{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:24:38Z","timestamp":1783020278835,"version":"3.54.6"},"reference-count":38,"publisher":"Royal Society of Chemistry (RSC)","issue":"4","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["5T32EB007509"],"award-info":[{"award-number":["5T32EB007509"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["P41 EB021911"],"award-info":[{"award-number":["P41 EB021911"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008565","name":"Case School of Engineering, Case Western Reserve University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008565","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["5T32GM007250"],"award-info":[{"award-number":["5T32GM007250"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["5TL1TR002549"],"award-info":[{"award-number":["5TL1TR002549"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS121374"],"award-info":[{"award-number":["R01 NS121374"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01 DE032670"],"award-info":[{"award-number":["R01 DE032670"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R56 DE030206"],"award-info":[{"award-number":["R56 DE030206"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Analyst"],"abstract":"<jats:p>A novel semi-quantitative imaging mass spectrometry approach using ToF-SIMS enables high-resolution, sensitive mapping of fibronectin gradients in microfluidic haptotaxis assays beyond the limits of fluorescence microscopy.<\/jats:p>","DOI":"10.1039\/d5an00962f","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T14:32:57Z","timestamp":1768833177000},"page":"1118-1129","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of ToF-SIMS imaging for semi-quantitative mapping of BODIPY-labeled fibronectin surface gradients"],"prefix":"10.1039","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3227-6813","authenticated-orcid":false,"given":"Chao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0748-7929","authenticated-orcid":false,"given":"Tae Kyong John","family":"Kim","sequence":"additional","affiliation":[{"name":"Swagelok Center for Surface Analysis of Materials, Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5018-4106","authenticated-orcid":false,"given":"Douglas H.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA"},{"name":"Medical Scientist Training Program, Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3492-6552","authenticated-orcid":false,"given":"Radhika","family":"Atit","sequence":"additional","affiliation":[{"name":"Department of Biology, Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8050-357X","authenticated-orcid":false,"given":"Rodrigo A.","family":"Somoza","sequence":"additional","affiliation":[{"name":"Department of Biology, Skeletal Research Center, Case Western Reserve University, Cleveland, OH, USA"},{"name":"Center for Modular Manufacturing of Structural Tissues, Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9206-6845","authenticated-orcid":false,"given":"Samuel E.","family":"Senyo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5AN00962F\/cit1\/1","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1092053","volume":"302","author":"Ridley","year":"2003","journal-title":"Science"},{"key":"D5AN00962F\/cit2\/1","first-page":"dev175596","volume":"147","author":"Walma","year":"2020","journal-title":"Dev. Camb. Engl."},{"key":"D5AN00962F\/cit3\/1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fbioe.2015.00040","volume":"3","author":"Ricoult","year":"2015","journal-title":"Front. Bioeng. Biotechnol."},{"key":"D5AN00962F\/cit4\/1","doi-asserted-by":"crossref","first-page":"2401717","DOI":"10.1002\/smll.202401717","volume":"20","author":"Liu","year":"2024","journal-title":"Small"},{"key":"D5AN00962F\/cit5\/1","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/s12195-015-0398-3","volume":"8","author":"Wen","year":"2015","journal-title":"Cell. Mol. Bioeng."},{"key":"D5AN00962F\/cit6\/1","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.cell.2011.12.034","volume":"148","author":"Wu","year":"2012","journal-title":"Cell"},{"key":"D5AN00962F\/cit7\/1","doi-asserted-by":"crossref","first-page":"36440","DOI":"10.1038\/srep36440","volume":"6","author":"Schwarz","year":"2016","journal-title":"Sci. Rep."},{"key":"D5AN00962F\/cit8\/1","first-page":"1884","volume":"143","author":"Demers","year":"2016","journal-title":"Dev. Camb. Engl."},{"key":"D5AN00962F\/cit9\/1","doi-asserted-by":"crossref","first-page":"1237408","DOI":"10.3389\/fchem.2023.1237408","volume":"11","author":"Jia","year":"2023","journal-title":"Front. Chem."},{"key":"D5AN00962F\/cit10\/1","doi-asserted-by":"crossref","first-page":"S0014","DOI":"10.5702\/massspectrometry.S0014","volume":"2","author":"Graham","year":"2013","journal-title":"Mass Spectrom."},{"key":"D5AN00962F\/cit11\/1","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1038\/s41598-020-60428-1","volume":"10","author":"Yu","year":"2020","journal-title":"Sci. Rep."},{"key":"D5AN00962F\/cit12\/1","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.1021\/la001209t","volume":"17","author":"Wagner","year":"2001","journal-title":"Langmuir"},{"key":"D5AN00962F\/cit13\/1","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1016\/j.apsusc.2005.04.060","volume":"253","author":"Hale","year":"2007","journal-title":"Appl. Surf. Sci."},{"key":"D5AN00962F\/cit14\/1","doi-asserted-by":"crossref","first-page":"7258","DOI":"10.1016\/j.apsusc.2006.02.267","volume":"252","author":"Poleunis","year":"2006","journal-title":"Appl. Surf. Sci."},{"key":"D5AN00962F\/cit15\/1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1163\/156856202320253938","volume":"13","author":"Wagner","year":"2002","journal-title":"J. Biomater. Sci., Polym. Ed."},{"key":"D5AN00962F\/cit16\/1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1021\/ac701720y","volume":"80","author":"Al-Bataineh","year":"2008","journal-title":"Anal. Chem."},{"key":"D5AN00962F\/cit17\/1","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1039\/C9JA00117D","volume":"34","author":"Kabatas","year":"2019","journal-title":"J. Anal. At. Spectrom."},{"key":"D5AN00962F\/cit18\/1","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/sia.3679","volume":"43","author":"Tyler","year":"2011","journal-title":"SIA, Surf. Interface Anal."},{"key":"D5AN00962F\/cit19\/1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/jbiol42","volume":"5","author":"Lechene","year":"2006","journal-title":"J. Biol."},{"issue":"23","key":"D5AN00962F\/cit20\/1","doi-asserted-by":"crossref","first-page":"5409","DOI":"10.1039\/D2AN01344D","volume":"147","author":"Watson","year":"2022","journal-title":"Analyst"},{"key":"D5AN00962F\/cit21\/1","doi-asserted-by":"crossref","first-page":"D609","DOI":"10.1093\/nar\/gkae1010","volume":"53","author":"The UniProt Consortium","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"D5AN00962F\/cit22\/1","doi-asserted-by":"crossref","first-page":"e2201157","DOI":"10.1002\/smtd.202201157","volume":"7","author":"Zimmermann","year":"2023","journal-title":"Small Methods"},{"key":"D5AN00962F\/cit23\/1","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/1097-4636(20011205)57:3<432::AID-JBM1186>3.0.CO;2-G","volume":"57","author":"Lhoest","year":"2001","journal-title":"J. Biomed. Mater. Res."},{"key":"D5AN00962F\/cit24\/1","doi-asserted-by":"crossref","first-page":"dev202371","DOI":"10.1242\/dev.202371","volume":"151","author":"Feng","year":"2024","journal-title":"Development"},{"key":"D5AN00962F\/cit25\/1","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.3390\/cells10092443","volume":"10","author":"Dalton","year":"2021","journal-title":"Cells"},{"key":"D5AN00962F\/cit26\/1","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1089\/biores.2014.0033","volume":"3","author":"Vanterpool","year":"2014","journal-title":"BioRes. Open Access"},{"key":"D5AN00962F\/cit27\/1","doi-asserted-by":"crossref","first-page":"C75","DOI":"10.1152\/ajpcell.00417.2019","volume":"319","author":"Roveimiab","year":"2020","journal-title":"Am. J. Physiol.: Cell Physiol."},{"key":"D5AN00962F\/cit28\/1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1021\/ac000771l","volume":"73","author":"Belu","year":"2001","journal-title":"Anal. Chem."},{"key":"D5AN00962F\/cit29\/1","doi-asserted-by":"crossref","first-page":"7558","DOI":"10.1039\/D2CC02290G","volume":"58","author":"Glowacki","year":"2022","journal-title":"Chem. Commun."},{"key":"D5AN00962F\/cit30\/1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.apsusc.2003.12.008","volume":"227","author":"Oran","year":"2004","journal-title":"Appl. Surf. Sci."},{"key":"D5AN00962F\/cit31\/1","doi-asserted-by":"crossref","first-page":"119335","DOI":"10.1016\/j.biomaterials.2019.119335","volume":"218","author":"Motta","year":"2019","journal-title":"Biomaterials"},{"key":"D5AN00962F\/cit32\/1","doi-asserted-by":"crossref","first-page":"11168","DOI":"10.1021\/la701435x","volume":"23","author":"Liu","year":"2007","journal-title":"Langmuir"},{"key":"D5AN00962F\/cit33\/1","doi-asserted-by":"crossref","first-page":"655","DOI":"10.3390\/ma9080655","volume":"9","author":"Chan","year":"2016","journal-title":"Materials"},{"key":"D5AN00962F\/cit34\/1","doi-asserted-by":"crossref","first-page":"8279","DOI":"10.1021\/la0489763","volume":"20","author":"Smith","year":"2004","journal-title":"Langmuir"},{"key":"D5AN00962F\/cit35\/1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-2121-10-16","volume":"10","author":"Peterson","year":"2009","journal-title":"BMC Cell Biol."},{"key":"D5AN00962F\/cit36\/1","doi-asserted-by":"crossref","first-page":"4798","DOI":"10.1021\/acsbiomaterials.1c00889","volume":"7","author":"Ender","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"key":"D5AN00962F\/cit37\/1","first-page":"88","volume":"8","author":"Wu","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"D5AN00962F\/cit38\/1","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1091\/mbc.e14-05-1026","volume":"26","author":"Gudzenko","year":"2015","journal-title":"Mol. Biol. Cell"}],"container-title":["The Analyst"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/AN\/D5AN00962F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:02:10Z","timestamp":1783015330000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/an\/article\/151\/4\/1118-1129\/312007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,2,16]]}},"URL":"https:\/\/doi.org\/10.1039\/d5an00962f","relation":{},"ISSN":["0003-2654","1364-5528"],"issn-type":[{"value":"0003-2654","type":"print"},{"value":"1364-5528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}