{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:18:28Z","timestamp":1783019908751,"version":"3.54.6"},"reference-count":40,"publisher":"Royal Society of Chemistry (RSC)","issue":"2","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"am","delay-in-days":334,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303475"],"award-info":[{"award-number":["82303475"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010814","name":"Anhui Department of Education","doi-asserted-by":"publisher","award":["2024zyxwjxalk048"],"award-info":[{"award-number":["2024zyxwjxalk048"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>Sub-50 nm large pore-sized hollow mesoporous organosilica nanoparticles featuring TA\u2013Cu capping and GOx loading are judiciously engineered for tumor-specific cascaded catalytic therapy through a three-step enzymatic\u2013metallic reaction cascade.<\/jats:p>","DOI":"10.1039\/d5bm01399b","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T11:36:02Z","timestamp":1764588962000},"page":"462-471","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Large pore-sized organosilica nanoparticles with controlled release of glucose oxidase for tumor-specific cascaded catalytic therapy"],"prefix":"10.1039","volume":"14","author":[{"given":"Xiaobing","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China"},{"name":"Department of Hepatic Surgery, The Third Affiliated Hospital of Second Military Medical University, Shanghai 200082, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 211198, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wennan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 211198, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuping","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery, The Third Affiliated Hospital of Second Military Medical University, Shanghai 200082, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Hou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 211198, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery, The Third Affiliated Hospital of Second Military Medical University, Shanghai 200082, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery, The Third Affiliated Hospital of Second Military Medical University, Shanghai 200082, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery, The Third Affiliated Hospital of Second Military Medical University, Shanghai 200082, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5057-3873","authenticated-orcid":false,"given":"Wenpei","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 211198, China"},{"name":"State Key Laboratory of Neurology and Oncology Drug Development, Nanjing 210042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5BM01399B\/cit1\/1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41586-020-2594-0","volume":"584","author":"Zhao","year":"2020","journal-title":"Nature"},{"key":"D5BM01399B\/cit2\/1","doi-asserted-by":"crossref","first-page":"214309","DOI":"10.1016\/j.ccr.2021.214309","volume":"452","author":"Zhou","year":"2022","journal-title":"Coord. Chem. Rev."},{"key":"D5BM01399B\/cit3\/1","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/s41578-021-00385-x","volume":"6","author":"Janjua","year":"2021","journal-title":"Nat. Rev. Mater."},{"key":"D5BM01399B\/cit4\/1","doi-asserted-by":"crossref","first-page":"1907035","DOI":"10.1002\/adma.201907035","volume":"32","author":"Kankala","year":"2020","journal-title":"Adv. Mater."},{"key":"D5BM01399B\/cit5\/1","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1002\/adma.201505147","volume":"28","author":"Chen","year":"2016","journal-title":"Adv. Mater."},{"key":"D5BM01399B\/cit6\/1","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1021\/acs.accounts.4c00502","volume":"57","author":"Huang","year":"2024","journal-title":"Acc. Chem. Res."},{"key":"D5BM01399B\/cit7\/1","doi-asserted-by":"crossref","first-page":"16326","DOI":"10.1021\/ja508721y","volume":"136","author":"Chen","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"D5BM01399B\/cit8\/1","doi-asserted-by":"crossref","first-page":"1902634","DOI":"10.1002\/adfm.201902634","volume":"30","author":"Manzano","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"D5BM01399B\/cit9\/1","doi-asserted-by":"crossref","first-page":"22896","DOI":"10.1021\/jacs.3c00393","volume":"145","author":"Picchetti","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"D5BM01399B\/cit10\/1","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/s41551-020-0599-5","volume":"4","author":"Li","year":"2020","journal-title":"Nat. Biomed. Eng."},{"key":"D5BM01399B\/cit11\/1","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1021\/jacs.7b10694","volume":"140","author":"Teng","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"D5BM01399B\/cit12\/1","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1002\/adma.201505524","volume":"28","author":"Wu","year":"2016","journal-title":"Adv. Mater."},{"key":"D5BM01399B\/cit13\/1","doi-asserted-by":"crossref","first-page":"1707612","DOI":"10.1002\/adma.201707612","volume":"31","author":"Teng","year":"2019","journal-title":"Adv. Mater."},{"key":"D5BM01399B\/cit14\/1","doi-asserted-by":"crossref","first-page":"16308","DOI":"10.1021\/acsnano.3c07621","volume":"17","author":"Noureddine","year":"2023","journal-title":"ACS Nano"},{"key":"D5BM01399B\/cit15\/1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.26599\/NBE.2023.9290044","volume":"15","author":"Zhang","year":"2023","journal-title":"Nano Biomed. Eng."},{"key":"D5BM01399B\/cit16\/1","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/s41467-019-09158-1","volume":"10","author":"Fan","year":"2019","journal-title":"Nat. Commun."},{"key":"D5BM01399B\/cit17\/1","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/s41578-021-00315-x","volume":"6","author":"Wang","year":"2021","journal-title":"Nat. Rev. Mater."},{"key":"D5BM01399B\/cit18\/1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/s41578-021-00405-w","volume":"7","author":"Li","year":"2022","journal-title":"Nat. Rev. Mater."},{"key":"D5BM01399B\/cit19\/1","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/s41551-021-00698-w","volume":"5","author":"Vargason","year":"2021","journal-title":"Nat. Biomed. Eng."},{"key":"D5BM01399B\/cit20\/1","doi-asserted-by":"crossref","first-page":"4062","DOI":"10.1021\/acsnano.3c00269","volume":"17","author":"Tang","year":"2023","journal-title":"ACS Nano"},{"key":"D5BM01399B\/cit21\/1","doi-asserted-by":"crossref","first-page":"e08400","DOI":"10.1002\/advs.202508400","volume":"12","author":"Wang","year":"2025","journal-title":"Adv. Sci."},{"key":"D5BM01399B\/cit22\/1","doi-asserted-by":"crossref","first-page":"5926","DOI":"10.1021\/acsnano.0c01336","volume":"14","author":"Yu","year":"2020","journal-title":"ACS Nano"},{"key":"D5BM01399B\/cit23\/1","doi-asserted-by":"crossref","first-page":"eabd7904","DOI":"10.1126\/sciadv.abd7904","volume":"10","author":"Zhu","year":"2024","journal-title":"Sci. Adv."},{"key":"D5BM01399B\/cit24\/1","doi-asserted-by":"crossref","first-page":"14928","DOI":"10.1021\/acsami.1c00430","volume":"13","author":"Yin","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D5BM01399B\/cit25\/1","doi-asserted-by":"crossref","first-page":"11023","DOI":"10.1021\/acsnano.5b04378","volume":"9","author":"Paris","year":"2015","journal-title":"ACS Nano"},{"key":"D5BM01399B\/cit26\/1","doi-asserted-by":"crossref","first-page":"2415814","DOI":"10.1002\/adma.202415814","volume":"37","author":"Wang","year":"2025","journal-title":"Adv. Mater."},{"key":"D5BM01399B\/cit27\/1","doi-asserted-by":"crossref","first-page":"e02783","DOI":"10.1002\/smll.202502783","volume":"21","author":"Xie","year":"2025","journal-title":"Small"},{"key":"D5BM01399B\/cit28\/1","doi-asserted-by":"crossref","first-page":"15055","DOI":"10.1021\/acsnano.5c01842","volume":"19","author":"Wang","year":"2025","journal-title":"ACS Nano"},{"key":"D5BM01399B\/cit29\/1","first-page":"371","volume":"54","author":"Yechuan","year":"2025","journal-title":"Bioact. Mater."},{"key":"D5BM01399B\/cit30\/1","doi-asserted-by":"crossref","first-page":"102071","DOI":"10.1016\/j.nantod.2023.102071","volume":"54","author":"Liu","year":"2024","journal-title":"Nano Today"},{"key":"D5BM01399B\/cit31\/1","doi-asserted-by":"crossref","first-page":"2006892","DOI":"10.1002\/adma.202006892","volume":"33","author":"Fu","year":"2021","journal-title":"Adv. Mater."},{"key":"D5BM01399B\/cit32\/1","doi-asserted-by":"crossref","first-page":"6050","DOI":"10.1038\/s41467-025-60858-3","volume":"16","author":"Cheng","year":"2025","journal-title":"Nat. Commun."},{"key":"D5BM01399B\/cit33\/1","doi-asserted-by":"crossref","first-page":"30033","DOI":"10.1021\/jacs.4c06338","volume":"146","author":"Wang","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"D5BM01399B\/cit34\/1","doi-asserted-by":"crossref","first-page":"2501435","DOI":"10.1002\/adma.202501435","volume":"37","author":"Wang","year":"2025","journal-title":"Adv. Mater."},{"key":"D5BM01399B\/cit35\/1","doi-asserted-by":"crossref","first-page":"9788","DOI":"10.1021\/nn2033105","volume":"5","author":"Gao","year":"2011","journal-title":"ACS Nano"},{"key":"D5BM01399B\/cit36\/1","doi-asserted-by":"crossref","first-page":"eaaz4462","DOI":"10.1126\/sciadv.aaz4462","volume":"6","author":"Hong","year":"2020","journal-title":"Sci. Adv."},{"key":"D5BM01399B\/cit37\/1","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1002\/smll.201101055","volume":"7","author":"Chen","year":"2011","journal-title":"Small"},{"key":"D5BM01399B\/cit38\/1","doi-asserted-by":"crossref","first-page":"9551","DOI":"10.1021\/acs.nanolett.1c03130","volume":"21","author":"Huang","year":"2021","journal-title":"Nano Lett."},{"key":"D5BM01399B\/cit39\/1","doi-asserted-by":"crossref","first-page":"2419209","DOI":"10.1002\/adma.202419209","volume":"37","author":"Qian","year":"2025","journal-title":"Adv. Mater."},{"key":"D5BM01399B\/cit40\/1","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/s41557-023-01183-4","volume":"15","author":"Zhao","year":"2023","journal-title":"Nat. Chem."}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/BM\/D5BM01399B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:00:30Z","timestamp":1783015230000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/14\/2\/462-471\/312260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,1,20]]}},"URL":"https:\/\/doi.org\/10.1039\/d5bm01399b","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}