{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:42:53Z","timestamp":1791686573507,"version":"4.3.4"},"reference-count":46,"publisher":"Royal Society of Chemistry (RSC)","issue":"14","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":49,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2020-114347RB-C31"],"award-info":[{"award-number":["PID2020-114347RB-C31"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2020-114347RB-C32"],"award-info":[{"award-number":["PID2020-114347RB-C32"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2022-136231NB-I00"],"award-info":[{"award-number":["PID2022-136231NB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2023- 151388OB-I00"],"award-info":[{"award-number":["PID2023- 151388OB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"publisher","award":["TED2021-132122B-C22"],"award-info":[{"award-number":["TED2021-132122B-C22"]}],"id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["J. Mater. Chem. B"],"abstract":"<jats:p>This study presents a novel BODIPY-carnitine probe with enhanced phototoxicity and dual organelle targeting, demonstrating significant efficacy in hypoxic tumor environments and offering a promising platform for advanced theranostic applications.<\/jats:p>","DOI":"10.1039\/d4tb02782e","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T02:01:17Z","timestamp":1739930477000},"page":"4330-4340","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A carnitine-based BODIPY photosensitizer"],"prefix":"10.1039","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0588-455X","authenticated-orcid":false,"given":"Larissa","family":"Maierhofer","sequence":"first","affiliation":[{"name":"Instituto de Qu\u00edmica Org\u00e1nica General (IQOG-CSIC), Juan de la Cierva 3, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6372-563X","authenticated-orcid":false,"given":"Ruth","family":"Prieto-Montero","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica F\u00edsica, Universidad del Pa\u00eds Vasco-EHU, Facultad de Ciencia y Tecnolog\u00eda, Apartado 644, 48080 Bilbao, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0484-5990","authenticated-orcid":false,"given":"Tamara","family":"Cubiella","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, Instituto Universitario de Oncolog\u00eda del Principado de Asturias, Universidad de Oviedo, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5353-5613","authenticated-orcid":false,"given":"Aitor","family":"D\u00edaz-Andr\u00e9s","sequence":"additional","affiliation":[{"name":"Donostia International Physics Center (DIPC), 20018 Donostia, Euskadi, Spain"},{"name":"Polimero eta Material Aurreratuak: Fisika, Kimika eta Teknologia Saila, Kimika Fakultatea, Euskal Herriko Unibertsitatea (UPV\/EHU), PK 1072, 20080 Donostia, Euskadi, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0503-3612","authenticated-orcid":false,"given":"Noelia","family":"Morales-Ben\u00edtez","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Org\u00e1nica General (IQOG-CSIC), Juan de la Cierva 3, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8893-7089","authenticated-orcid":false,"given":"David","family":"Casanova","sequence":"additional","affiliation":[{"name":"Donostia International Physics Center (DIPC), 20018 Donostia, Euskadi, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7551-3714","authenticated-orcid":false,"given":"Virginia","family":"Mart\u00ednez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica F\u00edsica, Universidad del Pa\u00eds Vasco-EHU, Facultad de Ciencia y Tecnolog\u00eda, Apartado 644, 48080 Bilbao, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1112-1583","authenticated-orcid":false,"given":"Mar\u00eda-Dolores","family":"Chiara","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, Instituto Universitario de Oncolog\u00eda del Principado de Asturias, Universidad de Oviedo, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2050-4295","authenticated-orcid":false,"given":"Enrique","family":"Mann","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Org\u00e1nica General (IQOG-CSIC), Juan de la Cierva 3, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8153-1852","authenticated-orcid":false,"given":"Jose Luis","family":"Chiara","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Org\u00e1nica General (IQOG-CSIC), Juan de la Cierva 3, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D4TB02782E\/cit1\/1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/tcr.201600121","volume":"17","author":"Chilakamarthi","year":"2017","journal-title":"Chem. Rec."},{"key":"D4TB02782E\/cit2\/1","doi-asserted-by":"crossref","first-page":"13454","DOI":"10.1021\/acs.chemrev.1c00381","volume":"121","author":"Pham","year":"2021","journal-title":"Chem. Rev."},{"key":"D4TB02782E\/cit3\/1","volume-title":"Die sensibilisierende Wirkung fluorescierender Substanzen: Gesammelte Untersuchungen \u00fcber die photodynamische Erscheinung: aus dem pharmakologischen Institute der K. Universit\u00e4t M\u00fcnchen","author":"Tappeiner","year":"1907","unstructured":"H. V.Tappeiner  and  A.Jodlbauer ,  Die sensibilisierende Wirkung fluorescierender Substanzen: Gesammelte Untersuchungen \u00fcber die photodynamische Erscheinung: aus dem pharmakologischen Institute der K. Universit\u00e4t M\u00fcnchen ,  Verlag von F.C.W. Vogel ,  Leipzig ,  1907"},{"key":"D4TB02782E\/cit4\/1","doi-asserted-by":"crossref","first-page":"9949","DOI":"10.1021\/acs.chemrev.4c00105","volume":"124","author":"Bregnh\u00f8j","year":"2024","journal-title":"Chem. Rev."},{"key":"D4TB02782E\/cit5\/1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s12094-008-0172-2","volume":"10","author":"Juarranz","year":"2008","journal-title":"Clin. Transl. Oncol."},{"key":"D4TB02782E\/cit6\/1","first-page":"25","volume":"5","author":"Dos Santos","year":"2019","journal-title":"J. Cancer Metastasis Treat."},{"key":"D4TB02782E\/cit7\/1","doi-asserted-by":"crossref","first-page":"6066","DOI":"10.1021\/acsomega.8b00692","volume":"3","author":"Mahalingam","year":"2018","journal-title":"ACS Omega"},{"key":"D4TB02782E\/cit8\/1","doi-asserted-by":"crossref","first-page":"10043","DOI":"10.1021\/acs.chemrev.7b00042","volume":"117","author":"Zielonka","year":"2017","journal-title":"Chem. Rev."},{"key":"D4TB02782E\/cit9\/1","doi-asserted-by":"crossref","first-page":"2007778","DOI":"10.1002\/adma.202007778","volume":"33","author":"Guo","year":"2021","journal-title":"Adv. Mater."},{"key":"D4TB02782E\/cit10\/1","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1039\/D3CS00456B","volume":"53","author":"Wang","year":"2024","journal-title":"Chem. Soc. Rev."},{"key":"D4TB02782E\/cit11\/1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1751-1097.1991.tb03669.x","volume":"53","author":"Moan","year":"1991","journal-title":"Photochem. Photobiol."},{"key":"D4TB02782E\/cit12\/1","doi-asserted-by":"crossref","first-page":"10657","DOI":"10.1038\/srep10657","volume":"5","author":"Kurokawa","year":"2015","journal-title":"Sci. Rep."},{"key":"D4TB02782E\/cit13\/1","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.freeradbiomed.2011.05.023","volume":"51","author":"Oliveira","year":"2011","journal-title":"Free Radical Biol. Med."},{"key":"D4TB02782E\/cit14\/1","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1039\/C9SC04852A","volume":"11","author":"Bl\u00e1zquez-Moraleja","year":"2020","journal-title":"Chem. Sci."},{"key":"D4TB02782E\/cit15\/1","doi-asserted-by":"crossref","first-page":"e202202366","DOI":"10.1002\/chem.202202366","volume":"28","author":"Crawford","year":"2022","journal-title":"Chem. \u2013 Eur. J."},{"key":"D4TB02782E\/cit16\/1","doi-asserted-by":"crossref","first-page":"124529","DOI":"10.1016\/j.talanta.2023.124529","volume":"259","author":"Huang","year":"2023","journal-title":"Talanta"},{"key":"D4TB02782E\/cit17\/1","doi-asserted-by":"crossref","first-page":"5842","DOI":"10.1039\/D3SC01036H","volume":"14","author":"Goshisht","year":"2023","journal-title":"Chem. Sci."},{"key":"D4TB02782E\/cit18\/1","doi-asserted-by":"crossref","first-page":"107545","DOI":"10.1016\/j.dyepig.2019.107545","volume":"170","author":"Bl\u00e1zquez-Moraleja","year":"2019","journal-title":"Dyes Pigm."},{"key":"D4TB02782E\/cit19\/1","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1002\/adfm.201505051","volume":"26","author":"Manzano","year":"2016","journal-title":"Adv. Funct. Mater."},{"key":"D4TB02782E\/cit20\/1","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.1002\/chem.201705698","volume":"24","author":"Bl\u00e1zquez-Moraleja","year":"2018","journal-title":"Chem. \u2013 Eur. J."},{"key":"D4TB02782E\/cit21\/1","doi-asserted-by":"crossref","first-page":"14733","DOI":"10.1021\/jacs.0c07136","volume":"142","author":"Stafford","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"D4TB02782E\/cit22\/1","doi-asserted-by":"crossref","first-page":"20403","DOI":"10.1039\/C9CP03454D","volume":"21","author":"Prieto-Montero","year":"2019","journal-title":"Phys. Chem. Chem. Phys."},{"key":"D4TB02782E\/cit23\/1","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.1021\/j100065a035","volume":"98","author":"Wilkinson","year":"1994","journal-title":"J. Phys. Chem."},{"key":"D4TB02782E\/cit24\/1","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1039\/D0SC05494A","volume":"12","author":"Wang","year":"2021","journal-title":"Chem. Sci."},{"key":"D4TB02782E\/cit25\/1","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1038\/s41467-022-29862-9","volume":"13","author":"An","year":"2022","journal-title":"Nat. Commun."},{"key":"D4TB02782E\/cit26\/1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jphotobiol.2007.02.003","volume":"87","author":"G\u00f6rner","year":"2007","journal-title":"J. Photochem. Photobiol., B"},{"key":"D4TB02782E\/cit27\/1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2147\/IJN.S494970","volume":"20","author":"Duan","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"D4TB02782E\/cit28\/1","doi-asserted-by":"crossref","first-page":"9110","DOI":"10.1021\/acsnano.2c12319","volume":"17","author":"Zhuang","year":"2023","journal-title":"ACS Nano"},{"key":"D4TB02782E\/cit29\/1","doi-asserted-by":"crossref","first-page":"691697","DOI":"10.3389\/fchem.2021.691697","volume":"9","author":"Gunaydin","year":"2021","journal-title":"Front. Chem."},{"key":"D4TB02782E\/cit30\/1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/php.13774","volume":"99","author":"Baptista","year":"2023","journal-title":"Photochem. Photobiol."},{"key":"D4TB02782E\/cit31\/1","doi-asserted-by":"crossref","first-page":"21302","DOI":"10.1063\/5.0084554","volume":"3","author":"Kim","year":"2022","journal-title":"Chem. Phys. Rev."},{"key":"D4TB02782E\/cit32\/1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nrc1071","volume":"3","author":"Dolmans","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"D4TB02782E\/cit33\/1","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1021\/cr5004198","volume":"115","author":"Lucky","year":"2015","journal-title":"Chem. Rev."},{"key":"D4TB02782E\/cit34\/1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1021\/ar50001a002","volume":"1","author":"El-Sayed","year":"1968","journal-title":"Acc. Chem. Res."},{"key":"D4TB02782E\/cit35\/1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1351\/pac200779030293","volume":"79","author":"Braslavsky","year":"2007","journal-title":"Pure Appl. Chem."},{"key":"D4TB02782E\/cit36\/1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/php.12692","volume":"93","author":"Kessel","year":"2017","journal-title":"Photochem. Photobiol."},{"key":"D4TB02782E\/cit37\/1","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1080\/15548627.2020.1783823","volume":"16","author":"Kessel","year":"2020","journal-title":"Autophagy"},{"key":"D4TB02782E\/cit38\/1","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/sj.cdd.4401048","volume":"9","author":"Reiners Jr","year":"2002","journal-title":"Cell Death Differ."},{"key":"D4TB02782E\/cit39\/1","first-page":"789","volume":"70","author":"MacDonald","year":"1999","journal-title":"Photochem. Photobiol."},{"key":"D4TB02782E\/cit40\/1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1021\/acsmedchemlett.9b00489","volume":"11","author":"Landry","year":"2020","journal-title":"ACS Med. Chem. Lett."},{"key":"D4TB02782E\/cit41\/1","doi-asserted-by":"crossref","first-page":"7082","DOI":"10.1016\/j.matpr.2022.01.220","volume":"62","author":"Mukherjee","year":"2022","journal-title":"Mater. Today Proc."},{"key":"D4TB02782E\/cit42\/1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0960-894X(01)81162-8","volume":"1","author":"Barltrop","year":"1991","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4TB02782E\/cit43\/1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1039\/a809656b","volume":"36","author":"Tominaga","year":"1999","journal-title":"Anal. Commun."},{"key":"D4TB02782E\/cit44\/1","doi-asserted-by":"crossref","first-page":"5770","DOI":"10.1016\/j.bmc.2013.07.017","volume":"21","author":"Gibbs","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"D4TB02782E\/cit45\/1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/cmdc.202000529","volume":"16","author":"Piskorz","year":"2021","journal-title":"ChemMedChem"},{"key":"D4TB02782E\/cit46\/1","doi-asserted-by":"crossref","first-page":"10409","DOI":"10.1039\/D4TB01609B","volume":"12","author":"Walter","year":"2024","journal-title":"J. Mater. Chem. B"}],"container-title":["Journal of Materials Chemistry B"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/TB\/D4TB02782E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:29:42Z","timestamp":1783013382000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/tb\/article\/13\/14\/4330-4340\/876913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":46,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2025,4,2]]}},"URL":"https:\/\/doi.org\/10.1039\/d4tb02782e","relation":{"has-preprint":[{"id-type":"doi","id":"10.26434\/chemrxiv-2024-38npb","asserted-by":"object"}]},"ISSN":["2050-750X","2050-7518"],"issn-type":[{"value":"2050-750X","type":"print"},{"value":"2050-7518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}