{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:52:16Z","timestamp":1792896736118,"version":"4.5.0"},"reference-count":59,"publisher":"Royal Society of Chemistry (RSC)","issue":"24","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":138,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004740","name":"Fondazione del Monte di Bologna e Ravenna","doi-asserted-by":"publisher","award":["AEP_C_2023_Prot. No. 1277bis\/2023"],"award-info":[{"award-number":["AEP_C_2023_Prot. No. 1277bis\/2023"]}],"id":[{"id":"10.13039\/501100004740","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["PRIN PNRR 2022 - 20224KF8HE"],"award-info":[{"award-number":["PRIN PNRR 2022 - 20224KF8HE"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["PNRR MUR - ECS_00000033_ECOSISTER"],"award-info":[{"award-number":["PNRR MUR - ECS_00000033_ECOSISTER"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["J. Mater. Chem. B"],"abstract":"<jats:p>A 3D-bioprinted scaffold containing fibroblasts and DRG neurons was developed to investigate PNS regeneration. This model supports neurite outgrowth and provides a platform for personalized therapies targeting neuropathic pain and sensory dysfunction.<\/jats:p>","DOI":"10.1039\/d4tb02823f","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T07:41:07Z","timestamp":1747640467000},"page":"7034-7047","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A 3D-bioprinted dermal-like scaffold incorporating fibroblasts and DRG neurons to investigate peripheral nerve regeneration"],"prefix":"10.1039","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7504-6607","authenticated-orcid":false,"given":"Francesco","family":"Formaggio","sequence":"first","affiliation":[{"name":"Department of Pharmacy and Biotechnology, University of Bologna, Via San Donato 19\/2, 40127 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9140-3128","authenticated-orcid":false,"given":"Emanuela","family":"Saracino","sequence":"additional","affiliation":[{"name":"Institute for the Organic Synthesis and Photoreactivity, National Research Council of Italy, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2143-2860","authenticated-orcid":false,"given":"Marianna","family":"Barbalinardo","sequence":"additional","affiliation":[{"name":"Institute for the Study of Nanostructured Materials, National Research Council of Italy, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7344-2529","authenticated-orcid":false,"given":"Eva","family":"Clemente","sequence":"additional","affiliation":[{"name":"Institute for the Study of Nanostructured Materials, National Research Council of Italy, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Corticelli","sequence":"additional","affiliation":[{"name":"Institute for Microelectronics and Microsystems, National Research Council, Via P. Gobetti 101, 40129 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2517-1693","authenticated-orcid":false,"given":"Sara","family":"Buoso","sequence":"additional","affiliation":[{"name":"Kerline srl, Via Piero Gobetti 101, 40129 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6341-4185","authenticated-orcid":false,"given":"Simone","family":"Bonetti","sequence":"additional","affiliation":[{"name":"Institute for the Study of Nanostructured Materials, National Research Council of Italy, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D4TB02823F\/cit1\/1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.brainresbull.2019.07.020","volume":"152","author":"Accardo","year":"2019","journal-title":"Brain Res. Bull."},{"key":"D4TB02823F\/cit2\/1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.pneurobio.2018.05.002","volume":"168","author":"Nascimento","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"D4TB02823F\/cit3\/1","doi-asserted-by":"crossref","first-page":"100151","DOI":"10.1016\/j.ynpai.2024.100151","volume":"15","author":"Jang","year":"2024","journal-title":"Neurobiol. Pain"},{"key":"D4TB02823F\/cit4\/1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1152\/physrev.00045.2019","volume":"101","author":"Finnerup","year":"2020","journal-title":"Physiol. Rev."},{"key":"D4TB02823F\/cit5\/1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neuroscience.2014.09.027","volume":"302","author":"DeFrancesco-Lisowitz","year":"2015","journal-title":"Neuroscience"},{"key":"D4TB02823F\/cit6\/1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41586-022-04777-z","volume":"606","author":"Gangadharan","year":"2022","journal-title":"Nature"},{"key":"D4TB02823F\/cit7\/1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neures.2004.07.005","volume":"50","author":"Senba","year":"2004","journal-title":"Neurosci. Res."},{"key":"D4TB02823F\/cit8\/1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuron.2006.09.021","volume":"52","author":"Campbell","year":"2006","journal-title":"Neuron"},{"key":"D4TB02823F\/cit9\/1","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1152\/physiol.00036.2016","author":"Duval","year":"2017","journal-title":"Physiology"},{"key":"D4TB02823F\/cit10\/1","doi-asserted-by":"crossref","first-page":"114223","DOI":"10.1016\/j.expneurol.2022.114223","volume":"358","author":"Labau","year":"2022","journal-title":"Exp. Neurol."},{"key":"D4TB02823F\/cit11\/1","first-page":"87","volume":"12","author":"Roumazeilles","year":"2018","journal-title":"Cell Adhes. Migr."},{"issue":"22","key":"D4TB02823F\/cit12\/1","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.4103\/1673-5374.145366","volume":"9","author":"de Luca","year":"2014","journal-title":"Neural Regener. Res."},{"key":"D4TB02823F\/cit13\/1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev-chembioeng-061010-114257","volume":"2","author":"Berthiaume","year":"2011","journal-title":"Annu. Rev. Chem. Biomol. Eng."},{"key":"D4TB02823F\/cit14\/1","doi-asserted-by":"crossref","first-page":"14621","DOI":"10.3390\/ijms232314621","volume":"23","author":"Kantaros","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"D4TB02823F\/cit15\/1","doi-asserted-by":"crossref","first-page":"e00148","DOI":"10.1016\/j.bprint.2021.e00148","volume":"23","author":"Yilmaz","year":"2021","journal-title":"Bioprinting"},{"key":"D4TB02823F\/cit16\/1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s43586-021-00073-8","volume":"1","author":"Zhang","year":"2021","journal-title":"Nat. Rev. Methods Primers"},{"key":"D4TB02823F\/cit17\/1","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.molmed.2021.05.001","volume":"27","author":"Freeman","year":"2021","journal-title":"Trends Mol. Med."},{"key":"D4TB02823F\/cit18\/1","doi-asserted-by":"crossref","first-page":"025002","DOI":"10.1088\/1758-5090\/ab6413","volume":"12","author":"Cheng","year":"2020","journal-title":"Biofabrication"},{"key":"D4TB02823F\/cit19\/1","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/s41551-020-0568-z","volume":"4","author":"Urciuolo","year":"2020","journal-title":"Nat. Biomed. Eng."},{"key":"D4TB02823F\/cit20\/1","doi-asserted-by":"crossref","first-page":"eaba7406","DOI":"10.1126\/sciadv.aba7406","volume":"6","author":"Chen","year":"2024","journal-title":"Sci. Adv."},{"key":"D4TB02823F\/cit21\/1","doi-asserted-by":"crossref","first-page":"21718","DOI":"10.1016\/S0021-9258(18)54695-0","volume":"266","author":"Di Marco","year":"1991","journal-title":"J. Biol. Chem."},{"key":"D4TB02823F\/cit22\/1","doi-asserted-by":"crossref","first-page":"035020","DOI":"10.1088\/1758-5090\/8\/3\/035020","volume":"8","author":"Ouyang","year":"2016","journal-title":"Biofabrication"},{"key":"D4TB02823F\/cit23\/1","volume-title":"github-Bioprinting","author":"Bonetti","unstructured":"S.Bonetti ,  github-Bioprinting ,  https:\/\/github.com\/simobone19 , (accessed 17 December 2024)"},{"issue":"6","key":"D4TB02823F\/cit24\/1","doi-asserted-by":"crossref","first-page":"e67439","DOI":"10.1371\/journal.pone.0067439","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"D4TB02823F\/cit25\/1","doi-asserted-by":"crossref","first-page":"045022","DOI":"10.1088\/1758-5090\/ad69c4","volume":"16","author":"Clair-Glover","year":"2024","journal-title":"Biofabrication"},{"key":"D4TB02823F\/cit26\/1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.stem.2023.12.009","volume":"31","author":"Yan","year":"2024","journal-title":"Cell Stem Cell"},{"key":"D4TB02823F\/cit27\/1","doi-asserted-by":"crossref","first-page":"e00147","DOI":"10.1016\/j.bprint.2021.e00147","volume":"23","author":"Harley","year":"2021","journal-title":"Bioprinting"},{"key":"D4TB02823F\/cit28\/1","doi-asserted-by":"crossref","first-page":"1601101","DOI":"10.1002\/adhm.201601101","volume":"6","author":"Pourchet","year":"2017","journal-title":"Adv. Healthcare Mater."},{"key":"D4TB02823F\/cit29\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bprint.2016.12.001","volume":"5","author":"England","year":"2017","journal-title":"Bioprinting"},{"key":"D4TB02823F\/cit30\/1","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.3390\/ma11081402","volume":"11","author":"Sodupe-Ortega","year":"2018","journal-title":"Materials"},{"key":"D4TB02823F\/cit31\/1","doi-asserted-by":"crossref","first-page":"e00119","DOI":"10.1016\/j.bprint.2020.e00119","volume":"21","author":"Lemari\u00e9","year":"2021","journal-title":"Bioprinting"},{"key":"D4TB02823F\/cit32\/1","doi-asserted-by":"crossref","first-page":"035001","DOI":"10.1088\/1758-5082\/6\/3\/035001","volume":"6","author":"Zhao","year":"2014","journal-title":"Biofabrication"},{"key":"D4TB02823F\/cit33\/1","doi-asserted-by":"crossref","first-page":"e37831","DOI":"10.1002\/jbm.a.37831","volume":"113","author":"Andrade","year":"2025","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"D4TB02823F\/cit34\/1","doi-asserted-by":"crossref","first-page":"114223","DOI":"10.1016\/j.expneurol.2022.114223","volume":"358","author":"Labau","year":"2022","journal-title":"Exp. Neurol."},{"key":"D4TB02823F\/cit35\/1","doi-asserted-by":"crossref","first-page":"6941","DOI":"10.1016\/j.biomaterials.2010.05.056","volume":"31","author":"Aubin","year":"2010","journal-title":"Biomaterials"},{"key":"D4TB02823F\/cit36\/1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1021\/nn203711s","volume":"6","author":"Shin","year":"2012","journal-title":"ACS Nano"},{"key":"D4TB02823F\/cit37\/1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1089\/ten.tea.2010.0273","volume":"17","author":"Hakkinen","year":"2011","journal-title":"Tissue Eng., Part A"},{"key":"D4TB02823F\/cit38\/1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41578-019-0169-1","volume":"5","author":"Guimar\u00e3es","year":"2020","journal-title":"Nat. Rev. Mater."},{"key":"D4TB02823F\/cit39\/1","doi-asserted-by":"crossref","first-page":"111503","DOI":"10.1016\/j.colsurfb.2020.111503","volume":"199","author":"Zhang","year":"2021","journal-title":"Colloids Surf., B"},{"key":"D4TB02823F\/cit40\/1","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3390\/mi12080865","volume":"12","author":"Roversi","year":"2021","journal-title":"Micromachines"},{"key":"D4TB02823F\/cit41\/1","doi-asserted-by":"crossref","first-page":"e00134","DOI":"10.1016\/j.bprint.2021.e00134","volume":"22","author":"Oliveira","year":"2021","journal-title":"Bioprinting"},{"key":"D4TB02823F\/cit42\/1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1023\/A:1010883320683","volume":"29","author":"Jerreg\u00e5rd","year":"2000","journal-title":"J. Neurocytol."},{"key":"D4TB02823F\/cit43\/1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1083\/jcb.107.1.341","volume":"107","author":"Seilheimer","year":"1988","journal-title":"J. Cell Biol."},{"key":"D4TB02823F\/cit44\/1","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1038\/sj.jid.5700270","volume":"126","author":"Botchkarev","year":"2006","journal-title":"J. Invest. Dermatol."},{"key":"D4TB02823F\/cit45\/1","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1111\/j.1365-2133.2007.08410.x","author":"Tominaga","year":"2008","journal-title":"Br. J. Dermatol."},{"key":"D4TB02823F\/cit46\/1","doi-asserted-by":"crossref","first-page":"9675","DOI":"10.1523\/JNEUROSCI.23-29-09675.2003","volume":"23","author":"Tanabe","year":"2003","journal-title":"J. Neurosci."},{"key":"D4TB02823F\/cit47\/1","doi-asserted-by":"crossref","first-page":"6659","DOI":"10.1523\/JNEUROSCI.22-15-06659.2002","author":"Dontchev","year":"2002","journal-title":"J. Neurosci."},{"key":"D4TB02823F\/cit48\/1","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1113\/EP090751","volume":"108","author":"Hara","year":"2023","journal-title":"Exp. Physiol."},{"key":"D4TB02823F\/cit49\/1","doi-asserted-by":"crossref","first-page":"e0171448","DOI":"10.1371\/journal.pone.0171448","volume":"12","author":"Yurie","year":"2017","journal-title":"PLoS One"},{"key":"D4TB02823F\/cit50\/1","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.1039\/C9TB00669A","volume":"7","author":"Ning","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"D4TB02823F\/cit51\/1","doi-asserted-by":"crossref","first-page":"064001","DOI":"10.1088\/1741-2552\/aae129","volume":"15","author":"Khoshakhlagh","year":"2018","journal-title":"J. Neural. Eng."},{"key":"D4TB02823F\/cit52\/1","first-page":"2402504","author":"Honkam\u00e4ki","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"D4TB02823F\/cit53\/1","doi-asserted-by":"crossref","first-page":"21547","DOI":"10.1038\/s41598-021-00931-1","volume":"11","author":"Engberg","year":"2021","journal-title":"Sci. Rep."},{"key":"D4TB02823F\/cit54\/1","unstructured":"imagej_fiji,  https:\/\/imagej.net\/software\/fiji\/ , (accessed 17 December 2024)"},{"key":"D4TB02823F\/cit55\/1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/bip.22806","volume":"105","author":"Pistone","year":"2016","journal-title":"Biopolymers"},{"key":"D4TB02823F\/cit56\/1","doi-asserted-by":"crossref","first-page":"17448069221087032","DOI":"10.1177\/17448069221087033","volume":"18","author":"Formaggio","year":"2022","journal-title":"Mol. Pain"},{"key":"D4TB02823F\/cit57\/1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/cyto.a.20660","volume":"75A","author":"Popko","year":"2009","journal-title":"Cytometry, Part A"},{"key":"D4TB02823F\/cit58\/1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/1471-2105-12-230","volume":"12","author":"Ho","year":"2011","journal-title":"BMC Bioinf."},{"key":"D4TB02823F\/cit59\/1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/cyto.a.20462","volume":"71A","author":"Vallotton","year":"2007","journal-title":"Cytometry, Part A"}],"container-title":["Journal of Materials Chemistry B"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/TB\/D4TB02823F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:13:04Z","timestamp":1782886384000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/tb\/article\/13\/24\/7034-7047\/876929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":59,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2025,6,18]]}},"URL":"https:\/\/doi.org\/10.1039\/d4tb02823f","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D4TB02823F\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4TB02823F\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4TB02823F\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4TB02823F\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4TB02823F\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D4TB02823F\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2050-750X","2050-7518"],"issn-type":[{"value":"2050-750X","type":"print"},{"value":"2050-7518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}