{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:04:58Z","timestamp":1782936298838,"version":"3.54.5"},"reference-count":25,"publisher":"Royal Society of Chemistry (RSC)","issue":"73","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":216,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100008109","name":"University of Notre Dame","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000893","name":"Simons Foundation","doi-asserted-by":"publisher","award":["290363"],"award-info":[{"award-number":["290363"]}],"id":[{"id":"10.13039\/100000893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2325198"],"award-info":[{"award-number":["2325198"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32 AG087642"],"award-info":[{"award-number":["F32 AG087642"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Commun."],"abstract":"<jats:p>Nonenzymatic assembly of RNA from chemically activated building blocks, such as phosphorimidazolides, would have been essential for the emergence of ribozymes on the early Earth.<\/jats:p>","DOI":"10.1039\/d5cc03937a","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T19:00:58Z","timestamp":1754420458000},"page":"13920-13923","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Potentially prebiotic isocyanide activation chemistry drives RNA assembly"],"prefix":"10.1039","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6308-5257","authenticated-orcid":false,"given":"Stephanie J.","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9094-9882","authenticated-orcid":false,"given":"Xiwen","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9064-9131","authenticated-orcid":false,"given":"Saurja","family":"DasGupta","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA"},{"name":"Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4131-1203","authenticated-orcid":false,"given":"Jack W.","family":"Szostak","sequence":"additional","affiliation":[{"name":"Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA"},{"name":"Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5CC03937A\/cit1\/1","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/319618a0","volume":"319","author":"Gilbert","year":"1986","journal-title":"Nature"},{"key":"D5CC03937A\/cit2\/1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/35053176","volume":"409","author":"Szostak","year":"2001","journal-title":"Nature"},{"key":"D5CC03937A\/cit3\/1","doi-asserted-by":"crossref","first-page":"15961","DOI":"10.1021\/jacs.0c06722","volume":"142","author":"Zhou","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"D5CC03937A\/cit4\/1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1126\/science.161.3839.387","volume":"161","author":"Weimann","year":"1968","journal-title":"Science"},{"key":"D5CC03937A\/cit5\/1","doi-asserted-by":"crossref","first-page":"14810","DOI":"10.1021\/jacs.0c05300","volume":"142","author":"Zhang","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"D5CC03937A\/cit6\/1","doi-asserted-by":"crossref","first-page":"8657","DOI":"10.1021\/jacs.8b05189","volume":"140","author":"Mariani","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"D5CC03937A\/cit7\/1","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.1021\/acs.biochem.7b00792","volume":"56","author":"Walton","year":"2017","journal-title":"Biochemistry"},{"key":"D5CC03937A\/cit8\/1","doi-asserted-by":"crossref","first-page":"e2116429119","DOI":"10.1073\/pnas.2116429119","volume":"119","author":"Zhang","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5CC03937A\/cit9\/1","doi-asserted-by":"crossref","first-page":"6528","DOI":"10.1093\/nar\/gkad439","volume":"51","author":"Ding","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"D5CC03937A\/cit10\/1","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.1021\/ja9537134","volume":"118","author":"Rohatgi","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"D5CC03937A\/cit11\/1","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1021\/ja953712b","volume":"118","author":"Rohatgi","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"D5CC03937A\/cit12\/1","doi-asserted-by":"crossref","first-page":"e17756","DOI":"10.7554\/eLife.17756","volume":"5","author":"Prywes","year":"2016","journal-title":"eLife"},{"key":"D5CC03937A\/cit13\/1","doi-asserted-by":"crossref","first-page":"4398","DOI":"10.1073\/pnas.84.13.4398","volume":"84","author":"Joyce","year":"1987","journal-title":"Prac. Natl. Acad. Sci. U. S. A."},{"key":"D5CC03937A\/cit14\/1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S1074-5521(97)90245-3","volume":"4","author":"James","year":"1997","journal-title":"Chem. Biol."},{"key":"D5CC03937A\/cit15\/1","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1098\/rstb.2011.0140","volume":"366","author":"Szostak","year":"2011","journal-title":"Philos. Trans. R. Soc., B"},{"key":"D5CC03937A\/cit16\/1","first-page":"5741","volume":"118","author":"Walton","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5CC03937A\/cit17\/1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1759-2208-3-2","volume":"3","author":"Szostak","year":"2012","journal-title":"J. Syst. Chem."},{"key":"D5CC03937A\/cit18\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1261\/rna.077693.120","volume":"27","author":"Zhou","year":"2021","journal-title":"RNA"},{"key":"D5CC03937A\/cit19\/1","doi-asserted-by":"crossref","first-page":"11037","DOI":"10.1002\/anie.201704048","volume":"56","author":"Szostak","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5CC03937A\/cit20\/1","doi-asserted-by":"crossref","first-page":"10388","DOI":"10.1039\/C9CC05265H","volume":"55","author":"Todd","year":"2019","journal-title":"Chem. Commun."},{"key":"D5CC03937A\/cit21\/1","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1038\/s41467-018-04783-8","volume":"9","author":"Saha","year":"2018","journal-title":"Nat. Commun."},{"key":"D5CC03937A\/cit22\/1","doi-asserted-by":"crossref","first-page":"e202301376","DOI":"10.1002\/chem.202301376","volume":"29","author":"DasGupta","year":"2023","journal-title":"Chem. Eur. J."},{"key":"D5CC03937A\/cit23\/1","doi-asserted-by":"crossref","first-page":"e202113625","DOI":"10.1002\/anie.202113625","volume":"61","author":"Lin","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5CC03937A\/cit24\/1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3390\/life7010005","volume":"7","author":"Deamer","year":"2017","journal-title":"Life"},{"key":"D5CC03937A\/cit25\/1","doi-asserted-by":"crossref","first-page":"eadn9657","DOI":"10.1126\/sciadv.adn9657","volume":"10","author":"Agrawal","year":"2024","journal-title":"Sci. Adv."}],"container-title":["Chemical Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/CC\/D5CC03937A","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/CC\/D5CC03937A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:19:32Z","timestamp":1782929972000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cc\/article\/61\/73\/13920-13923\/883389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":25,"journal-issue":{"issue":"73","published-print":{"date-parts":[[2025,9,9]]}},"URL":"https:\/\/doi.org\/10.1039\/d5cc03937a","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5CC03937A\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5CC03937A\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5CC03937A\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5CC03937A\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5CC03937A\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5CC03937A\/v2\/response1","asserted-by":"object"}]},"ISSN":["1359-7345","1364-548X"],"issn-type":[{"value":"1359-7345","type":"print"},{"value":"1364-548X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}