{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T22:24:37Z","timestamp":1786487077030,"version":"build-2736575974"},"reference-count":50,"publisher":"Royal Society of Chemistry (RSC)","issue":"16","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"am","delay-in-days":562,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2023YFC2812400"],"award-info":[{"award-number":["2023YFC2812400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021QC177"],"award-info":[{"award-number":["ZR2021QC177"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024MH074"],"award-info":[{"award-number":["ZR2024MH074"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32202023"],"award-info":[{"award-number":["32202023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003447"],"award-info":[{"award-number":["82003447"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473617"],"award-info":[{"award-number":["82473617"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>KO exerts profound protective effects against sarcopenia in both a T2DM mouse model and a HG\/AGEs\/LPS-induced C2C12 myotube atrophy model.<\/jats:p>","DOI":"10.1039\/d5fo02415c","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T03:00:50Z","timestamp":1752721250000},"page":"6434-6447","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Krill oil alleviates type 2 diabetes mellitus-induced sarcopenia in mice\n                    <i>via<\/i>\n                    attenuating insulin resistance, intestinal barrier dysfunction, and skeletal muscle protein turnover impairment"],"prefix":"10.1039","volume":"16","author":[{"given":"Shi-Xiang","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Cheeloo College of Medicine, Shandong University, No. 44 Wenhuaxi Road, Jinan, Shandong, 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Yue","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Cheeloo College of Medicine, Shandong University, No. 44 Wenhuaxi Road, Jinan, Shandong, 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hong","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, Qilu University of Technology (Shandong Academy of Sciences), No. 3501 Daxue Road, Jinan, Shandong, 250353, China"},{"name":"Shandong Key Laboratory of Healthy Food Resources Exploration and Creation, No. 3501 Daxue Road, Jinan, Shandong, 250353, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Qing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Cheeloo College of Medicine, Shandong University, No. 44 Wenhuaxi Road, Jinan, Shandong, 250012, China"},{"name":"Suzhou Centers for Diseases Prevention and Control, No. 498 Qingyunbei Road, Suzhou, Anhui, 234000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Research Center of Translational Medicine, Central Hospital Affiliated to Shandong First Medical University, No. 105 Jiefang Road, Jinan, Shandong, 250013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Jian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Cheeloo College of Medicine, Shandong University, No. 44 Wenhuaxi Road, Jinan, Shandong, 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Yan","family":"Zou","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, Qilu University of Technology (Shandong Academy of Sciences), No. 3501 Daxue Road, Jinan, Shandong, 250353, China"},{"name":"Shandong Key Laboratory of Healthy Food Resources Exploration and Creation, No. 3501 Daxue Road, Jinan, Shandong, 250353, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5162-0408","authenticated-orcid":false,"given":"Tian-Tian","family":"Zhang","sequence":"additional","affiliation":[{"name":"SKL of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, No. 1299 Sansha Road, Qingdao, Shandong, 266404, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8173-5575","authenticated-orcid":false,"given":"Lei","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Cheeloo College of Medicine, Shandong University, No. 44 Wenhuaxi Road, Jinan, Shandong, 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5FO02415C\/cit1\/1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s11892-022-01453-4","volume":"22","author":"Ortiz-Mart\u00ednez","year":"2022","journal-title":"Curr. Diabetes Rep."},{"key":"D5FO02415C\/cit2\/1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrendo.2017.151","volume":"14","author":"Zheng","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"D5FO02415C\/cit3\/1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12933-021-01289-4","volume":"20","author":"Ceriello","year":"2021","journal-title":"Cardiovasc. Diabetol."},{"key":"D5FO02415C\/cit4\/1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13098-018-0326-5","volume":"10","author":"Trierweiler","year":"2018","journal-title":"Diabetol. Metab. Syndr."},{"key":"D5FO02415C\/cit5\/1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3390\/nu13010183","volume":"13","author":"Izzo","year":"2021","journal-title":"Nutrients"},{"key":"D5FO02415C\/cit6\/1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1900\/RDS.2022.18.157","volume":"18","author":"Purnamasari","year":"2022","journal-title":"Rev. Diabet. Stud."},{"key":"D5FO02415C\/cit7\/1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41572-024-00550-w","volume":"10","author":"Sayer","year":"2024","journal-title":"Nat. Rev. Dis. Prim."},{"key":"D5FO02415C\/cit8\/1","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.7150\/ijbs.27173","volume":"14","author":"Huang","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"D5FO02415C\/cit9\/1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/bph.15693","volume":"179","author":"Tang","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"D5FO02415C\/cit10\/1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.freeradbiomed.2016.02.021","volume":"98","author":"Powers","year":"2016","journal-title":"Free Radicals Biol. Med."},{"key":"D5FO02415C\/cit11\/1","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1096\/fj.09-151480","volume":"24","author":"Zheng","year":"2010","journal-title":"FASEB J."},{"key":"D5FO02415C\/cit12\/1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/jdi.12365","volume":"6","author":"Umegaki","year":"2015","journal-title":"J. Diabetes Invest."},{"key":"D5FO02415C\/cit13\/1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s12192-008-0062-0","volume":"13","author":"Frier","year":"2008","journal-title":"Cell Stress Chaperones"},{"key":"D5FO02415C\/cit14\/1","doi-asserted-by":"crossref","first-page":"115664","DOI":"10.1016\/j.bcp.2023.115664","volume":"214","author":"Zhang","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"D5FO02415C\/cit15\/1","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1111\/jdi.13014","volume":"10","author":"Mori","year":"2019","journal-title":"J. Diabetes Investig."},{"key":"D5FO02415C\/cit16\/1","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.2337\/db07-1403","volume":"57","author":"Cani","year":"2008","journal-title":"Diabetes"},{"key":"D5FO02415C\/cit17\/1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.2147\/VHRM.S85165","volume":"11","author":"Ulven","year":"2015","journal-title":"Vasc. Health Risk Manag."},{"key":"D5FO02415C\/cit18\/1","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/1541-4337.12427","volume":"18","author":"Xie","year":"2019","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"D5FO02415C\/cit19\/1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s12944-017-0601-8","volume":"16","author":"Sun","year":"2017","journal-title":"Lipids Health Dis."},{"key":"D5FO02415C\/cit20\/1","doi-asserted-by":"crossref","first-page":"e000107","DOI":"10.1136\/bmjdrc-2015-000107","volume":"3","author":"Lobraico","year":"2015","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"D5FO02415C\/cit21\/1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s40168-020-00843-8","volume":"8","author":"Liu","year":"2020","journal-title":"Microbiome"},{"key":"D5FO02415C\/cit22\/1","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1039\/D3FO04980A","volume":"15","author":"Liu","year":"2024","journal-title":"Food Funct."},{"key":"D5FO02415C\/cit23\/1","doi-asserted-by":"crossref","first-page":"9250018","DOI":"10.26599\/FSHW.2024.9250018","volume":"14","author":"Zhou","year":"2025","journal-title":"Food Sci. Hum. Wellness"},{"key":"D5FO02415C\/cit24\/1","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.clnu.2022.04.007","volume":"41","author":"Alkhedhairi","year":"2022","journal-title":"Clin. Nutr."},{"key":"D5FO02415C\/cit25\/1","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1007\/s00394-022-03077-6","volume":"62","author":"Yang","year":"2023","journal-title":"Eur. J. Nutr."},{"key":"D5FO02415C\/cit26\/1","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1039\/D0FO02632H","volume":"12","author":"Gao","year":"2021","journal-title":"Food Funct."},{"key":"D5FO02415C\/cit27\/1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3390\/md15030074","volume":"15","author":"Bonaterra","year":"2017","journal-title":"Mar. Drugs"},{"key":"D5FO02415C\/cit28\/1","doi-asserted-by":"crossref","first-page":"e2100321","DOI":"10.1002\/mnfr.202100321","volume":"65","author":"Yu","year":"2021","journal-title":"Mol. Nutr. Food Res."},{"key":"D5FO02415C\/cit29\/1","doi-asserted-by":"crossref","first-page":"R67","DOI":"10.1530\/JOE-15-0533","volume":"229","author":"Cleasby","year":"2016","journal-title":"J. Endocrinol."},{"key":"D5FO02415C\/cit30\/1","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.cmet.2021.03.020","volume":"33","author":"Sylow","year":"2021","journal-title":"Cell Metab."},{"key":"D5FO02415C\/cit31\/1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/j.2040-4603.2020.tb00136.x","volume":"10","author":"Merz","year":"2020","journal-title":"Compr. Physiol."},{"key":"D5FO02415C\/cit32\/1","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.3390\/nu13103519","volume":"13","author":"Nishikawa","year":"2021","journal-title":"Nutrients"},{"key":"D5FO02415C\/cit33\/1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S2213-8587(14)70034-8","volume":"2","author":"Kalyani","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"key":"D5FO02415C\/cit34\/1","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s00592-022-01883-2","volume":"59","author":"Giha","year":"2022","journal-title":"Acta Diabetol."},{"key":"D5FO02415C\/cit35\/1","doi-asserted-by":"crossref","first-page":"131547","DOI":"10.1016\/j.ijbiomac.2024.131547","volume":"268","author":"Li","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"D5FO02415C\/cit36\/1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s13668-024-00561-9","volume":"13","author":"Bayram","year":"2024","journal-title":"Curr. Nutr. Rep."},{"key":"D5FO02415C\/cit37\/1","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1161\/01.CIR.0000034509.14906.AE","volume":"106","author":"Esposito","year":"2002","journal-title":"Circulation"},{"key":"D5FO02415C\/cit38\/1","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.2174\/0929867326666181129095309","volume":"27","author":"Sharma","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"D5FO02415C\/cit39\/1","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1111\/febs.12338","volume":"280","author":"Mu\u00f1oz-C\u00e1noves","year":"2013","journal-title":"FEBS J."},{"key":"D5FO02415C\/cit40\/1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s00109-008-0308-4","volume":"86","author":"Mourkioti","year":"2008","journal-title":"J. Mol. Med."},{"key":"D5FO02415C\/cit41\/1","first-page":"e42178","volume":"15","author":"Agrawal","year":"2023","journal-title":"Cureus"},{"key":"D5FO02415C\/cit42\/1","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.3390\/ijms11041509","volume":"11","author":"Meng","year":"2010","journal-title":"Int. J. Mol. Sci."},{"key":"D5FO02415C\/cit43\/1","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3390\/biom12040542","volume":"12","author":"Khalid","year":"2022","journal-title":"Biomolecules"},{"key":"D5FO02415C\/cit44\/1","doi-asserted-by":"crossref","first-page":"111744","DOI":"10.1016\/j.mad.2022.111744","volume":"209","author":"Granic","year":"2023","journal-title":"Mech. Ageing Dev."},{"key":"D5FO02415C\/cit45\/1","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1002\/jcsm.12350","volume":"9","author":"Riuzzi","year":"2018","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"D5FO02415C\/cit46\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0126-x","volume":"50","author":"Chelakkot","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"D5FO02415C\/cit47\/1","doi-asserted-by":"crossref","first-page":"bvz039","DOI":"10.1210\/jendso\/bvz039","volume":"4","author":"Ghosh","year":"2020","journal-title":"J. Endocr. Soc."},{"key":"D5FO02415C\/cit48\/1","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3390\/microorganisms7120670","volume":"7","author":"Lopes da Silva","year":"2019","journal-title":"Microorganisms"},{"key":"D5FO02415C\/cit49\/1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1039\/D4FO04341C","volume":"16","author":"Wu","year":"2025","journal-title":"Food Funct."},{"key":"D5FO02415C\/cit50\/1","first-page":"2941","volume":"20","author":"Wong","year":"2020","journal-title":"Exp. Ther. Med."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/FO\/D5FO02415C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:02:46Z","timestamp":1782964966000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/16\/16\/6434-6447\/893168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":50,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2025,8,11]]}},"URL":"https:\/\/doi.org\/10.1039\/d5fo02415c","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5FO02415C\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO02415C\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO02415C\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO02415C\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO02415C\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO02415C\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO02415C\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO02415C\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO02415C\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}