{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:10:05Z","timestamp":1790838605532,"version":"4.1.0"},"reference-count":43,"publisher":"Royal Society of Chemistry (RSC)","issue":"1","license":[{"start":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:00:00Z","timestamp":1793750400000},"content-version":"am","delay-in-days":307,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["DUT24YG208"],"award-info":[{"award-number":["DUT24YG208"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2022YFE0115400"],"award-info":[{"award-number":["2022YFE0115400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2022YFB400350"],"award-info":[{"award-number":["2022YFB400350"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>Ovarian cancer (OC) is one of the most fatal malignant tumors of the female reproductive system, and its high recurrence rate in advanced stages and drug resistance severely limit the efficacy of current treatment methods.<\/jats:p>","DOI":"10.1039\/d5bm01191d","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:36:18Z","timestamp":1762252578000},"page":"161-172","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Core\u2013shell hydrogel microspheres with sequential drug release and magnetothermal synergy for drug-resistant ovarian cancer"],"prefix":"10.1039","volume":"14","author":[{"given":"Peinan","family":"Yin","sequence":"first","affiliation":[{"name":"State Key Laboratory of Structural Analysis, Optimization and CAE Software for Industrial Equipment, School of Mechanics and Aerospace Engineering, Dalian University of Technology, Dalian 116024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6820-2173","authenticated-orcid":false,"given":"Anamaria","family":"Brozovic","sequence":"additional","affiliation":[{"name":"Division of Molecular Biology, Ru\u0111er Bo\u0161kovi\u0107 Institute, Bijeni\u010dka cesta 54, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8475-3143","authenticated-orcid":false,"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Analysis, Optimization and CAE Software for Industrial Equipment, School of Mechanics and Aerospace Engineering, Dalian University of Technology, Dalian 116024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengwei","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Analysis, Optimization and CAE Software for Industrial Equipment, School of Mechanics and Aerospace Engineering, Dalian University of Technology, Dalian 116024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5BM01191D\/cit1\/1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"Bray","year":"2024","journal-title":"CA-Cancer J. Clin."},{"key":"D5BM01191D\/cit2\/1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1757-2215-2-21","volume":"2","author":"Chauhan","year":"2009","journal-title":"J. Ovarian Res."},{"key":"D5BM01191D\/cit3\/1","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1245\/s10434-014-4157-9","volume":"22","author":"Spiliotis","year":"2014","journal-title":"Ann. Surg. Oncol."},{"key":"D5BM01191D\/cit4\/1","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/S0140-6736(13)62146-7","volume":"384","author":"Jayson","year":"2014","journal-title":"Lancet"},{"key":"D5BM01191D\/cit5\/1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41388-025-03275-6","volume":"44","author":"Ems","year":"2025","journal-title":"Oncogene"},{"key":"D5BM01191D\/cit6\/1","doi-asserted-by":"crossref","first-page":"22498","DOI":"10.1074\/jbc.M400479200","volume":"279","author":"Deng","year":"2004","journal-title":"J. Biol. Chem."},{"key":"D5BM01191D\/cit7\/1","doi-asserted-by":"crossref","first-page":"27790","DOI":"10.1074\/jbc.M403042200","volume":"279","author":"Zou","year":"2004","journal-title":"J. Biol. Chem."},{"key":"D5BM01191D\/cit8\/1","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1111\/febs.14347","volume":"285","author":"Becker","year":"2017","journal-title":"FEBS J."},{"key":"D5BM01191D\/cit9\/1","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1158\/0008-5472.CAN-08-2903","volume":"69","author":"Deng","year":"2009","journal-title":"Cancer Res."},{"key":"D5BM01191D\/cit10\/1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.18632\/genesandcancer.1","volume":"5","author":"Deng","year":"2014","journal-title":"Genes Cancer"},{"key":"D5BM01191D\/cit11\/1","doi-asserted-by":"crossref","first-page":"17019","DOI":"10.1073\/pnas.2002193117","volume":"117","author":"Dong","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5BM01191D\/cit12\/1","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1093\/nar\/gkaa1290","volume":"49","author":"Dong","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"D5BM01191D\/cit13\/1","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1136\/gutjnl-2023-331854","volume":"73","author":"Brichkina","year":"2024","journal-title":"Gut"},{"key":"D5BM01191D\/cit14\/1","doi-asserted-by":"crossref","first-page":"528","DOI":"10.3390\/pharmaceutics16040528","volume":"16","author":"Kokkorakis","year":"2024","journal-title":"Pharmaceutics"},{"key":"D5BM01191D\/cit15\/1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1042\/BJ20130461","volume":"457","author":"Ashford","year":"2013","journal-title":"Biochem. J."},{"key":"D5BM01191D\/cit16\/1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJMoa1708618","volume":"378","author":"van Driel","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"D5BM01191D\/cit17\/1","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1002\/cncr.32505","volume":"125","author":"Koole","year":"2019","journal-title":"Cancer"},{"key":"D5BM01191D\/cit18\/1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s12013-024-01483-7","volume":"83","author":"Chen","year":"2024","journal-title":"Cell Biochem. Biophys."},{"key":"D5BM01191D\/cit19\/1","doi-asserted-by":"crossref","first-page":"138412","DOI":"10.1016\/j.ijbiomac.2024.138412","volume":"287","author":"Yin","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"D5BM01191D\/cit20\/1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.biomaterials.2014.10.039","volume":"37","author":"Cho","year":"2015","journal-title":"Biomaterials"},{"key":"D5BM01191D\/cit21\/1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jconrel.2016.05.056","volume":"235","author":"Sun","year":"2016","journal-title":"J. Controlled Release"},{"key":"D5BM01191D\/cit22\/1","doi-asserted-by":"crossref","first-page":"21229","DOI":"10.1039\/C8RA03274B","volume":"8","author":"Xu","year":"2018","journal-title":"RSC Adv."},{"key":"D5BM01191D\/cit23\/1","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.1021\/acs.molpharmaceut.1c00514","volume":"18","author":"Yamaguchi","year":"2021","journal-title":"Mol. Pharm."},{"key":"D5BM01191D\/cit24\/1","doi-asserted-by":"crossref","first-page":"132275","DOI":"10.1016\/j.ijbiomac.2024.132275","volume":"270","author":"Han","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"D5BM01191D\/cit25\/1","doi-asserted-by":"crossref","first-page":"105326","DOI":"10.1016\/j.jtice.2023.105326","volume":"163","author":"Lim","year":"2024","journal-title":"J. Taiwan Inst. Chem. Eng."},{"key":"D5BM01191D\/cit26\/1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s40005-024-00705-7","volume":"55","author":"Jo","year":"2025","journal-title":"J. Pharm. Invest."},{"key":"D5BM01191D\/cit27\/1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.colsurfb.2014.12.012","volume":"126","author":"Gou","year":"2015","journal-title":"Colloids Surf., B"},{"key":"D5BM01191D\/cit28\/1","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.1021\/acsami.5b09340","volume":"8","author":"Wang","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D5BM01191D\/cit29\/1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.biopha.2018.09.039","volume":"108","author":"Zheng","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"D5BM01191D\/cit30\/1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.biomaterials.2014.09.017","volume":"36","author":"He","year":"2015","journal-title":"Biomaterials"},{"key":"D5BM01191D\/cit31\/1","doi-asserted-by":"crossref","first-page":"156907","DOI":"10.1016\/j.jallcom.2020.156907","volume":"851","author":"Yang","year":"2021","journal-title":"J. Alloys Compd."},{"key":"D5BM01191D\/cit32\/1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.14227\/DT180311P15","volume":"18","author":"Marques","year":"2011","journal-title":"Dissolution Technol."},{"key":"D5BM01191D\/cit33\/1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4174\/astr.2024.107.2.108","volume":"107","author":"Skach","year":"2024","journal-title":"Ann. Surg. Treat. Res."},{"key":"D5BM01191D\/cit34\/1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","volume":"22","author":"Reagan-Shaw","year":"2007","journal-title":"FASEB J."},{"key":"D5BM01191D\/cit35\/1","doi-asserted-by":"crossref","first-page":"13929","DOI":"10.1039\/C7NR02356A","volume":"9","author":"Zhang","year":"2017","journal-title":"Nanoscale"},{"key":"D5BM01191D\/cit36\/1","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1038\/s41467-020-14997-4","volume":"11","author":"Gong","year":"2020","journal-title":"Nat. Commun."},{"key":"D5BM01191D\/cit37\/1","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1021\/bm049335p","volume":"6","author":"Mi","year":"2005","journal-title":"Biomacromolecules"},{"key":"D5BM01191D\/cit38\/1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.molstruc.2005.12.053","volume":"792\u2013793","author":"Fuks","year":"2006","journal-title":"J. Mol. Struct."},{"key":"D5BM01191D\/cit39\/1","doi-asserted-by":"crossref","first-page":"2416390","DOI":"10.1002\/adfm.202416390","volume":"35","author":"Tordi","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"D5BM01191D\/cit40\/1","doi-asserted-by":"crossref","first-page":"18210","DOI":"10.1007\/s10853-021-06445-5","volume":"56","author":"Sun","year":"2021","journal-title":"J. Mater. Sci."},{"key":"D5BM01191D\/cit41\/1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1040-8428(01)00179-2","volume":"43","author":"Hildebrandt","year":"2002","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"D5BM01191D\/cit42\/1","first-page":"2591","volume":"53","author":"Morimoto","year":"1993","journal-title":"Cancer Res."},{"key":"D5BM01191D\/cit43\/1","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.4049\/jimmunol.147.8.2609","volume":"147","author":"Morimoto","year":"1991","journal-title":"J. Immunol."}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/BM\/D5BM01191D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:40:24Z","timestamp":1782963624000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/14\/1\/161-172\/312240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,6]]}},"URL":"https:\/\/doi.org\/10.1039\/d5bm01191d","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}