{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:20:36Z","timestamp":1791328836520,"version":"4.3.1"},"reference-count":46,"publisher":"Royal Society of Chemistry (RSC)","issue":"12","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":110,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/10.13039\/100006377","name":"Purdue University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/10.13039\/100006377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000153","name":"Division of Biological Infrastructure","doi-asserted-by":"publisher","award":["contract #2120200"],"award-info":[{"award-number":["contract #2120200"]}],"id":[{"id":"10.13039\/100000153","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016520","name":"Davidson School of Chemical Engineering, Purdue University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016520","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>In osteoarthritic-like environments, cartilage formation was reduced and inflammatory response was higher, and including hyaluronic acid in hydrogels modulated this response.<\/jats:p>","DOI":"10.1039\/d5bm00033e","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T17:01:06Z","timestamp":1745254866000},"page":"3252-3263","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chondrogenic and chondroprotective response of composite collagen I\/II-hyaluronic acid scaffolds within an inflammatory osteoarthritic environment"],"prefix":"10.1039","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7844-6211","authenticated-orcid":false,"given":"Carly M.","family":"Battistoni","sequence":"first","affiliation":[{"name":"Davidson School of Chemical Engineering, Purdue, University, West Lafayette, IN 47907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1129-8105","authenticated-orcid":false,"given":"Javier","family":"Munoz Briones","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA"},{"name":"Purdue Interdisciplinary Life Science Program, Purdue University, West Lafayette, IN 47907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5083-0334","authenticated-orcid":false,"given":"Douglas K.","family":"Brubaker","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA"},{"name":"Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, OH 44016, USA"},{"name":"Blood Heart Lung Immunology Research Center, University Hospitals, Cleveland, OH 44106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0360-1480","authenticated-orcid":false,"given":"Alyssa","family":"Panitch","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0784-2529","authenticated-orcid":false,"given":"Julie C.","family":"Liu","sequence":"additional","affiliation":[{"name":"Davidson School of Chemical Engineering, Purdue, University, West Lafayette, IN 47907, USA"},{"name":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"7","key":"D5BM00033E\/cit1\/1","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1002\/art.42089","volume":"74","author":"Long","year":"2022","journal-title":"Arthritis Rheumatol."},{"key":"D5BM00033E\/cit2\/1","doi-asserted-by":"crossref","first-page":"9208","DOI":"10.3390\/ijms22179208","volume":"22","author":"Molnar","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"D5BM00033E\/cit3\/1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.22203\/eCM.v021a16","volume":"21","author":"Goldring","year":"2011","journal-title":"Eur. Cells Mater."},{"issue":"11","key":"D5BM00033E\/cit4\/1","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/nrrheum.2016.148","volume":"12","author":"Goldring","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"D5BM00033E\/cit5\/1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.actbio.2019.01.061","volume":"93","author":"Patel","year":"2019","journal-title":"Acta Biomater."},{"issue":"1","key":"D5BM00033E\/cit6\/1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/J.ENG.2017.01.010","volume":"3","author":"Liu","year":"2017","journal-title":"Engineering"},{"key":"D5BM00033E\/cit7\/1","doi-asserted-by":"crossref","first-page":"109927","DOI":"10.1016\/j.msec.2019.109927","volume":"104","author":"Yang","year":"2019","journal-title":"Mater. Sci. Eng., C"},{"key":"D5BM00033E\/cit8\/1","doi-asserted-by":"crossref","first-page":"1909523","DOI":"10.1002\/adfm.201909523","volume":"30","author":"Teixeira","year":"2020","journal-title":"Adv. Funct. Mater."},{"issue":"4","key":"D5BM00033E\/cit9\/1","first-page":"1","volume":"10","author":"He","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"D5BM00033E\/cit10\/1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00296-012-2368-6","volume":"33","author":"Chen-An","year":"2013","journal-title":"Rheumatol. Int."},{"issue":"12","key":"D5BM00033E\/cit11\/1","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1002\/art.11333","volume":"48","author":"Hui","year":"2003","journal-title":"Arthritis Rheum."},{"issue":"3","key":"D5BM00033E\/cit12\/1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/BOR.0000000000000162","volume":"27","author":"Malemud","year":"2015","journal-title":"Curr. Opin. Rheumatol."},{"issue":"2","key":"D5BM00033E\/cit13\/1","doi-asserted-by":"crossref","first-page":"225S","DOI":"10.1177\/1947603521993217","volume":"13","author":"Pagani","year":"2021","journal-title":"Cartilage"},{"issue":"4","key":"D5BM00033E\/cit14\/1","doi-asserted-by":"crossref","first-page":"839","DOI":"10.3390\/polym14040839","volume":"14","author":"Tsanaktsidou","year":"2022","journal-title":"Polymers"},{"key":"D5BM00033E\/cit15\/1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1177\/1947603517749919","volume":"10","author":"Altman","year":"2019","journal-title":"Cartilage"},{"key":"D5BM00033E\/cit16\/1","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.3390\/biom11101518","volume":"11","author":"Marinho","year":"2021","journal-title":"Biomolecules"},{"issue":"2","key":"D5BM00033E\/cit17\/1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1089\/ten.teb.2015.0297","volume":"22","author":"Scotti","year":"2016","journal-title":"Tissue Eng., Part B"},{"key":"D5BM00033E\/cit18\/1","doi-asserted-by":"crossref","first-page":"7081","DOI":"10.1016\/j.actbio.2013.03.005","volume":"9","author":"Fakhari","year":"2013","journal-title":"Acta Biomater."},{"issue":"4","key":"D5BM00033E\/cit19\/1","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1039\/D1BM01417J","volume":"10","author":"Intini","year":"2022","journal-title":"Biomater. Sci."},{"issue":"1","key":"D5BM00033E\/cit20\/1","doi-asserted-by":"crossref","first-page":"015007","DOI":"10.1088\/1758-5090\/ad047a","volume":"16","author":"O\u2019Shea","year":"2024","journal-title":"Biofabrication"},{"issue":"7","key":"D5BM00033E\/cit21\/1","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1016\/j.actbio.2009.12.049","volume":"6","author":"Eng","year":"2010","journal-title":"Acta Biomater."},{"key":"D5BM00033E\/cit22\/1","doi-asserted-by":"crossref","first-page":"119451","DOI":"10.1016\/j.biomaterials.2019.119451","volume":"222","author":"Kwon","year":"2019","journal-title":"Biomaterials"},{"issue":"2","key":"D5BM00033E\/cit23\/1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/(SICI)1097-4652(199905)179:2<142::AID-JCP4>3.0.CO;2-Q","volume":"179","author":"Kawasaki","year":"1999","journal-title":"J. Cell Physiol."},{"issue":"6","key":"D5BM00033E\/cit24\/1","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1021\/acsbiomaterials.9b01939","volume":"6","author":"Kilmer","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"5","key":"D5BM00033E\/cit25\/1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.2144\/000112009","volume":"39","author":"Penick","year":"2005","journal-title":"BioTechniques"},{"issue":"4","key":"D5BM00033E\/cit26\/1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1089\/ten.tec.2017.0018","volume":"23","author":"Cissell","year":"2017","journal-title":"Tissue Eng., Part C"},{"issue":"1","key":"D5BM00033E\/cit27\/1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/0003-2697(88)90532-5","volume":"174","author":"Kim","year":"1988","journal-title":"Anal. Biochem."},{"issue":"1","key":"D5BM00033E\/cit28\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/0471142727.mb1508s73","volume":"73","author":"Bookout","year":"2006","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"D5BM00033E\/cit29\/1","author":"Munoz Briones","unstructured":"J.Munoz Briones , CartilageGel-Univariate-Linear-Models [Internet]. [cited 2024 Oct 21]. Available from:  https:\/\/github.com\/Brubaker-Lab\/CartilageGel-Univariate-Linear-Models"},{"key":"D5BM00033E\/cit30\/1","doi-asserted-by":"crossref","first-page":"100641","DOI":"10.1016\/j.mser.2021.100641","volume":"146","author":"Xu","year":"2021","journal-title":"Mater. Sci. Eng., R"},{"key":"D5BM00033E\/cit31\/1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nmeth.3839","volume":"13","author":"Caliari","year":"2016","journal-title":"Nat. Methods"},{"key":"D5BM00033E\/cit32\/1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jmbbm.2011.11.012","volume":"11","author":"Matsiko","year":"2012","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"D5BM00033E\/cit33\/1","doi-asserted-by":"crossref","first-page":"113123","DOI":"10.1016\/j.colsurfb.2023.113123","volume":"222","author":"Hakim","year":"2023","journal-title":"Colloids Surf., B"},{"key":"D5BM00033E\/cit34\/1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1089\/ten.teb.2013.0771","volume":"20","author":"Somoza","year":"2014","journal-title":"Tissue Eng., Part B"},{"issue":"5","key":"D5BM00033E\/cit35\/1","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1021\/acsbiomaterials.4c00200","volume":"10","author":"Nguyen","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"35","key":"D5BM00033E\/cit36\/1","doi-asserted-by":"crossref","first-page":"8967","DOI":"10.1016\/j.biomaterials.2012.08.045","volume":"33","author":"Ousema","year":"2012","journal-title":"Biomaterials"},{"key":"D5BM00033E\/cit37\/1","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1021\/acsbiomaterials.2c00026","volume":"8","author":"Madamsetty","year":"2022","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"32","key":"D5BM00033E\/cit38\/1","doi-asserted-by":"crossref","first-page":"24751","DOI":"10.1074\/jbc.M110.104950","volume":"285","author":"Asari","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"4","key":"D5BM00033E\/cit39\/1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s00296-003-0428-7","volume":"25","author":"Sezgin","year":"2005","journal-title":"Rheumatol. Int."},{"issue":"1","key":"D5BM00033E\/cit40\/1","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1186\/s12891-022-05767-y","volume":"23","author":"Jin","year":"2022","journal-title":"BMC Musculoskelet Disord"},{"key":"D5BM00033E\/cit41\/1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","volume":"7","author":"Kapoor","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"issue":"12","key":"D5BM00033E\/cit42\/1","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.joca.2006.05.009","volume":"14","author":"Wang","year":"2006","journal-title":"Osteoarthr. Cartil."},{"issue":"3","key":"D5BM00033E\/cit43\/1","first-page":"78","volume":"28","author":"Litwiniuk","year":"2016","journal-title":"Index Wounds"},{"key":"D5BM00033E\/cit44\/1","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.joca.2019.09.008","volume":"28","author":"Chisari","year":"2020","journal-title":"Osteoarthr. Cartil."},{"issue":"1","key":"D5BM00033E\/cit45\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13075-016-1210-z","volume":"19","author":"Li","year":"2017","journal-title":"Arthritis Res. Ther."},{"issue":"1","key":"D5BM00033E\/cit46\/1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.bbapap.2011.06.020","volume":"1824","author":"Troeberg","year":"2012","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/BM\/D5BM00033E","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/BM\/D5BM00033E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:22:42Z","timestamp":1782940962000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/13\/12\/3252-3263\/881228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":46,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,6,10]]}},"URL":"https:\/\/doi.org\/10.1039\/d5bm00033e","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}