{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:15:40Z","timestamp":1791947740630,"version":"4.3.4"},"reference-count":27,"publisher":"Royal Society of Chemistry (RSC)","issue":"13","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"am","delay-in-days":511,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372114"],"award-info":[{"award-number":["82372114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>A core\u2013shell structured biphasic microneedle system is designed for the treatment of melanoma, which achieves enhanced drug loading capacity, tunable mechanical properties, and protection of drug activity.<\/jats:p>","DOI":"10.1039\/d5bm00371g","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T05:56:27Z","timestamp":1748325387000},"page":"3662-3677","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A core\u2013shell structured biphasic microneedle system as an elite squad for combating melanoma with \u201cthree-in-one\u201d therapeutic power"],"prefix":"10.1039","volume":"13","author":[{"given":"Qiling","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Chemistry, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Chemistry, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Chemistry, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keqiang","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicine, The School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3944-9716","authenticated-orcid":false,"given":"Lingzhi","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicine, The School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3931-0439","authenticated-orcid":false,"given":"Wenying","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Chemistry, China Pharmaceutical University, Nanjing 210009, China"},{"name":"Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing 210009, China"},{"name":"Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5662-7502","authenticated-orcid":false,"given":"Keming","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, China Pharmaceutical University, Nanjing 210009, China"},{"name":"Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5BM00371G\/cit1\/1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.actbio.2024.08.032","volume":"187","author":"Yi","year":"2024","journal-title":"Acta Biomater."},{"key":"D5BM00371G\/cit2\/1","doi-asserted-by":"crossref","first-page":"2303388","DOI":"10.1002\/adma.202303388","volume":"35","author":"Lu","year":"2023","journal-title":"Adv. Mater."},{"key":"D5BM00371G\/cit3\/1","first-page":"2412160","author":"Kim","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"D5BM00371G\/cit4\/1","doi-asserted-by":"crossref","first-page":"2303580","DOI":"10.1002\/adfm.202303580","volume":"33","author":"Xie","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"D5BM00371G\/cit5\/1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/s44222-023-00141-6","volume":"2","author":"Zheng","year":"2023","journal-title":"Nat. Rev. Bioeng."},{"key":"D5BM00371G\/cit6\/1","first-page":"303","volume":"27","author":"Lyu","year":"2023","journal-title":"Bioact. Mater."},{"key":"D5BM00371G\/cit7\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2018.03.010","volume":"127","author":"Zhao","year":"2018","journal-title":"Adv. Drug Delivery Rev."},{"key":"D5BM00371G\/cit8\/1","doi-asserted-by":"crossref","first-page":"2309920","DOI":"10.1002\/adma.202309920","volume":"36","author":"Choi","year":"2024","journal-title":"Adv. Mater."},{"key":"D5BM00371G\/cit9\/1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jconrel.2021.05.009","volume":"335","author":"Zhi","year":"2021","journal-title":"J. Controlled Release"},{"key":"D5BM00371G\/cit10\/1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.addr.2018.01.015","volume":"127","author":"Ye","year":"2018","journal-title":"Adv. Drug Delivery Rev."},{"key":"D5BM00371G\/cit11\/1","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.addr.2012.04.005","volume":"64","author":"Kim","year":"2012","journal-title":"Adv. Drug Delivery Rev."},{"key":"D5BM00371G\/cit12\/1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/jbm.a.35869","volume":"105","author":"Lee","year":"2017","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"D5BM00371G\/cit13\/1","doi-asserted-by":"crossref","first-page":"2103359","DOI":"10.1002\/adfm.202103359","volume":"31","author":"Li","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"D5BM00371G\/cit14\/1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jddst.2017.01.003","volume":"38","author":"Kim","year":"2017","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"D5BM00371G\/cit15\/1","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1007\/s13346-020-00883-5","volume":"11","author":"McAlister","year":"2021","journal-title":"Drug Delivery Transl. Res."},{"key":"D5BM00371G\/cit16\/1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.msec.2017.11.009","volume":"83","author":"Wang","year":"2018","journal-title":"Mater. Sci. Eng., C"},{"key":"D5BM00371G\/cit17\/1","first-page":"2202124","volume":"8","author":"Chen","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"D5BM00371G\/cit18\/1","doi-asserted-by":"crossref","first-page":"1700113","DOI":"10.1002\/advs.201700113","volume":"4","author":"Wu","year":"2017","journal-title":"Adv. Sci."},{"key":"D5BM00371G\/cit19\/1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3322\/caac.20114","volume":"61","author":"Agostinis","year":"2011","journal-title":"CA Cancer J. Clin."},{"key":"D5BM00371G\/cit20\/1","first-page":"465","volume":"37","author":"Davids","year":"2011","journal-title":"Cancer Treat. Rev."},{"key":"D5BM00371G\/cit21\/1","doi-asserted-by":"crossref","first-page":"1701041","DOI":"10.1002\/advs.201701041","volume":"5","author":"Yin","year":"2018","journal-title":"Adv. Sci."},{"key":"D5BM00371G\/cit22\/1","doi-asserted-by":"crossref","first-page":"106075","DOI":"10.1016\/j.ejps.2021.106075","volume":"168","author":"Chi","year":"2022","journal-title":"Eur. J. Pharm. Sci."},{"key":"D5BM00371G\/cit23\/1","doi-asserted-by":"crossref","first-page":"2405696","DOI":"10.1002\/adfm.202405696","volume":"34","author":"Pan","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"D5BM00371G\/cit24\/1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.actbio.2023.11.038","volume":"174","author":"Chi","year":"2024","journal-title":"Acta Biomater."},{"key":"D5BM00371G\/cit25\/1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jconrel.2015.08.015","volume":"216","author":"Xu","year":"2015","journal-title":"J. Controlled Release"},{"key":"D5BM00371G\/cit26\/1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jconrel.2013.01.008","volume":"166","author":"Xu","year":"2013","journal-title":"J. Controlled Release"},{"key":"D5BM00371G\/cit27\/1","doi-asserted-by":"crossref","first-page":"eaaz0575","DOI":"10.1126\/sciadv.aaz0575","volume":"6","author":"Zhao","year":"2020","journal-title":"Sci. Adv."}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/BM\/D5BM00371G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:33:09Z","timestamp":1783531989000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/13\/13\/3662-3677\/881305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":27,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2025,6,25]]}},"URL":"https:\/\/doi.org\/10.1039\/d5bm00371g","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}