{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:00:44Z","timestamp":1784588444757,"version":"3.55.0"},"reference-count":65,"publisher":"Royal Society of Chemistry (RSC)","issue":"2","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a Telov\u00fdchovy","doi-asserted-by":"publisher","award":["CZ.02.01.01\/00\/22_008\/0004558"],"award-info":[{"award-number":["CZ.02.01.01\/00\/22_008\/0004558"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004240","name":"Akademie Ved Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["Praemium Academiae"],"award-info":[{"award-number":["Praemium Academiae"]}],"id":[{"id":"10.13039\/501100004240","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Phys. Chem. Chem. Phys."],"abstract":"<jats:p>Selected ion flow tube mass spectrometry (SIFT-MS) is routinely used for real-time detection of volatile organic compounds (VOCs), including amines that are relevant in pharmaceutical, environmental, and food safety applications.<\/jats:p>","DOI":"10.1039\/d5cp03987h","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T08:20:43Z","timestamp":1766132443000},"page":"1963-1975","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["SIFT-MS analysis of amines: unusually efficient O\n                    <sub>2<\/sub>\n                    addition to the radical cation product"],"prefix":"10.1039","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0687-078X","authenticated-orcid":false,"given":"Christoph","family":"Schaefer","sequence":"first","affiliation":[{"name":"J. Heyrovsk\u00fd Institute of Physical Chemistry of the Czech Academy of Sciences, Dolej\u0161kova 3, 18223 Prague 8, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4247-3642","authenticated-orcid":false,"given":"Kseniya","family":"Dryahina","sequence":"additional","affiliation":[{"name":"J. Heyrovsk\u00fd Institute of Physical Chemistry of the Czech Academy of Sciences, Dolej\u0161kova 3, 18223 Prague 8, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9868-8282","authenticated-orcid":false,"given":"Patrik","family":"\u0160pan\u011bl","sequence":"additional","affiliation":[{"name":"J. Heyrovsk\u00fd Institute of Physical Chemistry of the Czech Academy of Sciences, Dolej\u0161kova 3, 18223 Prague 8, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Da Vinci Laboratory Solutions UK & Ireland Limited, Cambridge CB3 0NA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8059-5750","authenticated-orcid":false,"given":"Vaughan S.","family":"Langford","sequence":"additional","affiliation":[{"name":"Syft Technologies Limited, Christchurch 8011, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5CP03987H\/cit1\/1","volume-title":"Assessment report: Nitrosamine impurities in human medicinal products","year":"2020","unstructured":"European Medicines Agency,  Assessment report: Nitrosamine impurities in human medicinal products , Report EMA\/369136\/2020, European Medicines Agency, Amsterdam, The Netherlands,  2020"},{"key":"D5CP03987H\/cit2\/1","doi-asserted-by":"crossref","first-page":"105355","DOI":"10.1016\/j.yrtph.2023.105355","volume":"139","author":"Akkaraju","year":"2023","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"D5CP03987H\/cit3\/1","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.xphs.2022.11.013","volume":"112","author":"Schlingemann","year":"2023","journal-title":"J. Pharm. Sci."},{"key":"D5CP03987H\/cit4\/1","volume-title":"Control of Nitrosamine Impurities in Human Drugs: Guidance for Industry","year":"2024","unstructured":"U.S. Food and Drug Administration,  Control of Nitrosamine Impurities in Human Drugs: Guidance for Industry , Report FDA-2020-D-1530, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD,  2024"},{"key":"D5CP03987H\/cit5\/1","year":"1978","unstructured":"International Agency for Research on Cancer,  IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Volume 17: Some N-Nitroso Compounds , International Agency for Research on Cancer, Lyon, France,  1978"},{"key":"D5CP03987H\/cit6\/1","year":"2023","unstructured":"International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use,  ICH harmonised guideline: Assessment and control of DNA reactive (mutagenic) impurities in pharmaceuticals to limit potential carcinogenic risk , Report EMA\/CHMP\/ICH\/83812\/2013, ICH, Geneva, Switzerland,  2023"},{"key":"D5CP03987H\/cit7\/1","doi-asserted-by":"crossref","first-page":"116735","DOI":"10.1016\/j.ces.2021.116735","volume":"243","author":"Shewchuk","year":"2021","journal-title":"Chem. Eng. Sci."},{"key":"D5CP03987H\/cit8\/1","author":"Eide-Haugmo","year":"2009","unstructured":"I.Eide-Haugmo ,  O. G.Brakstad ,  K. A.Hoff ,  K. R.S\u00f8rheim ,  E. F.da Silva  and  H. F.Svendsen , presented in part at the Greenhouse Gas Control Technologies 9: Proceedings of the 9th International Conference on Greenhouse Gas Control Technologies (GHGT-9), Washington, DC, USA,  2009"},{"key":"D5CP03987H\/cit9\/1","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1021\/acssensors.2c00639","volume":"7","author":"Andre","year":"2022","journal-title":"ACS Sens."},{"key":"D5CP03987H\/cit10\/1","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1007\/s13197-020-04686-x","volume":"58","author":"Sivamaruthi","year":"2021","journal-title":"J. Food Sci. Technol."},{"key":"D5CP03987H\/cit11\/1","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1002\/jsfa.7570","volume":"96","author":"Dehaut","year":"2016","journal-title":"J. Sci. Food Agric."},{"key":"D5CP03987H\/cit12\/1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0003-2670(02)00378-1","volume":"463","author":"Karpas","year":"2002","journal-title":"Anal. Chim. Acta"},{"key":"D5CP03987H\/cit13\/1","doi-asserted-by":"crossref","first-page":"e24501","DOI":"10.1016\/j.heliyon.2024.e24501","volume":"10","author":"Turna","year":"2024","journal-title":"Heliyon"},{"key":"D5CP03987H\/cit14\/1","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.3389\/fmicb.2016.01218","volume":"7","author":"Gardini","year":"2016","journal-title":"Front. Microbiol."},{"key":"D5CP03987H\/cit15\/1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0308-8146(96)00031-3","volume":"57","author":"Veciana-Nogues","year":"1996","journal-title":"Food Chem."},{"key":"D5CP03987H\/cit16\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9673(03)01296-2","volume":"1016","author":"Namiesnik","year":"2003","journal-title":"J. Chromatogr. A"},{"key":"D5CP03987H\/cit17\/1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1080\/10408340903517495","volume":"40","author":"Fekete","year":"2010","journal-title":"Crit. Rev. Anal. Chem."},{"key":"D5CP03987H\/cit18\/1","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1080\/19440049.2013.775606","volume":"30","author":"Viana","year":"2013","journal-title":"Food Addit. Contam.,:Part A"},{"key":"D5CP03987H\/cit19\/1","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1016\/j.chroma.2008.08.102","volume":"1216","author":"Vanhoenacker","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"D5CP03987H\/cit20\/1","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1039\/D3AY00956D","volume":"15","author":"You","year":"2023","journal-title":"Anal. Methods"},{"key":"D5CP03987H\/cit21\/1","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1021\/jasms.3c00312","volume":"34","author":"Langford","year":"2023","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"D5CP03987H\/cit22\/1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/mas.21835","volume":"44","author":"Smith","year":"2022","journal-title":"Mass Spectrom. Rev."},{"key":"D5CP03987H\/cit23\/1","doi-asserted-by":"crossref","first-page":"12750","DOI":"10.1021\/acs.analchem.0c03050","volume":"92","author":"Smith","year":"2020","journal-title":"Anal. Chem."},{"key":"D5CP03987H\/cit24\/1","doi-asserted-by":"crossref","first-page":"12046","DOI":"10.1021\/jp0550614","volume":"109","author":"Hammerum","year":"2005","journal-title":"J. Phys. Chem. A"},{"key":"D5CP03987H\/cit25\/1","doi-asserted-by":"crossref","first-page":"5524","DOI":"10.1002\/chem.200400401","volume":"10","author":"Janovsky","year":"2004","journal-title":"Chem. \u2013 Eur. J."},{"key":"D5CP03987H\/cit26\/1","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1016\/S0040-4039(00)98310-2","volume":"26","author":"Sozzi","year":"1985","journal-title":"Tetrahedron Lett."},{"key":"D5CP03987H\/cit27\/1","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1021\/ja00220a023","volume":"110","author":"Bjoernholm","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"D5CP03987H\/cit28\/1","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1021\/jp076395r","volume":"112","author":"Clarke","year":"2008","journal-title":"J. Phys. Chem. A"},{"key":"D5CP03987H\/cit29\/1","doi-asserted-by":"crossref","first-page":"11002","DOI":"10.1039\/c2cp41306j","volume":"14","author":"Sch\u00fcmperli","year":"2012","journal-title":"Phys. Chem. Chem. Phys."},{"key":"D5CP03987H\/cit30\/1","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1007\/s13361-014-0945-5","volume":"25","author":"Jariwala","year":"2014","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"D5CP03987H\/cit31\/1","doi-asserted-by":"crossref","first-page":"16719","DOI":"10.1039\/c2cp43507a","volume":"14","author":"Kirk","year":"2012","journal-title":"Phys. Chem. Chem. Phys."},{"key":"D5CP03987H\/cit32\/1","doi-asserted-by":"crossref","first-page":"20577","DOI":"10.1039\/c3cp53690d","volume":"15","author":"Prendergast","year":"2013","journal-title":"Phys. Chem. Chem. Phys."},{"key":"D5CP03987H\/cit33\/1","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1039\/D4SC06333C","volume":"16","author":"Shiels","year":"2025","journal-title":"Chem. Sci."},{"key":"D5CP03987H\/cit34\/1","doi-asserted-by":"crossref","first-page":"7424","DOI":"10.3390\/ijms24087424","volume":"24","author":"Ortega","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D5CP03987H\/cit35\/1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1039\/B614390C","volume":"9","author":"Harvey","year":"2007","journal-title":"Phys. Chem. Chem. Phys."},{"key":"D5CP03987H\/cit36\/1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0168-1176(95)04353-5","volume":"153","author":"Bouchoux","year":"1996","journal-title":"Int. J. Mass Spectrom. Ion Processes"},{"key":"D5CP03987H\/cit37\/1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1063\/1.556018","volume":"27","author":"Hunter","year":"1998","journal-title":"J. Phys. Chem. Ref. Data"},{"key":"D5CP03987H\/cit38\/1","volume-title":"NIST Chemistry WebBook, NIST Standard Reference Database Number 69","author":"Linstrom","year":"2025","unstructured":"P. J.Linstrom  and  W. G.Mallard ,  NIST Chemistry WebBook, NIST Standard Reference Database Number 69 ,  National Institute of Standards and Technology ,  Gaithersburg MD ,  2025"},{"key":"D5CP03987H\/cit39\/1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ijms.2010.11.021","volume":"300","author":"Sovov\u00e1","year":"2011","journal-title":"Int. J. Mass Spectrom."},{"key":"D5CP03987H\/cit40\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2199(08)60229-8","volume":"24","author":"Smith","year":"1988","journal-title":"Adv. At. Mol. Phys."},{"key":"D5CP03987H\/cit41\/1","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.1063\/1.442828","volume":"76","author":"Su","year":"1982","journal-title":"J. Chem. Phys."},{"key":"D5CP03987H\/cit42\/1","first-page":"e70019","volume":"15","author":"Neese","year":"2025","journal-title":"Wiley Interdiscip. Rev.: Comput. Mol. Sci."},{"key":"D5CP03987H\/cit43\/1","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1002\/jcc.10318","volume":"24","author":"Neese","year":"2003","journal-title":"J. Comput. Chem."},{"key":"D5CP03987H\/cit44\/1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.chemphys.2008.10.036","volume":"356","author":"Neese","year":"2009","journal-title":"Chem. Phys."},{"key":"D5CP03987H\/cit45\/1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1758-2946-4-17","volume":"4","author":"Hanwell","year":"2012","journal-title":"J. Cheminf."},{"key":"D5CP03987H\/cit46\/1","doi-asserted-by":"crossref","first-page":"8499","DOI":"10.1039\/D0CP00502A","volume":"22","author":"Caldeweyher","year":"2020","journal-title":"Phys. Chem. Chem. Phys."},{"key":"D5CP03987H\/cit47\/1","doi-asserted-by":"crossref","first-page":"21379","DOI":"10.1039\/D4CP01514B","volume":"26","author":"Wittmann","year":"2024","journal-title":"Phys. Chem. Chem. Phys."},{"key":"D5CP03987H\/cit48\/1","doi-asserted-by":"crossref","first-page":"034112","DOI":"10.1063\/1.4993215","volume":"147","author":"Caldeweyher","year":"2017","journal-title":"J. Chem. Phys."},{"key":"D5CP03987H\/cit49\/1","doi-asserted-by":"crossref","first-page":"8579","DOI":"10.1021\/jp011702t","volume":"105","author":"Flammang","year":"2001","journal-title":"J. Phys. Chem. A"},{"key":"D5CP03987H\/cit50\/1","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.jasms.2006.03.008","volume":"17","author":"Tomazela","year":"2006","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"D5CP03987H\/cit51\/1","doi-asserted-by":"crossref","first-page":"7169","DOI":"10.1039\/C9CP06869D","volume":"22","author":"Pracht","year":"2020","journal-title":"Phys. Chem. Chem. Phys."},{"key":"D5CP03987H\/cit52\/1","volume-title":"Thermochemistry in Gaussian","author":"Ochterski","year":"2000","unstructured":"J. W.Ochterski ,  Thermochemistry in Gaussian ,  Gaussian, Inc. ,  Pittsburg, PA ,  2000"},{"key":"D5CP03987H\/cit53\/1","doi-asserted-by":"publisher","DOI":"10.48700\/datst.zkt15-an280","volume-title":"Data on \u2018SIFT-MS Analysis of Amines: Unusually efficient O2 Addition to the Radical Cation Product\u2019","author":"Schaefer","year":"2025","unstructured":"C.Schaefer ,  K.Dryahina ,  P.\u0160pan\u011bl ,  M. J.Perkins  and  V. S.Langford ,  Data on \u2018SIFT-MS Analysis of Amines: Unusually efficient O2 Addition to the Radical Cation Product\u2019 ,  National Data Repository ,  2025 10.48700\/datst.zkt15-an280"},{"key":"D5CP03987H\/cit54\/1","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1063\/1.1743639","volume":"26","author":"Watanabe","year":"1957","journal-title":"J. Chem. Phys."},{"key":"D5CP03987H\/cit55\/1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S1387-3806(98)14031-9","volume":"176","author":"\u0160pan\u011bl","year":"1998","journal-title":"Int. J. Mass Spectrom."},{"key":"D5CP03987H\/cit56\/1","doi-asserted-by":"crossref","first-page":"7359","DOI":"10.1039\/C9AN01478K","volume":"144","author":"Pugliese","year":"2019","journal-title":"Analyst"},{"key":"D5CP03987H\/cit57\/1","doi-asserted-by":"crossref","first-page":"9733","DOI":"10.1021\/acs.jpca.8b08580","volume":"122","author":"Spesyvyi","year":"2018","journal-title":"J. Phys. Chem. A"},{"key":"D5CP03987H\/cit58\/1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0020-7381(76)80133-7","volume":"21","author":"Adams","year":"1976","journal-title":"Int. J. Mass Spectrom. Ion Phys."},{"key":"D5CP03987H\/cit59\/1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0040-4039(81)80175-X","volume":"22","author":"Hammerum","year":"1981","journal-title":"Tetrahedron Lett."},{"key":"D5CP03987H\/cit60\/1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1021\/jasms.0c00386","volume":"32","author":"Shiels","year":"2021","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"D5CP03987H\/cit61\/1","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1021\/ja00244a009","volume":"109","author":"Yates","year":"1987","journal-title":"J. Am. Chem. Soc."},{"key":"D5CP03987H\/cit62\/1","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1039\/D3AN00545C","volume":"148","author":"Haack","year":"2023","journal-title":"Analyst"},{"key":"D5CP03987H\/cit63\/1","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1007\/s13361-017-1661-8","volume":"28","author":"Shrivastav","year":"2017","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"D5CP03987H\/cit64\/1","doi-asserted-by":"crossref","first-page":"e9767","DOI":"10.1002\/rcm.9767","volume":"38","author":"Gnioua","year":"2024","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"D5CP03987H\/cit65\/1","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1002\/rcm.7679","volume":"30","author":"Spesyvyi","year":"2016","journal-title":"Rapid Commun. Mass Spectrom."}],"container-title":["Physical Chemistry Chemical Physics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/CP\/D5CP03987H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:16:11Z","timestamp":1783448171000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cp\/article\/28\/2\/1963-1975\/887625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,1,14]]}},"URL":"https:\/\/doi.org\/10.1039\/d5cp03987h","relation":{"has-preprint":[{"id-type":"doi","id":"10.26434\/chemrxiv-2025-3g3fp","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.1039\/D5CP03987H\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5CP03987H\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5CP03987H\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5CP03987H\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5CP03987H\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5CP03987H\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1463-9076","1463-9084"],"issn-type":[{"value":"1463-9076","type":"print"},{"value":"1463-9084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}