{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T19:36:00Z","timestamp":1782934560412,"version":"3.54.5"},"reference-count":36,"publisher":"Royal Society of Chemistry (RSC)","issue":"8","license":[{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"am","delay-in-days":416,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2021YFB3800900"],"award-info":[{"award-number":["2021YFB3800900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52233007"],"award-info":[{"award-number":["52233007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071765"],"award-info":[{"award-number":["82071765"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>Unleashing T cell function is critical for efficacious cancer immunotherapy.<\/jats:p>","DOI":"10.1039\/d5bm00001g","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T20:41:01Z","timestamp":1740084061000},"page":"2036-2046","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polymersome-mediated Cbl-b silencing activates T cells against solid tumors"],"prefix":"10.1039","volume":"13","author":[{"given":"Guanhong","family":"Cui","sequence":"first","affiliation":[{"name":"Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Shao","sequence":"additional","affiliation":[{"name":"Institutes of Biology and Medical Sciences, Soochow University, Suzhou, 215123, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyao","family":"Wang","sequence":"additional","affiliation":[{"name":"Institutes of Biology and Medical Sciences, Soochow University, Suzhou, 215123, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0710-3750","authenticated-orcid":false,"given":"Congcong","family":"Xu","sequence":"additional","affiliation":[{"name":"Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, P. R. China"},{"name":"International College of Pharmaceutical Innovation, Soochow University, Suzhou, 215222, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institutes of Biology and Medical Sciences, Soochow University, Suzhou, 215123, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4175-4741","authenticated-orcid":false,"given":"Zhiyuan","family":"Zhong","sequence":"additional","affiliation":[{"name":"Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, P. R. China"},{"name":"International College of Pharmaceutical Innovation, Soochow University, Suzhou, 215222, P.R. China"},{"name":"College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5BM00001G\/cit1\/1","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/s41573-021-00155-y","volume":"20","author":"Kubli","year":"2021","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D5BM00001G\/cit2\/1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/s41586-023-06243-w","volume":"619","author":"Baker","year":"2023","journal-title":"Nature"},{"key":"D5BM00001G\/cit3\/1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/s43018-022-00418-6","volume":"3","author":"Lin","year":"2022","journal-title":"Nat. Cancer"},{"key":"D5BM00001G\/cit4\/1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.ccell.2018.03.012","volume":"33","author":"Thommen","year":"2018","journal-title":"Cancer Cell"},{"key":"D5BM00001G\/cit5\/1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.it.2013.10.001","volume":"35","author":"Schietinger","year":"2014","journal-title":"Trends Immunol."},{"key":"D5BM00001G\/cit6\/1","doi-asserted-by":"crossref","first-page":"216043","DOI":"10.1016\/j.canlet.2022.216043","volume":"559","author":"Wang","year":"2023","journal-title":"Cancer Lett."},{"key":"D5BM00001G\/cit7\/1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.canlet.2021.04.021","volume":"511","author":"Wei","year":"2021","journal-title":"Cancer Lett."},{"key":"D5BM00001G\/cit8\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/bjc.2017.434","volume":"118","author":"Jenkins","year":"2018","journal-title":"Br. J. Cancer"},{"key":"D5BM00001G\/cit9\/1","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S0140-6736(21)01206-X","volume":"398","author":"Carlino","year":"2021","journal-title":"Lancet"},{"key":"D5BM00001G\/cit10\/1","doi-asserted-by":"crossref","first-page":"eabe8219","DOI":"10.1126\/sciimmunol.abe8219","volume":"6","author":"Galy","year":"2021","journal-title":"Sci. Immunol."},{"key":"D5BM00001G\/cit11\/1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41586-019-1821-z","volume":"576","author":"Wei","year":"2019","journal-title":"Nature"},{"key":"D5BM00001G\/cit12\/1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/35003228","volume":"403","author":"Bachmaier","year":"2000","journal-title":"Nature"},{"key":"D5BM00001G\/cit13\/1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/35003235","volume":"403","author":"Chiang","year":"2000","journal-title":"Nature"},{"key":"D5BM00001G\/cit14\/1","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.4049\/jimmunol.1003390","volume":"186","author":"Paolino","year":"2011","journal-title":"J. Immunol."},{"key":"D5BM00001G\/cit15\/1","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1182\/blood-2023-172875","volume":"142","author":"Collins","year":"2023","journal-title":"Blood"},{"key":"D5BM00001G\/cit16\/1","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/s42003-023-05655-8","volume":"6","author":"Kimani","year":"2023","journal-title":"Commun. Biol."},{"key":"D5BM00001G\/cit17\/1","doi-asserted-by":"crossref","first-page":"P175","DOI":"10.1186\/2051-1426-3-S2-P175","volume":"3","author":"Triozzi","year":"2015","journal-title":"J. Immunother. Cancer"},{"key":"D5BM00001G\/cit18\/1","first-page":"A755","volume":"10","author":"Gugenberger","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"D5BM00001G\/cit19\/1","doi-asserted-by":"crossref","first-page":"e001688","DOI":"10.1136\/jitc-2020-001688","volume":"9","author":"Kumar","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"D5BM00001G\/cit20\/1","doi-asserted-by":"crossref","first-page":"e44295","DOI":"10.1371\/journal.pone.0044295","volume":"7","author":"Hinterleitner","year":"2012","journal-title":"PLoS One"},{"key":"D5BM00001G\/cit21\/1","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1200\/JCO.2018.36.15_suppl.3055","volume":"36","author":"Loibner","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"D5BM00001G\/cit22\/1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41568-020-00323-z","volume":"21","author":"Larson","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"D5BM00001G\/cit23\/1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.addr.2018.12.002","volume":"141","author":"Ramishetti","year":"2019","journal-title":"Adv. Drug Delivery Rev."},{"key":"D5BM00001G\/cit24\/1","doi-asserted-by":"crossref","first-page":"2007421","DOI":"10.1002\/adma.202007421","volume":"33","author":"Kumar","year":"2021","journal-title":"Adv. Mater."},{"key":"D5BM00001G\/cit25\/1","doi-asserted-by":"crossref","first-page":"115215","DOI":"10.1016\/j.addr.2024.115215","volume":"208","author":"Berdecka","year":"2024","journal-title":"Adv. Drug Delivery Rev."},{"key":"D5BM00001G\/cit26\/1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.actbio.2021.10.043","volume":"138","author":"Wang","year":"2022","journal-title":"Acta Biomater."},{"key":"D5BM00001G\/cit27\/1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.actbio.2023.07.008","volume":"168","author":"Huang","year":"2023","journal-title":"Acta Biomater."},{"key":"D5BM00001G\/cit28\/1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.jconrel.2021.07.048","volume":"337","author":"Wei","year":"2021","journal-title":"J. Controlled Release"},{"key":"D5BM00001G\/cit29\/1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.jconrel.2023.09.001","volume":"362","author":"Casper","year":"2023","journal-title":"J. Controlled Release"},{"key":"D5BM00001G\/cit30\/1","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.2174\/0929867325666181031094759","volume":"26","author":"Hao","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"D5BM00001G\/cit31\/1","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1038\/s41587-022-01334-x","volume":"40","author":"Brown","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"D5BM00001G\/cit32\/1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s43586-022-00104-y","volume":"2","author":"Mendes","year":"2022","journal-title":"Nat. Rev. Methods Primers"},{"key":"D5BM00001G\/cit33\/1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jconrel.2019.12.047","volume":"319","author":"Abreu","year":"2020","journal-title":"J. Controlled Release"},{"key":"D5BM00001G\/cit34\/1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13045-022-01247-x","volume":"15","author":"Liu","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"D5BM00001G\/cit35\/1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.immuni.2004.07.013","volume":"21","author":"Jeon","year":"2004","journal-title":"Immunity"},{"key":"D5BM00001G\/cit36\/1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fonc.2015.00058","volume":"5","author":"Lutz-Nicoladoni","year":"2015","journal-title":"Front. Oncol."}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/BM\/D5BM00001G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:47:26Z","timestamp":1782928046000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/13\/8\/2036-2046\/881222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,4,8]]}},"URL":"https:\/\/doi.org\/10.1039\/d5bm00001g","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}