{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:06:46Z","timestamp":1782889606222,"version":"3.54.5"},"reference-count":41,"publisher":"Royal Society of Chemistry (RSC)","issue":"5","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":43,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673666"],"award-info":[{"award-number":["81673666"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073861"],"award-info":[{"award-number":["82073861"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174049"],"award-info":[{"award-number":["82174049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574423"],"award-info":[{"award-number":["82574423"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>Arctigenin enhances the autophagic degradation of paxillin by reducing excitatory amino acid transport to promote focal adhesion disassembly in colonic epithelial cells, thereby facilitating mucosal healing in the context of ulcerative colitis.<\/jats:p>","DOI":"10.1039\/d5fo04195c","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T14:53:05Z","timestamp":1770994385000},"page":"2311-2326","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Arctigenin, a natural ER\u03b2 ligand occurring in edible burdock, accelerates focal adhesion disassembly of colon epithelial cells\n                    <i>via<\/i>\n                    enhancing autophagic degradation of paxillin to facilitate mucosal healing in ulcerative colitis"],"prefix":"10.1039","volume":"17","author":[{"given":"Mianjiang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Long Mian Avenue, Nanjing 211198, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Long Mian Avenue, Nanjing 211198, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Long Mian Avenue, Nanjing 211198, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Long Mian Avenue, Nanjing 211198, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifeng","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Long Mian Avenue, Nanjing 211198, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4872-2064","authenticated-orcid":false,"given":"Yue","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Long Mian Avenue, Nanjing 211198, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Long Mian Avenue, Nanjing 211198, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5FO04195C\/cit1\/1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","volume":"402","author":"Le Berre","year":"2023","journal-title":"Lancet"},{"key":"D5FO04195C\/cit2\/1","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.tips.2024.08.003","volume":"45","author":"Wangchuk","year":"2024","journal-title":"Trends Pharmacol. Sci."},{"key":"D5FO04195C\/cit3\/1","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1002\/ueg2.12671","volume":"12","author":"Parigi","year":"2024","journal-title":"United Eur. Gastroenterol. J."},{"key":"D5FO04195C\/cit4\/1","doi-asserted-by":"crossref","first-page":"1298186","DOI":"10.3389\/fimmu.2023.1298186","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Immunol."},{"key":"D5FO04195C\/cit5\/1","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1080\/03007995.2022.2081453","volume":"38","author":"Pandey","year":"2022","journal-title":"Curr. Med. Res. Opin."},{"key":"D5FO04195C\/cit6\/1","doi-asserted-by":"crossref","first-page":"113544","DOI":"10.1016\/j.intimp.2024.113544","volume":"144","author":"Mansouri","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"D5FO04195C\/cit7\/1","doi-asserted-by":"crossref","first-page":"17562848221092597","DOI":"10.1177\/17562848221092597","volume":"15","author":"Lin","year":"2022","journal-title":"Ther. Adv. Gastroenterol."},{"key":"D5FO04195C\/cit8\/1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41575-022-00604-y","volume":"19","author":"Villablanca","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"D5FO04195C\/cit9\/1","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/mi.2015.63","volume":"8","author":"Leoni","year":"2015","journal-title":"Mucosal Immunol."},{"key":"D5FO04195C\/cit10\/1","doi-asserted-by":"crossref","first-page":"102152","DOI":"10.1016\/j.ceb.2023.102152","volume":"80","author":"Mavrakis","year":"2023","journal-title":"Curr. Opin. Cell Biol."},{"key":"D5FO04195C\/cit11\/1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nature14323","volume":"519","author":"Vitorino","year":"2015","journal-title":"Nature"},{"key":"D5FO04195C\/cit12\/1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12964-020-00629-3","volume":"18","author":"Valdivia","year":"2020","journal-title":"Cell Commun. Signaling"},{"key":"D5FO04195C\/cit13\/1","doi-asserted-by":"crossref","first-page":"7173","DOI":"10.1002\/jcp.26546","volume":"233","author":"He","year":"2018","journal-title":"J. Cell Physiol."},{"key":"D5FO04195C\/cit14\/1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/s41556-022-00886-z","volume":"24","author":"Chen","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"D5FO04195C\/cit15\/1","doi-asserted-by":"crossref","first-page":"131035","DOI":"10.1016\/j.ijbiomac.2024.131035","volume":"265","author":"Li","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"D5FO04195C\/cit16\/1","doi-asserted-by":"crossref","first-page":"154647","DOI":"10.1016\/j.phymed.2023.154647","volume":"110","author":"Wang","year":"2023","journal-title":"Phytomedicine"},{"key":"D5FO04195C\/cit17\/1","doi-asserted-by":"crossref","first-page":"111552","DOI":"10.1016\/j.intimp.2024.111552","volume":"128","author":"Guo","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"D5FO04195C\/cit18\/1","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.apsb.2022.09.020","volume":"13","author":"Chen","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"D5FO04195C\/cit19\/1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/pro.4014","volume":"30","author":"Zhu","year":"2021","journal-title":"Protein Sci."},{"key":"D5FO04195C\/cit20\/1","doi-asserted-by":"crossref","first-page":"e202209027","DOI":"10.1083\/jcb.202209027","volume":"223","author":"Liang","year":"2024","journal-title":"J. Cell Biol."},{"key":"D5FO04195C\/cit21\/1","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/s41423-021-00662-3","volume":"18","author":"Metur","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"D5FO04195C\/cit22\/1","doi-asserted-by":"crossref","first-page":"815279","DOI":"10.3389\/fncel.2021.815279","volume":"15","author":"Kovermann","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"D5FO04195C\/cit23\/1","doi-asserted-by":"crossref","first-page":"655731","DOI":"10.3389\/fcell.2021.655731","volume":"9","author":"Deleyto-Seldas","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"D5FO04195C\/cit24\/1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1210\/endrev\/bnac017","volume":"44","author":"Chakraborty","year":"2023","journal-title":"Endocr. Rev."},{"key":"D5FO04195C\/cit25\/1","doi-asserted-by":"crossref","first-page":"113207","DOI":"10.1016\/j.ecoenv.2022.113207","volume":"231","author":"Wen","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"D5FO04195C\/cit26\/1","doi-asserted-by":"crossref","first-page":"e2202737","DOI":"10.1002\/adhm.202202737","volume":"12","author":"Li","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"D5FO04195C\/cit27\/1","doi-asserted-by":"crossref","first-page":"111931","DOI":"10.1016\/j.biopha.2021.111931","volume":"141","author":"Chang","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"D5FO04195C\/cit28\/1","doi-asserted-by":"crossref","first-page":"1016578","DOI":"10.3389\/fimmu.2022.1016578","volume":"13","author":"Ge","year":"2022","journal-title":"Front. Immunol."},{"key":"D5FO04195C\/cit29\/1","doi-asserted-by":"crossref","first-page":"1429427","DOI":"10.3389\/fmed.2024.1429427","volume":"11","author":"Jin","year":"2024","journal-title":"Front. Med."},{"key":"D5FO04195C\/cit30\/1","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1007\/s00535-023-02013-7","volume":"58","author":"Parkes","year":"2023","journal-title":"J. Gastroenterol."},{"key":"D5FO04195C\/cit31\/1","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1136\/gutjnl-2023-329964","volume":"72","author":"Neurath","year":"2023","journal-title":"Gut"},{"key":"D5FO04195C\/cit32\/1","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1053\/j.gastro.2021.08.047","volume":"161","author":"Kuo","year":"2021","journal-title":"Gastroenterology"},{"key":"D5FO04195C\/cit33\/1","doi-asserted-by":"crossref","first-page":"e1011500","DOI":"10.1371\/journal.pcbi.1011500","volume":"19","author":"Honasoge","year":"2023","journal-title":"PLoS Comput. Biol."},{"key":"D5FO04195C\/cit34\/1","doi-asserted-by":"crossref","first-page":"110046","DOI":"10.1016\/j.cellsig.2021.110046","volume":"85","author":"Mishra","year":"2021","journal-title":"Cell. Signalling"},{"key":"D5FO04195C\/cit35\/1","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1042\/CS20201528","volume":"135","author":"Ribeiro-Silva","year":"2021","journal-title":"Clin. Sci."},{"key":"D5FO04195C\/cit36\/1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41580-023-00585-z","volume":"24","author":"Debnath","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"D5FO04195C\/cit37\/1","doi-asserted-by":"crossref","first-page":"753092","DOI":"10.3389\/fimmu.2021.753092","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Immunol."},{"key":"D5FO04195C\/cit38\/1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3390\/jpm13020165","volume":"13","author":"Lungaro","year":"2023","journal-title":"J. Pers. Med."},{"key":"D5FO04195C\/cit39\/1","doi-asserted-by":"crossref","first-page":"1756284820915043","DOI":"10.1177\/1756284820915043","volume":"13","author":"Rustgi","year":"2020","journal-title":"Ther. Adv. Gastroenterol."},{"key":"D5FO04195C\/cit40\/1","doi-asserted-by":"crossref","first-page":"120149","DOI":"10.1016\/j.biomaterials.2020.120149","volume":"255","author":"Ahn","year":"2020","journal-title":"Biomaterials"},{"key":"D5FO04195C\/cit41\/1","doi-asserted-by":"crossref","first-page":"4314","DOI":"10.3390\/ijms21124314","volume":"21","author":"Aryan","year":"2020","journal-title":"Int. J. Mol. Sci."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/FO\/D5FO04195C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:30:34Z","timestamp":1782883834000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/17\/5\/2311-2326\/311734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,3,9]]}},"URL":"https:\/\/doi.org\/10.1039\/d5fo04195c","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5FO04195C\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04195C\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04195C\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04195C\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04195C\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04195C\/v1\/review1","asserted-by":"object"}]},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}