{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:06:52Z","timestamp":1787004412882,"version":"build-2736575974"},"reference-count":44,"publisher":"Royal Society of Chemistry (RSC)","issue":"21","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":279,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100010608","name":"Universit\u00e1 degli Studi di Urbino Carlo Bo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>\n                    The functional beverage obtained from\n                    <jats:italic>Prunus spinosa<\/jats:italic>\n                    L. drupes is naturally rich in phenolic compounds and exerts selective cytotoxicity against gastric cancer, without affecting the viability of healthy gastric epithelial cells.\n                  <\/jats:p>","DOI":"10.1039\/d5fo02227d","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T16:01:04Z","timestamp":1759852864000},"page":"8548-8563","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Blackthorn juice from central Italy exhibits selective anticancer activity by inducing apoptosis and autophagy in gastric carcinoma cells"],"prefix":"10.1039","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3525-1531","authenticated-orcid":false,"given":"Matteo","family":"Micucci","sequence":"first","affiliation":[{"name":"Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5530-877X","authenticated-orcid":false,"given":"Giovanni","family":"Caprioli","sequence":"additional","affiliation":[{"name":"Chemistry Interdisciplinary Project (ChIP), School of Pharmacy, University of Camerino, 62032 Camerino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Versari","sequence":"additional","affiliation":[{"name":"Department of Biomedical and NeuroMotor Sciences, University of Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Acquaticci","sequence":"additional","affiliation":[{"name":"Chemistry Interdisciplinary Project (ChIP), School of Pharmacy, University of Camerino, 62032 Camerino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Sagratini","sequence":"additional","affiliation":[{"name":"Chemistry Interdisciplinary Project (ChIP), School of Pharmacy, University of Camerino, 62032 Camerino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9696-7280","authenticated-orcid":false,"given":"Federico","family":"Gianfanti","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Onesimo","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Faenza","sequence":"additional","affiliation":[{"name":"Department of Biomedical and NeuroMotor Sciences, University of Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Burattini","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3763-3587","authenticated-orcid":false,"given":"Michele","family":"Mari","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0218-8505","authenticated-orcid":false,"given":"Michele","family":"Retini","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riham","family":"Osman","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Salucci","sequence":"additional","affiliation":[{"name":"Department of Biomedical and NeuroMotor Sciences, University of Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4028-0652","authenticated-orcid":false,"given":"Michela","family":"Battistelli","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5FO02227D\/cit1\/1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41571-023-00747-0","volume":"20","author":"Thrift","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"D5FO02227D\/cit2\/1","author":"European Cancer Information System","year":"2022","unstructured":"European Cancer Information System ,  2022"},{"key":"D5FO02227D\/cit3\/1","volume-title":"EU Country Cancer Profile","author":"OECD\/European Commission (2025)","year":"2025","unstructured":"OECD\/European Commission (2025) .  EU Country Cancer Profile ,  Italy ,  2025 , EU Country Cancer Profiles, OECD Publishing, Paris"},{"key":"D5FO02227D\/cit4\/1","doi-asserted-by":"crossref","first-page":"3798","DOI":"10.4251\/wjgo.v16.i9.3798","volume":"16","author":"Micucci","year":"2024","journal-title":"World J. Gastrointes. Oncol."},{"key":"D5FO02227D\/cit5\/1","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1097\/MEG.0000000000002643","volume":"35","author":"Bai","year":"2023","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"D5FO02227D\/cit6\/1","doi-asserted-by":"crossref","first-page":"102518","DOI":"10.1016\/j.canep.2023.102518","volume":"88","author":"De Ara\u00fajo Fagundes","year":"2024","journal-title":"Cancer Epidemiol."},{"key":"D5FO02227D\/cit7\/1","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.3390\/nu12113281","volume":"12","author":"Rub\u00edn-Garc\u00eda","year":"2020","journal-title":"Nutrients"},{"key":"D5FO02227D\/cit8\/1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.17344\/acsi.2023.8196","volume":"71","author":"D\u017eud\u017eevi\u0107-\u010can\u010dar","year":"2024","journal-title":"Acta Chim. Slov."},{"key":"D5FO02227D\/cit9\/1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/bcp.13496","volume":"84","author":"Santini","year":"2018","journal-title":"Br. J. Clin. Pharmacol."},{"key":"D5FO02227D\/cit10\/1","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1007\/s10495-022-01742-z","volume":"27","author":"Sritharan","year":"2022","journal-title":"Apoptosis"},{"key":"D5FO02227D\/cit11\/1","doi-asserted-by":"crossref","first-page":"16003","DOI":"10.3390\/ijms242116003","volume":"24","author":"Micucci","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D5FO02227D\/cit12\/1","doi-asserted-by":"crossref","first-page":"9603271211064534","DOI":"10.1177\/09603271211064534","volume":"41","author":"Cheshomi","year":"2022","journal-title":"Hum. Exp. Toxicol."},{"key":"D5FO02227D\/cit13\/1","doi-asserted-by":"crossref","first-page":"e70350","DOI":"10.1002\/fsn3.70350","volume":"13","author":"Micucci","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"D5FO02227D\/cit14\/1","doi-asserted-by":"crossref","first-page":"130743","DOI":"10.1016\/j.foodchem.2021.130743","volume":"367","author":"Mustafa","year":"2022","journal-title":"Food Chem."},{"key":"D5FO02227D\/cit15\/1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/jemt.22663","volume":"79","author":"Salucci","year":"2016","journal-title":"Microsc, Res, Tech."},{"key":"D5FO02227D\/cit16\/1","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.3390\/molecules27051691","volume":"27","author":"Magiera","year":"2022","journal-title":"Molecules"},{"key":"D5FO02227D\/cit17\/1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2298\/HEMIND130312054V","volume":"68","author":"Veli\u010dkovi\u0107","year":"2014","journal-title":"Hem. Ind."},{"key":"D5FO02227D\/cit18\/1","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1038\/nprot.2007.397","volume":"2","author":"Ferlini","year":"2017","journal-title":"Nat. Protoc."},{"key":"D5FO02227D\/cit19\/1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.mito.2011.01.010","volume":"11","author":"H\u00fcttemann","year":"2011","journal-title":"Mitochondrion"},{"key":"D5FO02227D\/cit20\/1","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/sj.cdd.4401950","volume":"13","author":"Garrido","year":"2006","journal-title":"Cell Death Differ."},{"key":"D5FO02227D\/cit21\/1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10120-014-0437-0","volume":"18","author":"Sjoquist","year":"2015","journal-title":"Gastric Cancer"},{"key":"D5FO02227D\/cit22\/1","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1186\/s12889-024-19104-6","volume":"24","author":"Lin","year":"2024","journal-title":"BMC Public Health"},{"key":"D5FO02227D\/cit23\/1","first-page":"1","volume":"86","author":"Yuan","year":"2025","journal-title":"Br. J. Hosp. Med."},{"key":"D5FO02227D\/cit24\/1","doi-asserted-by":"crossref","first-page":"e2134","DOI":"10.1002\/biof.2134","volume":"51","author":"Wiraswati","year":"2025","journal-title":"Biofactors"},{"key":"D5FO02227D\/cit25\/1","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.3390\/nu15081896","volume":"15","author":"Rudzi\u0144ska","year":"2023","journal-title":"Nutrients"},{"key":"D5FO02227D\/cit26\/1","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1080\/01635581.2022.2069274","volume":"74","author":"Ng","year":"2022","journal-title":"Nutr. Cancer"},{"key":"D5FO02227D\/cit27\/1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3892\/or.2022.8423","volume":"48","author":"Xi","year":"2022","journal-title":"Oncol. Rep."},{"key":"D5FO02227D\/cit28\/1","doi-asserted-by":"crossref","first-page":"1412565","DOI":"10.3389\/fphar.2024.1412565","volume":"15","author":"El Mahi","year":"2024","journal-title":"Front. Pharmacol."},{"key":"D5FO02227D\/cit29\/1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s12672-024-01281-w","volume":"15","author":"Huang","year":"2024","journal-title":"Discover Oncol."},{"key":"D5FO02227D\/cit30\/1","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.3390\/molecules21091264","volume":"21","author":"Olivas-Aguirre","year":"2016","journal-title":"Molecules"},{"key":"D5FO02227D\/cit31\/1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.2174\/1871520618666171219121449","volume":"18","author":"Jafari","year":"2018","journal-title":"Anticancer Agents Med. Chem."},{"key":"D5FO02227D\/cit32\/1","doi-asserted-by":"crossref","first-page":"115885","DOI":"10.1016\/j.jep.2022.115885","volume":"302","author":"Liao","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"D5FO02227D\/cit33\/1","first-page":"2057","volume":"38","author":"Tsai","year":"2018","journal-title":"Anticancer Res."},{"key":"D5FO02227D\/cit34\/1","doi-asserted-by":"crossref","first-page":"820","DOI":"10.3390\/nu2080820","volume":"2","author":"Del Rio","year":"2010","journal-title":"Nutrients"},{"key":"D5FO02227D\/cit35\/1","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1007\/s00204-013-1075-8","volume":"87","author":"Chang","year":"2013","journal-title":"Arch. Toxicol."},{"key":"D5FO02227D\/cit36\/1","volume-title":"Natural Products","author":"Faria","year":"2013","unstructured":"A.Faria ,  I.Fernandes ,  N.Mateus  and  C.Calhau ,  Bioavailability of Anthocyanins , in  Natural Products , ed.  K. Ramawat  and  J. M. M\u00e9rillon ,  Springer ,  Berlin, Heidelberg ,  2013"},{"key":"D5FO02227D\/cit37\/1","doi-asserted-by":"crossref","first-page":"132451","DOI":"10.1016\/j.foodchem.2022.132451","volume":"383","author":"Victoria-Campos","year":"2022","journal-title":"Food Chem."},{"key":"D5FO02227D\/cit38\/1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0014-5793(97)00467-5","volume":"409","author":"Manach","year":"1977","journal-title":"FEBS Lett."},{"key":"D5FO02227D\/cit39\/1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.freeradbiomed.2024.01.002","volume":"213","author":"Ding","year":"2024","journal-title":"Free Radicals Biol. Med."},{"key":"D5FO02227D\/cit40\/1","doi-asserted-by":"crossref","first-page":"e09309","DOI":"10.1016\/j.heliyon.2022.e09309","volume":"8","author":"Han","year":"2022","journal-title":"Heliyon"},{"key":"D5FO02227D\/cit41\/1","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1038\/cddis.2010.86","volume":"1","author":"McCoy","year":"2010","journal-title":"Cell Death Dis."},{"key":"D5FO02227D\/cit42\/1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1039\/C9NP00011A","volume":"36","author":"Caesar","year":"2019","journal-title":"Nat. Prod. Rep."},{"key":"D5FO02227D\/cit43\/1","doi-asserted-by":"crossref","first-page":"155743","DOI":"10.1016\/j.prp.2024.155743","volume":"265","author":"Vickram","year":"2025","journal-title":"Pathol., Res. Pract."},{"key":"D5FO02227D\/cit44\/1","doi-asserted-by":"crossref","first-page":"100812","DOI":"10.1016\/j.xgen.2025.100812","volume":"5","author":"Bian","year":"2025","journal-title":"Cell Genomics"}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/FO\/D5FO02227D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:58:24Z","timestamp":1782881904000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/16\/21\/8548-8563\/893151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":44,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2025,10,27]]}},"URL":"https:\/\/doi.org\/10.1039\/d5fo02227d","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5FO02227D\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO02227D\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO02227D\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO02227D\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO02227D\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO02227D\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}