{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:42:16Z","timestamp":1787870536044,"version":"build-2784847793"},"reference-count":56,"publisher":"Royal Society of Chemistry (RSC)","issue":"1","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["2025-67017-44988"],"award-info":[{"award-number":["2025-67017-44988"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007114","name":"Ralph W. and Grace M. Showalter Research Trust Fund","doi-asserted-by":"publisher","award":["41001324"],"award-info":[{"award-number":["41001324"]}],"id":[{"id":"10.13039\/100007114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006377","name":"Purdue University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>Hemp seed, as a whole-food dietary approach, confers protection against colitis by regulating macrophage polarization, preserving barrier integrity, and modulating gut microbiota.<\/jats:p>","DOI":"10.1039\/d5fo04119h","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T13:21:55Z","timestamp":1763990515000},"page":"231-242","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hemp seed mitigates colonic inflammation through macrophage polarization and microbiota-barrier axis restoration"],"prefix":"10.1039","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4715-4611","authenticated-orcid":false,"given":"Jieun","family":"Woo","sequence":"first","affiliation":[{"name":"Department of Food Science, Purdue University, West Lafayette, IN, USA"},{"name":"Interdepartmental Nutrition Graduate Program, Purdue University, West Lafayette, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dekun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Food Science, Purdue University, West Lafayette, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica A.","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, Purdue University, West Lafayette, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin L.","family":"Whitney","sequence":"additional","affiliation":[{"name":"Department of Food Science, Purdue University, West Lafayette, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyi","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Food Science, Purdue University, West Lafayette, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0473-4311","authenticated-orcid":false,"given":"Lavanya","family":"Reddivari","sequence":"additional","affiliation":[{"name":"Department of Food Science, Purdue University, West Lafayette, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Interdepartmental Nutrition Graduate Program, Purdue University, West Lafayette, IN, USA"},{"name":"Department of Nutrition Science, Purdue University, West Lafayette, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0238-5947","authenticated-orcid":false,"given":"Senay","family":"Simsek","sequence":"additional","affiliation":[{"name":"Department of Food Science, Purdue University, West Lafayette, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, Purdue University, West Lafayette, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2722-507X","authenticated-orcid":false,"given":"Weicang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Food Science, Purdue University, West Lafayette, IN, USA"},{"name":"Interdepartmental Nutrition Graduate Program, Purdue University, West Lafayette, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5FO04119H\/cit1\/1","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41586-025-08940-0","volume":"642","author":"Hracs","year":"2025","journal-title":"Nature"},{"key":"D5FO04119H\/cit2\/1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrgastro.2015.34","volume":"12","author":"Ananthakrishnan","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"D5FO04119H\/cit3\/1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000522039","volume":"103","author":"Okafuji","year":"2022","journal-title":"Digestion"},{"key":"D5FO04119H\/cit4\/1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.5217\/ir.2019.00084","volume":"18","author":"Mizuno","year":"2020","journal-title":"Intest. Res."},{"key":"D5FO04119H\/cit5\/1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/ecco-jcc\/jjz189","volume":"14","author":"Cruz-Lebron","year":"2020","journal-title":"J. Crohn\u2019s Colitis"},{"key":"D5FO04119H\/cit6\/1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/can.2020.0001","volume":"6","author":"Cerino","year":"2021","journal-title":"Cannabis Cannabinoid Res."},{"key":"D5FO04119H\/cit7\/1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s42238-022-00156-7","volume":"4","author":"Burton","year":"2022","journal-title":"J. Cannabis Res."},{"key":"D5FO04119H\/cit8\/1","doi-asserted-by":"crossref","first-page":"1669375","DOI":"10.3389\/fnut.2025.1669375","volume":"12","author":"Ka\u00e7ar","year":"2025","journal-title":"Front. Nutr."},{"key":"D5FO04119H\/cit9\/1","doi-asserted-by":"crossref","first-page":"104071","DOI":"10.1016\/j.jff.2020.104071","volume":"72","author":"Jurgo\u0144ski","year":"2020","journal-title":"J. Funct. Foods"},{"key":"D5FO04119H\/cit10\/1","doi-asserted-by":"crossref","first-page":"678421","DOI":"10.3389\/fnut.2021.678421","volume":"8","author":"Sun","year":"2021","journal-title":"Front. Nutr."},{"key":"D5FO04119H\/cit11\/1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10681-004-4811-6","volume":"140","author":"Callaway","year":"2004","journal-title":"Euphytica"},{"key":"D5FO04119H\/cit12\/1","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1021\/jf404278q","volume":"62","author":"Montserrat-de la Paz","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"D5FO04119H\/cit13\/1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3390\/antiox8100491","volume":"8","author":"Irakli","year":"2019","journal-title":"Antioxidants"},{"key":"D5FO04119H\/cit14\/1","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.3390\/app15042178","volume":"15","author":"Oarga","year":"2025","journal-title":"Appl. Sci."},{"key":"D5FO04119H\/cit15\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/01652176.2023.2260448","volume":"43","author":"Tufarelli","year":"2023","journal-title":"Vet. Q."},{"key":"D5FO04119H\/cit16\/1","doi-asserted-by":"crossref","first-page":"882455","DOI":"10.3389\/fimmu.2022.882455","volume":"13","author":"Necib","year":"2022","journal-title":"Front. Immunol."},{"key":"D5FO04119H\/cit17\/1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/jpn.13052","volume":"103","author":"Vispute","year":"2019","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"D5FO04119H\/cit18\/1","doi-asserted-by":"crossref","first-page":"8121","DOI":"10.1038\/s41598-023-35241-1","volume":"13","author":"Winders","year":"2023","journal-title":"Sci. Rep."},{"key":"D5FO04119H\/cit19\/1","doi-asserted-by":"crossref","first-page":"106962","DOI":"10.1016\/j.jff.2025.106962","volume":"131","author":"Yang","year":"2025","journal-title":"J. Funct. Foods"},{"key":"D5FO04119H\/cit20\/1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J."},{"key":"D5FO04119H\/cit21\/1","doi-asserted-by":"crossref","first-page":"eaan4116","DOI":"10.1126\/scitranslmed.aan4116","volume":"10","author":"Yang","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"D5FO04119H\/cit22\/1","doi-asserted-by":"crossref","first-page":"1690364","DOI":"10.1080\/19490976.2019.1690364","volume":"12","author":"Yang","year":"2020","journal-title":"Gut Microbes"},{"key":"D5FO04119H\/cit23\/1","doi-asserted-by":"crossref","first-page":"1103617","DOI":"10.3389\/fimmu.2023.1103617","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Immunol."},{"key":"D5FO04119H\/cit24\/1","doi-asserted-by":"crossref","first-page":"4306","DOI":"10.1007\/s10620-023-08122-w","volume":"68","author":"Dunleavy","year":"2023","journal-title":"Dig. Dis Sci."},{"key":"D5FO04119H\/cit25\/1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nri.2016.42","volume":"16","author":"Rooks","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"D5FO04119H\/cit26\/1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jfca.2014.11.004","volume":"39","author":"Vonapartis","year":"2015","journal-title":"J. Food Compos. Anal."},{"key":"D5FO04119H\/cit27\/1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.foodhyd.2014.08.001","volume":"43","author":"Malomo","year":"2015","journal-title":"Food Hydrocolloids"},{"key":"D5FO04119H\/cit28\/1","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.3390\/foods12183505","volume":"12","author":"Rizzo","year":"2023","journal-title":"Foods"},{"key":"D5FO04119H\/cit29\/1","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1039\/C7FO00465F","volume":"8","author":"Moura","year":"2017","journal-title":"Food Funct."},{"key":"D5FO04119H\/cit30\/1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12970-014-0061-8","volume":"11","author":"Cruzat","year":"2014","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"D5FO04119H\/cit31\/1","doi-asserted-by":"crossref","first-page":"108900","DOI":"10.1016\/j.foodhyd.2023.108900","volume":"143","author":"Julakanti","year":"2023","journal-title":"Food Hydrocolloids"},{"key":"D5FO04119H\/cit32\/1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ijbiomac.2019.05.082","volume":"135","author":"Wen","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"D5FO04119H\/cit33\/1","first-page":"1813798","volume":"2020","author":"Xue","year":"2020","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"D5FO04119H\/cit34\/1","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1002\/ptr.5623","volume":"30","author":"Smeriglio","year":"2016","journal-title":"Phytother. Res."},{"key":"D5FO04119H\/cit35\/1","doi-asserted-by":"crossref","first-page":"1390351","DOI":"10.3389\/fendo.2024.1390351","volume":"15","author":"Muro","year":"2024","journal-title":"Front. Endocrinol."},{"key":"D5FO04119H\/cit36\/1","first-page":"1297","volume":"21","author":"Lissner","year":"2015","journal-title":"Inflammatory Bowel Dis."},{"key":"D5FO04119H\/cit37\/1","doi-asserted-by":"crossref","first-page":"6078","DOI":"10.1038\/s41598-020-63143-z","volume":"10","author":"Horuluoglu","year":"2020","journal-title":"Sci. Rep."},{"key":"D5FO04119H\/cit38\/1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s12079-022-00695-x","volume":"17","author":"Shahini","year":"2023","journal-title":"J. Cell Commun. Signaling"},{"key":"D5FO04119H\/cit39\/1","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1002\/ibd.20148","volume":"13","author":"Mudter","year":"2007","journal-title":"Inflammatory Bowel Dis."},{"key":"D5FO04119H\/cit40\/1","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.3390\/foods11152366","volume":"11","author":"Claro-Cala","year":"2022","journal-title":"Foods"},{"key":"D5FO04119H\/cit41\/1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S2468-1253(24)00390-X","volume":"10","author":"Neurath","year":"2025","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"D5FO04119H\/cit42\/1","doi-asserted-by":"crossref","first-page":"9955","DOI":"10.3390\/ijms23179955","volume":"23","author":"Eom","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"D5FO04119H\/cit43\/1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12964-021-00771-6","volume":"19","author":"Guo","year":"2021","journal-title":"Cell Commun. Signaling"},{"key":"D5FO04119H\/cit44\/1","doi-asserted-by":"crossref","first-page":"31649","DOI":"10.1038\/srep31649","volume":"6","author":"Kumar","year":"2016","journal-title":"Sci. Rep."},{"key":"D5FO04119H\/cit45\/1","first-page":"270","volume":"21","author":"Alshehri","year":"2021","journal-title":"Bosnian J. Basic Med. Sci."},{"key":"D5FO04119H\/cit46\/1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ccell.2022.02.014","volume":"40","author":"Matson","year":"2022","journal-title":"Cancer Cell"},{"key":"D5FO04119H\/cit47\/1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41569-021-00537-0","volume":"18","author":"Fernandez-Ruiz","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"D5FO04119H\/cit48\/1","doi-asserted-by":"crossref","first-page":"6359","DOI":"10.1002\/jsfa.13370","volume":"104","author":"Dasriya","year":"2024","journal-title":"J. Sci. Food Agric."},{"key":"D5FO04119H\/cit49\/1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s13668-024-00539-7","volume":"13","author":"Ayten","year":"2024","journal-title":"Curr. Nutr. Rep."},{"key":"D5FO04119H\/cit50\/1","doi-asserted-by":"crossref","first-page":"13593","DOI":"10.1021\/acs.jafc.4c00365","volume":"72","author":"Han","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"D5FO04119H\/cit51\/1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/den.12553","volume":"28","author":"Tamaki","year":"2016","journal-title":"Dig. Endosc."},{"key":"D5FO04119H\/cit52\/1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/ajg.2009.581","volume":"105","author":"Nguyen","year":"2010","journal-title":"Am. J. Gastroenterol."},{"key":"D5FO04119H\/cit53\/1","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s00203-022-03294-x","volume":"204","author":"Devi","year":"2022","journal-title":"Arch. Microbiol."},{"key":"D5FO04119H\/cit54\/1","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1136\/gutjnl-2024-334604","volume":"74","author":"Sun","year":"2025","journal-title":"Gut"},{"key":"D5FO04119H\/cit55\/1","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.chom.2024.04.020","volume":"32","author":"Li","year":"2024","journal-title":"Cell Host Microbe"},{"key":"D5FO04119H\/cit56\/1","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1038\/s41598-023-27726-w","volume":"13","author":"Nissen","year":"2023","journal-title":"Sci. Rep."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/FO\/D5FO04119H","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/FO\/D5FO04119H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:17:01Z","timestamp":1782886621000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/17\/1\/231-242\/313693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,12]]}},"URL":"https:\/\/doi.org\/10.1039\/d5fo04119h","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5FO04119H\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04119H\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04119H\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04119H\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04119H\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04119H\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}