{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T19:32:56Z","timestamp":1785785576277,"version":"3.56.0"},"reference-count":54,"publisher":"Royal Society of Chemistry (RSC)","issue":"19","license":[{"start":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:00:00Z","timestamp":1786752000000},"content-version":"am","delay-in-days":591,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/100010956","name":"State University of New York Upstate Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["EB032579"],"award-info":[{"award-number":["EB032579"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>A lung-targeted sulfonium lipid nanoparticle (sLNP) formulation of sparstolonin B (SsnB) effectively inhibited inflammation and tissue injury in a murine model of LPS-induced acute lung injury (ALI) following intravenous administration.<\/jats:p>","DOI":"10.1039\/d5bm00590f","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T12:20:52Z","timestamp":1755260452000},"page":"5429-5441","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lung-targeting lipid nanoparticle-mediated sparstolonin B delivery improves acute lung injury"],"prefix":"10.1039","volume":"13","author":[{"given":"Qinghe","family":"Meng","sequence":"first","affiliation":[{"name":"Departments of Surgery, State University of New York, Upstate Medical University, USA"},{"name":"Sepsis Interdisciplinary Research Center (SIRC), State University of New York, Upstate Medical, University, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David O.","family":"Popoola","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, State University of New York, Upstate Medical University, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Departments of Surgery, State University of New York, Upstate Medical University, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Men","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, State University of New York, Upstate Medical University, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Song","sequence":"additional","affiliation":[{"name":"Departments of Surgery, State University of New York, Upstate Medical University, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, State University of New York, Upstate Medical University, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Novak","sequence":"additional","affiliation":[{"name":"Departments of Surgery, State University of New York, Upstate Medical University, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5535-1807","authenticated-orcid":false,"given":"Yamin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, State University of New York, Upstate Medical University, USA"},{"name":"Sepsis Interdisciplinary Research Center (SIRC), State University of New York, Upstate Medical, University, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N.","family":"Cooney","sequence":"additional","affiliation":[{"name":"Departments of Surgery, State University of New York, Upstate Medical University, USA"},{"name":"Sepsis Interdisciplinary Research Center (SIRC), State University of New York, Upstate Medical, University, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"8","key":"D5BM00590F\/cit1\/1","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1172\/JCI60331","volume":"122","author":"Matthay","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"1","key":"D5BM00590F\/cit2\/1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s13054-024-04943-x","volume":"28","author":"Evrard","year":"2024","journal-title":"Crit. Care"},{"issue":"12","key":"D5BM00590F\/cit3\/1","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1136\/thoraxjnl-2020-215950","volume":"76","author":"Torres","year":"2021","journal-title":"Thorax"},{"key":"D5BM00590F\/cit4\/1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fped.2016.00069","volume":"4","author":"Meduri","year":"2016","journal-title":"Front. Pediatr."},{"issue":"12","key":"D5BM00590F\/cit5\/1","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1056\/NEJMoa1005372","volume":"363","author":"Papazian","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"D5BM00590F\/cit6\/1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jcrc.2018.10.019","volume":"49","author":"Torbic","year":"2019","journal-title":"J. Crit. Care"},{"issue":"2","key":"D5BM00590F\/cit7\/1","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1097\/CCM.0b013e3182a27909","volume":"42","author":"Adhikari","year":"2014","journal-title":"Crit. Care Med."},{"issue":"6","key":"D5BM00590F\/cit8\/1","first-page":"CD002787","volume":"2016","author":"Gebistorf","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"issue":"1","key":"D5BM00590F\/cit9\/1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1378\/chest.105.1.190","volume":"105","author":"Suter","year":"1994","journal-title":"Chest"},{"issue":"6","key":"D5BM00590F\/cit10\/1","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/resp.12820","volume":"21","author":"Xiong","year":"2016","journal-title":"Respirology"},{"issue":"18","key":"D5BM00590F\/cit11\/1","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.3390\/diagnostics13182964","volume":"13","author":"Dushianthan","year":"2023","journal-title":"Diagnostics"},{"issue":"24","key":"D5BM00590F\/cit12\/1","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1056\/NEJMoa2028836","volume":"383","author":"Stone","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"D5BM00590F\/cit13\/1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1001\/jamainternmed.2020.6252","volume":"181","author":"Gupta","year":"2021","journal-title":"JAMA Intern. Med."},{"issue":"5","key":"D5BM00590F\/cit14\/1","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/jth.14810","volume":"18","author":"Thachil","year":"2020","journal-title":"J. Thromb. Haemostasis"},{"issue":"6","key":"D5BM00590F\/cit15\/1","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s00134-020-06062-x","volume":"46","author":"Helms","year":"2020","journal-title":"Intensive Care Med."},{"issue":"30","key":"D5BM00590F\/cit16\/1","doi-asserted-by":"crossref","first-page":"26470","DOI":"10.1074\/jbc.M111.227934","volume":"286","author":"Liang","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"6","key":"D5BM00590F\/cit17\/1","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/SHK.0000000000001326","volume":"52","author":"Yepuri","year":"2019","journal-title":"Shock"},{"issue":"10","key":"D5BM00590F\/cit18\/1","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1002\/bmc.3447","volume":"29","author":"Zou","year":"2015","journal-title":"Biomed. Chromatogr."},{"issue":"26","key":"D5BM00590F\/cit19\/1","doi-asserted-by":"crossref","first-page":"8080","DOI":"10.1021\/acs.nanolett.4c01854","volume":"24","author":"Popoola","year":"2024","journal-title":"Nano Lett."},{"issue":"5","key":"D5BM00590F\/cit20\/1","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1002\/anie.201509401","volume":"55","author":"Li","year":"2016","journal-title":"Angew. Chem., Int. Ed."},{"issue":"11","key":"D5BM00590F\/cit21\/1","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1021\/bm301425j","volume":"13","author":"Li","year":"2012","journal-title":"Biomacromolecules"},{"issue":"12","key":"D5BM00590F\/cit22\/1","first-page":"e1504","volume":"5","author":"Ortiz-Munoz","year":"2015","journal-title":"Bio-Protoc."},{"issue":"5","key":"D5BM00590F\/cit23\/1","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1097\/SHK.0000000000001927","volume":"57","author":"Meng","year":"2022","journal-title":"Shock"},{"key":"D5BM00590F\/cit24\/1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/978-1-4939-8935-5_26","volume":"1897","author":"Im","year":"2019","journal-title":"Methods Mol. Biol."},{"issue":"5","key":"D5BM00590F\/cit25\/1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1165\/rcmb.2009-0210ST","volume":"44","author":"Matute-Bello","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"1","key":"D5BM00590F\/cit26\/1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12951-022-01307-x","volume":"20","author":"He","year":"2022","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"D5BM00590F\/cit27\/1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12931-024-02678-5","volume":"25","author":"Huang","year":"2024","journal-title":"Respir. Res."},{"issue":"9","key":"D5BM00590F\/cit28\/1","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/s41551-021-00786-x","volume":"5","author":"Lokugamage","year":"2021","journal-title":"Nat. Biomed. Eng."},{"issue":"51","key":"D5BM00590F\/cit29\/1","doi-asserted-by":"crossref","first-page":"e2303261","DOI":"10.1002\/adma.202303261","volume":"35","author":"Zong","year":"2023","journal-title":"Adv. Mater."},{"issue":"8","key":"D5BM00590F\/cit30\/1","doi-asserted-by":"crossref","first-page":"e2116271119","DOI":"10.1073\/pnas.2116271119","volume":"119","author":"Qiu","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"D5BM00590F\/cit31\/1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1021\/acsmaterialsau.3c00032","volume":"3","author":"Mehta","year":"2023","journal-title":"ACS Mater. Au"},{"issue":"2","key":"D5BM00590F\/cit32\/1","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1021\/acsbiomaterials.9b01722","volume":"6","author":"Liu","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"6","key":"D5BM00590F\/cit33\/1","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1016\/j.apsb.2022.04.013","volume":"12","author":"Li","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"D5BM00590F\/cit34\/1","doi-asserted-by":"crossref","first-page":"580118","DOI":"10.3389\/fchem.2021.580118","volume":"9","author":"Dhiman","year":"2021","journal-title":"Front. Chem."},{"issue":"21","key":"D5BM00590F\/cit35\/1","doi-asserted-by":"crossref","first-page":"15764","DOI":"10.3390\/ijms242115764","volume":"24","author":"Ashfaq","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"D5BM00590F\/cit36\/1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0939-6411(00)00087-4","volume":"50","author":"Muller","year":"2000","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"2","key":"D5BM00590F\/cit37\/1","doi-asserted-by":"crossref","first-page":"656","DOI":"10.3390\/pharmaceutics15020656","volume":"15","author":"Akombaetwa","year":"2023","journal-title":"Pharmaceutics"},{"issue":"8","key":"D5BM00590F\/cit38\/1","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.3390\/ph17081059","volume":"17","author":"Cojocaru","year":"2024","journal-title":"Pharmaceuticals"},{"issue":"13","key":"D5BM00590F\/cit39\/1","doi-asserted-by":"crossref","first-page":"e2100302","DOI":"10.1002\/adhm.202100302","volume":"10","author":"Marulanda","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"D5BM00590F\/cit40\/1","doi-asserted-by":"crossref","first-page":"7865","DOI":"10.2147\/IJN.S432839","volume":"18","author":"Aryal","year":"2023","journal-title":"Int. J. Nanomed."},{"issue":"16","key":"D5BM00590F\/cit41\/1","doi-asserted-by":"crossref","first-page":"6580","DOI":"10.1021\/acs.nanolett.2c01784","volume":"22","author":"Cao","year":"2022","journal-title":"Nano Lett."},{"issue":"52","key":"D5BM00590F\/cit42\/1","doi-asserted-by":"crossref","first-page":"e2109256118","DOI":"10.1073\/pnas.2109256118","volume":"118","author":"Dilliard","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5BM00590F\/cit43\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/978-1-4939-7163-3_2","volume":"1639","author":"Kalfopoulos","year":"2017","journal-title":"Methods Mol. Biol."},{"issue":"7","key":"D5BM00590F\/cit44\/1","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1182\/blood.V75.7.1509.1509","volume":"75","author":"Dejana","year":"1990","journal-title":"Blood"},{"issue":"3","key":"D5BM00590F\/cit45\/1","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1182\/blood.V73.3.734.734","volume":"73","author":"Languino","year":"1989","journal-title":"Blood"},{"issue":"5","key":"D5BM00590F\/cit46\/1","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1021\/acsbiomaterials.9b00445","volume":"5","author":"Li","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"2","key":"D5BM00590F\/cit47\/1","doi-asserted-by":"crossref","first-page":"2100109","DOI":"10.1002\/anbr.202100109","volume":"2","author":"Xu","year":"2021","journal-title":"Adv. NanoBioMed Res."},{"issue":"2","key":"D5BM00590F\/cit48\/1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41565-022-01266-2","volume":"18","author":"Chen","year":"2023","journal-title":"Nat. Nanotechnol."},{"issue":"2","key":"D5BM00590F\/cit49\/1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.cyto.2014.12.003","volume":"75","author":"Liang","year":"2015","journal-title":"Cytokine"},{"issue":"7","key":"D5BM00590F\/cit50\/1","first-page":"G510","volume":"310","author":"Dattaroy","year":"2016","journal-title":"Am. J. Physiol.: Gastrointest. Liver Physiol."},{"key":"D5BM00590F\/cit51\/1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejphar.2018.08.040","volume":"841","author":"Dattaroy","year":"2018","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"D5BM00590F\/cit52\/1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/jcmm.17099","volume":"26","author":"Ma","year":"2022","journal-title":"J. Cell. Mol. Med."},{"issue":"6","key":"D5BM00590F\/cit53\/1","first-page":"5436","volume":"15","author":"Wang","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"D5BM00590F\/cit54\/1","doi-asserted-by":"crossref","first-page":"1532391","DOI":"10.3389\/fphar.2025.1532391","volume":"16","author":"Meng","year":"2025","journal-title":"Front. Pharmacol."}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/BM\/D5BM00590F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:38:12Z","timestamp":1782877092000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/13\/19\/5429-5441\/881348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":54,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2025,9,23]]}},"URL":"https:\/\/doi.org\/10.1039\/d5bm00590f","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}