{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:47:37Z","timestamp":1790898457364,"version":"4.1.0"},"reference-count":57,"publisher":"Royal Society of Chemistry (RSC)","issue":"1","license":[{"start":{"date-parts":[[2026,11,15]],"date-time":"2026-11-15T00:00:00Z","timestamp":1794700800000},"content-version":"am","delay-in-days":318,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32402088"],"award-info":[{"award-number":["32402088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004862","name":"Zhejiang University of Science and Technology","doi-asserted-by":"publisher","award":["2024F701103P08"],"award-info":[{"award-number":["2024F701103P08"]}],"id":[{"id":"10.13039\/501100004862","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>Wheat peptides (WP) have been claimed to have the potential to regulate metabolism and effectively prevent\/mitigate gut microbiota dysbiosis.<\/jats:p>","DOI":"10.1039\/d5fo03412d","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T02:40:58Z","timestamp":1763174458000},"page":"288-303","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Amelioration of diet-induced hyperglycemia by wheat peptides in a multi-target manner: integrated modulation of inflammation, lipid metabolism, gut microbiota, and DPP-IV inhibition"],"prefix":"10.1039","volume":"17","author":[{"given":"Fei","family":"Shen","sequence":"first","affiliation":[{"name":"School of Biological and Chemical Engineering, Zhejiang University of Science & Technology, Hangzhou 310023, China"},{"name":"College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China"},{"name":"Beingmate (Hangzhou) Food Research Institute Co., Ltd, Hangzhou, 310000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Engineering, Zhejiang University of Science & Technology, Hangzhou 310023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishan","family":"Song","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, 650500, China"},{"name":"College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghua","family":"He","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Engineering, Zhejiang University of Science & Technology, Hangzhou 310023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Chu","sequence":"additional","affiliation":[{"name":"Beingmate (Hangzhou) Food Research Institute Co., Ltd, Hangzhou, 310000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5429-9824","authenticated-orcid":false,"given":"Minjie","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[{"name":"Hangzhou Kangyuan Food Science & Technology Co., Ltd, Hangzhou 310012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4162-1316","authenticated-orcid":false,"given":"Fengqin","family":"Feng","sequence":"additional","affiliation":[{"name":"College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9206-3715","authenticated-orcid":false,"given":"Hao","family":"Zhong","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5FO03412D\/cit1\/1","doi-asserted-by":"crossref","first-page":"107843","DOI":"10.1016\/j.diabres.2019.107843","volume":"157","author":"Saeedi","year":"2019","journal-title":"Diabetes Res. Clin. Pract."},{"key":"D5FO03412D\/cit2\/1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2021.12.012","volume":"34","author":"Klein","year":"2022","journal-title":"Cell Metab."},{"key":"D5FO03412D\/cit3\/1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1152\/physrev.00045.2011","volume":"93","author":"Forbes","year":"2013","journal-title":"Physiol. Rev."},{"key":"D5FO03412D\/cit4\/1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s10822-017-0009-6","volume":"31","author":"Cai","year":"2017","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"D5FO03412D\/cit5\/1","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s40257-021-00625-4","volume":"22","author":"Jedlowski","year":"2021","journal-title":"Am. J. Clin. Dermatol."},{"key":"D5FO03412D\/cit6\/1","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1021\/acs.jafc.1c07438","volume":"70","author":"Sato","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"D5FO03412D\/cit7\/1","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s10989-019-09890-8","volume":"26","author":"Mada","year":"2020","journal-title":"Int. J. Pept. Res. Ther."},{"key":"D5FO03412D\/cit8\/1","doi-asserted-by":"crossref","first-page":"5917","DOI":"10.1021\/acs.jafc.2c08835","volume":"71","author":"Wang","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"D5FO03412D\/cit9\/1","doi-asserted-by":"crossref","first-page":"5577","DOI":"10.1080\/10408398.2021.2021139","volume":"63","author":"Weng","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"D5FO03412D\/cit10\/1","doi-asserted-by":"crossref","first-page":"129473","DOI":"10.1016\/j.foodchem.2021.129473","volume":"354","author":"Rivero-Pino","year":"2021","journal-title":"Food Chem."},{"key":"D5FO03412D\/cit11\/1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.foodchem.2012.02.183","volume":"134","author":"Hatanaka","year":"2012","journal-title":"Food Chem."},{"key":"D5FO03412D\/cit12\/1","doi-asserted-by":"crossref","first-page":"107427","DOI":"10.1016\/j.fbio.2025.107427","volume":"72","author":"Liu","year":"2025","journal-title":"Food Biosci."},{"key":"D5FO03412D\/cit13\/1","doi-asserted-by":"crossref","first-page":"111948","DOI":"10.1016\/j.foodres.2022.111948","volume":"162","author":"Shen","year":"2022","journal-title":"Food Res. Int."},{"key":"D5FO03412D\/cit14\/1","doi-asserted-by":"crossref","first-page":"103208","DOI":"10.1016\/j.fbio.2023.103208","volume":"56","author":"Shen","year":"2023","journal-title":"Food Biosci."},{"key":"D5FO03412D\/cit15\/1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1039\/D2FO03059D","volume":"14","author":"Zhang","year":"2023","journal-title":"Food Funct."},{"key":"D5FO03412D\/cit16\/1","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1039\/D3FO03259K","volume":"15","author":"Shen","year":"2024","journal-title":"Food Funct."},{"key":"D5FO03412D\/cit17\/1","doi-asserted-by":"crossref","first-page":"106195","DOI":"10.1016\/j.fbio.2025.106195","volume":"66","author":"Shen","year":"2025","journal-title":"Food Biosci."},{"key":"D5FO03412D\/cit18\/1","doi-asserted-by":"crossref","first-page":"104476","DOI":"10.1016\/j.fbio.2024.104476","volume":"60","author":"Wang","year":"2024","journal-title":"Food Biosci."},{"key":"D5FO03412D\/cit19\/1","doi-asserted-by":"crossref","first-page":"106030","DOI":"10.1016\/j.fbio.2025.106030","volume":"67","author":"Lan","year":"2025","journal-title":"Food Biosci."},{"key":"D5FO03412D\/cit20\/1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4070\/kcj.2022.0210","volume":"53","author":"Kim","year":"2023","journal-title":"Korean Circ. J."},{"key":"D5FO03412D\/cit21\/1","first-page":"S1043276025001249","volume":"27","author":"Wang","year":"2025","journal-title":"Trends Endocrinol. Metab."},{"key":"D5FO03412D\/cit22\/1","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1080\/10286020.2025.2469690","volume":"27","author":"Peng","year":"2025","journal-title":"J. Asian Nat. Prod. Res."},{"key":"D5FO03412D\/cit23\/1","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.3390\/microorganisms8111715","volume":"8","author":"Stojanov","year":"2020","journal-title":"Microorganisms"},{"key":"D5FO03412D\/cit24\/1","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1039\/C7FO00165G","volume":"8","author":"Nongonierma","year":"2017","journal-title":"Food Funct."},{"key":"D5FO03412D\/cit25\/1","doi-asserted-by":"crossref","first-page":"105359","DOI":"10.1016\/j.fbio.2024.105359","volume":"62","author":"Pan","year":"2024","journal-title":"Food Bioscience"},{"key":"D5FO03412D\/cit26\/1","doi-asserted-by":"crossref","first-page":"104700","DOI":"10.1016\/j.jff.2021.104700","volume":"86","author":"Luo","year":"2021","journal-title":"J. Funct. Foods"},{"key":"D5FO03412D\/cit27\/1","doi-asserted-by":"crossref","first-page":"117181","DOI":"10.1016\/j.foodres.2025.117181","volume":"221","author":"Wang","year":"2025","journal-title":"Food Res. Int."},{"key":"D5FO03412D\/cit28\/1","doi-asserted-by":"crossref","first-page":"111803","DOI":"10.1016\/j.fct.2020.111803","volume":"146","author":"Xia","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"D5FO03412D\/cit29\/1","doi-asserted-by":"crossref","first-page":"1801417","DOI":"10.1002\/mnfr.201801417","volume":"63","author":"Zhao","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"D5FO03412D\/cit30\/1","doi-asserted-by":"crossref","first-page":"6066","DOI":"10.2174\/0929867328666210208182326","volume":"28","author":"Ganjali","year":"2021","journal-title":"Curr. Med. Chem."},{"key":"D5FO03412D\/cit31\/1","doi-asserted-by":"crossref","first-page":"101073","DOI":"10.1016\/j.ajpc.2025.101073","volume":"23","author":"Gluba-Sagr","year":"2025","journal-title":"Am. J. Prev. Cardiol."},{"key":"D5FO03412D\/cit32\/1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1152\/physrev.00024.2006","volume":"87","author":"Savage","year":"2007","journal-title":"Physiol. Rev."},{"key":"D5FO03412D\/cit33\/1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11892-018-1101-6","volume":"18","author":"Bjornstad","year":"2018","journal-title":"Curr. Diabetes Rep."},{"key":"D5FO03412D\/cit34\/1","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.4049\/jimmunol.170.3.1399","volume":"170","author":"Vreugdenhil","year":"2003","journal-title":"J. Immunol."},{"key":"D5FO03412D\/cit35\/1","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"D5FO03412D\/cit36\/1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1139\/apnm-2021-0378","volume":"47","author":"Makena","year":"2022","journal-title":"Appl. Physiol., Nutr., Metab."},{"key":"D5FO03412D\/cit37\/1","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1073\/pnas.1219451110","volume":"110","author":"Everard","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5FO03412D\/cit38\/1","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.1039\/D4FO00369A","volume":"15","author":"Wang","year":"2024","journal-title":"Food Funct."},{"key":"D5FO03412D\/cit39\/1","doi-asserted-by":"crossref","first-page":"106548","DOI":"10.1016\/j.jff.2024.106548","volume":"122","author":"Im","year":"2024","journal-title":"J. Funct. Foods"},{"key":"D5FO03412D\/cit40\/1","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.1039\/C8FO01967C","volume":"10","author":"Li","year":"2019","journal-title":"Food Funct."},{"key":"D5FO03412D\/cit41\/1","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1021\/acs.jafc.8b07109","volume":"67","author":"Han","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"D5FO03412D\/cit42\/1","doi-asserted-by":"crossref","first-page":"104194","DOI":"10.1016\/j.jff.2020.104194","volume":"74","author":"Wang","year":"2020","journal-title":"J. Funct. Foods"},{"key":"D5FO03412D\/cit43\/1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3390\/metabo15060411","volume":"15","author":"Mindrescu","year":"2025","journal-title":"Metabolites"},{"key":"D5FO03412D\/cit44\/1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nm.4236","volume":"23","author":"Plovier","year":"2017","journal-title":"Nat. Med."},{"key":"D5FO03412D\/cit45\/1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3389\/fcimb.2019.00239","volume":"9","author":"Zhai","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"D5FO03412D\/cit46\/1","doi-asserted-by":"crossref","first-page":"16850","DOI":"10.3390\/ijms242316850","volume":"24","author":"Sun","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D5FO03412D\/cit47\/1","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1093\/jn\/136.12.3005","volume":"136","author":"Hartz","year":"2006","journal-title":"J. Nutr."},{"key":"D5FO03412D\/cit48\/1","doi-asserted-by":"crossref","first-page":"e92647","DOI":"10.1371\/journal.pone.0092647","volume":"9","author":"Watanabe","year":"2014","journal-title":"PLoS One"},{"key":"D5FO03412D\/cit49\/1","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.3390\/nu11122866","volume":"11","author":"Chen","year":"2019","journal-title":"Nutrients"},{"key":"D5FO03412D\/cit50\/1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10522-020-09856-0","volume":"21","author":"Kim","year":"2020","journal-title":"Biogerontology"},{"key":"D5FO03412D\/cit51\/1","doi-asserted-by":"crossref","first-page":"e2400385121","DOI":"10.1073\/pnas.2400385121","volume":"121","author":"Du","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5FO03412D\/cit52\/1","doi-asserted-by":"crossref","first-page":"6874","DOI":"10.1073\/pnas.120069197","volume":"97","author":"Marguet","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5FO03412D\/cit53\/1","doi-asserted-by":"crossref","first-page":"6825","DOI":"10.1073\/pnas.0631828100","volume":"100","author":"Conarello","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5FO03412D\/cit54\/1","doi-asserted-by":"crossref","first-page":"10604","DOI":"10.1021\/acs.jafc.9b03164","volume":"67","author":"Zheng","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"D5FO03412D\/cit55\/1","doi-asserted-by":"crossref","first-page":"138370","DOI":"10.1016\/j.foodchem.2024.138370","volume":"441","author":"Xu","year":"2024","journal-title":"Food Chem."},{"key":"D5FO03412D\/cit56\/1","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1021\/acs.jafc.5b05429","volume":"64","author":"Zhang","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"D5FO03412D\/cit57\/1","doi-asserted-by":"crossref","first-page":"134232","DOI":"10.1016\/j.ijbiomac.2024.134232","volume":"277","author":"Xie","year":"2024","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/FO\/D5FO03412D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:26:33Z","timestamp":1782883593000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/17\/1\/288-303\/313660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,12]]}},"URL":"https:\/\/doi.org\/10.1039\/d5fo03412d","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5FO03412D\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO03412D\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO03412D\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO03412D\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO03412D\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO03412D\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO03412D\/v1\/review1","asserted-by":"object"}]},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}