{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:25:03Z","timestamp":1782930303939,"version":"3.54.5"},"reference-count":35,"publisher":"Royal Society of Chemistry (RSC)","issue":"16","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"am","delay-in-days":547,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Analyst"],"abstract":"<jats:p>Raman spectroscopy, coupled with machine learning, can be used to effectively assess liver health. Our models achieved up to 91.6% accuracy in classifying spectral data, showing high potential for NAFLD diagnosis and monitoring.<\/jats:p>","DOI":"10.1039\/d5an00533g","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T11:41:20Z","timestamp":1751456480000},"page":"3740-3749","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["NAFLD progression in metabolic syndrome: a Raman spectroscopy and machine learning approach in an animal model"],"prefix":"10.1039","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5158-0434","authenticated-orcid":false,"given":"Ad\u00e1n","family":"Ram\u00edrez","sequence":"first","affiliation":[{"name":"Facultad de Ciencias, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8299-3201","authenticated-orcid":false,"given":"Guadalupe","family":"Donju\u00e1n-Loredo","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4917-1727","authenticated-orcid":false,"given":"Ricardo","family":"Espinosa-Tanguma","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5230-962X","authenticated-orcid":false,"given":"Roberto C.","family":"Salgado-Delgado","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0632-2265","authenticated-orcid":false,"given":"M. C.","family":"Rodr\u00edguez-Aranda","sequence":"additional","affiliation":[{"name":"Coordinaci\u00f3n para la Innovaci\u00f3n y Aplicaci\u00f3n de la Ciencia y la Tecnolog\u00eda, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2313-2810","authenticated-orcid":false,"given":"Edgar","family":"Guevara","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed, Mexico"},{"name":"Coordinaci\u00f3n para la Innovaci\u00f3n y Aplicaci\u00f3n de la Ciencia y la Tecnolog\u00eda, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5233-9581","authenticated-orcid":false,"given":"Miguel G.","family":"Ram\u00edrez-El\u00edas","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5AN00533G\/cit1\/1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41392-024-02072-z","volume":"10","author":"Gan","year":"2025","journal-title":"Signal Transduction Targeted Ther."},{"key":"D5AN00533G\/cit2\/1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1053\/j.sult.2016.08.003","volume":"37","author":"Idilman","year":"2016","journal-title":"Semin. Ultrasound CT MR."},{"key":"D5AN00533G\/cit3\/1","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"D5AN00533G\/cit4\/1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3390\/antiox10020270","volume":"10","author":"Rinaldi","year":"2021","journal-title":"Antioxidant."},{"key":"D5AN00533G\/cit5\/1","doi-asserted-by":"crossref","first-page":"e0214","DOI":"10.1097\/MD.0000000000010214","volume":"97","author":"Golabi","year":"2018","journal-title":"Medicine"},{"key":"D5AN00533G\/cit6\/1","doi-asserted-by":"crossref","first-page":"5888","DOI":"10.3390\/ijms21165888","volume":"21","author":"Lonardo","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"D5AN00533G\/cit7\/1","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.mayocp.2015.06.013","volume":"90","author":"Spengler","year":"2015","journal-title":"Mayo Clin. Proc."},{"key":"D5AN00533G\/cit8\/1","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1111\/liv.14118","volume":"39","author":"Besutti","year":"2019","journal-title":"Liver Int."},{"key":"D5AN00533G\/cit9\/1","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1364\/BOE.6.002724","volume":"6","author":"Pence","year":"2015","journal-title":"Biomed. Opt. Express"},{"key":"D5AN00533G\/cit10\/1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/jrs.2163","volume":"40","author":"Shen","year":"2009","journal-title":"J. Raman Spectrosc."},{"key":"D5AN00533G\/cit11\/1","doi-asserted-by":"crossref","first-page":"117483","DOI":"10.1016\/j.saa.2019.117483","volume":"225","author":"Li","year":"2020","journal-title":"Spectrochim. Acta, Part A"},{"key":"D5AN00533G\/cit12\/1","doi-asserted-by":"crossref","first-page":"4723","DOI":"10.1039\/C8AN00289D","volume":"143","author":"Pacia","year":"2018","journal-title":"Analyst"},{"key":"D5AN00533G\/cit13\/1","doi-asserted-by":"crossref","first-page":"6666","DOI":"10.1021\/ac501395g","volume":"86","author":"Majzner","year":"2014","journal-title":"Anal. Chem."},{"key":"D5AN00533G\/cit14\/1","first-page":"e68","volume":"2","author":"Cao","year":"2023","journal-title":"MedComm: Future Med."},{"key":"D5AN00533G\/cit15\/1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41467-022-35696-2","volume":"14","author":"Huang","year":"2023","journal-title":"Nat. Commun."},{"key":"D5AN00533G\/cit16\/1","doi-asserted-by":"crossref","first-page":"7472","DOI":"10.3390\/molecules28227472","volume":"28","author":"Donju\u00e1n-Loredo","year":"2023","journal-title":"Molecules"},{"key":"D5AN00533G\/cit17\/1","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1038\/s41596-020-0322-8","volume":"15","author":"Morais","year":"2020","journal-title":"Nat. Protoc."},{"key":"D5AN00533G\/cit18\/1","doi-asserted-by":"crossref","first-page":"025002","DOI":"10.1117\/1.JBO.28.2.025002","volume":"28","author":"Sheehy","year":"2023","journal-title":"J. Biomed. Opt."},{"key":"D5AN00533G\/cit19\/1","doi-asserted-by":"crossref","first-page":"5999","DOI":"10.1039\/C8AN01307A","volume":"143","author":"Czamara","year":"2018","journal-title":"Analyst"},{"key":"D5AN00533G\/cit20\/1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s11745-011-3567-8","volume":"46","author":"Giarola","year":"2011","journal-title":"Lipids"},{"key":"D5AN00533G\/cit21\/1","doi-asserted-by":"crossref","first-page":"37068","DOI":"10.1038\/srep37068","volume":"6","author":"Meksiarun","year":"2016","journal-title":"Sci. Rep."},{"key":"D5AN00533G\/cit22\/1","doi-asserted-by":"crossref","first-page":"e202200055","DOI":"10.1002\/jbio.202200055","volume":"15","author":"Guevara","year":"2022","journal-title":"J. Biophotonics"},{"key":"D5AN00533G\/cit23\/1","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1364\/BOE.9.004998","volume":"9","author":"Guevara","year":"2018","journal-title":"Biomed. Opt. Express"},{"key":"D5AN00533G\/cit24\/1","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.1039\/C7AY01363A","volume":"9","author":"Guo","year":"2017","journal-title":"Anal. Methods"},{"key":"D5AN00533G\/cit25\/1","doi-asserted-by":"crossref","first-page":"e91436","DOI":"10.1371\/journal.pone.0091436","volume":"9","author":"Yaligar","year":"2014","journal-title":"PLoS One"},{"key":"D5AN00533G\/cit26\/1","doi-asserted-by":"crossref","first-page":"165526","DOI":"10.1016\/j.bbadis.2019.08.002","volume":"1865","author":"Szafraniec","year":"2019","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"D5AN00533G\/cit27\/1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1080\/05704928.2014.923902","volume":"50","author":"Talari","year":"2015","journal-title":"Appl. Spectrosc. Rev."},{"key":"D5AN00533G\/cit28\/1","doi-asserted-by":"crossref","first-page":"e0256045","DOI":"10.1371\/journal.pone.0256045","volume":"16","author":"Staritzbichler","year":"2021","journal-title":"PLoS One"},{"key":"D5AN00533G\/cit29\/1","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1039\/C4AN01878H","volume":"140","author":"Kochan","year":"2015","journal-title":"Analyst"},{"key":"D5AN00533G\/cit30\/1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3390\/nu10010029","volume":"10","author":"Saeed","year":"2018","journal-title":"Nutrients"},{"key":"D5AN00533G\/cit31\/1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3390\/antiox8070229","volume":"8","author":"Elvira-Torales","year":"2019","journal-title":"Antioxidants"},{"key":"D5AN00533G\/cit32\/1","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1002\/1873-3468.14600","volume":"597","author":"Helal","year":"2023","journal-title":"FEBS Lett."},{"key":"D5AN00533G\/cit33\/1","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.3390\/app9142807","volume":"9","author":"Qiu","year":"2019","journal-title":"Appl. Sci."},{"key":"D5AN00533G\/cit34\/1","doi-asserted-by":"crossref","first-page":"18548","DOI":"10.1038\/s41598-020-75604-6","volume":"10","author":"Minamikawa","year":"2020","journal-title":"Sci. Rep."},{"key":"D5AN00533G\/cit35\/1","doi-asserted-by":"crossref","first-page":"e201800290","DOI":"10.1002\/jbio.201800290","volume":"12","author":"Szafraniec","year":"2019","journal-title":"J. Biophotonics"}],"container-title":["The Analyst"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/AN\/D5AN00533G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:39:07Z","timestamp":1782927547000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/an\/article\/150\/16\/3740-3749\/879961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":35,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2025,8,4]]}},"URL":"https:\/\/doi.org\/10.1039\/d5an00533g","relation":{},"ISSN":["0003-2654","1364-5528"],"issn-type":[{"value":"0003-2654","type":"print"},{"value":"1364-5528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}