{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:52:29Z","timestamp":1788306749141,"version":"build-2803163510"},"reference-count":68,"publisher":"Royal Society of Chemistry (RSC)","issue":"1","license":[{"start":{"date-parts":[[2026,11,26]],"date-time":"2026-11-26T00:00:00Z","timestamp":1795651200000},"content-version":"am","delay-in-days":329,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304178"],"award-info":[{"award-number":["82304178"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>\n                    Oenothein B from Eucalyptus leaves exhibited great anti-inflammatory activity\n                    <jats:italic>In vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    , and ameliorated the symptoms of colitis mice by regulating fecal microbiota and metabolism.\n                  <\/jats:p>","DOI":"10.1039\/d5fo03016a","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T15:10:44Z","timestamp":1764169844000},"page":"133-149","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>In vitro<\/i>\n                    and\n                    <i>in vivo<\/i>\n                    anti-inflammatory activity of oenothein B from\n                    <i>Eucalyptus<\/i>\n                    leaves and its amelioration mechanism on colitis in mice by regulating fecal microbiota and metabolism"],"prefix":"10.1039","volume":"17","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science, South China Agricultural University, Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, Guangdong Research Center for Engineering Technology in Bioactive Natural Products, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Food Science, South China Agricultural University, Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, Guangdong Research Center for Engineering Technology in Bioactive Natural Products, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5674-6547","authenticated-orcid":false,"given":"Yunjiao","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Food Science, South China Agricultural University, Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, Guangdong Research Center for Engineering Technology in Bioactive Natural Products, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Food Science, South China Agricultural University, Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, Guangdong Research Center for Engineering Technology in Bioactive Natural Products, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6079-6299","authenticated-orcid":false,"given":"Ziyin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5FO03016A\/cit1\/1","doi-asserted-by":"crossref","first-page":"112630","DOI":"10.1016\/j.foodres.2023.112630","volume":"167","author":"Lu","year":"2023","journal-title":"Food Res. Int."},{"key":"D5FO03016A\/cit2\/1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41575-025-01038-y","volume":"22","author":"Tshikudi","year":"2025","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"D5FO03016A\/cit3\/1","doi-asserted-by":"crossref","first-page":"1172963","DOI":"10.3389\/fphar.2023.1172963","volume":"14","author":"Sun","year":"2023","journal-title":"Front. Pharmacol."},{"key":"D5FO03016A\/cit4\/1","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1093\/ibd\/izad058","volume":"29","author":"Herrera-deGuise","year":"2023","journal-title":"Inflamm. Bowel Dis."},{"key":"D5FO03016A\/cit5\/1","doi-asserted-by":"crossref","first-page":"142391","DOI":"10.1016\/j.foodchem.2024.142391","volume":"468","author":"Li","year":"2025","journal-title":"Food Chem."},{"key":"D5FO03016A\/cit6\/1","doi-asserted-by":"crossref","first-page":"7397","DOI":"10.1021\/acs.jafc.3c06883","volume":"72","author":"Yang","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"D5FO03016A\/cit7\/1","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1039\/D2FO02523J","volume":"14","author":"Zhou","year":"2023","journal-title":"Food Funct."},{"key":"D5FO03016A\/cit8\/1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tifs.2019.08.003","volume":"91","author":"Salehi","year":"2019","journal-title":"Trends Food Sci. Technol."},{"key":"D5FO03016A\/cit9\/1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s000110050639","volume":"49","author":"Hart","year":"2000","journal-title":"Inflammation Res."},{"key":"D5FO03016A\/cit10\/1","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1055\/s-0034-1372609","volume":"64","author":"Juergens","year":"2014","journal-title":"Drug Res."},{"key":"D5FO03016A\/cit11\/1","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1007\/s10787-023-01237-6","volume":"31","author":"Arooj","year":"2023","journal-title":"Inflammopharmacology"},{"key":"D5FO03016A\/cit12\/1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.71336\/jabs.927","volume":"16","author":"Belkhodja","year":"2022","journal-title":"J. Appl. Biol. Sci."},{"key":"D5FO03016A\/cit13\/1","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.3390\/ma15051982","volume":"15","author":"Almeida","year":"2022","journal-title":"Materials"},{"key":"D5FO03016A\/cit14\/1","first-page":"53","volume":"15","author":"Bencheikh","year":"2021","journal-title":"J. Appl. Biol. Sci."},{"key":"D5FO03016A\/cit15\/1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/jpn.12680","volume":"102","author":"Chen","year":"2018","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"D5FO03016A\/cit16\/1","doi-asserted-by":"crossref","first-page":"109302","DOI":"10.1016\/j.foodres.2020.109302","volume":"136","author":"Li","year":"2020","journal-title":"Food Res. Int."},{"key":"D5FO03016A\/cit17\/1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/10942912.2019.1573255","volume":"22","author":"Yuan","year":"2019","journal-title":"Int. J. Food Prop."},{"key":"D5FO03016A\/cit18\/1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ijbiomac.2014.07.046","volume":"72","author":"Giese","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"D5FO03016A\/cit19\/1","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.lwt.2014.08.007","volume":"60","author":"Smolskait\u0117","year":"2015","journal-title":"LWT \u2013 Food Sci. Technol."},{"key":"D5FO03016A\/cit20\/1","doi-asserted-by":"crossref","first-page":"138343","DOI":"10.1016\/j.ijbiomac.2024.138343","volume":"286","author":"Yin","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"D5FO03016A\/cit21\/1","doi-asserted-by":"crossref","first-page":"9157","DOI":"10.1039\/D0FO01635G","volume":"11","author":"Li","year":"2020","journal-title":"Food Funct."},{"key":"D5FO03016A\/cit22\/1","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1039\/C9FO02472G","volume":"11","author":"Chen","year":"2020","journal-title":"Food Funct."},{"key":"D5FO03016A\/cit23\/1","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1039\/p19900002735","volume":"37","author":"Hatano","year":"1990","journal-title":"J. Chem. Soc., Perkin Trans."},{"key":"D5FO03016A\/cit24\/1","doi-asserted-by":"crossref","first-page":"6754","DOI":"10.4049\/jimmunol.0901827","volume":"183","author":"Schepetkin","year":"2009","journal-title":"J. Immunol."},{"key":"D5FO03016A\/cit25\/1","doi-asserted-by":"crossref","first-page":"177390","DOI":"10.1016\/j.ejphar.2025.177390","volume":"995","author":"Zhao","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"D5FO03016A\/cit26\/1","doi-asserted-by":"crossref","first-page":"7153","DOI":"10.3390\/molecules28207153","volume":"28","author":"Elkolli","year":"2023","journal-title":"Molecules"},{"key":"D5FO03016A\/cit27\/1","doi-asserted-by":"crossref","first-page":"18214","DOI":"10.1038\/s41598-023-45480-x","volume":"13","author":"Taha","year":"2023","journal-title":"Sci. Rep."},{"key":"D5FO03016A\/cit28\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/7432797","volume":"2016","author":"Hussain","year":"2016","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"D5FO03016A\/cit29\/1","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1038\/s41598-023-28221-y","volume":"13","author":"Ali","year":"2023","journal-title":"Sci. Rep."},{"key":"D5FO03016A\/cit30\/1","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1007\/s00044-021-02806-6","volume":"30","author":"Qiujian","year":"2021","journal-title":"Med. Chem. Res."},{"key":"D5FO03016A\/cit31\/1","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1021\/np200756f","volume":"75","author":"Schmid","year":"2012","journal-title":"J. Nat. Prod."},{"key":"D5FO03016A\/cit32\/1","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1001\/jama.2023.15389","volume":"330","author":"Gros","year":"2023","journal-title":"J. Am. Med. Assoc."},{"key":"D5FO03016A\/cit33\/1","doi-asserted-by":"crossref","first-page":"6604","DOI":"10.3390\/molecules26216604","volume":"26","author":"Cao","year":"2021","journal-title":"Molecules"},{"key":"D5FO03016A\/cit34\/1","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.3390\/nu14051069","volume":"14","author":"Li","year":"2022","journal-title":"Nutrients"},{"key":"D5FO03016A\/cit35\/1","first-page":"185","volume-title":"Medicinal and nutritional importance of Eucalyptus camaldulensis in human health","author":"Syukri","year":"2024","unstructured":"D. M.Syukri  and  S.Singh ,  Medicinal and nutritional importance of Eucalyptus camaldulensis in human health ,  In Springer ,  2024 , pp.  185\u2013199"},{"key":"D5FO03016A\/cit36\/1","doi-asserted-by":"crossref","first-page":"155897","DOI":"10.1016\/j.phymed.2024.155897","volume":"132","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"key":"D5FO03016A\/cit37\/1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jnutbio.2018.03.005","volume":"57","author":"Ren","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"D5FO03016A\/cit38\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00394-024-03577-7","volume":"64","author":"Xiong","year":"2025","journal-title":"Eur. J. Nutr."},{"key":"D5FO03016A\/cit39\/1","doi-asserted-by":"crossref","first-page":"552","DOI":"10.3390\/molecules23030552","volume":"23","author":"Yoshida","year":"2018","journal-title":"Molecules"},{"key":"D5FO03016A\/cit40\/1","doi-asserted-by":"crossref","first-page":"116257","DOI":"10.1016\/j.foodres.2025.116257","volume":"209","author":"Yang","year":"2025","journal-title":"Food Res. Int."},{"key":"D5FO03016A\/cit41\/1","doi-asserted-by":"crossref","first-page":"3536","DOI":"10.1021\/acs.jafc.3c08050","volume":"72","author":"Zeng","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"D5FO03016A\/cit42\/1","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/apt.15375","volume":"50","author":"R\u00fchlemann","year":"2019","journal-title":"Aliment. Pharmacol. Ther."},{"key":"D5FO03016A\/cit43\/1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.trsl.2016.06.002","volume":"179","author":"Miyoshi","year":"2017","journal-title":"Transl. Res."},{"key":"D5FO03016A\/cit44\/1","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.3390\/ani10071154","volume":"10","author":"Dou","year":"2020","journal-title":"Animals"},{"key":"D5FO03016A\/cit45\/1","first-page":"1966","volume":"74","author":"Yin","year":"2025","journal-title":"J. Med. Microbiol."},{"key":"D5FO03016A\/cit46\/1","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.jcmgh.2023.08.002","volume":"16","author":"Umeda","year":"2023","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"D5FO03016A\/cit47\/1","doi-asserted-by":"crossref","first-page":"105646","DOI":"10.1016\/j.jff.2023.105646","volume":"107","author":"Yu","year":"2023","journal-title":"J. Funct. Foods"},{"key":"D5FO03016A\/cit48\/1","doi-asserted-by":"crossref","first-page":"103546","DOI":"10.1016\/j.fbio.2023.103546","volume":"57","author":"Li","year":"2024","journal-title":"Food Biosci."},{"key":"D5FO03016A\/cit49\/1","doi-asserted-by":"crossref","first-page":"142156","DOI":"10.1016\/j.foodchem.2024.142156","volume":"467","author":"Feng","year":"2025","journal-title":"Food Chem."},{"key":"D5FO03016A\/cit50\/1","doi-asserted-by":"crossref","first-page":"e32838","DOI":"10.1016\/j.heliyon.2024.e32838","volume":"10","author":"Arif","year":"2024","journal-title":"Heliyon"},{"key":"D5FO03016A\/cit51\/1","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.3390\/antiox11091716","volume":"11","author":"Leung","year":"2022","journal-title":"Antioxidants"},{"key":"D5FO03016A\/cit52\/1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41385-020-0296-4","volume":"14","author":"Iljazovic","year":"2021","journal-title":"Mucosal Immunol."},{"key":"D5FO03016A\/cit53\/1","doi-asserted-by":"crossref","first-page":"2200340","DOI":"10.1002\/mnfr.202200340","volume":"67","author":"Liu","year":"2023","journal-title":"Mol. Nutr. Food Res."},{"key":"D5FO03016A\/cit54\/1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.amjms.2021.04.011","volume":"362","author":"Lin","year":"2021","journal-title":"Am. J. Med. Sci."},{"key":"D5FO03016A\/cit55\/1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41563-019-0462-9","volume":"19","author":"Lee","year":"2020","journal-title":"Nat. Mater."},{"key":"D5FO03016A\/cit56\/1","doi-asserted-by":"crossref","first-page":"106706","DOI":"10.1016\/j.jff.2025.106706","volume":"126","author":"Chen","year":"2025","journal-title":"J. Funct. Foods"},{"key":"D5FO03016A\/cit57\/1","doi-asserted-by":"crossref","first-page":"8894","DOI":"10.1021\/acs.jafc.2c08897","volume":"71","author":"Yang","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"D5FO03016A\/cit58\/1","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.3390\/ijms20153683","volume":"20","author":"Wang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"D5FO03016A\/cit59\/1","doi-asserted-by":"crossref","first-page":"5205","DOI":"10.1073\/pnas.1218091110","volume":"110","author":"Murata","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5FO03016A\/cit60\/1","doi-asserted-by":"crossref","first-page":"112872","DOI":"10.1016\/j.jep.2020.112872","volume":"259","author":"Yuan","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"D5FO03016A\/cit61\/1","doi-asserted-by":"crossref","first-page":"10210","DOI":"10.1039\/D1FO02288A","volume":"12","author":"Li","year":"2021","journal-title":"Food Funct."},{"key":"D5FO03016A\/cit62\/1","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1007\/s10787-024-01455-6","volume":"32","author":"Niu","year":"2024","journal-title":"Inflammopharmacology"},{"key":"D5FO03016A\/cit63\/1","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s11101-023-09866-z","volume":"24","author":"Zhong","year":"2025","journal-title":"Phytochem. Rev."},{"key":"D5FO03016A\/cit64\/1","doi-asserted-by":"crossref","first-page":"902337","DOI":"10.3389\/fphar.2022.902337","volume":"13","author":"Xiao","year":"2022","journal-title":"Front. Pharmacol."},{"key":"D5FO03016A\/cit65\/1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1142\/S0192415X23500325","volume":"51","author":"Wu","year":"2023","journal-title":"Am. J. Chin. Med."},{"key":"D5FO03016A\/cit66\/1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.5217\/ir.2021.00054","volume":"20","author":"Bamba","year":"2022","journal-title":"Intest. Res."},{"key":"D5FO03016A\/cit67\/1","doi-asserted-by":"crossref","first-page":"1426049","DOI":"10.3389\/fphar.2024.1426049","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"D5FO03016A\/cit68\/1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrgastro.2017.119","volume":"15","author":"Jia","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/FO\/D5FO03016A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:12:54Z","timestamp":1782886374000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/17\/1\/133-149\/893227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,12]]}},"URL":"https:\/\/doi.org\/10.1039\/d5fo03016a","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5FO03016A\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO03016A\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO03016A\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO03016A\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO03016A\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO03016A\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO03016A\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO03016A\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO03016A\/v3\/decision1","asserted-by":"object"}]},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}