{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:36:08Z","timestamp":1793424968044,"version":"4.5.0"},"reference-count":132,"publisher":"Royal Society of Chemistry (RSC)","issue":"37","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"am","delay-in-days":573,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2021\/002267"],"award-info":[{"award-number":["CRG\/2021\/002267"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004728","name":"VIT University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004728","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Dalton Trans."],"abstract":"<jats:p>This review explores how nanocarriers improve targeted delivery and efficacy of metallic anticancer drugs while addressing toxicity and resistance, highlighting advances and promoting research to optimize metal-based therapies for better outcome.<\/jats:p>","DOI":"10.1039\/d5dt01704a","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T07:40:37Z","timestamp":1753688437000},"page":"13820-13850","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Advances in nano-drug delivery systems for metallic compounds in cancer therapy: challenges and future perspectives"],"prefix":"10.1039","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6866-5944","authenticated-orcid":false,"given":"Subin","family":"Joseph","sequence":"first","affiliation":[{"name":"Centre for Nanotechnology Research (CNR), Vellore Institute of Technology, Vellore-632014, Tamil Nadu, India"},{"name":"Department of Chemistry, School of Advanced Sciences (SAS), Vellore Institute of Technology, Vellore-632014, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7524-3152","authenticated-orcid":false,"given":"Rinku","family":"Chakrabarty","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Alipurduar University, Alipurduar-736122, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1698-4895","authenticated-orcid":false,"given":"Priyankar","family":"Paira","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Advanced Sciences (SAS), Vellore Institute of Technology, Vellore-632014, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5DT01704A\/cit1\/1","first-page":"229","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"D5DT01704A\/cit2\/1","doi-asserted-by":"crossref","first-page":"316","DOI":"10.2174\/1874467211666180813095050","volume":"11","author":"Hua","year":"2018","journal-title":"Curr. Mol. Pharmacol."},{"key":"D5DT01704A\/cit3\/1","doi-asserted-by":"crossref","first-page":"10596","DOI":"10.1039\/C7NR09606B","volume":"10","author":"Gill","year":"2018","journal-title":"Nanoscale"},{"key":"D5DT01704A\/cit4\/1","doi-asserted-by":"crossref","first-page":"12966","DOI":"10.1039\/C6DT02152B","volume":"45","author":"Hoeschele","year":"2016","journal-title":"Dalton Trans."},{"key":"D5DT01704A\/cit5\/1","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1021\/acs.chemrev.5b00597","volume":"116","author":"Johnstone","year":"2016","journal-title":"Chem. Rev."},{"key":"D5DT01704A\/cit6\/1","doi-asserted-by":"crossref","first-page":"10835","DOI":"10.1039\/D2DT01875F","volume":"51","author":"Alassadi","year":"2022","journal-title":"Dalton Trans."},{"key":"D5DT01704A\/cit7\/1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41568-020-00308-y","volume":"21","author":"Rottenberg","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"D5DT01704A\/cit8\/1","doi-asserted-by":"crossref","first-page":"824","DOI":"10.3390\/molecules29040824","volume":"29","author":"Lucaciu","year":"2024","journal-title":"Molecules"},{"key":"D5DT01704A\/cit9\/1","doi-asserted-by":"crossref","first-page":"780","DOI":"10.3390\/cancers11060780","volume":"11","author":"M\u00e1rmol","year":"2019","journal-title":"Cancers"},{"key":"D5DT01704A\/cit10\/1","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.2147\/DDDT.S275007","volume":"14","author":"Lee","year":"2020","journal-title":"Drug Des., Dev. Ther."},{"key":"D5DT01704A\/cit11\/1","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.3390\/molecules24101995","volume":"24","author":"Alessio","year":"2019","journal-title":"Molecules"},{"key":"D5DT01704A\/cit12\/1","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.3390\/ph16121729","volume":"16","author":"D'Amato","year":"2023","journal-title":"Pharmaceuticals"},{"key":"D5DT01704A\/cit13\/1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1039\/D1MD00220A","volume":"13","author":"Sonkar","year":"2022","journal-title":"RSC Med. Chem."},{"key":"D5DT01704A\/cit14\/1","doi-asserted-by":"crossref","first-page":"8608","DOI":"10.1021\/jm100801e","volume":"53","author":"Rubbiani","year":"2010","journal-title":"J. Med. Chem."},{"key":"D5DT01704A\/cit15\/1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bcp.2009.07.023","volume":"79","author":"Gandin","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"D5DT01704A\/cit16\/1","doi-asserted-by":"crossref","first-page":"20670","DOI":"10.1021\/acsomega.3c08890","volume":"9","author":"Roy","year":"2024","journal-title":"ACS Omega"},{"key":"D5DT01704A\/cit17\/1","doi-asserted-by":"crossref","first-page":"739481","DOI":"10.3389\/fphar.2021.739481","volume":"12","author":"Zhou","year":"2021","journal-title":"Front. Pharmacol."},{"key":"D5DT01704A\/cit18\/1","doi-asserted-by":"crossref","first-page":"e202400060","DOI":"10.1002\/cmdc.202400060","volume":"19","author":"Wang","year":"2024","journal-title":"ChemMedChem"},{"key":"D5DT01704A\/cit19\/1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3390\/biom10020240","volume":"10","author":"Hu","year":"2020","journal-title":"Biomolecules"},{"key":"D5DT01704A\/cit20\/1","doi-asserted-by":"crossref","first-page":"5744","DOI":"10.1021\/acs.jmedchem.3c02378","volume":"67","author":"Man","year":"2024","journal-title":"J. Med. Chem."},{"key":"D5DT01704A\/cit21\/1","doi-asserted-by":"crossref","first-page":"16296","DOI":"10.1021\/acs.jmedchem.4c01175","volume":"67","author":"Jiang","year":"2024","journal-title":"J. Med. Chem."},{"key":"D5DT01704A\/cit22\/1","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.1021\/acs.jmedchem.3c02227","volume":"67","author":"Li","year":"2024","journal-title":"J. Med. Chem."},{"key":"D5DT01704A\/cit23\/1","doi-asserted-by":"crossref","first-page":"5669","DOI":"10.1021\/acs.jmedchem.3c00001","volume":"66","author":"Zhang","year":"2023","journal-title":"J. Med. Chem."},{"key":"D5DT01704A\/cit24\/1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s12598-024-02871-x","volume":"44","author":"Li","year":"2025","journal-title":"Rare Met."},{"key":"D5DT01704A\/cit25\/1","doi-asserted-by":"crossref","first-page":"8564","DOI":"10.1021\/acs.jmedchem.3c00248","volume":"66","author":"Li","year":"2023","journal-title":"J. Med. Chem."},{"key":"D5DT01704A\/cit26\/1","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1007\/s12598-024-03058-0","volume":"44","author":"Man","year":"2025","journal-title":"Rare Met."},{"key":"D5DT01704A\/cit27\/1","doi-asserted-by":"crossref","first-page":"30637","DOI":"10.1021\/acsami.5c03956","volume":"17","author":"Lu","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D5DT01704A\/cit28\/1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s13346-021-00908-7","volume":"11","author":"Plaza-Oliver","year":"2021","journal-title":"Drug Delivery Transl. Res."},{"key":"D5DT01704A\/cit29\/1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1021\/acsmaterialsau.3c00032","volume":"3","author":"Mehta","year":"2023","journal-title":"ACS Mater. Au"},{"key":"D5DT01704A\/cit30\/1","doi-asserted-by":"crossref","first-page":"128331","DOI":"10.1016\/j.talanta.2025.128331","volume":"295","author":"St\u0119pie\u0144","year":"2025","journal-title":"Talanta"},{"key":"D5DT01704A\/cit31\/1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.3390\/pharmaceutics14030543","volume":"14","author":"Lombardo","year":"2022","journal-title":"Pharmaceutics"},{"key":"D5DT01704A\/cit32\/1","first-page":"1005","volume":"9","author":"Hafner","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"D5DT01704A\/cit33\/1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ejps.2017.09.041","volume":"111","author":"Chen","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"D5DT01704A\/cit34\/1","doi-asserted-by":"crossref","first-page":"144357","DOI":"10.1016\/j.ijbiomac.2025.144357","author":"Wu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"D5DT01704A\/cit35\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1556-276X-8-102","volume":"8","author":"Akbarzadeh","year":"2013","journal-title":"Nanoscale Res. Lett."},{"key":"D5DT01704A\/cit36\/1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/pharmaceutics9020012","volume":"9","author":"Bulbake","year":"2017","journal-title":"Pharmaceutics"},{"key":"D5DT01704A\/cit37\/1","doi-asserted-by":"crossref","first-page":"103045","DOI":"10.1016\/j.jddst.2021.103045","volume":"67","author":"Tasharrofi","year":"2022","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"D5DT01704A\/cit38\/1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.apsb.2018.06.005","volume":"9","author":"He","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"D5DT01704A\/cit39\/1","doi-asserted-by":"crossref","first-page":"101509","DOI":"10.1016\/j.jddst.2020.101509","volume":"56","author":"Mehta","year":"2020","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"D5DT01704A\/cit40\/1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s00403-011-1166-4","volume":"303","author":"Pierre","year":"2011","journal-title":"Arch. Dermatol. Res."},{"key":"D5DT01704A\/cit41\/1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3390\/pharmaceutics12060559","volume":"12","author":"Cevenini","year":"2020","journal-title":"Pharmaceutics"},{"key":"D5DT01704A\/cit42\/1","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1002\/adhm.201400738","volume":"4","author":"Kirui","year":"2015","journal-title":"Adv. Healthc. Mater."},{"key":"D5DT01704A\/cit43\/1","doi-asserted-by":"crossref","first-page":"14587","DOI":"10.1021\/acs.jmedchem.1c01068","volume":"64","author":"Jiang","year":"2021","journal-title":"J. Med. Chem."},{"key":"D5DT01704A\/cit44\/1","doi-asserted-by":"crossref","first-page":"7585","DOI":"10.1021\/acsabm.4c01165","volume":"7","author":"Opoku-Damoah","year":"2024","journal-title":"ACS Appl. Bio Mater."},{"key":"D5DT01704A\/cit45\/1","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1021\/acsabm.2c00231","volume":"5","author":"Sumithaa","year":"2022","journal-title":"ACS Appl. Bio Mater."},{"key":"D5DT01704A\/cit46\/1","doi-asserted-by":"crossref","first-page":"5310","DOI":"10.1021\/acsabm.3c00587","volume":"6","author":"Siva","year":"2023","journal-title":"ACS Appl. Bio Mater."},{"key":"D5DT01704A\/cit47\/1","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1039\/D3BM01514A","volume":"12","author":"Li","year":"2023","journal-title":"Biomater. Sci."},{"key":"D5DT01704A\/cit48\/1","doi-asserted-by":"crossref","first-page":"20047","DOI":"10.1039\/D0NJ03664A","volume":"44","author":"Gopalakrishnan","year":"2020","journal-title":"New J. Chem."},{"key":"D5DT01704A\/cit49\/1","doi-asserted-by":"crossref","first-page":"903210","DOI":"10.3389\/fphar.2022.903210","volume":"13","author":"Liew","year":"2022","journal-title":"Front. Pharmacol."},{"key":"D5DT01704A\/cit50\/1","doi-asserted-by":"crossref","first-page":"13113","DOI":"10.1021\/acs.jmedchem.5c01235","volume":"68","author":"Zhu","year":"2025","journal-title":"J. Med. Chem."},{"key":"D5DT01704A\/cit51\/1","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1021\/acs.langmuir.2c02910","volume":"39","author":"Idlas","year":"2023","journal-title":"Langmuir"},{"key":"D5DT01704A\/cit52\/1","first-page":"1","volume":"3","author":"Gaballa","year":"2020","journal-title":"J. Adv. Biomed. Pharm. Sci."},{"key":"D5DT01704A\/cit53\/1","doi-asserted-by":"crossref","first-page":"100561","DOI":"10.1016\/j.colcom.2021.100561","volume":"46","author":"Varghese","year":"2022","journal-title":"Colloid Interface Sci. Commun."},{"key":"D5DT01704A\/cit54\/1","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1039\/D2QI02678C","volume":"10","author":"Giacomazzo","year":"2023","journal-title":"Inorg. Chem. Front."},{"key":"D5DT01704A\/cit55\/1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3390\/nano6020026","volume":"6","author":"Wang","year":"2016","journal-title":"Nanomaterials"},{"key":"D5DT01704A\/cit56\/1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/pi.2010","volume":"55","author":"Fukushima","year":"2006","journal-title":"Polym. Int."},{"key":"D5DT01704A\/cit57\/1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/B978-0-12-814029-1.00018-1","volume-title":"Applications of Targeted Nano Drugs and Delivery Systems: Nanoscience and Nanotechnology in Drug Delivery","author":"Sharma","year":"2019","unstructured":"M.Sharma ,  Transdermal and intravenous nano drug delivery systems: present and future ,  Applications of Targeted Nano Drugs and Delivery Systems: Nanoscience and Nanotechnology in Drug Delivery ,  2019 , pp.  499\u2013550"},{"key":"D5DT01704A\/cit58\/1","doi-asserted-by":"crossref","first-page":"100048","DOI":"10.1016\/j.onano.2022.100048","volume":"7","author":"Herdiana","year":"2022","journal-title":"OpenNano"},{"key":"D5DT01704A\/cit59\/1","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.3390\/nano10071403","volume":"10","author":"Begines","year":"2020","journal-title":"Nanomaterials"},{"key":"D5DT01704A\/cit60\/1","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1021\/acsabm.2c00998","volume":"6","author":"Sumit","year":"2023","journal-title":"ACS Appl. Bio Mater."},{"key":"D5DT01704A\/cit61\/1","first-page":"5496","volume":"21","author":"Das","year":"2024","journal-title":"Mol. Pharm."},{"key":"D5DT01704A\/cit62\/1","doi-asserted-by":"crossref","first-page":"13576","DOI":"10.1021\/acs.inorgchem.2c02214","volume":"61","author":"Vinck","year":"2022","journal-title":"Inorg. Chem."},{"key":"D5DT01704A\/cit63\/1","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1021\/acs.biomac.1c01651","volume":"23","author":"He","year":"2022","journal-title":"Biomacromolecules"},{"key":"D5DT01704A\/cit64\/1","doi-asserted-by":"crossref","first-page":"12870","DOI":"10.1021\/acs.inorgchem.4c01323","volume":"63","author":"Coloma","year":"2024","journal-title":"Inorg. Chem."},{"key":"D5DT01704A\/cit65\/1","doi-asserted-by":"crossref","first-page":"8945","DOI":"10.1039\/D2TB01280D","volume":"10","author":"Maciel","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"D5DT01704A\/cit66\/1","doi-asserted-by":"crossref","first-page":"43345","DOI":"10.1021\/acsami.3c07157","volume":"15","author":"Pragti","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D5DT01704A\/cit67\/1","doi-asserted-by":"crossref","first-page":"16500","DOI":"10.1039\/D4NR01901F","volume":"16","author":"Watson","year":"2024","journal-title":"Nanoscale"},{"key":"D5DT01704A\/cit68\/1","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1021\/acs.nanolett.0c04915","volume":"21","author":"Wang","year":"2021","journal-title":"Nano Lett."},{"key":"D5DT01704A\/cit69\/1","doi-asserted-by":"crossref","first-page":"6283","DOI":"10.1021\/acs.inorgchem.1c00001","volume":"60","author":"Pal","year":"2021","journal-title":"Inorg. Chem."},{"key":"D5DT01704A\/cit70\/1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.canlet.2016.01.006","volume":"372","author":"Jing","year":"2016","journal-title":"Cancer Lett."},{"key":"D5DT01704A\/cit71\/1","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.1038\/onc.2014.404","volume":"34","author":"Zhang","year":"2015","journal-title":"Oncogene"},{"key":"D5DT01704A\/cit72\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers12092351","volume":"12","author":"Bruce","year":"2020","journal-title":"Cancers"},{"key":"D5DT01704A\/cit73\/1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.semcancer.2019.12.006","volume":"72","author":"O'Grady","year":"2021","journal-title":"Semin. Cancer Biol."},{"key":"D5DT01704A\/cit74\/1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.molmed.2010.01.005","volume":"16","author":"Prevarskaya","year":"2010","journal-title":"Trends Mol. Med."},{"key":"D5DT01704A\/cit75\/1","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1039\/D2QI00951J","volume":"9","author":"Shen","year":"2022","journal-title":"Inorg. Chem. Front."},{"key":"D5DT01704A\/cit76\/1","doi-asserted-by":"crossref","first-page":"4394","DOI":"10.1021\/acsabm.1c00151","volume":"4","author":"Karges","year":"2021","journal-title":"ACS Appl. Bio Mater."},{"key":"D5DT01704A\/cit77\/1","first-page":"032019","volume":"263","author":"Ealias","year":"2017","journal-title":"IOP Conf. Ser.: Mater. Sci. Eng."},{"key":"D5DT01704A\/cit78\/1","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1007\/s10311-020-01033-6","volume":"18","author":"Sengul","year":"2020","journal-title":"Environ. Chem. Lett."},{"key":"D5DT01704A\/cit79\/1","doi-asserted-by":"crossref","first-page":"13376","DOI":"10.1039\/D4CC04276J","volume":"60","author":"Babu","year":"2024","journal-title":"Chem. Commun."},{"key":"D5DT01704A\/cit80\/1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1021\/jacs.2c09820","volume":"145","author":"Marciano","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"D5DT01704A\/cit81\/1","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.ijbiomac.2018.11.053","volume":"123","author":"Rabbani","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"D5DT01704A\/cit82\/1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jconrel.2014.03.013","volume":"190","author":"Kratz","year":"2014","journal-title":"J. Controlled Release"},{"key":"D5DT01704A\/cit83\/1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.mam.2011.12.002","volume":"33","author":"Fanali","year":"2012","journal-title":"Mol. Aspects Med."},{"key":"D5DT01704A\/cit84\/1","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1039\/C5CS00158G","volume":"45","author":"Liu","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"D5DT01704A\/cit85\/1","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1021\/acs.molpharmaceut.7b00976","volume":"15","author":"Rabbani","year":"2018","journal-title":"Mol. Pharm."},{"key":"D5DT01704A\/cit86\/1","doi-asserted-by":"crossref","first-page":"9447","DOI":"10.1021\/acs.jmedchem.2c00698","volume":"65","author":"Jiang","year":"2022","journal-title":"J. Med. Chem."},{"key":"D5DT01704A\/cit87\/1","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1021\/acs.molpharmaceut.3c00881","volume":"21","author":"Xu","year":"2024","journal-title":"Mol. Pharm."},{"key":"D5DT01704A\/cit88\/1","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.1021\/acs.jmedchem.1c01790","volume":"65","author":"Zhang","year":"2022","journal-title":"J. Med. Chem."},{"key":"D5DT01704A\/cit89\/1","doi-asserted-by":"crossref","first-page":"6006","DOI":"10.1007\/s12598-024-02759-w","volume":"43","author":"Man","year":"2024","journal-title":"Rare Met."},{"key":"D5DT01704A\/cit90\/1","doi-asserted-by":"crossref","first-page":"14900","DOI":"10.1073\/pnas.1407808111","volume":"111","author":"Liang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5DT01704A\/cit91\/1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ijbiomac.2022.10.126","volume":"224","author":"Sudarev","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"D5DT01704A\/cit92\/1","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1021\/ic701740q","volume":"47","author":"Klem","year":"2008","journal-title":"Inorg. Chem."},{"key":"D5DT01704A\/cit93\/1","doi-asserted-by":"crossref","first-page":"14077","DOI":"10.1016\/S0021-9258(19)49681-6","volume":"267","author":"Santambrogio","year":"1992","journal-title":"J. Biol. Chem."},{"key":"D5DT01704A\/cit94\/1","doi-asserted-by":"crossref","first-page":"16527","DOI":"10.1021\/ja807655t","volume":"130","author":"Kang","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"D5DT01704A\/cit95\/1","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.bbagen.2009.12.005","volume":"1800","author":"Uchida","year":"2010","journal-title":"Biochim. Biophys. Acta, Gen. Subj."},{"key":"D5DT01704A\/cit96\/1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s11427-021-1976-0","volume":"65","author":"Jiang","year":"2022","journal-title":"Sci. China: Life Sci."},{"key":"D5DT01704A\/cit97\/1","first-page":"2619","volume":"10","author":"Cai","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"D5DT01704A\/cit98\/1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nnano.2012.90","volume":"7","author":"Fan","year":"2012","journal-title":"Nat. Nanotechnol."},{"key":"D5DT01704A\/cit99\/1","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1021\/acsnano.7b06969","volume":"12","author":"Fan","year":"2018","journal-title":"ACS Nano"},{"key":"D5DT01704A\/cit100\/1","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1073\/pnas.0913192107","volume":"107","author":"Li","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5DT01704A\/cit101\/1","doi-asserted-by":"crossref","first-page":"5909","DOI":"10.1021\/acsami.4c18072","volume":"17","author":"Tang","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D5DT01704A\/cit102\/1","doi-asserted-by":"crossref","first-page":"30824","DOI":"10.1021\/acsami.6b11798","volume":"8","author":"Ghosh","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D5DT01704A\/cit103\/1","doi-asserted-by":"crossref","first-page":"22756","DOI":"10.1021\/acsami.6b07038","volume":"8","author":"Li","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D5DT01704A\/cit104\/1","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1039\/b705326f","author":"Yang","year":"2007","journal-title":"Chem. Commun."},{"key":"D5DT01704A\/cit105\/1","doi-asserted-by":"crossref","first-page":"38959","DOI":"10.1021\/acsami.1c07223","volume":"13","author":"Xiong","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D5DT01704A\/cit106\/1","doi-asserted-by":"crossref","first-page":"e202411846","DOI":"10.1002\/anie.202411846","volume":"63","author":"Man","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5DT01704A\/cit107\/1","doi-asserted-by":"crossref","first-page":"19573","DOI":"10.1021\/acs.jmedchem.4c01908","volume":"67","author":"Xu","year":"2024","journal-title":"J. Med. Chem."},{"key":"D5DT01704A\/cit108\/1","doi-asserted-by":"crossref","first-page":"17243","DOI":"10.1021\/acs.jmedchem.4c01133","volume":"67","author":"Li","year":"2024","journal-title":"J. Med. Chem."},{"key":"D5DT01704A\/cit109\/1","doi-asserted-by":"crossref","first-page":"15606","DOI":"10.1021\/acs.jmedchem.4c01273","volume":"67","author":"Man","year":"2024","journal-title":"J. Med. Chem."},{"key":"D5DT01704A\/cit110\/1","doi-asserted-by":"crossref","first-page":"7268","DOI":"10.1021\/acs.jmedchem.2c01904","volume":"66","author":"Man","year":"2023","journal-title":"J. Med. Chem."},{"key":"D5DT01704A\/cit111\/1","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1080\/10408398.2017.1381583","volume":"59","author":"Wang","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"D5DT01704A\/cit112\/1","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.3390\/nu12092562","volume":"12","author":"Superti","year":"2020","journal-title":"Nutrients"},{"key":"D5DT01704A\/cit113\/1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3390\/biom10030456","volume":"10","author":"Cutone","year":"2020","journal-title":"Biomolecules"},{"key":"D5DT01704A\/cit114\/1","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.ijbiomac.2020.07.167","volume":"164","author":"Sabra","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"D5DT01704A\/cit115\/1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1139\/bcb-2016-0175","volume":"95","author":"Arias","year":"2017","journal-title":"Biochem. Cell Biol."},{"key":"D5DT01704A\/cit116\/1","doi-asserted-by":"crossref","first-page":"120355","DOI":"10.1016\/j.biomaterials.2020.120355","volume":"263","author":"Elzoghby","year":"2020","journal-title":"Biomaterials"},{"key":"D5DT01704A\/cit117\/1","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1021\/acs.jmedchem.2c01684","volume":"66","author":"Yang","year":"2023","journal-title":"J. Med. Chem."},{"key":"D5DT01704A\/cit118\/1","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1039\/D4BM00650J","volume":"12","author":"Zhang","year":"2024","journal-title":"Biomater. Sci."},{"key":"D5DT01704A\/cit119\/1","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1039\/D4NR04210G","volume":"17","author":"Nsubuga","year":"2025","journal-title":"Nanoscale"},{"key":"D5DT01704A\/cit120\/1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1021\/acsabm.1c01041","volume":"5","author":"Kundu","year":"2021","journal-title":"ACS Appl. Bio Mater."},{"key":"D5DT01704A\/cit121\/1","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1039\/D3DT02940A","volume":"53","author":"Ishaniya","year":"2024","journal-title":"Dalton Trans."},{"key":"D5DT01704A\/cit122\/1","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1039\/D2DT03809A","volume":"52","author":"Wang","year":"2023","journal-title":"Dalton Trans."},{"key":"D5DT01704A\/cit123\/1","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1021\/acsanm.3c05145","volume":"7","author":"Wei","year":"2024","journal-title":"ACS Appl. Nano Mater."},{"key":"D5DT01704A\/cit124\/1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bmt.2023.09.001","volume":"5","author":"Elumalai","year":"2024","journal-title":"Biomed. Technol."},{"key":"D5DT01704A\/cit125\/1","doi-asserted-by":"crossref","first-page":"4746","DOI":"10.1039\/C6TB01070A","volume":"4","author":"Shi","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"D5DT01704A\/cit126\/1","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.coph.2012.04.006","volume":"12","author":"Lain\u00e9","year":"2012","journal-title":"Curr. Opin. Pharmacol."},{"key":"D5DT01704A\/cit127\/1","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.2174\/1381612825666190709221141","volume":"25","author":"Saravanakumar","year":"2019","journal-title":"Curr. Pharm. Des."},{"key":"D5DT01704A\/cit128\/1","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.3390\/molecules21121715","volume":"21","author":"Ding","year":"2016","journal-title":"Molecules"},{"key":"D5DT01704A\/cit129\/1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.17219\/acem\/186846","volume":"34","author":"Roszkowski","year":"2025","journal-title":"Adv. Clin. Exp. Med."},{"key":"D5DT01704A\/cit130\/1","doi-asserted-by":"crossref","first-page":"2407793","DOI":"10.1002\/adma.202407793","volume":"36","author":"Gao","year":"2024","journal-title":"Adv. Mater."},{"key":"D5DT01704A\/cit131\/1","doi-asserted-by":"crossref","first-page":"102363","DOI":"10.1016\/j.cbpa.2023.102363","volume":"76","author":"Wilson","year":"2023","journal-title":"Curr. Opin. Chem. Biol."},{"key":"D5DT01704A\/cit132\/1","doi-asserted-by":"crossref","first-page":"215579","DOI":"10.1016\/j.ccr.2023.215579","volume":"501","author":"Abdolmaleki","year":"2024","journal-title":"Coord. Chem. Rev."}],"container-title":["Dalton Transactions"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/DT\/D5DT01704A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:07:05Z","timestamp":1783015625000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/dt\/article\/54\/37\/13820-13850\/890110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":132,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2025,9,23]]}},"URL":"https:\/\/doi.org\/10.1039\/d5dt01704a","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5DT01704A\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1477-9226","1477-9234"],"issn-type":[{"value":"1477-9226","type":"print"},{"value":"1477-9234","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}