{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:36:53Z","timestamp":1784673413162,"version":"3.55.0"},"reference-count":45,"publisher":"Royal Society of Chemistry (RSC)","issue":"4","license":[{"start":{"date-parts":[[2027,1,8]],"date-time":"2027-01-08T00:00:00Z","timestamp":1799366400000},"content-version":"am","delay-in-days":372,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32202057"],"award-info":[{"award-number":["32202057"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473610"],"award-info":[{"award-number":["82473610"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY23C200007"],"award-info":[{"award-number":["LY23C200007"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010097","name":"China Association for Science and Technology","doi-asserted-by":"publisher","award":["YESS20220066"],"award-info":[{"award-number":["YESS20220066"]}],"id":[{"id":"10.13039\/100010097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>Fish oil supplementation was associated with a lower risk of severe non-alcoholic fatty liver disease, mediated by C-reactive protein, HDL-C, and cystatin C, with no significant interactions between supplementation and genetic variants.<\/jats:p>","DOI":"10.1039\/d5fo02448j","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T14:40:55Z","timestamp":1767883255000},"page":"1876-1884","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of fish oil supplementation with risk of incident severe non-alcoholic fatty liver disease: a prospective study of 488\u2009888 individuals"],"prefix":"10.1039","volume":"17","author":[{"given":"Youyou","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Endocrinology, The Second Affiliated Hospital, Department of Nutrition, School of Public Health, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou 310058, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Ao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Second Affiliated Hospital, Department of Nutrition, School of Public Health, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou 310058, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Second Affiliated Hospital, Department of Nutrition, School of Public Health, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou 310058, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1202-3771","authenticated-orcid":false,"given":"Xiaohui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Second Affiliated Hospital, Department of Nutrition, School of Public Health, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou 310058, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Second Affiliated Hospital, Department of Nutrition, School of Public Health, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou 310058, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1025-906X","authenticated-orcid":false,"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Agri-food Resources and High-value Utilization, Department of Food Science and Nutrition, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4167-1567","authenticated-orcid":false,"given":"Jingjing","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Second Affiliated Hospital, Department of Nutrition, School of Public Health, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou 310058, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"2","key":"D5FO02448J\/cit1\/1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/03602532.2017.1293683","volume":"49","author":"Cobbina","year":"2017","journal-title":"Drug Metab. Rev."},{"issue":"1","key":"D5FO02448J\/cit2\/1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"issue":"4","key":"D5FO02448J\/cit3\/1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.5604\/01.3001.0012.0922","volume":"17","author":"Strey","year":"2018","journal-title":"Ann. Hepatol."},{"issue":"3","key":"D5FO02448J\/cit4\/1","doi-asserted-by":"crossref","first-page":"592S","DOI":"10.3945\/jn.111.155259","volume":"142","author":"Calder","year":"2012","journal-title":"J. Nutr."},{"key":"D5FO02448J\/cit5\/1","doi-asserted-by":"crossref","first-page":"g2272","DOI":"10.1136\/bmj.g2272","volume":"348","author":"Micha","year":"2014","journal-title":"Br. Med. J."},{"key":"D5FO02448J\/cit6\/1","doi-asserted-by":"crossref","first-page":"952451","DOI":"10.3389\/fnut.2022.952451","volume":"9","author":"Lu","year":"2022","journal-title":"Front. Nutr."},{"issue":"10","key":"D5FO02448J\/cit7\/1","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/ejcn.2010.139","volume":"64","author":"Oya","year":"2010","journal-title":"Eur. J. Clin. Nutr."},{"issue":"5","key":"D5FO02448J\/cit8\/1","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.jhep.2007.06.020","volume":"47","author":"Zelber-Sagi","year":"2007","journal-title":"J. Hepatol."},{"issue":"3","key":"D5FO02448J\/cit9\/1","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s00394-019-01953-2","volume":"59","author":"Chen","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"D5FO02448J\/cit10\/1","doi-asserted-by":"crossref","first-page":"876909","DOI":"10.3389\/fnut.2022.876909","volume":"9","author":"Tan","year":"2022","journal-title":"Front. Nutr."},{"issue":"6","key":"D5FO02448J\/cit11\/1","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1136\/gutjnl-2017-315940","volume":"68","author":"Alferink","year":"2019","journal-title":"Gut"},{"issue":"6","key":"D5FO02448J\/cit12\/1","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1002\/hep.30967","volume":"71","author":"Noureddin","year":"2020","journal-title":"Hepatology"},{"issue":"8","key":"D5FO02448J\/cit13\/1","first-page":"e68002","volume":"16","author":"Aziz","year":"2024","journal-title":"Cureus"},{"issue":"7","key":"D5FO02448J\/cit14\/1","doi-asserted-by":"crossref","first-page":"e1002193","DOI":"10.1371\/journal.pgen.1002193","volume":"7","author":"Lemaitre","year":"2011","journal-title":"PLoS Genet."},{"issue":"10","key":"D5FO02448J\/cit15\/1","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.cell.2021.04.015","volume":"184","author":"Loomba","year":"2021","journal-title":"Cell"},{"issue":"1","key":"D5FO02448J\/cit16\/1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/s12876-025-03924-w","volume":"25","author":"Xi","year":"2025","journal-title":"BMC Gastroenterol."},{"issue":"12","key":"D5FO02448J\/cit17\/1","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3390\/biomedicines8120625","volume":"8","author":"Di Costanzo","year":"2020","journal-title":"Biomedicines"},{"issue":"15","key":"D5FO02448J\/cit18\/1","first-page":"261","volume":"113","author":"Parhofer","year":"2016","journal-title":"Dtsch Arztebl Int"},{"issue":"7","key":"D5FO02448J\/cit19\/1","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.cgh.2013.08.014","volume":"12","author":"Corey","year":"2014","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"5","key":"D5FO02448J\/cit20\/1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.amjmed.2008.01.040","volume":"121","author":"Servais","year":"2008","journal-title":"Am. J. Med."},{"key":"D5FO02448J\/cit21\/1","doi-asserted-by":"crossref","first-page":"664100","DOI":"10.3389\/fphys.2021.664100","volume":"12","author":"Li","year":"2021","journal-title":"Front. Physiol."},{"issue":"7","key":"D5FO02448J\/cit22\/1","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.3390\/nu13072421","volume":"13","author":"Djuricic","year":"2021","journal-title":"Nutrients"},{"issue":"5","key":"D5FO02448J\/cit23\/1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1097\/MEG.0000000000002297","volume":"34","author":"Musazadeh","year":"2022","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"issue":"9822","key":"D5FO02448J\/cit24\/1","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/S0140-6736(12)60404-8","volume":"379","author":"Collins","year":"2012","journal-title":"Lancet"},{"issue":"3","key":"D5FO02448J\/cit25\/1","doi-asserted-by":"crossref","first-page":"e1001779","DOI":"10.1371\/journal.pmed.1001779","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med."},{"issue":"1","key":"D5FO02448J\/cit26\/1","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/hep.31726","volume":"74","author":"Hagstr\u00f6m","year":"2021","journal-title":"Hepatology"},{"key":"D5FO02448J\/cit27\/1","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1017\/jns.2017.66","volume":"7","author":"Bradbury","year":"2018","journal-title":"J. Nutr. Sci."},{"issue":"3","key":"D5FO02448J\/cit28\/1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.clnu.2022.01.002","volume":"41","author":"Liu","year":"2022","journal-title":"Clin. Nutr."},{"issue":"10","key":"D5FO02448J\/cit29\/1","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1093\/aje\/kwz165","volume":"188","author":"Greenwood","year":"2019","journal-title":"Am. J. Epidemiol."},{"issue":"3","key":"D5FO02448J\/cit30\/1","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s00394-019-01953-2","volume":"59","author":"Chen","year":"2020","journal-title":"Eur. J. Nutr."},{"issue":"5","key":"D5FO02448J\/cit31\/1","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1097\/MPG.0b013e3182a1df77","volume":"57","author":"St-Jules","year":"2013","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"issue":"6","key":"D5FO02448J\/cit32\/1","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1002\/hep4.1906","volume":"6","author":"\u0160m\u00edd","year":"2022","journal-title":"Hepatol. Commun."},{"issue":"7","key":"D5FO02448J\/cit33\/1","doi-asserted-by":"crossref","first-page":"e0133496","DOI":"10.1371\/journal.pone.0133496","volume":"10","author":"Qin","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"D5FO02448J\/cit34\/1","doi-asserted-by":"crossref","first-page":"e000871","DOI":"10.1136\/bmjdrc-2019-000871","volume":"8","author":"Green","year":"2020","journal-title":"BMJ Open Diab. Res. Care"},{"issue":"2","key":"D5FO02448J\/cit35\/1","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/hep.30429","volume":"70","author":"Khan","year":"2019","journal-title":"Hepatology"},{"issue":"4","key":"D5FO02448J\/cit36\/1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.cell.2013.01.041","volume":"152","author":"Johnson","year":"2013","journal-title":"Cell"},{"key":"D5FO02448J\/cit37\/1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fphar.2019.00040","volume":"10","author":"Bian","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"5","key":"D5FO02448J\/cit38\/1","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1042\/BST20160474","volume":"45","author":"Calder","year":"2017","journal-title":"Biochem. Soc. Trans."},{"issue":"2","key":"D5FO02448J\/cit39\/1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.metabol.2009.07.019","volume":"59","author":"Lee","year":"2010","journal-title":"Metabolism"},{"issue":"7","key":"D5FO02448J\/cit40\/1","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.3390\/ijms23073967","volume":"23","author":"Cho","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"D5FO02448J\/cit41\/1","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1111\/liv.14597","volume":"40","author":"Verwer","year":"2020","journal-title":"Liver Int."},{"issue":"10","key":"D5FO02448J\/cit42\/1","doi-asserted-by":"crossref","first-page":"634","DOI":"10.21037\/atm-19-4516","volume":"8","author":"Feng","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"D5FO02448J\/cit43\/1","doi-asserted-by":"crossref","first-page":"1039056","DOI":"10.3389\/fnut.2022.1039056","volume":"9","author":"Yang","year":"2022","journal-title":"Front. Nutr."},{"issue":"4","key":"D5FO02448J\/cit44\/1","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S0026-0495(00)80017-7","volume":"49","author":"Marmillot","year":"2000","journal-title":"Metabolism"},{"issue":"5","key":"D5FO02448J\/cit45\/1","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1002\/hep.27695","volume":"61","author":"Arendt","year":"2015","journal-title":"Hepatology"}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/FO\/D5FO02448J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:36:23Z","timestamp":1782851783000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/17\/4\/1876-1884\/893170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,2,23]]}},"URL":"https:\/\/doi.org\/10.1039\/d5fo02448j","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5FO02448J\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO02448J\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO02448J\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO02448J\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO02448J\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO02448J\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO02448J\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO02448J\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO02448J\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO02448J\/v2\/review1","asserted-by":"object"}]},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}