":"2020","journal-title":"Maturitas"},{"key":"D4TB02764G\/cit21\/1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.sajb.2021.03.040","volume":"140","author":"Ajaghaku","year":"2021","journal-title":"S. Afr. J. Bot."},{"key":"D4TB02764G\/cit22\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijbiomac.2015.02.044","volume":"77","author":"Unnithan","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"D4TB02764G\/cit23\/1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.colsurfb.2017.03.047","volume":"155","author":"Takeuchi","year":"2017","journal-title":"Colloids Surf., B"},{"key":"D4TB02764G\/cit24\/1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1039\/C4MD00331D","volume":"6","author":"Chen","year":"2015","journal-title":"MedChemComm"},{"key":"D4TB02764G\/cit25\/1","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1021\/jo01063a026","volume":"26","author":"Kovacs","year":"1961","journal-title":"J. Org. Chem."},{"key":"D4TB02764G\/cit26\/1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.thromres.2020.05.008","volume":"192","author":"Abou-Ismail","year":"2020","journal-title":"Thromb. Res."}],"container-title":["Journal of Materials Chemistry B"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/TB\/D4TB02764G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:56:27Z","timestamp":1782942987000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/tb\/article\/13\/23\/6679-6688\/876906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":26,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2025,6,11]]}},"URL":"https:\/\/doi.org\/10.1039\/d4tb02764g","relation":{},"ISSN":["2050-750X","2050-7518"],"issn-type":[{"value":"2050-750X","type":"print"},{"value":"2050-7518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}