{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:10:39Z","timestamp":1785773439960,"version":"3.56.0"},"reference-count":54,"publisher":"Royal Society of Chemistry (RSC)","issue":"16","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"am","delay-in-days":552,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ24E030004"],"award-info":[{"award-number":["LQ24E030004"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012175","name":"Zhejiang Traditional Chinese Medicine Administration","doi-asserted-by":"publisher","award":["GZY-ZJ-KJ-24032"],"award-info":[{"award-number":["GZY-ZJ-KJ-24032"]}],"id":[{"id":"10.13039\/501100012175","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270670"],"award-info":[{"award-number":["82270670"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470669"],"award-info":[{"award-number":["82470669"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>We developed a heparin-modified emodin carrier (HEZ) that targets inflamed pancreatic tissue via CD44-mediated macrophage activation. HEZ restored mitochondrial function and reduced oxidative stress by blocking the JNK pathway.<\/jats:p>","DOI":"10.1039\/d5bm00018a","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T03:12:46Z","timestamp":1751857966000},"page":"4461-4481","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Macrophage-targeted emodin nanomaterials for effective acute pancreatitis treatment\n                    <i>via<\/i>\n                    modulation of the JNK pathway"],"prefix":"10.1039","volume":"13","author":[{"given":"Liying","family":"Wang","sequence":"first","affiliation":[{"name":"Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China"},{"name":"Zhejiang Key Laboratory of Precise Diagnosis and Treatment of Abdominal Infection, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxiang","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China"},{"name":"Zhejiang Key Laboratory of Precise Diagnosis and Treatment of Abdominal Infection, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingzhi","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China"},{"name":"Zhejiang Key Laboratory of Precise Diagnosis and Treatment of Abdominal Infection, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China"},{"name":"Zhejiang Key Laboratory of Precise Diagnosis and Treatment of Abdominal Infection, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China"},{"name":"Zhejiang Key Laboratory of Precise Diagnosis and Treatment of Abdominal Infection, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China"},{"name":"Zhejiang Key Laboratory of Precise Diagnosis and Treatment of Abdominal Infection, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Xu","sequence":"additional","affiliation":[{"name":"Innovation Institute for Artificial Intelligence in Medicine and Liangzhu Laboratory, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China"},{"name":"Zhejiang Key Laboratory of Precise Diagnosis and Treatment of Abdominal Infection, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5990-3720","authenticated-orcid":false,"given":"Hong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China"},{"name":"Zhejiang Key Laboratory of Precise Diagnosis and Treatment of Abdominal Infection, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"10252","key":"D5BM00018A\/cit1\/1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0140-6736(20)31310-6","volume":"396","author":"Boxhoorn","year":"2020","journal-title":"Lancet"},{"issue":"3","key":"D5BM00018A\/cit2\/1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.14309\/ajg.0000000000002645","volume":"119","author":"Tenner","year":"2024","journal-title":"Am. J. Gastroenterol."},{"issue":"4","key":"D5BM00018A\/cit3\/1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1053\/j.gastro.2024.02.052","volume":"167","author":"Trikudanathan","year":"2024","journal-title":"Gastroenterology"},{"issue":"3","key":"D5BM00018A\/cit4\/1","first-page":"485","volume":"73","author":"Ammer-Herrmenau","year":"2024","journal-title":"Gut"},{"issue":"2","key":"D5BM00018A\/cit5\/1","doi-asserted-by":"crossref","first-page":"Itc17","DOI":"10.7326\/AITC202102160","volume":"174","author":"Gardner","year":"2021","journal-title":"Ann. Intern. Med."},{"issue":"4","key":"D5BM00018A\/cit6\/1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/jama.2020.20317","volume":"325","author":"Mederos","year":"2021","journal-title":"J. Am. Med. Assoc."},{"issue":"5","key":"D5BM00018A\/cit7\/1","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1136\/gutjnl-2024-331915","volume":"73","author":"Gunjan","year":"2024","journal-title":"Gut"},{"issue":"8","key":"D5BM00018A\/cit8\/1","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/nrgastro.2014.39","volume":"11","author":"Bakker","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"D5BM00018A\/cit9\/1","doi-asserted-by":"crossref","first-page":"156393","DOI":"10.1016\/j.phymed.2025.156393","volume":"138","author":"Deng","year":"2025","journal-title":"Phytomedicine"},{"issue":"20","key":"D5BM00018A\/cit10\/1","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.3748\/wjg.v23.i20.3615","volume":"23","author":"Li","year":"2017","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"D5BM00018A\/cit11\/1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jep.2014.05.040","volume":"155","author":"Lu","year":"2014","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"D5BM00018A\/cit12\/1","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1097\/MPA.0000000000001931","volume":"50","author":"Yang","year":"2021","journal-title":"Pancreas"},{"issue":"8","key":"D5BM00018A\/cit13\/1","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1002\/ptr.6096","volume":"32","author":"Hu","year":"2018","journal-title":"Phytother. Res."},{"issue":"11","key":"D5BM00018A\/cit14\/1","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.3109\/00365521.2014.958523","volume":"49","author":"Wan","year":"2014","journal-title":"Scand. J. Gastroenterol."},{"issue":"5","key":"D5BM00018A\/cit15\/1","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1097\/MPA.0000000000000339","volume":"44","author":"Yao","year":"2015","journal-title":"Pancreas"},{"issue":"8","key":"D5BM00018A\/cit16\/1","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1002\/ptr.5631","volume":"30","author":"Dong","year":"2016","journal-title":"Phytother. Res."},{"key":"D5BM00018A\/cit17\/1","doi-asserted-by":"crossref","first-page":"112877","DOI":"10.1016\/j.biopha.2022.112877","volume":"149","author":"Mitra","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"D5BM00018A\/cit18\/1","doi-asserted-by":"crossref","first-page":"114539","DOI":"10.1016\/j.biopha.2023.114539","volume":"161","author":"Wang","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"10","key":"D5BM00018A\/cit19\/1","doi-asserted-by":"crossref","first-page":"3986","DOI":"10.1016\/j.apsb.2021.10.008","volume":"12","author":"Hu","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"D5BM00018A\/cit20\/1","doi-asserted-by":"crossref","first-page":"114585","DOI":"10.1016\/j.biopha.2023.114585","volume":"162","author":"Hu","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"D5BM00018A\/cit21\/1","doi-asserted-by":"crossref","first-page":"153328","DOI":"10.1016\/j.phymed.2020.153328","volume":"79","author":"Wen","year":"2020","journal-title":"Phytomedicine"},{"issue":"2","key":"D5BM00018A\/cit22\/1","doi-asserted-by":"crossref","first-page":"e2204994","DOI":"10.1002\/adma.202204994","volume":"35","author":"Gao","year":"2023","journal-title":"Adv. Mater."},{"key":"D5BM00018A\/cit23\/1","doi-asserted-by":"crossref","first-page":"116483","DOI":"10.1016\/j.ecoenv.2024.116483","volume":"279","author":"Sherekar","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"D5BM00018A\/cit24\/1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s12951-023-02045-4","volume":"21","author":"Lei","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"D5BM00018A\/cit25\/1","doi-asserted-by":"crossref","first-page":"118612","DOI":"10.1016\/j.carbpol.2021.118612","volume":"273","author":"Pu","year":"2021","journal-title":"Carbohydr. Polym."},{"issue":"21","key":"D5BM00018A\/cit26\/1","doi-asserted-by":"crossref","first-page":"13885","DOI":"10.1021\/acsnano.4c03044","volume":"18","author":"Kang","year":"2024","journal-title":"ACS Nano"},{"issue":"18","key":"D5BM00018A\/cit27\/1","doi-asserted-by":"crossref","first-page":"11778","DOI":"10.1021\/acsnano.4c00218","volume":"18","author":"Wang","year":"2024","journal-title":"ACS Nano"},{"key":"D5BM00018A\/cit28\/1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jconrel.2015.06.011","volume":"212","author":"Li","year":"2015","journal-title":"J. Controlled Release"},{"key":"D5BM00018A\/cit29\/1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jconrel.2024.11.022","volume":"377","author":"Lin","year":"2025","journal-title":"J. Controlled Release"},{"issue":"34","key":"D5BM00018A\/cit30\/1","doi-asserted-by":"crossref","first-page":"e1803549","DOI":"10.1002\/adma.201803549","volume":"31","author":"Choi","year":"2019","journal-title":"Adv. Mater."},{"key":"D5BM00018A\/cit31\/1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jconrel.2016.06.021","volume":"236","author":"Lee","year":"2016","journal-title":"J. Controlled Release"},{"issue":"20","key":"D5BM00018A\/cit32\/1","doi-asserted-by":"crossref","first-page":"e2206393","DOI":"10.1002\/advs.202206393","volume":"10","author":"Xia","year":"2023","journal-title":"Adv. Sci."},{"issue":"5","key":"D5BM00018A\/cit33\/1","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1053\/j.gastro.2017.08.071","volume":"153","author":"Gukovskaya","year":"2017","journal-title":"Gastroenterology"},{"issue":"6","key":"D5BM00018A\/cit34\/1","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1053\/j.gastro.2021.08.033","volume":"161","author":"Manohar","year":"2021","journal-title":"Gastroenterology"},{"key":"D5BM00018A\/cit35\/1","doi-asserted-by":"crossref","first-page":"102920","DOI":"10.1016\/j.ebiom.2020.102920","volume":"58","author":"Wu","year":"2020","journal-title":"EBioMedicine"},{"issue":"9","key":"D5BM00018A\/cit36\/1","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.bbabio.2018.05.019","volume":"1859","author":"Cadenas","year":"2018","journal-title":"Biochim. Biophys. Acta, Bioenerg."},{"issue":"Suppl 1","key":"D5BM00018A\/cit37\/1","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1093\/ntr\/ntaa177","volume":"22","author":"Correia-\u00c1lvarez","year":"2020","journal-title":"Nicotine Tob. Res."},{"issue":"7","key":"D5BM00018A\/cit38\/1","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.3390\/ijms22073701","volume":"22","author":"Rehfeldt","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"D5BM00018A\/cit39\/1","doi-asserted-by":"crossref","first-page":"155105","DOI":"10.1016\/j.phymed.2023.155105","volume":"121","author":"Dai","year":"2023","journal-title":"Phytomedicine"},{"key":"D5BM00018A\/cit40\/1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.freeradbiomed.2023.06.025","volume":"206","author":"He","year":"2023","journal-title":"Free Radicals Biol. Med."},{"key":"D5BM00018A\/cit41\/1","doi-asserted-by":"crossref","first-page":"104315","DOI":"10.1016\/j.phrs.2019.104315","volume":"146","author":"Yu","year":"2019","journal-title":"Pharmacol. Res."},{"issue":"4","key":"D5BM00018A\/cit42\/1","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1021\/acs.nanolett.1c05003","volume":"22","author":"Wang","year":"2022","journal-title":"Nano Lett."},{"issue":"7","key":"D5BM00018A\/cit43\/1","doi-asserted-by":"crossref","first-page":"6389","DOI":"10.1021\/acsnano.8b00470","volume":"12","author":"Chuang","year":"2018","journal-title":"ACS Nano"},{"issue":"5","key":"D5BM00018A\/cit44\/1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1471-4914(01)01963-3","volume":"7","author":"Pur\u00e9","year":"2001","journal-title":"Trends Mol. Med."},{"issue":"11","key":"D5BM00018A\/cit45\/1","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.3390\/pharmaceutics12111065","volume":"12","author":"Khattak","year":"2020","journal-title":"Pharmaceutics"},{"key":"D5BM00018A\/cit46\/1","doi-asserted-by":"crossref","first-page":"154757","DOI":"10.1016\/j.phymed.2023.154757","volume":"114","author":"Cheng","year":"2023","journal-title":"Phytomedicine"},{"issue":"4","key":"D5BM00018A\/cit47\/1","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.ijrobp.2017.11.043","volume":"100","author":"Rahal","year":"2018","journal-title":"Int. J. Radiat. Oncol., Biol., Phys."},{"issue":"1","key":"D5BM00018A\/cit48\/1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s13046-018-0878-0","volume":"37","author":"Xu","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"D5BM00018A\/cit49\/1","doi-asserted-by":"crossref","first-page":"4386","DOI":"10.1038\/s41467-021-24506-w","volume":"12","author":"Bruce","year":"2021","journal-title":"Nat. Commun."},{"issue":"8","key":"D5BM00018A\/cit50\/1","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1136\/gutjnl-2012-304058","volume":"63","author":"Huang","year":"2014","journal-title":"Gut"},{"issue":"2","key":"D5BM00018A\/cit51\/1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1136\/gutjnl-2015-309363","volume":"66","author":"Huang","year":"2017","journal-title":"Gut"},{"issue":"8","key":"D5BM00018A\/cit52\/1","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1136\/gutjnl-2014-308553","volume":"65","author":"Mukherjee","year":"2016","journal-title":"Gut"},{"issue":"11","key":"D5BM00018A\/cit53\/1","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1080\/15548627.2019.1596486","volume":"15","author":"Wang","year":"2019","journal-title":"Autophagy"},{"issue":"6","key":"D5BM00018A\/cit54\/1","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1053\/j.gastro.2018.01.065","volume":"154","author":"Zhao","year":"2018","journal-title":"Gastroenterology"}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/BM\/D5BM00018A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:56:29Z","timestamp":1782881789000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/13\/16\/4461-4481\/881224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":54,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2025,8,5]]}},"URL":"https:\/\/doi.org\/10.1039\/d5bm00018a","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5BM00018A\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5BM00018A\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5BM00018A\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5BM00018A\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5BM00018A\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5BM00018A\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5BM00018A\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5BM00018A\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5BM00018A\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5BM00018A\/v3\/decision1","asserted-by":"object"}]},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}